CN1988848B - 碳硼烷基卟啉及其应用 - Google Patents

碳硼烷基卟啉及其应用 Download PDF

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Publication number
CN1988848B
CN1988848B CN2005800251742A CN200580025174A CN1988848B CN 1988848 B CN1988848 B CN 1988848B CN 2005800251742 A CN2005800251742 A CN 2005800251742A CN 200580025174 A CN200580025174 A CN 200580025174A CN 1988848 B CN1988848 B CN 1988848B
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CN
China
Prior art keywords
independently
aryl
porphyrin
carborane
boron
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN2005800251742A
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English (en)
Chinese (zh)
Other versions
CN1988848A (zh
Inventor
吴海涛
米希科·缪拉
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Brookhaven Science Associates LLC
Original Assignee
Brookhaven Science Associates LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Brookhaven Science Associates LLC filed Critical Brookhaven Science Associates LLC
Publication of CN1988848A publication Critical patent/CN1988848A/zh
Application granted granted Critical
Publication of CN1988848B publication Critical patent/CN1988848B/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
    • A61K41/0071—PDT with porphyrins having exactly 20 ring atoms, i.e. based on the non-expanded tetrapyrrolic ring system, e.g. bacteriochlorin, chlorin-e6, or phthalocyanines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/009—Neutron capture therapy, e.g. using uranium or non-boron material
    • A61K41/0095—Boron neutron capture therapy, i.e. BNCT, e.g. using boronated porphyrins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/101—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals
    • A61K49/106—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals the complex-forming compound being cyclic, e.g. DOTA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
    • A61K51/0485—Porphyrins, texaphyrins wherein the nitrogen atoms forming the central ring system complex the radioactive metal
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F1/00—Compounds containing elements of Groups 1 or 11 of the Periodic Table
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F1/00—Compounds containing elements of Groups 1 or 11 of the Periodic Table
    • C07F1/08—Copper compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F3/00—Compounds containing elements of Groups 2 or 12 of the Periodic Table

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Molecular Biology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Biochemistry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Radiation-Therapy Devices (AREA)
CN2005800251742A 2004-06-28 2005-06-22 碳硼烷基卟啉及其应用 Expired - Fee Related CN1988848B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US10/878,138 US6989443B2 (en) 2004-06-28 2004-06-28 Carboranylporphyrins and uses thereof
US10/878,138 2004-06-28
PCT/US2005/022061 WO2006012140A1 (en) 2004-06-28 2005-06-22 Carboranylporphyrins and uses thereof

Publications (2)

Publication Number Publication Date
CN1988848A CN1988848A (zh) 2007-06-27
CN1988848B true CN1988848B (zh) 2010-12-15

Family

ID=35505984

Family Applications (1)

Application Number Title Priority Date Filing Date
CN2005800251742A Expired - Fee Related CN1988848B (zh) 2004-06-28 2005-06-22 碳硼烷基卟啉及其应用

Country Status (11)

Country Link
US (1) US6989443B2 (enExample)
EP (1) EP1778082A4 (enExample)
JP (1) JP2008504365A (enExample)
KR (1) KR20070033006A (enExample)
CN (1) CN1988848B (enExample)
AU (1) AU2005267390B2 (enExample)
CA (1) CA2572287A1 (enExample)
IL (1) IL180365A (enExample)
NO (1) NO20070509L (enExample)
NZ (1) NZ552877A (enExample)
WO (1) WO2006012140A1 (enExample)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070093463A1 (en) * 2004-05-20 2007-04-26 Brookhaven Science Associates, Llc Radiation enhancement agent for X-ray radiation therapy and boron neutron-capture therapy
US8287839B2 (en) * 2006-12-04 2012-10-16 Brookhaven Science Associates, Llc Carboranylporphyrins and uses thereof
US8444953B2 (en) * 2007-03-22 2013-05-21 Brookhaven Science Associates, Llc Symmetric and asymmetric halogen-containing metallocarboranylporphyrins and uses thereof
US20080279781A1 (en) * 2007-05-10 2008-11-13 Brookhaven Science Associates, Llc Glycosylated Carboranylporphyrins and Uses Thereof
JP5745415B2 (ja) * 2009-09-17 2015-07-08 国立大学法人九州大学 ポルフィリン化合物
CN102260269B (zh) * 2010-05-25 2013-11-06 苏州和健医药科技有限公司 一种含有卟啉或二氢卟吩的树状化合物及其应用
GB201212409D0 (en) 2012-07-12 2012-08-22 Morex Dev Partners Llp Cancer treatment
JP6699004B2 (ja) * 2015-08-25 2020-05-27 住友重機械工業株式会社 中性子捕捉療法システム及び中性子捕捉療法システムの制御方法

