JP2010510223A5 - - Google Patents
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- Publication number
- JP2010510223A5 JP2010510223A5 JP2009537223A JP2009537223A JP2010510223A5 JP 2010510223 A5 JP2010510223 A5 JP 2010510223A5 JP 2009537223 A JP2009537223 A JP 2009537223A JP 2009537223 A JP2009537223 A JP 2009537223A JP 2010510223 A5 JP2010510223 A5 JP 2010510223A5
- Authority
- JP
- Japan
- Prior art keywords
- agent
- tim
- antigen
- activity
- polypeptide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 238000000034 method Methods 0.000 claims description 61
- 239000003795 chemical substances by application Substances 0.000 claims description 39
- 102100034458 Hepatitis A virus cellular receptor 2 Human genes 0.000 claims description 37
- 101710083479 Hepatitis A virus cellular receptor 2 homolog Proteins 0.000 claims description 37
- 229940126547 T-cell immunoglobulin mucin-3 Drugs 0.000 claims description 37
- 229920001184 polypeptide Polymers 0.000 claims description 27
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 27
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 27
- 102100031351 Galectin-9 Human genes 0.000 claims description 17
- 101710121810 Galectin-9 Proteins 0.000 claims description 17
- 239000000427 antigen Substances 0.000 claims description 17
- 102000036639 antigens Human genes 0.000 claims description 17
- 108091007433 antigens Proteins 0.000 claims description 17
- 230000000694 effects Effects 0.000 claims description 17
- 239000003446 ligand Substances 0.000 claims description 14
- 210000000612 antigen-presenting cell Anatomy 0.000 claims description 12
- 206010028980 Neoplasm Diseases 0.000 claims description 9
- 241001465754 Metazoa Species 0.000 claims description 8
- 102000002689 Toll-like receptor Human genes 0.000 claims description 7
- 108020000411 Toll-like receptor Proteins 0.000 claims description 7
- 230000028993 immune response Effects 0.000 claims description 7
- 210000003169 central nervous system Anatomy 0.000 claims description 3
- 201000007455 central nervous system cancer Diseases 0.000 claims description 3
- 208000025997 central nervous system neoplasm Diseases 0.000 claims description 3
- 229940123384 Toll-like receptor (TLR) agonist Drugs 0.000 claims description 2
- 239000000556 agonist Substances 0.000 claims description 2
- 230000002708 enhancing effect Effects 0.000 claims description 2
- 239000000203 mixture Substances 0.000 description 15
- 229960005486 vaccine Drugs 0.000 description 15
- 125000003275 alpha amino acid group Chemical group 0.000 description 8
- 239000012634 fragment Substances 0.000 description 7
- 101001046686 Homo sapiens Integrin alpha-M Proteins 0.000 description 5
- 102100022338 Integrin alpha-M Human genes 0.000 description 5
- 150000001720 carbohydrates Chemical class 0.000 description 5
- 150000001413 amino acids Chemical class 0.000 description 4
- 210000004443 dendritic cell Anatomy 0.000 description 4
- 102000008394 Immunoglobulin Fragments Human genes 0.000 description 3
- 108010021625 Immunoglobulin Fragments Proteins 0.000 description 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 3
- 208000035475 disorder Diseases 0.000 description 3
- 239000003814 drug Substances 0.000 description 3
- 210000000274 microglia Anatomy 0.000 description 3
- 201000006417 multiple sclerosis Diseases 0.000 description 3
- 206010018338 Glioma Diseases 0.000 description 2
- 241000124008 Mammalia Species 0.000 description 2
- GUBGYTABKSRVRQ-QKKXKWKRSA-N lactose group Chemical group OC1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@H](O)[C@@H](O)[C@@H](O)[C@H](O2)CO)[C@H](O1)CO GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 210000001616 monocyte Anatomy 0.000 description 2
- 235000010987 pectin Nutrition 0.000 description 2
- 229920001277 pectin Polymers 0.000 description 2
- 239000001814 pectin Substances 0.000 description 2
