AU2007327765B2 - Crystalline potassium salt of lipoxin A4 analogs - Google Patents

Crystalline potassium salt of lipoxin A4 analogs Download PDF

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Publication number
AU2007327765B2
AU2007327765B2 AU2007327765A AU2007327765A AU2007327765B2 AU 2007327765 B2 AU2007327765 B2 AU 2007327765B2 AU 2007327765 A AU2007327765 A AU 2007327765A AU 2007327765 A AU2007327765 A AU 2007327765A AU 2007327765 B2 AU2007327765 B2 AU 2007327765B2
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AU
Australia
Prior art keywords
potassium salt
crystalline
crystalline potassium
monohydrate
dihydrate
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Ceased
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AU2007327765A
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English (en)
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AU2007327765A1 (en
Inventor
Klaus Bartel
Wolfgang Beckmann
Christian Dinter
Danja Grossbach
Tilo Haag
Michael Sander
Gabriele Winter
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Brigham and Womens Hospital Inc
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Bayer Intellectual Property GmbH
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Assigned to BAYER INTELLECTUAL PROPERTY GMBH reassignment BAYER INTELLECTUAL PROPERTY GMBH Request for Assignment Assignors: BAYER PHARMA AKTIENGESELLSCHAFT
Assigned to BRIGHAM AND WOMEN'S HOSPITAL, INC. reassignment BRIGHAM AND WOMEN'S HOSPITAL, INC. Request for Assignment Assignors: BAYER INTELLECTUAL PROPERTY GMBH
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
    • C07C59/64—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings
    • C07C59/66—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings the non-carboxylic part of the ether containing six-membered aromatic rings
    • C07C59/68—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings the non-carboxylic part of the ether containing six-membered aromatic rings the oxygen atom of the ether group being bound to a non-condensed six-membered aromatic ring
    • C07C59/70—Ethers of hydroxy-acetic acid, e.g. substitutes on the ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/42—Unsaturated compounds containing hydroxy or O-metal groups
    • C07C59/48—Unsaturated compounds containing hydroxy or O-metal groups containing six-membered aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • A61K31/202—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids having three or more double bonds, e.g. linolenic
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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    • C—CHEMISTRY; METALLURGY
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    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/41—Preparation of salts of carboxylic acids
    • C07C51/412—Preparation of salts of carboxylic acids by conversion of the acids, their salts, esters or anhydrides with the same carboxylic acid part
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Neurosurgery (AREA)
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  • Pulmonology (AREA)
  • Immunology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Dermatology (AREA)
  • Pain & Pain Management (AREA)
  • Urology & Nephrology (AREA)
  • Psychology (AREA)
  • Rheumatology (AREA)
  • Epidemiology (AREA)
  • Communicable Diseases (AREA)
  • Otolaryngology (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
AU2007327765A 2006-12-04 2007-12-04 Crystalline potassium salt of lipoxin A4 analogs Ceased AU2007327765B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US87283006P 2006-12-04 2006-12-04
US60/872,830 2006-12-04
PCT/EP2007/010785 WO2008068041A1 (en) 2006-12-04 2007-12-04 Crystalline potassium salt of lipoxin a4 analogs

Publications (2)

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AU2007327765A1 AU2007327765A1 (en) 2008-06-12
AU2007327765B2 true AU2007327765B2 (en) 2012-04-12

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AU2007327765A Ceased AU2007327765B2 (en) 2006-12-04 2007-12-04 Crystalline potassium salt of lipoxin A4 analogs