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5149801A (en) * 1990-11-21 1992-09-22 The Regents Of The University Of California Boronated porphyrin compounds
US5877165A (en) * 1995-11-02 1999-03-02 Brookhaven Science Associates Boronated porhyrins and methods for their use
US20030083494A1 (en) * 2001-06-06 2003-05-01 Michiko Miura Novel metalloporphyrins and their uses as radiosensitizers for radiation therapy

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4783529A (en) 1985-12-03 1988-11-08 Research Corporation Technologies Rapid synthesis of radiolabeled porphyrin complexes for medical application
US5162231A (en) 1989-10-25 1992-11-10 Cole Dean A Method of using 5,10,15,20-tetrakis(carboxyphenyl)porphine for detecting cancers of the lung
US4959356A (en) 1989-05-26 1990-09-25 The United States Of America As Represented By The United States Department Of Energy Porphyrins for boron neutron capture therapy
FR2656866B1 (fr) 1990-01-10 1992-05-15 Cis Bio Int Derives de porphyrine et metalloporphyrines eventuellement couples a une molecule biologiquement active, et composition pharmaceutique les contenant.
US5654423A (en) 1990-11-21 1997-08-05 Regents Of The University Of California Boronated metalloporphyrine and therapeutic methods
US5312896A (en) 1992-10-09 1994-05-17 Sri International Metal ion porphyrin-containing poly(imide)
DE4305523A1 (de) 1993-02-17 1994-08-18 Diagnostikforschung Inst Meso-Tetraphenylporphyrin-Komplexverbindungen, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Mittel
IT232801Y1 (it) * 1994-03-07 2000-01-19 Imbac Spa Fianco di cassonetto con gambo laterale di innesto asportabile e intercambiabile
US5563132A (en) 1994-06-21 1996-10-08 Bodaness; Richard S. Two-step cancer treatment method
US5955586A (en) 1996-03-22 1999-09-21 Sessler; Jonathan L. Highly boronated derivatives of texaphyrins
WO1998030102A1 (en) 1997-01-09 1998-07-16 Emory University Non-iron metalloporphyrins and methods of use
US6010805A (en) 1998-05-26 2000-01-04 United States Of America As Represented By The Secretary Of The Air Force Ion conducting electrolyte material containing a lithium porphyrin complex
AU2001274827A1 (en) 2000-05-09 2001-11-20 The Regents Of The University Of California Porphyrin-based neutron capture agents for cancer therapy
DE60210074T2 (de) * 2001-06-06 2006-10-19 Brookhaven Science Associates Neue metalloporphyrine und ihre verwendung als radiosensibilisatoren für die strahlentherapie

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5149801A (en) * 1990-11-21 1992-09-22 The Regents Of The University Of California Boronated porphyrin compounds
US5877165A (en) * 1995-11-02 1999-03-02 Brookhaven Science Associates Boronated porhyrins and methods for their use
US20030083494A1 (en) * 2001-06-06 2003-05-01 Michiko Miura Novel metalloporphyrins and their uses as radiosensitizers for radiation therapy

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
HARTH ET AL.The Effect of Macromolecular Architecture in Nanomaterials:A comparison of Site Isolation in PorphyrinCore Dendrimersand Their Isomeric Linear Analogues.J. AM. CHEM. SOC.124.2002,1243934-3936.
HARTH ET AL.The Effect of Macromolecular Architecture in Nanomaterials:A comparison of Site Isolation in PorphyrinCore Dendrimersand Their Isomeric Linear Analogues.J. AM. CHEM. SOC.124.2002,1243934-3936. *

Also Published As

Publication number Publication date
NZ552877A (en) 2010-03-26
AU2005267390B2 (en) 2011-01-20
IL180365A0 (en) 2007-06-03
CN1988848A (zh) 2007-06-27
EP1778082A1 (en) 2007-05-02
CA2572287A1 (en) 2006-02-02
US6989443B2 (en) 2006-01-24
US20050287073A1 (en) 2005-12-29
KR20070033006A (ko) 2007-03-23
AU2005267390A1 (en) 2006-02-02
WO2006012140A1 (en) 2006-02-02
HK1109039A1 (en) 2008-05-30
IL180365A (en) 2011-09-27
NO20070509L (no) 2007-01-29
EP1778082A4 (en) 2010-09-22
JP2008504365A (ja) 2008-02-14

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