JP2010510818A5 - - Google Patents
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- Publication number
- JP2010510818A5 JP2010510818A5 JP2009537703A JP2009537703A JP2010510818A5 JP 2010510818 A5 JP2010510818 A5 JP 2010510818A5 JP 2009537703 A JP2009537703 A JP 2009537703A JP 2009537703 A JP2009537703 A JP 2009537703A JP 2010510818 A5 JP2010510818 A5 JP 2010510818A5
- Authority
- JP
- Japan
- Prior art keywords
- carrier
- biogel
- fibrinogen
- fibrinogen binding
- immobilized
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 108010049003 Fibrinogen Proteins 0.000 claims description 115
- 102000008946 Fibrinogen Human genes 0.000 claims description 115
- 229940012952 fibrinogen Drugs 0.000 claims description 114
- BWGVNKXGVNDBDI-UHFFFAOYSA-N Fibrin monomer Chemical group CNC(=O)CNC(=O)CN BWGVNKXGVNDBDI-UHFFFAOYSA-N 0.000 claims description 26
- 239000000969 carrier Substances 0.000 claims description 24
- 239000003814 drug Substances 0.000 claims description 23
- 238000000034 method Methods 0.000 claims description 22
- 229940079593 drug Drugs 0.000 claims description 21
- 108010073385 Fibrin Proteins 0.000 claims description 17
- 102000009123 Fibrin Human genes 0.000 claims description 17
- 229950003499 fibrin Drugs 0.000 claims description 17
- 239000003795 chemical substances by application Substances 0.000 claims description 13
- 230000000740 bleeding effect Effects 0.000 claims description 9
- 108010073651 fibrinmonomer Proteins 0.000 claims description 9
- 230000015572 biosynthetic process Effects 0.000 claims description 8
- 239000000178 monomer Substances 0.000 claims description 8
- 238000007789 sealing Methods 0.000 claims description 5
- 238000012377 drug delivery Methods 0.000 claims description 4
- 230000023597 hemostasis Effects 0.000 claims description 4
- 239000000565 sealant Substances 0.000 claims description 4
- 238000004519 manufacturing process Methods 0.000 claims description 3
- 239000000843 powder Substances 0.000 claims description 3
- 239000000725 suspension Substances 0.000 claims description 2
- 239000002274 desiccant Substances 0.000 claims 1
- 238000009472 formulation Methods 0.000 claims 1
- 238000004108 freeze drying Methods 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000000825 pharmaceutical preparation Substances 0.000 claims 1
- 238000001694 spray drying Methods 0.000 claims 1
- 238000011200 topical administration Methods 0.000 claims 1
- 239000002243 precursor Substances 0.000 description 19
- 206010052428 Wound Diseases 0.000 description 10
- 208000027418 Wounds and injury Diseases 0.000 description 10
- 102000015081 Blood Coagulation Factors Human genes 0.000 description 9
- 108010039209 Blood Coagulation Factors Proteins 0.000 description 9
- 239000003114 blood coagulation factor Substances 0.000 description 9
- 230000001105 regulatory effect Effects 0.000 description 6
- 239000003106 tissue adhesive Substances 0.000 description 5
- 108090000190 Thrombin Proteins 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- 229960004072 thrombin Drugs 0.000 description 2
- FBPFZTCFMRRESA-ZXXMMSQZSA-N D-iditol Chemical compound OC[C@@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-ZXXMMSQZSA-N 0.000 description 1
- 108010000196 Factor XIIIa Proteins 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 229920000249 biocompatible polymer Polymers 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 238000005507 spraying Methods 0.000 description 1
