JP2010511704A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2010511704A5 JP2010511704A5 JP2009540246A JP2009540246A JP2010511704A5 JP 2010511704 A5 JP2010511704 A5 JP 2010511704A5 JP 2009540246 A JP2009540246 A JP 2009540246A JP 2009540246 A JP2009540246 A JP 2009540246A JP 2010511704 A5 JP2010511704 A5 JP 2010511704A5
- Authority
- JP
- Japan
- Prior art keywords
- formula
- metal ion
- group
- represented
- substituent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 229910021645 metal ion Inorganic materials 0.000 claims 44
- 125000001424 substituent group Chemical group 0.000 claims 27
- 125000003118 aryl group Chemical group 0.000 claims 20
- 150000001875 compounds Chemical class 0.000 claims 19
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 claims 16
- 229910052739 hydrogen Inorganic materials 0.000 claims 16
- 239000001257 hydrogen Substances 0.000 claims 16
- -1 —NH 2 Inorganic materials 0.000 claims 16
- 239000000203 mixture Substances 0.000 claims 15
- CYRMSUTZVYGINF-UHFFFAOYSA-N trichlorofluoromethane Chemical compound FC(Cl)(Cl)Cl CYRMSUTZVYGINF-UHFFFAOYSA-N 0.000 claims 15
- ZOXJGFHDIHLPTG-UHFFFAOYSA-N Boron Chemical group [B] ZOXJGFHDIHLPTG-UHFFFAOYSA-N 0.000 claims 12
- 229910052736 halogen Inorganic materials 0.000 claims 11
- 150000002367 halogens Chemical class 0.000 claims 11
- 125000002877 alkyl aryl group Chemical group 0.000 claims 10
- 125000006615 aromatic heterocyclic group Chemical group 0.000 claims 10
- 125000003710 aryl alkyl group Chemical group 0.000 claims 10
- 125000002837 carbocyclic group Chemical group 0.000 claims 10
- 125000004432 carbon atom Chemical group C* 0.000 claims 10
- 125000001183 hydrocarbyl group Chemical group 0.000 claims 10
- 206010028980 Neoplasm Diseases 0.000 claims 9
- PXHVJJICTQNCMI-UHFFFAOYSA-N Nickel Chemical compound [Ni] PXHVJJICTQNCMI-UHFFFAOYSA-N 0.000 claims 8
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 8
- 150000002431 hydrogen Chemical class 0.000 claims 8
- 229910052760 oxygen Inorganic materials 0.000 claims 8
- 239000001301 oxygen Substances 0.000 claims 8
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 8
- 230000002902 bimodal effect Effects 0.000 claims 7
- 201000011510 cancer Diseases 0.000 claims 7
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 claims 6
- FTJHKZQHQDKPFJ-UHFFFAOYSA-N (carbamoylamino)carbamic acid Chemical compound NC(=O)NNC(O)=O FTJHKZQHQDKPFJ-UHFFFAOYSA-N 0.000 claims 5
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 5
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims 5
- 125000003545 alkoxy group Chemical group 0.000 claims 5
- 125000003368 amide group Chemical group 0.000 claims 5
- 229910052799 carbon Inorganic materials 0.000 claims 5
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 5
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 5
- 229920000233 poly(alkylene oxides) Polymers 0.000 claims 5
- 229910052717 sulfur Chemical group 0.000 claims 5
- 239000011593 sulfur Chemical group 0.000 claims 5
- VYZAMTAEIAYCRO-UHFFFAOYSA-N Chromium Chemical compound [Cr] VYZAMTAEIAYCRO-UHFFFAOYSA-N 0.000 claims 4
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 claims 4
- 229910052688 Gadolinium Inorganic materials 0.000 claims 4