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US (2) US7906678B2 (cg-RX-API-DMAC7.html)
EP (2) EP3489214A1 (cg-RX-API-DMAC7.html)
JP (1) JP5410984B2 (cg-RX-API-DMAC7.html)
KR (3) KR20160054030A (cg-RX-API-DMAC7.html)
CN (1) CN101553456B (cg-RX-API-DMAC7.html)
AR (1) AR064116A1 (cg-RX-API-DMAC7.html)
AU (1) AU2007327765B2 (cg-RX-API-DMAC7.html)
BR (1) BRPI0719679A2 (cg-RX-API-DMAC7.html)
CA (1) CA2670791C (cg-RX-API-DMAC7.html)
CL (1) CL2007003468A1 (cg-RX-API-DMAC7.html)
CO (1) CO6190608A2 (cg-RX-API-DMAC7.html)
CR (1) CR10837A (cg-RX-API-DMAC7.html)
DO (1) DOP2009000130A (cg-RX-API-DMAC7.html)
EA (1) EA018615B1 (cg-RX-API-DMAC7.html)
EC (1) ECSP099380A (cg-RX-API-DMAC7.html)
IL (1) IL198434A (cg-RX-API-DMAC7.html)
MA (1) MA31079B1 (cg-RX-API-DMAC7.html)
MX (1) MX2009005911A (cg-RX-API-DMAC7.html)
MY (1) MY147951A (cg-RX-API-DMAC7.html)
NO (1) NO20092528L (cg-RX-API-DMAC7.html)
NZ (1) NZ577338A (cg-RX-API-DMAC7.html)
PE (2) PE20081200A1 (cg-RX-API-DMAC7.html)
SV (1) SV2009003286A (cg-RX-API-DMAC7.html)
TN (1) TN2009000167A1 (cg-RX-API-DMAC7.html)
TW (1) TWI415833B (cg-RX-API-DMAC7.html)
UY (1) UY30755A1 (cg-RX-API-DMAC7.html)
WO (1) WO2008068041A1 (cg-RX-API-DMAC7.html)
ZA (1) ZA200904689B (cg-RX-API-DMAC7.html)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PE20081200A1 (es) * 2006-12-04 2008-11-06 Bayer Schering Pharma Ag Sal de potasio cristalina de analogos de lipoxina a4
US20090036530A1 (en) * 2006-12-04 2009-02-05 Bayer Schering Pharma Aktiengesellschaft Crystalline acid of lipoxin A4 analogs and method of making
EP2135610A1 (en) 2008-06-20 2009-12-23 Laboratorios Almirall, S.A. Combination comprising DHODH inhibitors and methotrexate
AU2010286681A1 (en) * 2009-08-27 2012-02-09 Merck Sharp & Dohme Corp. Processes for preparing protease inhibitors of hepatitis C virus
CA3149053A1 (en) 2013-02-21 2014-08-28 Forsyth Dental Infirmary For Children Methods for increasing oral osteogenesis using lipoxin a4 (lxa4) and its analogs
WO2016149582A1 (en) * 2015-03-18 2016-09-22 The Forsyth Institute Methods for stabilizing atherosclerotic plaques using lipoxins, resolvins, and analogs thereof
ES2827796T3 (es) * 2016-06-03 2021-05-24 Thetis Pharmaceuticals Llc Composiciones y procedimientos relativos a sales de mediadores pro-resolutivos especializados de inflamación
CA3052271A1 (en) 2017-01-31 2018-08-09 The Brigham And Women's Hospital, Inc. Alx receptor ligands define a biochemical endotype for inflammation-based diseases
CN111875530A (zh) * 2020-08-17 2020-11-03 浙江朗华制药有限公司 一种普拉西坦水合物晶体及其制备方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003040080A2 (en) * 2001-11-06 2003-05-15 Schering Aktiengesellschaft Lipoxin a4 analogs