- 230000029663 wound healing Effects 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0623607.9 | 2006-11-27 | ||
| GBGB0623607.9A GB0623607D0 (en) | 2006-11-27 | 2006-11-27 | Tissue adhesive |
| PCT/GB2007/004538 WO2008065388A2 (en) | 2006-11-27 | 2007-11-27 | Biogel |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013130066A Division JP2013188550A (ja) | 2006-11-27 | 2013-06-20 | バイオゲル |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010510818A JP2010510818A (ja) | 2010-04-08 |
| JP2010510818A5 true JP2010510818A5 (cg-RX-API-DMAC10.html) | 2011-01-20 |
| JP5801994B2 JP5801994B2 (ja) | 2015-10-28 |
Family
ID=37636565
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009537703A Active JP5801994B2 (ja) | 2006-11-27 | 2007-11-27 | バイオゲル |
| JP2013130066A Pending JP2013188550A (ja) | 2006-11-27 | 2013-06-20 | バイオゲル |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013130066A Pending JP2013188550A (ja) | 2006-11-27 | 2013-06-20 | バイオゲル |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US9339584B2 (cg-RX-API-DMAC10.html) |
| EP (2) | EP2099505B1 (cg-RX-API-DMAC10.html) |
| JP (2) | JP5801994B2 (cg-RX-API-DMAC10.html) |
| CN (1) | CN101687061B (cg-RX-API-DMAC10.html) |
| AU (1) | AU2007327100B2 (cg-RX-API-DMAC10.html) |
| CA (1) | CA2669738C (cg-RX-API-DMAC10.html) |
| DK (1) | DK2099505T3 (cg-RX-API-DMAC10.html) |
| ES (2) | ES2896053T3 (cg-RX-API-DMAC10.html) |
| GB (1) | GB0623607D0 (cg-RX-API-DMAC10.html) |
| IL (1) | IL198699A (cg-RX-API-DMAC10.html) |
| PL (1) | PL2099505T3 (cg-RX-API-DMAC10.html) |
| RU (1) | RU2503464C2 (cg-RX-API-DMAC10.html) |
| WO (1) | WO2008065388A2 (cg-RX-API-DMAC10.html) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2358761B1 (en) | 2008-12-15 | 2015-08-05 | Council of Scientific & Industrial Research | A transparent xyloglucan/chitosan gel and a process for the preparation thereof |
| MX344402B (es) * | 2010-06-01 | 2016-12-14 | Baxter Int Inc * | Proceso para elaborar composiciones hemostaticas secas y estables. |
| GB201101740D0 (en) * | 2011-02-01 | 2011-03-16 | Haemostatix Ltd | Therapeutic agents with improved fibrinogen binding |
| GB201201751D0 (en) * | 2012-02-01 | 2012-03-14 | Haemostatix Ltd | Haemostatic wound dressing |
| EP2928511B1 (en) * | 2012-12-07 | 2020-04-22 | Baxter International Inc. | Hemostatic foam |
| IL230151A0 (en) * | 2013-12-24 | 2014-09-30 | Omrix Biopharmaceuticals Ltd | One-component fibrin glue containing a polymerization inhibitor |
| GB201400292D0 (en) * | 2014-01-08 | 2014-02-26 | Haemostatix Ltd | Peptide dendrimers and agents |
| IL231792A0 (en) | 2014-03-27 | 2014-08-31 | Omrix Biopharmaceuticals Ltd | Device and method for the preparation and administration of one-component fibrin glue |
| EA028039B1 (ru) * | 2014-09-05 | 2017-09-29 | Частное Учреждение Лаборатория Биотехнологических Исследований "3Д Биопринтинг Солюшенс" | Устройство и способы печати биологических тканей и органов |
| IL235751A0 (en) * | 2014-11-18 | 2015-02-26 | Omrix Biopharmaceuticals Ltd | An addition to the spray dryer |
| GB201508024D0 (en) | 2015-05-11 | 2015-06-24 | Haemostatix Ltd | Haemostatic compositions |
| GB201508014D0 (en) * | 2015-05-11 | 2015-06-24 | Haemostatix Ltd | Haemostatic device |