- KJTLSVCANCCWHF-UHFFFAOYSA-N Ruthenium Chemical compound [Ru] KJTLSVCANCCWHF-UHFFFAOYSA-N 0.000 claims 4
- ATJFFYVFTNAWJD-UHFFFAOYSA-N Tin Chemical compound [Sn] ATJFFYVFTNAWJD-UHFFFAOYSA-N 0.000 claims 4
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 claims 4
- 229910052788 barium Inorganic materials 0.000 claims 4
- DSAJWYNOEDNPEQ-UHFFFAOYSA-N barium atom Chemical compound [Ba] DSAJWYNOEDNPEQ-UHFFFAOYSA-N 0.000 claims 4
- 229910052804 chromium Inorganic materials 0.000 claims 4
- 239000011651 chromium Substances 0.000 claims 4
- 229910017052 cobalt Inorganic materials 0.000 claims 4
- 239000010941 cobalt Substances 0.000 claims 4
- GUTLYIVDDKVIGB-UHFFFAOYSA-N cobalt atom Chemical compound [Co] GUTLYIVDDKVIGB-UHFFFAOYSA-N 0.000 claims 4
- 229910052802 copper Inorganic materials 0.000 claims 4
- 239000010949 copper Substances 0.000 claims 4
- UIWYJDYFSGRHKR-UHFFFAOYSA-N gadolinium atom Chemical compound [Gd] UIWYJDYFSGRHKR-UHFFFAOYSA-N 0.000 claims 4
- 229910052732 germanium Inorganic materials 0.000 claims 4
- GNPVGFCGXDBREM-UHFFFAOYSA-N germanium atom Chemical compound [Ge] GNPVGFCGXDBREM-UHFFFAOYSA-N 0.000 claims 4
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 claims 4
- 229910052737 gold Inorganic materials 0.000 claims 4
- 239000010931 gold Substances 0.000 claims 4
- 238000003384 imaging method Methods 0.000 claims 4
- 229910052738 indium Inorganic materials 0.000 claims 4
- APFVFJFRJDLVQX-UHFFFAOYSA-N indium atom Chemical compound [In] APFVFJFRJDLVQX-UHFFFAOYSA-N 0.000 claims 4
- 229910052742 iron Inorganic materials 0.000 claims 4
- WPBNNNQJVZRUHP-UHFFFAOYSA-L manganese(2+);methyl n-[[2-(methoxycarbonylcarbamothioylamino)phenyl]carbamothioyl]carbamate;n-[2-(sulfidocarbothioylamino)ethyl]carbamodithioate Chemical group [Mn+2].[S-]C(=S)NCCNC([S-])=S.COC(=O)NC(=S)NC1=CC=CC=C1NC(=S)NC(=O)OC WPBNNNQJVZRUHP-UHFFFAOYSA-L 0.000 claims 4
- 229910052759 nickel Inorganic materials 0.000 claims 4
- 238000002600 positron emission tomography Methods 0.000 claims 4
- 229910052707 ruthenium Inorganic materials 0.000 claims 4
- 238000002603 single-photon emission computed tomography Methods 0.000 claims 4
- 229910052713 technetium Inorganic materials 0.000 claims 4
- GKLVYJBZJHMRIY-UHFFFAOYSA-N technetium atom Chemical compound [Tc] GKLVYJBZJHMRIY-UHFFFAOYSA-N 0.000 claims 4
- 229910052718 tin Inorganic materials 0.000 claims 4
- WFKWXMTUELFFGS-UHFFFAOYSA-N tungsten Chemical compound [W] WFKWXMTUELFFGS-UHFFFAOYSA-N 0.000 claims 4
- 229910052721 tungsten Inorganic materials 0.000 claims 4
- 239000010937 tungsten Substances 0.000 claims 4
- 229910052720 vanadium Inorganic materials 0.000 claims 4
- GPPXJZIENCGNKB-UHFFFAOYSA-N vanadium Chemical group [V]#[V] GPPXJZIENCGNKB-UHFFFAOYSA-N 0.000 claims 4
- 229910052727 yttrium Inorganic materials 0.000 claims 4
- VWQVUPCCIRVNHF-UHFFFAOYSA-N yttrium atom Chemical compound [Y] VWQVUPCCIRVNHF-UHFFFAOYSA-N 0.000 claims 4
- 229910052725 zinc Inorganic materials 0.000 claims 4
- 239000011701 zinc Substances 0.000 claims 4
- 150000001768 cations Chemical class 0.000 claims 3
- 238000002595 magnetic resonance imaging Methods 0.000 claims 3
- 238000000034 method Methods 0.000 claims 3
