JP2008504365A5 - - Google Patents
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- JP2008504365A5 JP2008504365A5 JP2007519285A JP2007519285A JP2008504365A5 JP 2008504365 A5 JP2008504365 A5 JP 2008504365A5 JP 2007519285 A JP2007519285 A JP 2007519285A JP 2007519285 A JP2007519285 A JP 2007519285A JP 2008504365 A5 JP2008504365 A5 JP 2008504365A5
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- JP
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- Prior art keywords
- compound according
- meta
- compound
- phenyl ring
- independently
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 150000001875 compounds Chemical class 0.000 claims 38
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 16
- 229910021645 metal ion Inorganic materials 0.000 claims 14
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 claims 8
- 125000001424 substituent group Chemical group 0.000 claims 8
- 206010028980 Neoplasm Diseases 0.000 claims 6
- PXHVJJICTQNCMI-UHFFFAOYSA-N Nickel Chemical compound [Ni] PXHVJJICTQNCMI-UHFFFAOYSA-N 0.000 claims 6
- 229910052739 hydrogen Inorganic materials 0.000 claims 6
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 claims 6
- 125000003545 alkoxy group Chemical group 0.000 claims 5
- 201000011510 cancer Diseases 0.000 claims 5
- 239000001257 hydrogen Substances 0.000 claims 5
- ZOXJGFHDIHLPTG-UHFFFAOYSA-N Boron Chemical group [B] ZOXJGFHDIHLPTG-UHFFFAOYSA-N 0.000 claims 4
- VYZAMTAEIAYCRO-UHFFFAOYSA-N Chromium Chemical compound [Cr] VYZAMTAEIAYCRO-UHFFFAOYSA-N 0.000 claims 3
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 claims 3
- 229910052688 Gadolinium Inorganic materials 0.000 claims 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 3
- KJTLSVCANCCWHF-UHFFFAOYSA-N Ruthenium Chemical compound [Ru] KJTLSVCANCCWHF-UHFFFAOYSA-N 0.000 claims 3
- ATJFFYVFTNAWJD-UHFFFAOYSA-N Tin Chemical compound [Sn] ATJFFYVFTNAWJD-UHFFFAOYSA-N 0.000 claims 3
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 claims 3
- 229910052788 barium Inorganic materials 0.000 claims 3
- DSAJWYNOEDNPEQ-UHFFFAOYSA-N barium atom Chemical compound [Ba] DSAJWYNOEDNPEQ-UHFFFAOYSA-N 0.000 claims 3
- 229910052804 chromium Inorganic materials 0.000 claims 3
- 239000011651 chromium Substances 0.000 claims 3
- 229910017052 cobalt Inorganic materials 0.000 claims 3
- 239000010941 cobalt Substances 0.000 claims 3
- GUTLYIVDDKVIGB-UHFFFAOYSA-N cobalt atom Chemical compound [Co] GUTLYIVDDKVIGB-UHFFFAOYSA-N 0.000 claims 3
- 229910052802 copper Inorganic materials 0.000 claims 3
- 239000010949 copper Substances 0.000 claims 3
- UIWYJDYFSGRHKR-UHFFFAOYSA-N gadolinium atom Chemical compound [Gd] UIWYJDYFSGRHKR-UHFFFAOYSA-N 0.000 claims 3
- 229910052732 germanium Inorganic materials 0.000 claims 3
- GNPVGFCGXDBREM-UHFFFAOYSA-N germanium atom Chemical compound [Ge] GNPVGFCGXDBREM-UHFFFAOYSA-N 0.000 claims 3
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 claims 3
- 229910052737 gold Inorganic materials 0.000 claims 3
- 239000010931 gold Substances 0.000 claims 3
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 3
- 238000003384 imaging method Methods 0.000 claims 3
- 229910052738 indium Inorganic materials 0.000 claims 3