| IL242984A0 (en) | 2015-12-08 | 2016-02-29 | Omrix Biopharmaceuticals Ltd | Thrombin microcapsules, their preparation and how to use them |
| US10159720B2 (en) | 2015-12-08 | 2018-12-25 | Omrix Biopharmaceuticals Ltd | Thrombin microcapsules, preparation and uses thereof |
| CN107432955B (zh) * | 2016-09-14 | 2020-09-04 | 四川蓝光英诺生物科技股份有限公司 | 用于制备生物构建体的方法和试剂盒 |
| WO2018065789A1 (en) | 2016-10-06 | 2018-04-12 | Matoke Holdings Limited | Antimicrobial compositions |
| EP3522717B1 (en) | 2016-10-06 | 2024-01-24 | Matoke Holdings Limited | Antimicrobial compositions |
| EP3749774A1 (en) | 2018-04-23 | 2020-12-16 | Danisco US Inc. | Synthesis of glucan comprising beta-1,3 glycosidic linkages with phosphorylase enzymes |
| CN110448719B (zh) * | 2019-06-28 | 2020-05-22 | 浙江大学 | 一种促进凝血的丝素-多肽电纺膜及其制备方法 |
| US20230105440A1 (en) * | 2021-10-06 | 2023-04-06 | Medtronic, Inc. | Anti-thrombogenic coating |
Family Cites Families (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AT359653B (de) | 1979-02-15 | 1980-11-25 | Immuno Ag | Verfahren zur herstellung eines gewebekleb- stoffes |
| ATE13810T1 (de) | 1981-06-25 | 1985-07-15 | Serapharm Gmbh & Co Kg | Angereichertes plasmaderivat zur unterstuetzung von wundverschluss und wundabdeckung. |
| US5357042A (en) | 1984-04-23 | 1994-10-18 | The General Hospital Corporation | Synthetic peptides capable of eliciting fibrin-specific monoclonal antibodies lacking fibrinogen-cross-reactivity |
| US6391343B1 (en) | 1991-01-15 | 2002-05-21 | Hemosphere, Inc. | Fibrinogen-coated particles for therapeutic use |
| IL103252A (en) | 1991-09-30 | 1997-03-18 | Du Pont Merck Pharma | CYCLIC COMPOUNDS USEFUL AS INHIBITORS OF PLATELET GLYCOPROTEIN IIb/IIIa AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM |
| US5635477A (en) | 1991-09-30 | 1997-06-03 | The Dupont Merck Pharmaceutical Company | Cyclic compounds useful as inhibitors of platelet glycoprotein IIB/IIIA |
| RU2096415C1 (ru) * | 1991-09-30 | 1997-11-20 | Дзе Дюпон Мерк Фармасьютикал Компани | Циклические пептиды или их фармацевтически приемлемые соли, фармацевтическая композиция |
| EP0691987A1 (en) | 1993-03-29 | 1996-01-17 | The Du Pont Merck Pharmaceutical Company | CYCLIC COMPOUNDS USEFUL AS INHIBITORS OF PLATELET GLYCOPROTEIN IIb/IIIa |
| EP0759762A4 (en) | 1994-05-02 | 1999-09-01 | Squibb & Sons Inc | RECOMBINANT FIBRIN CHAINS, FIBRIN AND FIBRIN APPROVED |
| AU717906B2 (en) * | 1994-12-07 | 2000-04-06 | American National Red Cross, The | Supplemented and unsupplemented tissue sealants, methods of their production and use |
| DE69529917T2 (de) | 1994-12-16 | 2003-12-11 | Elan Drug Delivery Ltd., Ruddington | Vernetzte mikropartikel und ihre verwendung als arzneiträger |
| EP0831793A4 (en) | 1995-06-06 | 2000-11-15 | Hemosphere Inc | PROTEIN PARTICLES FOR THERAPEUTIC AND DIAGNOSTIC USE |
| JP4024302B2 (ja) | 1996-05-17 | 2007-12-19 | クアドラント、 ドラッグ、 デリバリー、 リミテッド | 微粒子および創傷治療におけるその用途 |
| AU718956B2 (en) | 1996-10-21 | 2000-05-04 | Quadrant Healthcare (Uk) Limited | Platelet substitutes and conjugation methods suitable for their preparation |
| GB9724143D0 (en) * | 1997-11-14 | 1998-01-14 | Andaris Ltd | Pharmaceutical conjugate |
| DE19849589C1 (de) * | 1998-10-27 | 2000-06-15 | Glatt Process Technology Gmbh | Fibrin-Gewebekleber-Formulierung und Verfahren zu dessen Herstellung |
| AU7362301A (en) * | 2000-06-22 | 2002-01-02 | Sam L Austin | Bioadhesive compositions and methods of preparation and use |