- 229910052697 platinum Inorganic materials 0.000 claims 3
- 238000002560 therapeutic procedure Methods 0.000 claims 3
- 229910052796 boron Inorganic materials 0.000 claims 2
- 230000001678 irradiating effect Effects 0.000 claims 2
- 230000003902 lesion Effects 0.000 claims 2
- 230000005298 paramagnetic effect Effects 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 238000002428 photodynamic therapy Methods 0.000 claims 2
- 230000002285 radioactive effect Effects 0.000 claims 2
- 229910000832 white gold Inorganic materials 0.000 claims 1
- 239000010938 white gold Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11/633,139 US8287839B2 (en) | 2006-12-04 | 2006-12-04 | Carboranylporphyrins and uses thereof |
| US11/633,139 | 2006-12-04 | ||
| PCT/US2007/024767 WO2008133664A2 (en) | 2006-12-04 | 2007-12-03 | Carboranylporphyrins and uses thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010511704A JP2010511704A (ja) | 2010-04-15 |
| JP2010511704A5 true JP2010511704A5 (enExample) | 2011-01-13 |
| JP5340953B2 JP5340953B2 (ja) | 2013-11-13 |
Family
ID=39476019
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009540246A Expired - Fee Related JP5340953B2 (ja) | 2006-12-04 | 2007-12-03 | カルボラニルポルフィリンとその使用 |
Country Status (17)
| Country | Link |
|---|---|
| US (2) | US8287839B2 (enExample) |
| EP (1) | EP2099304B1 (enExample) |
| JP (1) | JP5340953B2 (enExample) |
| CN (1) | CN101605459B (enExample) |
| AU (1) | AU2007352392B2 (enExample) |
| CA (1) | CA2671849C (enExample) |
| CY (1) | CY1115816T1 (enExample) |
| DK (1) | DK2099304T3 (enExample) |
| ES (1) | ES2504173T3 (enExample) |
| MX (1) | MX2009005904A (enExample) |
| NZ (1) | NZ577386A (enExample) |
| PL (1) | PL2099304T3 (enExample) |
| PT (1) | PT2099304E (enExample) |
| RU (1) | RU2477161C2 (enExample) |
| SI (1) | SI2099304T1 (enExample) |
| WO (1) | WO2008133664A2 (enExample) |
| ZA (1) | ZA200903906B (enExample) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2810197B1 (en) * | 2012-02-02 | 2018-04-04 | Brainlab AG | Method for determining an infusion parameter |
| GB201212409D0 (en) | 2012-07-12 | 2012-08-22 | Morex Dev Partners Llp | Cancer treatment |
| GB201221125D0 (en) * | 2012-11-23 | 2013-01-09 | Morex Dev Partners Llp | Pharmaceutial formulations |
| CN104151339B (zh) * | 2013-05-17 | 2017-05-03 | 中国科学院近代物理研究所 | 含硼吖啶衍生物、其制备方法和应用 |
| CN103936747B (zh) * | 2014-04-18 | 2016-06-22 | 济南大学 | 一种烷基取代树枝状金属卟啉及其制备方法和应用 |
| US10297179B2 (en) * | 2015-02-03 | 2019-05-21 | Sony Corporation | Information processing apparatus, information processing method, and program |
| JP6699004B2 (ja) * | 2015-08-25 | 2020-05-27 | 住友重機械工業株式会社 | 中性子捕捉療法システム及び中性子捕捉療法システムの制御方法 |
| IT202000001048A1 (it) | 2020-01-21 | 2021-07-21 | Univ Degli Studi Padova | Nanoparticelle multifunzionali a base di nanoleghe metalliche per usi diagnostici e terapeutici. |
| CN112358494B (zh) * | 2020-04-09 | 2021-09-28 | 南京大学 | 一种基于吖啶的碳硼烷衍生物及其在生物显影中的应用 |
| CN113735886B (zh) * | 2020-05-13 | 2022-06-03 | 北京大学 | Pdt化合物及其制备方法和用途 |
| IT202100001049A1 (it) | 2021-01-21 | 2022-07-21 | Univ Degli Studi Padova | Nanoparticelle multifunzionali a base di nanoleghe metalliche per usi diagnostici e terapeutici. |
