JP2010511649A5 - - Google Patents
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- Publication number
- JP2010511649A5 JP2010511649A5 JP2009539669A JP2009539669A JP2010511649A5 JP 2010511649 A5 JP2010511649 A5 JP 2010511649A5 JP 2009539669 A JP2009539669 A JP 2009539669A JP 2009539669 A JP2009539669 A JP 2009539669A JP 2010511649 A5 JP2010511649 A5 JP 2010511649A5
- Authority
- JP
- Japan
- Prior art keywords
- potassium salt
- diffraction pattern
- ray powder
- powder diffraction
- crystalline potassium
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- XAEFZNCEHLXOMS-UHFFFAOYSA-M potassium benzoate Chemical compound [K+].[O-]C(=O)C1=CC=CC=C1 XAEFZNCEHLXOMS-UHFFFAOYSA-M 0.000 claims description 30
- 238000000634 powder X-ray diffraction Methods 0.000 claims description 29
- 239000002904 solvent Substances 0.000 claims description 11
- 238000000034 method Methods 0.000 claims 15
- 150000004683 dihydrates Chemical group 0.000 claims 13
- 150000004682 monohydrates Chemical group 0.000 claims 13
- 239000013078 crystal Substances 0.000 claims 8
- 238000001035 drying Methods 0.000 claims 8
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 6
- 239000003960 organic solvent Substances 0.000 claims 5
- 239000000203 mixture Substances 0.000 claims 4
- 238000005406 washing Methods 0.000 claims 4
- 150000004677 hydrates Chemical class 0.000 claims 3
- 239000000725 suspension Substances 0.000 claims 3
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 claims 2
- 239000002253 acid Substances 0.000 claims 2
- 230000000694 effects Effects 0.000 claims 2
- 229910052700 potassium Inorganic materials 0.000 claims 2
- 239000011591 potassium Substances 0.000 claims 2
- LTUDISCZKZHRMJ-UHFFFAOYSA-N potassium;hydrate Chemical compound O.[K] LTUDISCZKZHRMJ-UHFFFAOYSA-N 0.000 claims 2
- HLADOSSHOHRFMH-ZXOMLLCBSA-N 2-[(2s,3r,4e,6e,10e,12s)-13-(4-fluorophenoxy)-2,3,12-trihydroxytrideca-4,6,10-trien-8-ynoxy]acetic acid Chemical compound OC(=O)COC[C@H](O)[C@H](O)/C=C/C=C/C#C/C=C/[C@H](O)COC1=CC=C(F)C=C1 HLADOSSHOHRFMH-ZXOMLLCBSA-N 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 238000001816 cooling Methods 0.000 claims 1
- 238000010438 heat treatment Methods 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 230000002194 synthesizing effect Effects 0.000 claims 1
- HLADOSSHOHRFMH-ZXOMLLCBSA-M [O-]C(COC[C@@H]([C@@H](/C=C/C=C/C#C/C=C/[C@@H](COc(cc1)ccc1F)O)O)O)=O Chemical compound [O-]C(COC[C@@H]([C@@H](/C=C/C=C/C#C/C=C/[C@@H](COc(cc1)ccc1F)O)O)O)=O HLADOSSHOHRFMH-ZXOMLLCBSA-M 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US87283006P | 2006-12-04 | 2006-12-04 | |
| US60/872,830 | 2006-12-04 | ||
| PCT/EP2007/010785 WO2008068041A1 (en) | 2006-12-04 | 2007-12-04 | Crystalline potassium salt of lipoxin a4 analogs |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010511649A JP2010511649A (ja) | 2010-04-15 |
| JP2010511649A5 true JP2010511649A5 (cg-RX-API-DMAC7.html) | 2013-10-31 |
| JP5410984B2 JP5410984B2 (ja) | 2014-02-05 |
Family
ID=39076610
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009539669A Expired - Fee Related JP5410984B2 (ja) | 2006-12-04 | 2007-12-04 | リポキシンａ４類似体の結晶カリウム塩 |
Country Status (28)
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PE20081200A1 (es) * | 2006-12-04 | 2008-11-06 | Bayer Schering Pharma Ag | Sal de potasio cristalina de analogos de lipoxina a4 |