| PL206194B1 (pl) * | 2001-01-25 | 2010-07-30 | Nycomed Pharma Asnycomed Pharma As | Sposób wytwarzania zawiesiny cząstek fibrynogenu i trombiny, zawiesina zawierająca fibrynogen, trombinę i alkohol oraz sposób powlekania nośnika taką zawiesiną |
| KR20050044725A (ko) * | 2001-12-04 | 2005-05-12 | 크리스토퍼 제이 울버튼 | 저장-안정성 피브린 밀봉제 |
| ES2325358T3 (es) * | 2002-01-14 | 2009-09-02 | "VLAAMSE INSTELLING VOOR TECHNOLOGISCH ONDERZOEK", AFGEKORT "V.I.T.O." | Procedimiento para producir productos metalicos y ceramicos. |
| WO2003086494A1 (en) * | 2002-04-05 | 2003-10-23 | Baxter International Inc. | Storage stable liquid sealer protein complex |
| CN100525829C (zh) | 2002-04-15 | 2009-08-12 | 美国国家红十字会 | 检测混合物中配体和靶标的方法 |
| WO2004045494A2 (en) | 2002-11-20 | 2004-06-03 | Bar-Ilan University | Biological glue based on thrombin-conjugated nanoparticles |
| CA2489996A1 (en) * | 2003-05-08 | 2004-11-18 | Kaneka Corporation | Low density lipoprotein/fibrinogen adsorbent and adsorption apparatus capable of whole blood treatment |
| EP1638491A4 (en) | 2003-06-16 | 2008-05-28 | Univ Loma Linda Med | ABLEABLE MULTIFUNCTIONAL HEMOSTASIS |
| US7129210B2 (en) * | 2003-07-23 | 2006-10-31 | Covalent Medical, Inc. | Tissue adhesive sealant |
| US7927626B2 (en) | 2003-08-07 | 2011-04-19 | Ethicon, Inc. | Process of making flowable hemostatic compositions and devices containing such compositions |
| GB0323378D0 (en) | 2003-10-07 | 2003-11-05 | Univ Leicester | Therapeutic agent |
| CN1544098A (zh) * | 2003-11-12 | 2004-11-10 | 邹金生 | 高效神经生长因子生物胶及其制备和使用方法 |
| WO2005076827A2 (en) * | 2004-02-04 | 2005-08-25 | Universita' Degli Studi Di Pavia | Fbsa compositions for use in promoting fibrinogen aggregation and potentiating fibrin polymerization |
| US7833978B2 (en) * | 2004-02-20 | 2010-11-16 | Emory University | Thrombomodulin derivatives and conjugates |
| US20060034935A1 (en) | 2004-07-22 | 2006-02-16 | Pronovost Allan D | Compositions and methods for treating excessive bleeding |
| ES2530989T3 (es) | 2004-10-20 | 2015-03-09 | Ethicon Inc | Hemostático absorbible |
| GB0516091D0 (en) * | 2005-08-04 | 2005-09-14 | Haemostatix Ltd | Therapeutic agent |
-
2006
- 2006-11-27 GB GBGB0623607.9A patent/GB0623607D0/en not_active Ceased
-
2007
- 2007-11-27 EP EP07824729.3A patent/EP2099505B1/en active Active
- 2007-11-27 RU RU2009119257/15A patent/RU2503464C2/ru active
- 2007-11-27 US US12/515,721 patent/US9339584B2/en active Active
- 2007-11-27 EP EP16155589.1A patent/EP3095468B1/en active Active
- 2007-11-27 DK DK07824729.3T patent/DK2099505T3/en active
- 2007-11-27 CA CA2669738A patent/CA2669738C/en active Active
- 2007-11-27 ES ES16155589T patent/ES2896053T3/es active Active
- 2007-11-27 ES ES07824729T patent/ES2570760T3/es active Active
- 2007-11-27 CN CN200780044184XA patent/CN101687061B/zh active Active
- 2007-11-27 PL PL07824729T patent/PL2099505T3/pl unknown
- 2007-11-27 WO PCT/GB2007/004538 patent/WO2008065388A2/en not_active Ceased
- 2007-11-27 JP JP2009537703A patent/JP5801994B2/ja active Active
- 2007-11-27 AU AU2007327100A patent/AU2007327100B2/en active Active
-
2009
- 2009-05-12 IL IL198699A patent/IL198699A/en active IP Right Grant
-
2013
- 2013-06-20 JP JP2013130066A patent/JP2013188550A/ja active Pending
-
2016
- 2016-04-13 US US15/098,028 patent/US9913876B2/en active Active
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