| CN116333037A (zh) * | 2021-12-17 | 2023-06-27 | 化学与精细化工广东省实验室 | 含巯基肽与氟代卟啉类偶联用作生物探针 |
Family Cites Families (49)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4824659A (en) | 1985-06-07 | 1989-04-25 | Immunomedics, Inc. | Antibody conjugates |
| US4783529A (en) | 1985-12-03 | 1988-11-08 | Research Corporation Technologies | Rapid synthesis of radiolabeled porphyrin complexes for medical application |
| US5707604A (en) | 1986-11-18 | 1998-01-13 | Access Pharmaceuticals, Inc. | Vivo agents comprising metal-ion chelates with acidic saccharides and glycosaminoglycans, giving improved site-selective localization, uptake mechanism, sensitivity and kinetic-spatial profiles |
| US5672334A (en) | 1991-01-16 | 1997-09-30 | Access Pharmaceuticals, Inc. | Invivo agents comprising cationic metal chelators with acidic saccharides and glycosaminoglycans |
| US5162231A (en) | 1989-10-25 | 1992-11-10 | Cole Dean A | Method of using 5,10,15,20-tetrakis(carboxyphenyl)porphine for detecting cancers of the lung |
| US4892941A (en) | 1987-04-17 | 1990-01-09 | Dolphin David H | Porphyrins |
| US4977268A (en) | 1988-04-08 | 1990-12-11 | Duke University | Boron dipeptide compounds |
| US4959356A (en) | 1989-05-26 | 1990-09-25 | The United States Of America As Represented By The United States Department Of Energy | Porphyrins for boron neutron capture therapy |
| FR2656866B1 (fr) | 1990-01-10 | 1992-05-15 | Cis Bio Int | Derives de porphyrine et metalloporphyrines eventuellement couples a une molecule biologiquement active, et composition pharmaceutique les contenant. |
| US5149801A (en) | 1990-11-21 | 1992-09-22 | The Regents Of The University Of California | Boronated porphyrin compounds |
| US5654423A (en) | 1990-11-21 | 1997-08-05 | Regents Of The University Of California | Boronated metalloporphyrine and therapeutic methods |
| US5312896A (en) | 1992-10-09 | 1994-05-17 | Sri International | Metal ion porphyrin-containing poly(imide) |
| DE4305523A1 (de) | 1993-02-17 | 1994-08-18 | Diagnostikforschung Inst | Meso-Tetraphenylporphyrin-Komplexverbindungen, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Mittel |
| US5466679A (en) | 1993-05-17 | 1995-11-14 | The Ohio State University Research Foundation | Carboranyl uridines and their use in boron neutron capture therapy |
| US5489673A (en) | 1993-08-16 | 1996-02-06 | University Of Washington | Iodinated borane cage molecules as X-ray contrast media |
| US5599796A (en) | 1993-12-02 | 1997-02-04 | Emory University | Treatment of urogenital cancer with boron neutron capture therapy |
| JPH07330773A (ja) * | 1994-06-07 | 1995-12-19 | Toyo Hatsuka Kogyo Kk | ポルフィリン誘導体とその用途 |
| US5563132A (en) | 1994-06-21 | 1996-10-08 | Bodaness; Richard S. | Two-step cancer treatment method |
| JP2685128B2 (ja) * | 1995-07-21 | 1997-12-03 | 東北大学長 | カルボラン含有ガドリニウム−ｄｔｐａ錯体、その中間体、およびこれらの製造方法 |
| US5877165A (en) | 1995-11-02 | 1999-03-02 | Brookhaven Science Associates | Boronated porhyrins and methods for their use |
| US5776925A (en) | 1996-01-25 | 1998-07-07 | Pharmacyclics, Inc. | Methods for cancer chemosensitization |
| US5955586A (en) | 1996-03-22 | 1999-09-21 | Sessler; Jonathan L. | Highly boronated derivatives of texaphyrins |