- 230000011664 signaling Effects 0.000 description 2
- MZOFCQQQCNRIBI-VMXHOPILSA-N (3s)-4-[[(2s)-1-[[(2s)-1-[[(1s)-1-carboxy-2-hydroxyethyl]amino]-4-methyl-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-3-[[2-[[(2s)-2,6-diaminohexanoyl]amino]acetyl]amino]-4-oxobutanoic acid Chemical compound OC[C@@H](C(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@@H](N)CCCCN MZOFCQQQCNRIBI-VMXHOPILSA-N 0.000 description 1
- 108091032973 (ribonucleotides)n+m Proteins 0.000 description 1
- 102000040650 (ribonucleotides)n+m Human genes 0.000 description 1
- 206010003571 Astrocytoma Diseases 0.000 description 1
- 206010014967 Ependymoma Diseases 0.000 description 1
- 201000004066 Ganglioglioma Diseases 0.000 description 1
- 208000032612 Glial tumor Diseases 0.000 description 1
- 201000010915 Glioblastoma multiforme Diseases 0.000 description 1
- 102000008100 Human Serum Albumin Human genes 0.000 description 1
- 108091006905 Human Serum Albumin Proteins 0.000 description 1
- 108060003951 Immunoglobulin Proteins 0.000 description 1
- 201000010133 Oligodendroglioma Diseases 0.000 description 1
- 108091034117 Oligonucleotide Proteins 0.000 description 1
- 108060008682 Tumor Necrosis Factor Proteins 0.000 description 1
- 102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 description 1
- 239000013543 active substance Substances 0.000 description 1
- 239000003085 diluting agent Substances 0.000 description 1
- 239000003937 drug carrier Substances 0.000 description 1
- 208000005017 glioblastoma Diseases 0.000 description 1
- 102000018358 immunoglobulin Human genes 0.000 description 1
- 230000002757 inflammatory effect Effects 0.000 description 1
- 239000008101 lactose Substances 0.000 description 1
- 201000004058 mixed glioma Diseases 0.000 description 1
- 206010073131 oligoastrocytoma Diseases 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US85939106P | 2006-11-15 | 2006-11-15 | |
| US92394507P | 2007-04-17 | 2007-04-17 | |
| PCT/US2007/024067 WO2008060617A2 (en) | 2006-11-15 | 2007-11-15 | Therapeutic uses of tim-3 modulators |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2010510223A JP2010510223A (ja) | 2010-04-02 |
| JP2010510223A5 true JP2010510223A5 (cg-RX-API-DMAC7.html) | 2012-01-26 |
Family
ID=39402274
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009537223A Withdrawn JP2010510223A (ja) | 2006-11-15 | 2007-11-15 | Tim−3調節物質の治療的使用 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20100061992A1 (cg-RX-API-DMAC7.html) |
| EP (1) | EP2081961A2 (cg-RX-API-DMAC7.html) |
| JP (1) | JP2010510223A (cg-RX-API-DMAC7.html) |
| AU (1) | AU2007319806A1 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2668693A1 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2008060617A2 (cg-RX-API-DMAC7.html) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2010084999A1 (en) * | 2009-01-26 | 2010-07-29 | Protegene, Inc. | Immunosuppressive agents and prophylactic and therapeutic agents for autoimmune diseases |
| US8883174B2 (en) * | 2009-03-25 | 2014-11-11 | The Board Of Regents, The University Of Texas System | Compositions for stimulation of mammalian innate immune resistance to pathogens |
| TR201807750T4 (tr) * | 2010-06-11 | 2018-06-21 | Kyowa Hakko Kirin Co Ltd | Anti-TIM-3 antikoru. |
| US8841418B2 (en) | 2011-07-01 | 2014-09-23 | Cellerant Therapeutics, Inc. | Antibodies that specifically bind to TIM3 |
| US10513540B2 (en) | 2012-07-31 | 2019-12-24 | The Brigham And Women's Hospital, Inc. | Modulation of the immune response |
| US20140120157A1 (en) * | 2012-09-19 | 2014-05-01 | Georgetown University | Targeted liposomes |
| EP3679950A1 (en) | 2012-10-12 | 2020-07-15 | The Brigham and Women's Hospital, Inc. | Enhancement of the immune response |
| PL2911676T3 (pl) | 2012-10-29 | 2020-12-28 | The Board Of Trustees Of The University Of Arkansas | Nowe adiuwanty śluzówkowe oraz systemy dostarczania |