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5650435A (en) * 1991-04-01 1997-07-22 Madara; James L. Modulation of inflammation related to columnar epithelia
US5441951A (en) * 1994-06-15 1995-08-15 Brigham & Women's Hospital Lipoxin compounds
US6048897A (en) 1993-06-15 2000-04-11 Brigham And Women's Hospital Lipoxin compounds and their use in treating cell proliferative disorders
EP1657233A1 (en) 1993-06-15 2006-05-17 The Brigham & Women's Hospital, Inc. Lipoxin compounds
WO1995001179A1 (en) 1993-06-29 1995-01-12 Brigham & Women's Hospital Modulation of inflammation related to columnar epithelia
US6008205A (en) 1997-04-04 1999-12-28 The Brigham & Women's Hospital, Inc. Polyisoprenyl phosphate stable analogs for regulation of neutrophil responses
US6236978B1 (en) * 1997-11-14 2001-05-22 New York University System and method for dynamic profiling of users in one-to-one applications
US6006466A (en) * 1998-08-20 1999-12-28 Washecka; John Concealed linear payout holder for fishing leader
SE9900274D0 (sv) 1999-01-28 1999-01-28 Astra Ab New compound
DE60044335D1 (de) 1999-03-18 2010-06-17 Brigham & Womens Hospital 16-phenoxy-lipoxin analoge zur medizinischen verwendung
AU775140B2 (en) 1999-03-18 2004-07-22 Brigham And Women's Hospital Use of lipoxin compounds for inhibiting of TNF-(alfa) initiated neutrophil response
PT1163204E (pt) 1999-03-18 2005-11-30 Brigham & Womens Hospital Compostos a base de lipoxina e sua utilizacao
PT1237549E (pt) 1999-11-09 2004-06-30 Alcon Inc Lipoxina a4 e seus analogos para o tratamento de olho seco
AU2001249329A1 (en) 2000-03-20 2001-10-03 Brigham And Women's Hospital Lipoxin analogs and methods for the treatment of periodontal disease
EP1458728A1 (en) 2001-12-13 2004-09-22 Ranbaxy Laboratories Limited Crystalline cefdinir potassium dihydrate
ATE531713T1 (de) 2002-03-15 2011-11-15 Reddys Lab Ltd Dr Polymorphin von 5-ä4-ää3-methyl-4-oxo-3,4- dihydrochinazolin-2-ylümethoxyübenzylü thiazolidin-2,4-dion kalium salz
WO2004066997A2 (en) 2003-01-30 2004-08-12 Lek Pharmaceuticals D.D. Preparation of new pharmaceutically suitable salt of losartan and forms thereof with new purification and isolation methods
WO2006035291A1 (en) 2004-09-27 2006-04-06 Ranbaxy Laboratories Limited Crystalline forms of cefdinir potassium
US7223718B2 (en) * 2005-03-07 2007-05-29 Falcon Lab Llc Enhanced glyphosate herbicidal concentrates
JP2008525531A (ja) 2005-10-31 2008-07-17 テバ ファーマシューティカル インダストリーズ リミティド セフジニルカリウム塩の結晶形
PE20081200A1 (es) * 2006-12-04 2008-11-06 Bayer Schering Pharma Ag Sal de potasio cristalina de analogos de lipoxina a4

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003040080A2 (en) * 2001-11-06 2003-05-15 Schering Aktiengesellschaft Lipoxin a4 analogs

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Fiorucci S. et al., PNAS, 2004, Vol. 10, No. 44, pages 15736-15741. *

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CA2670791A1 (en) 2008-06-12
ZA200904689B (en) 2011-10-26
BRPI0719679A2 (pt) 2014-01-14
CA2670791C (en) 2017-01-03
CN101553456B (zh) 2013-08-28
IL198434A0 (en) 2010-02-17
JP5410984B2 (ja) 2014-02-05
AU2007327765A1 (en) 2008-06-12
MX2009005911A (es) 2009-09-07
JP2010511649A (ja) 2010-04-15
AR064116A1 (es) 2009-03-11
US8049035B2 (en) 2011-11-01
DOP2009000130A (es) 2009-08-15
CO6190608A2 (es) 2010-08-19
PE20120395A1 (es) 2012-05-23
US7906678B2 (en) 2011-03-15
NZ577338A (en) 2011-02-25
CN101553456A (zh) 2009-10-07
MY147951A (en) 2013-02-15
IL198434A (en) 2012-09-24
KR20140135847A (ko) 2014-11-26
EP2089350A1 (en) 2009-08-19
KR20090101169A (ko) 2009-09-24
WO2008068041A1 (en) 2008-06-12
CR10837A (es) 2009-07-23
EA018615B1 (ru) 2013-09-30
PE20081200A1 (es) 2008-11-06
TN2009000167A1 (en) 2010-10-18
MA31079B1 (fr) 2010-01-04
HK1135961A1 (en) 2010-06-18
US20110124910A1 (en) 2011-05-26
TWI415833B (zh) 2013-11-21
NO20092528L (no) 2009-08-26
KR20160054030A (ko) 2016-05-13
EA200900732A1 (ru) 2009-12-30
EP3489214A1 (en) 2019-05-29
SV2009003286A (es) 2009-10-02
TW200838847A (en) 2008-10-01
UY30755A1 (es) 2008-07-31
EP2089350B1 (en) 2018-08-22
ECSP099380A (es) 2009-11-30
US20080182897A1 (en) 2008-07-31
CL2007003468A1 (es) 2008-07-04

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