| US6375930B2 (en) | 1996-06-04 | 2002-04-23 | Board Of Regents, The University Of Texas System | Membrane incorporation of texaphyrins |
| US6270749B1 (en) | 1996-12-11 | 2001-08-07 | Pharmacyclics, Inc. | Use of Texaphyrin in ocular diagnosis and therapy |
| WO1998030102A1 (en) | 1997-01-09 | 1998-07-16 | Emory University | Non-iron metalloporphyrins and methods of use |
| US6010805A (en) | 1998-05-26 | 2000-01-04 | United States Of America As Represented By The Secretary Of The Air Force | Ion conducting electrolyte material containing a lithium porphyrin complex |
| TW474840B (en) * | 1999-12-03 | 2002-02-01 | Bhp Innovation Pty Ltd | Method of coating substrate surfaces |
| AU2001274827A1 (en) | 2000-05-09 | 2001-11-20 | The Regents Of The University Of California | Porphyrin-based neutron capture agents for cancer therapy |
| US6765092B2 (en) | 2000-07-21 | 2004-07-20 | North Carolina State University | Regioisomerically pure oxochlorins and methods of synthesis |
| FR2812637B1 (fr) | 2000-08-01 | 2002-10-25 | Anulm Ass Nantaise Pour L Util | Nouveaux composes derives de dihydroporphyrine et leurs applications |
| AU2001284466A1 (en) | 2000-09-08 | 2002-03-22 | San-Ei Gen F.F.I., Inc. | Tetraphenylbacteriochlorin derivatives and compositions containing the same |
| US6849607B2 (en) | 2001-05-09 | 2005-02-01 | Health Research, Inc. | Galectin recognized photosensitizers for photodynamic therapy |
| EP1401430A4 (en) | 2001-05-31 | 2005-10-19 | Miravant Pharm Inc | SUBSTITUTED PORPHYRIN AND AZAPORPHYRIN DERIVATIVES AND USE IN PHOTODYNAMIC THERAPY, RADIOIMAGING, AND MRI DIAGNOSIS |
| DE60210074T2 (de) * | 2001-06-06 | 2006-10-19 | Brookhaven Science Associates | Neue metalloporphyrine und ihre verwendung als radiosensibilisatoren für die strahlentherapie |
| US6566517B2 (en) | 2001-06-06 | 2003-05-20 | Brookhaven Science Associates, Llc | Metalloporphyrins and their uses as imageable tumor-targeting agents for radiation therapy |
| EP1279676A1 (en) | 2001-07-19 | 2003-01-29 | Institut Curie | Porphyrin derivatives for photodynamic therapy |
| US20040019095A1 (en) | 2002-01-29 | 2004-01-29 | Ziwei Xiao | N, N'-dimethylated N-confused porphyrins |
| US7087214B2 (en) | 2002-02-01 | 2006-08-08 | Zentaris Gmbh | Water-soluble porphyrin platinum compounds with high tumor selectivity and their use for the treatment of benign and malignant tumor diseases |
| RU2236411C2 (ru) * | 2002-06-06 | 2004-09-20 | Московская государственная академия тонкой химической технологии им. М.В. Ломоносова | Металлокомплексы карборанилпорфиринов, обладающие противоопухолевой активностью |
| AU2003262833A1 (en) | 2002-08-23 | 2004-03-11 | The Board Of Trustees Of The Leland Stanford Junior University | Fluorescent glycosides and methods for their use |
| GB0222945D0 (en) | 2002-10-03 | 2002-11-13 | Psimei Pharmaceuticals Plc | Therapeutic compositions |
| US7267990B2 (en) | 2002-11-15 | 2007-09-11 | Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College | Chelation of charged and uncharged molecules with porphyrin-based compounds |
| ITFI20030063A1 (it) * | 2003-03-11 | 2004-09-12 | Molteni & C | Metallo ftalocianine boronate, loro preparazione, composizioni |