| EP3049442A4 (en) | 2013-09-26 | 2017-06-28 | Costim Pharmaceuticals Inc. | Methods for treating hematologic cancers |
| JOP20200094A1 (ar) | 2014-01-24 | 2017-06-16 | Dana Farber Cancer Inst Inc | جزيئات جسم مضاد لـ pd-1 واستخداماتها |
| JOP20200096A1 (ar) | 2014-01-31 | 2017-06-16 | Children’S Medical Center Corp | جزيئات جسم مضاد لـ tim-3 واستخداماتها |
| BR112016020919A2 (pt) | 2014-03-12 | 2018-01-23 | Yeda Res & Dev | redução dos níveis ou da atividade sistêmica de células t regulatórias para o tratamento de doença e lesão do snc |
| US10618963B2 (en) | 2014-03-12 | 2020-04-14 | Yeda Research And Development Co. Ltd | Reducing systemic regulatory T cell levels or activity for treatment of disease and injury of the CNS |
| US10519237B2 (en) | 2014-03-12 | 2019-12-31 | Yeda Research And Development Co. Ltd | Reducing systemic regulatory T cell levels or activity for treatment of disease and injury of the CNS |
| UY36032A (es) | 2014-03-14 | 2015-10-30 | Novartis Ag | Moléculas de anticuerpo que se unen a lag-3 y usos de las mismas |
| RS61678B1 (sr) | 2014-05-28 | 2021-05-31 | Agenus Inc | Anti-gitr antitela i postupci za njihovu primenu |
| CN107206071A (zh) | 2014-09-13 | 2017-09-26 | 诺华股份有限公司 | Alk抑制剂的联合疗法 |
| US20180298095A1 (en) * | 2015-04-24 | 2018-10-18 | The Brigham And Women's Hospital, Inc. | Interactions between ceacam and tim family members |
| WO2016179194A1 (en) * | 2015-05-04 | 2016-11-10 | Jounce Therapeutics, Inc. | Lilra3 and method of using the same |
| US10682390B2 (en) | 2015-07-16 | 2020-06-16 | Biokine Therapeutics Ltd. | Compositions and methods for treating cancer |
| IL299072A (en) | 2015-12-02 | 2023-02-01 | Memorial Sloan Kettering Cancer Center | Antibodies and methods of use thereof |
| AU2017228365B2 (en) * | 2016-03-04 | 2021-05-27 | Galectin Sciences, Llc | Selenogalactoside compounds for the prevention and treatment of diseases associated with galectin and the use thereof |
| FR3051192B1 (fr) * | 2016-05-13 | 2020-12-25 | Univ De Lorraine | Methode de purification de proteines recombinantes par affinite basee sur l'activite lectinique du domaine crd d'une galectine |
| NZ749355A (en) | 2016-05-27 | 2023-04-28 | Agenus Inc | Anti-tim-3 antibodies and methods of use thereof |
| EP4512829A3 (en) | 2016-07-14 | 2025-06-11 | Bristol-Myers Squibb Company | Antibodies against tim3 and uses thereof |
| BR112019023722A2 (pt) | 2017-05-12 | 2020-05-26 | Galectin Sciences, Llc | Compostos para a prevenção e tratamento de doenças e o uso dos mesmos |
| CN111201030B (zh) * | 2017-07-25 | 2024-11-01 | 真和制药有限公司 | 通过阻断tim-3和其配体的相互作用治疗癌症 |
| CA3127113A1 (en) | 2019-01-30 | 2020-08-06 | Dongxu Sun | Anti-gal3 antibodies and uses thereof |
| EP3725370A1 (en) | 2019-04-19 | 2020-10-21 | ImmunoBrain Checkpoint, Inc. | Modified anti-pd-l1 antibodies and methods and uses for treating a neurodegenerative disease |
| KR102536302B1 (ko) * | 2020-02-25 | 2023-05-26 | 국립암센터 | Tim-3 에 특이적으로 결합하는 단일클론항체 및 이의 용도 |
| JP2023528797A (ja) | 2020-05-26 | 2023-07-06 | トゥルーバインディング,インコーポレイテッド | ガレクチン-3を遮断することにより炎症性疾患を処置する方法 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2003063792A2 (en) * | 2002-01-30 | 2003-08-07 | The Brigham And Women's Hospital, Inc. | Compositions and methods related to tim-3, a th1-specific cell surface molecule |
| EP1685159B1 (en) * | 2003-10-03 | 2012-08-01 | Brigham & Women's Hospital | Tim-3 polypeptides |
-
2007
- 2007-11-15 CA CA002668693A patent/CA2668693A1/en not_active Abandoned
- 2007-11-15 EP EP07867488A patent/EP2081961A2/en not_active Withdrawn
- 2007-11-15 WO PCT/US2007/024067 patent/WO2008060617A2/en not_active Ceased
- 2007-11-15 AU AU2007319806A patent/AU2007319806A1/en not_active Abandoned
- 2007-11-15 JP JP2009537223A patent/JP2010510223A/ja not_active Withdrawn
- 2007-11-15 US US12/514,602 patent/US20100061992A1/en not_active Abandoned
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