| US20090036530A1 (en) * | 2006-12-04 | 2009-02-05 | Bayer Schering Pharma Aktiengesellschaft | Crystalline acid of lipoxin A4 analogs and method of making |
| EP2135610A1 (en) | 2008-06-20 | 2009-12-23 | Laboratorios Almirall, S.A. | Combination comprising DHODH inhibitors and methotrexate |
| EP2470189A4 (en) * | 2009-08-27 | 2013-01-23 | Merck Sharp & Dohme | METHOD FOR PRODUCING PROTEASE INHIBITORS OF HEPATITIS C VIRUS |
| CA3149053A1 (en) * | 2013-02-21 | 2014-08-28 | Forsyth Dental Infirmary For Children | Methods for increasing oral osteogenesis using lipoxin a4 (lxa4) and its analogs |
| CN114377138A (zh) * | 2015-03-18 | 2022-04-22 | 福塞斯儿童牙科医院 | 使用脂氧素、消退素及其类似物稳定动脉粥状硬化斑块的方法 |
| ES2827796T3 (es) | 2016-06-03 | 2021-05-24 | Thetis Pharmaceuticals Llc | Composiciones y procedimientos relativos a sales de mediadores pro-resolutivos especializados de inflamación |
| WO2018144316A1 (en) | 2017-01-31 | 2018-08-09 | The Brigham And Women's Hospital, Inc. | Alx receptor ligands define a biochemical endotype for inflammation-based diseases |
| CN111875530A (zh) * | 2020-08-17 | 2020-11-03 | 浙江朗华制药有限公司 | 一种普拉西坦水合物晶体及其制备方法 |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5650435A (en) | 1991-04-01 | 1997-07-22 | Madara; James L. | Modulation of inflammation related to columnar epithelia |
| DE69435125D1 (de) | 1993-06-15 | 2008-10-02 | Brigham & Womens Hospital | Lipoxinverbindungen mit verlängerter halbwertszeit |
| US6048897A (en) | 1993-06-15 | 2000-04-11 | Brigham And Women's Hospital | Lipoxin compounds and their use in treating cell proliferative disorders |
| US5441951A (en) | 1994-06-15 | 1995-08-15 | Brigham & Women's Hospital | Lipoxin compounds |
| WO1995001179A1 (en) | 1993-06-29 | 1995-01-12 | Brigham & Women's Hospital | Modulation of inflammation related to columnar epithelia |
| US6008205A (en) | 1997-04-04 | 1999-12-28 | The Brigham & Women's Hospital, Inc. | Polyisoprenyl phosphate stable analogs for regulation of neutrophil responses |
| US6236978B1 (en) * | 1997-11-14 | 2001-05-22 | New York University | System and method for dynamic profiling of users in one-to-one applications |
| US6006466A (en) * | 1998-08-20 | 1999-12-28 | Washecka; John | Concealed linear payout holder for fishing leader |
| SE9900274D0 (sv) | 1999-01-28 | 1999-01-28 | Astra Ab | New compound |
| CA2367909C (en) | 1999-03-18 | 2008-02-12 | Brigham And Women's Hospital | Use of lipoxin compounds for inhibiting of tnf-(alpha) initiated neutrophil response |
| US6353026B1 (en) | 1999-03-18 | 2002-03-05 | Brigham And Women's Hospital | Regulation of phospholipase D activity |
| JP2002539181A (ja) | 1999-03-18 | 2002-11-19 | ブリガム・アンド・ウイメンズ・ホスピタル | リポキシン化合物およびこれらの使用 |
| ATE258791T1 (de) | 1999-11-09 | 2004-02-15 | Alcon Inc | Lipoxin-a4 und deren analoge zur behandlung von trockenen augen |
| US7700650B2 (en) | 2000-03-20 | 2010-04-20 | Trustees Of Boston University | Lipoxin analogs and method for the treatment of periodontal disease |
| US6831186B2 (en) * | 2001-11-06 | 2004-12-14 | Schering Aktiengesellschft | Lipoxin A4 analogs |
| AU2002347539A1 (en) | 2001-12-13 | 2003-06-23 | Ranbaxy Laboratories Limited | Crystalline cefdinir potassium dihydrate |