- APFVFJFRJDLVQX-UHFFFAOYSA-N indium atom Chemical compound [In] APFVFJFRJDLVQX-UHFFFAOYSA-N 0.000 claims 3
- 229910052742 iron Inorganic materials 0.000 claims 3
- 238000002595 magnetic resonance imaging Methods 0.000 claims 3
- WPBNNNQJVZRUHP-UHFFFAOYSA-L manganese(2+);methyl n-[[2-(methoxycarbonylcarbamothioylamino)phenyl]carbamothioyl]carbamate;n-[2-(sulfidocarbothioylamino)ethyl]carbamodithioate Chemical group [Mn+2].[S-]C(=S)NCCNC([S-])=S.COC(=O)NC(=S)NC1=CC=CC=C1NC(=S)NC(=O)OC WPBNNNQJVZRUHP-UHFFFAOYSA-L 0.000 claims 3
- 229910052759 nickel Inorganic materials 0.000 claims 3
- 229910052697 platinum Inorganic materials 0.000 claims 3
- 238000002600 positron emission tomography Methods 0.000 claims 3
- 229910052707 ruthenium Inorganic materials 0.000 claims 3
- 238000002603 single-photon emission computed tomography Methods 0.000 claims 3
- 229910052713 technetium Inorganic materials 0.000 claims 3
- GKLVYJBZJHMRIY-UHFFFAOYSA-N technetium atom Chemical compound [Tc] GKLVYJBZJHMRIY-UHFFFAOYSA-N 0.000 claims 3
- 238000002560 therapeutic procedure Methods 0.000 claims 3
- 229910052718 tin Inorganic materials 0.000 claims 3
- WFKWXMTUELFFGS-UHFFFAOYSA-N tungsten Chemical compound [W] WFKWXMTUELFFGS-UHFFFAOYSA-N 0.000 claims 3
- 229910052721 tungsten Inorganic materials 0.000 claims 3
- 239000010937 tungsten Substances 0.000 claims 3
- 229910052720 vanadium Inorganic materials 0.000 claims 3
- GPPXJZIENCGNKB-UHFFFAOYSA-N vanadium Chemical group [V]#[V] GPPXJZIENCGNKB-UHFFFAOYSA-N 0.000 claims 3
- 229910052727 yttrium Inorganic materials 0.000 claims 3
- VWQVUPCCIRVNHF-UHFFFAOYSA-N yttrium atom Chemical compound [Y] VWQVUPCCIRVNHF-UHFFFAOYSA-N 0.000 claims 3
- 229910052725 zinc Inorganic materials 0.000 claims 3
- 239000011701 zinc Substances 0.000 claims 3
- 125000002877 alkyl aryl group Chemical group 0.000 claims 2
- 125000000217 alkyl group Chemical group 0.000 claims 2
- 125000003368 amide group Chemical group 0.000 claims 2
- 125000003710 aryl alkyl group Chemical group 0.000 claims 2
- 125000003118 aryl group Chemical group 0.000 claims 2
- 229910052796 boron Inorganic materials 0.000 claims 2
- 125000001951 carbamoylamino group Chemical group C(N)(=O)N* 0.000 claims 2
- 125000004432 carbon atom Chemical group C* 0.000 claims 2
- 125000000753 cycloalkyl group Chemical group 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 125000001072 heteroaryl group Chemical group 0.000 claims 2
- 150000002431 hydrogen Chemical class 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 229910052751 metal Inorganic materials 0.000 claims 2
- 239000002184 metal Substances 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 2
- 230000005298 paramagnetic effect Effects 0.000 claims 2
- 238000002428 photodynamic therapy Methods 0.000 claims 2
- 229920000233 poly(alkylene oxides) Polymers 0.000 claims 2
- -1 porphyrin compound Chemical class 0.000 claims 2
- 150000004032 porphyrins Chemical class 0.000 claims 2
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 1
- 230000002902 bimodal effect Effects 0.000 claims 1
- 229910052799 carbon Inorganic materials 0.000 claims 1
- 150000001768 cations Chemical class 0.000 claims 1
- 150000004985 diamines Chemical class 0.000 claims 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 1