| US20070093463A1 (en) * | 2004-05-20 | 2007-04-26 | Brookhaven Science Associates, Llc | Radiation enhancement agent for X-ray radiation therapy and boron neutron-capture therapy |
| US6989443B2 (en) | 2004-06-28 | 2006-01-24 | Brookhaven Science Associates, Llc | Carboranylporphyrins and uses thereof |
| US6995260B2 (en) | 2004-05-20 | 2006-02-07 | Brookhaven Science Associates, Llc | Carboranylporphyrins and uses thereof |
| GB0415663D0 (en) * | 2004-07-13 | 2004-08-18 | Psimei Pharmaceuticals Plc | Compound |
| GB0427589D0 (en) * | 2004-12-16 | 2005-01-19 | Psimei Pharmaceuticals Plc | Process for the preparation of a substituted porphyrin |
| US7582751B2 (en) * | 2005-07-29 | 2009-09-01 | North Carolina State University | Methods and intermediates for the synthesis of porphyrins |
-
2006
- 2006-12-04 US US11/633,139 patent/US8287839B2/en not_active Expired - Fee Related
-
2007
- 2007-12-03 ES ES07874160.0T patent/ES2504173T3/es active Active
- 2007-12-03 NZ NZ577386A patent/NZ577386A/en not_active IP Right Cessation
- 2007-12-03 PT PT78741600T patent/PT2099304E/pt unknown
- 2007-12-03 ZA ZA200903906A patent/ZA200903906B/xx unknown
- 2007-12-03 CA CA2671849A patent/CA2671849C/en not_active Expired - Fee Related
- 2007-12-03 RU RU2009121323/04A patent/RU2477161C2/ru active
- 2007-12-03 JP JP2009540246A patent/JP5340953B2/ja not_active Expired - Fee Related
- 2007-12-03 DK DK07874160.0T patent/DK2099304T3/da active
- 2007-12-03 SI SI200731513T patent/SI2099304T1/sl unknown
- 2007-12-03 PL PL07874160T patent/PL2099304T3/pl unknown
- 2007-12-03 AU AU2007352392A patent/AU2007352392B2/en not_active Ceased
- 2007-12-03 CN CN200780044807.3A patent/CN101605459B/zh not_active Expired - Fee Related
- 2007-12-03 WO PCT/US2007/024767 patent/WO2008133664A2/en not_active Ceased
- 2007-12-03 MX MX2009005904A patent/MX2009005904A/es active IP Right Grant
- 2007-12-03 EP EP07874160.0A patent/EP2099304B1/en not_active Not-in-force
-
2012
- 2012-09-10 US US13/608,305 patent/US8673265B2/en not_active Expired - Fee Related
-
2014
- 2014-09-24 CY CY20141100781T patent/CY1115816T1/el unknown
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2010511704A5 (enExample) | ||
| RU2009121323A (ru) | Карборанилпорферины и их применение | |
| Aihara et al. | First clinical case of boron neutron capture therapy for head and neck malignancies using 18F‐BPA PET | |
| KR100899752B1 (ko) | 신규한 금속포르피린 및 방사선요법용 방사선감작제로서의이의 용도 | |
| CN1279907C (zh) | 新的金属卟啉化合物及其在放射疗法中用作放射增敏剂的用途 | |
| JP2008505983A5 (enExample) | ||
| JP2008504365A5 (enExample) | ||
| US9750809B2 (en) | Cancer treatment | |
| CA2572287A1 (en) | Carboranylporphyrins and uses thereof | |
| Fujibayashi et al. | Imaging and therapy against hypoxic tumors with 64Cu-ATSM | |
| JP2014177421A (ja) | 陽子線治療用増感剤、及びそれを用いた陽子線治療法 | |
| Kawabata et al. | Clinical study on modified boron neutron capture therapy for newly diagnosed glioblastoma | |
| HK1242977A1 (en) | Carboranylporphyrins for use in the treatment of cancer | |
| HK1210023B (en) | Carboranylporphyrins for use in the treatment of cancer | |
| HK1078472B (en) | Novel metalloporphyrins and their uses as radiosensitizers for radiation therapy | |
| HK1133552B (en) | Carboranylporphyrins and uses thereof |