| AU2003209562A1 (en) | 2002-03-15 | 2003-09-29 | Dr. Reddy's Laboratories Limited | Novel crystalline form of 5-(4-((3-methyl-4-oxo-3,4-dihydroquinazolin-2-yl)methoxy)benzyl)thiazolidine-2,4-dione potassium salt |
| ATE487478T1 (de) | 2003-01-30 | 2010-11-15 | Lek Pharmaceuticals | Herstellung eines neuen pharmazeutisch geeigneten losartan-salzes und von seinen formen mittels neuer reinigungs- und isolationsverfahren |
| WO2006035291A1 (en) | 2004-09-27 | 2006-04-06 | Ranbaxy Laboratories Limited | Crystalline forms of cefdinir potassium |
| US7223718B2 (en) * | 2005-03-07 | 2007-05-29 | Falcon Lab Llc | Enhanced glyphosate herbicidal concentrates |
| US20070191331A1 (en) | 2005-10-31 | 2007-08-16 | Kansal Vinod K | Crystalline forms of cefdinir potassium salt |
| PE20081200A1 (es) * | 2006-12-04 | 2008-11-06 | Bayer Schering Pharma Ag | Sal de potasio cristalina de analogos de lipoxina a4 |
-
2007
- 2007-12-03 PE PE2007001704A patent/PE20081200A1/es not_active Application Discontinuation
- 2007-12-03 CL CL200703468A patent/CL2007003468A1/es unknown
- 2007-12-03 UY UY30755A patent/UY30755A1/es not_active Application Discontinuation
- 2007-12-03 PE PE2012000006A patent/PE20120395A1/es not_active Application Discontinuation
- 2007-12-03 US US11/999,000 patent/US7906678B2/en active Active
- 2007-12-04 BR BRPI0719679-2A2A patent/BRPI0719679A2/pt not_active IP Right Cessation
- 2007-12-04 JP JP2009539669A patent/JP5410984B2/ja not_active Expired - Fee Related
- 2007-12-04 TW TW096146154A patent/TWI415833B/zh not_active IP Right Cessation
- 2007-12-04 CA CA2670791A patent/CA2670791C/en not_active Expired - Fee Related
- 2007-12-04 KR KR1020147030409A patent/KR20140135847A/ko not_active Ceased
- 2007-12-04 NZ NZ577338A patent/NZ577338A/en not_active IP Right Cessation
- 2007-12-04 CN CN2007800448571A patent/CN101553456B/zh not_active Expired - Fee Related
- 2007-12-04 EP EP18190069.7A patent/EP3489214A1/en not_active Withdrawn
- 2007-12-04 WO PCT/EP2007/010785 patent/WO2008068041A1/en not_active Ceased
- 2007-12-04 AU AU2007327765A patent/AU2007327765B2/en not_active Ceased
- 2007-12-04 MX MX2009005911A patent/MX2009005911A/es active IP Right Grant
- 2007-12-04 KR KR1020167011173A patent/KR20160054030A/ko not_active Ceased
- 2007-12-04 EP EP07847057.2A patent/EP2089350B1/en active Active
- 2007-12-04 KR KR1020097011427A patent/KR20090101169A/ko not_active Ceased
- 2007-12-04 EA EA200900732A patent/EA018615B1/ru not_active IP Right Cessation
- 2007-12-04 AR ARP070105403A patent/AR064116A1/es unknown
- 2007-12-04 MY MYPI20092224A patent/MY147951A/en unknown
-
2009
- 2009-04-28 IL IL198434A patent/IL198434A/en not_active IP Right Cessation
- 2009-04-29 TN TNP2009000167A patent/TN2009000167A1/fr unknown
- 2009-06-03 EC EC2009009380A patent/ECSP099380A/es unknown
- 2009-06-04 DO DO2009000130A patent/DOP2009000130A/es unknown
- 2009-06-04 CR CR10837A patent/CR10837A/es unknown
- 2009-06-04 CO CO09057912A patent/CO6190608A2/es not_active Application Discontinuation
- 2009-06-04 SV SV2009003286A patent/SV2009003286A/es unknown
- 2009-06-29 MA MA32056A patent/MA31079B1/fr unknown
- 2009-07-03 NO NO20092528A patent/NO20092528L/no not_active Application Discontinuation
- 2009-07-03 ZA ZA2009/04689A patent/ZA200904689B/en unknown
-
2011
- 2011-02-07 US US13/022,139 patent/US8049035B2/en active Active
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