- 230000001404 mediated effect Effects 0.000 claims 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 1
- UUEVFMOUBSLVJW-UHFFFAOYSA-N oxo-[[1-[2-[2-[2-[4-(oxoazaniumylmethylidene)pyridin-1-yl]ethoxy]ethoxy]ethyl]pyridin-4-ylidene]methyl]azanium;dibromide Chemical compound [Br-].[Br-].C1=CC(=C[NH+]=O)C=CN1CCOCCOCCN1C=CC(=C[NH+]=O)C=C1 UUEVFMOUBSLVJW-UHFFFAOYSA-N 0.000 claims 1
- 229910052760 oxygen Inorganic materials 0.000 claims 1
- 239000001301 oxygen Substances 0.000 claims 1
- 230000005855 radiation Effects 0.000 claims 1
- 230000002285 radioactive effect Effects 0.000 claims 1
- 229910052717 sulfur Inorganic materials 0.000 claims 1
- 239000011593 sulfur Substances 0.000 claims 1
- YXFVVABEGXRONW-UHFFFAOYSA-N Cc1ccccc1 Chemical compound Cc1ccccc1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10/878,138 US6989443B2 (en) | 2004-06-28 | 2004-06-28 | Carboranylporphyrins and uses thereof |
| PCT/US2005/022061 WO2006012140A1 (en) | 2004-06-28 | 2005-06-22 | Carboranylporphyrins and uses thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2008504365A JP2008504365A (ja) | 2008-02-14 |
| JP2008504365A5 true JP2008504365A5 (enExample) | 2008-08-07 |
Family
ID=35505984
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007519285A Pending JP2008504365A (ja) | 2004-06-28 | 2005-06-22 | カルボラニルポルフィリン及びそれらの使用 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US6989443B2 (enExample) |
| EP (1) | EP1778082A4 (enExample) |
| JP (1) | JP2008504365A (enExample) |
| KR (1) | KR20070033006A (enExample) |
| CN (1) | CN1988848B (enExample) |
| AU (1) | AU2005267390B2 (enExample) |
| CA (1) | CA2572287A1 (enExample) |
| IL (1) | IL180365A (enExample) |
| NO (1) | NO20070509L (enExample) |
| NZ (1) | NZ552877A (enExample) |
| WO (1) | WO2006012140A1 (enExample) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20070093463A1 (en) * | 2004-05-20 | 2007-04-26 | Brookhaven Science Associates, Llc | Radiation enhancement agent for X-ray radiation therapy and boron neutron-capture therapy |
| US8287839B2 (en) * | 2006-12-04 | 2012-10-16 | Brookhaven Science Associates, Llc | Carboranylporphyrins and uses thereof |
| US8444953B2 (en) * | 2007-03-22 | 2013-05-21 | Brookhaven Science Associates, Llc | Symmetric and asymmetric halogen-containing metallocarboranylporphyrins and uses thereof |
| US20080279781A1 (en) * | 2007-05-10 | 2008-11-13 | Brookhaven Science Associates, Llc | Glycosylated Carboranylporphyrins and Uses Thereof |
| JP5745415B2 (ja) * | 2009-09-17 | 2015-07-08 | 国立大学法人九州大学 | ポルフィリン化合物 |
| CN102260269B (zh) * | 2010-05-25 | 2013-11-06 | 苏州和健医药科技有限公司 | 一种含有卟啉或二氢卟吩的树状化合物及其应用 |
| GB201212409D0 (en) | 2012-07-12 | 2012-08-22 | Morex Dev Partners Llp | Cancer treatment |
| JP6699004B2 (ja) * | 2015-08-25 | 2020-05-27 | 住友重機械工業株式会社 | 中性子捕捉療法システム及び中性子捕捉療法システムの制御方法 |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4783529A (en) | 1985-12-03 | 1988-11-08 | Research Corporation Technologies | Rapid synthesis of radiolabeled porphyrin complexes for medical application |
| US5162231A (en) | 1989-10-25 | 1992-11-10 | Cole Dean A | Method of using 5,10,15,20-tetrakis(carboxyphenyl)porphine for detecting cancers of the lung |
| US4959356A (en) | 1989-05-26 | 1990-09-25 | The United States Of America As Represented By The United States Department Of Energy | Porphyrins for boron neutron capture therapy |
| FR2656866B1 (fr) | 1990-01-10 | 1992-05-15 | Cis Bio Int | Derives de porphyrine et metalloporphyrines eventuellement couples a une molecule biologiquement active, et composition pharmaceutique les contenant. |
| US5149801A (en) | 1990-11-21 | 1992-09-22 | The Regents Of The University Of California | Boronated porphyrin compounds |
| US5654423A (en) | 1990-11-21 | 1997-08-05 | Regents Of The University Of California | Boronated metalloporphyrine and therapeutic methods |
| US5312896A (en) | 1992-10-09 | 1994-05-17 | Sri International | Metal ion porphyrin-containing poly(imide) |
| DE4305523A1 (de) | 1993-02-17 | 1994-08-18 | Diagnostikforschung Inst | Meso-Tetraphenylporphyrin-Komplexverbindungen, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Mittel |
| IT232801Y1 (it) * | 1994-03-07 | 2000-01-19 | Imbac Spa | Fianco di cassonetto con gambo laterale di innesto asportabile e intercambiabile |
| US5563132A (en) | 1994-06-21 | 1996-10-08 | Bodaness; Richard S. | Two-step cancer treatment method |
| US5877165A (en) | 1995-11-02 | 1999-03-02 | Brookhaven Science Associates | Boronated porhyrins and methods for their use |
| US5955586A (en) | 1996-03-22 | 1999-09-21 | Sessler; Jonathan L. | Highly boronated derivatives of texaphyrins |
| WO1998030102A1 (en) | 1997-01-09 | 1998-07-16 | Emory University | Non-iron metalloporphyrins and methods of use |
| US6010805A (en) | 1998-05-26 | 2000-01-04 | United States Of America As Represented By The Secretary Of The Air Force | Ion conducting electrolyte material containing a lithium porphyrin complex |
| AU2001274827A1 (en) | 2000-05-09 | 2001-11-20 | The Regents Of The University Of California | Porphyrin-based neutron capture agents for cancer therapy |
| DE60210074T2 (de) * | 2001-06-06 | 2006-10-19 | Brookhaven Science Associates | Neue metalloporphyrine und ihre verwendung als radiosensibilisatoren für die strahlentherapie |
| US6566517B2 (en) | 2001-06-06 | 2003-05-20 | Brookhaven Science Associates, Llc | Metalloporphyrins and their uses as imageable tumor-targeting agents for radiation therapy |
-
2004
- 2004-06-28 US US10/878,138 patent/US6989443B2/en not_active Expired - Fee Related
-
2005
- 2005-06-22 NZ NZ552877A patent/NZ552877A/en not_active IP Right Cessation
- 2005-06-22 WO PCT/US2005/022061 patent/WO2006012140A1/en not_active Ceased
- 2005-06-22 EP EP05785045A patent/EP1778082A4/en not_active Withdrawn
- 2005-06-22 CA CA002572287A patent/CA2572287A1/en not_active Abandoned
- 2005-06-22 AU AU2005267390A patent/AU2005267390B2/en not_active Ceased
- 2005-06-22 JP JP2007519285A patent/JP2008504365A/ja active Pending
- 2005-06-22 KR KR1020077002041A patent/KR20070033006A/ko not_active Ceased
- 2005-06-22 CN CN2005800251742A patent/CN1988848B/zh not_active Expired - Fee Related
-
2006
- 2006-12-26 IL IL180365A patent/IL180365A/en not_active IP Right Cessation
-
2007
- 2007-01-26 NO NO20070509A patent/NO20070509L/no not_active Application Discontinuation
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