JP2010509936A5 - - Google Patents

Info

Publication number

JP2010509936A5

JP2010509936A5 JP2009538403A JP2009538403A JP2010509936A5 JP 2010509936 A5 JP2010509936 A5 JP 2010509936A5 JP 2009538403 A JP2009538403 A JP 2009538403A JP 2009538403 A JP2009538403 A JP 2009538403A JP 2010509936 A5 JP2010509936 A5 JP 2010509936A5

Authority

JP

Japan

Prior art keywords

cells

islet

bone marrow

cell

cultured

Prior art date

2007-11-20

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
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• 210000000227 basophil cell of anterior lobe of hypophysis Anatomy 0.000 claims 26
• 238000000034 method Methods 0.000 claims 14
• 210000002798 bone marrow cell Anatomy 0.000 claims 11
• 210000004153 islets of langerhan Anatomy 0.000 claims 8
• 238000012258 culturing Methods 0.000 claims 6
• 108090000623 proteins and genes Proteins 0.000 claims 5
• 238000000338 in vitro Methods 0.000 claims 4
• 210000004027 cell Anatomy 0.000 claims 3
• 230000003833 cell viability Effects 0.000 claims 3
• 239000008194 pharmaceutical composition Substances 0.000 claims 3
• 108090000695 Cytokines Proteins 0.000 claims 2
• 102000004127 Cytokines Human genes 0.000 claims 2
• 102100024392 Insulin gene enhancer protein ISL-1 Human genes 0.000 claims 2
• 102100038553 Neurogenin-3 Human genes 0.000 claims 2
• 101710096141 Neurogenin-3 Proteins 0.000 claims 2
• 102000007354 PAX6 Transcription Factor Human genes 0.000 claims 2
• 108010032788 PAX6 Transcription Factor Proteins 0.000 claims 2
• 102100041030 Pancreas/duodenum homeobox protein 1 Human genes 0.000 claims 2
• 230000003915 cell function Effects 0.000 claims 2
• 210000003890 endocrine cell Anatomy 0.000 claims 2
• 230000006870 function Effects 0.000 claims 2
• NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 claims 2
• 108010090448 insulin gene enhancer binding protein Isl-1 Proteins 0.000 claims 2
• 230000003914 insulin secretion Effects 0.000 claims 2
• 101150023803 Bhlha15 gene Proteins 0.000 claims 1
• 102000051325 Glucagon Human genes 0.000 claims 1
• 108060003199 Glucagon Proteins 0.000 claims 1
• WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims 1
• 101000612089 Homo sapiens Pancreas/duodenum homeobox protein 1 Proteins 0.000 claims 1
• 102000004877 Insulin Human genes 0.000 claims 1
• 102100023915 Insulin Human genes 0.000 claims 1
• 108090001061 Insulin Proteins 0.000 claims 1
• 108700020796 Oncogene Proteins 0.000 claims 1
• 108010084438 Oncogene Protein v-maf Proteins 0.000 claims 1
• 101710183548 Pyridoxal 5'-phosphate synthase subunit PdxS Proteins 0.000 claims 1
• 102000005157 Somatostatin Human genes 0.000 claims 1
• 108010056088 Somatostatin Proteins 0.000 claims 1
• 108091023040 Transcription factor Proteins 0.000 claims 1
• 102000040945 Transcription factor Human genes 0.000 claims 1
• 230000006907 apoptotic process Effects 0.000 claims 1
• 206010012601 diabetes mellitus Diseases 0.000 claims 1
• 230000002183 duodenal effect Effects 0.000 claims 1
• MASNOZXLGMXCHN-ZLPAWPGGSA-N glucagon Chemical compound C([C@@H](C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(O)=O)C(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC=1NC=NC=1)[C@@H](C)O)[C@@H](C)O)C1=CC=CC=C1 MASNOZXLGMXCHN-ZLPAWPGGSA-N 0.000 claims 1
• 229960004666 glucagon Drugs 0.000 claims 1
• 239000008103 glucose Substances 0.000 claims 1
• 229940125396 insulin Drugs 0.000 claims 1
• 210000000496 pancreas Anatomy 0.000 claims 1
• 230000002062 proliferating effect Effects 0.000 claims 1
• NHXLMOGPVYXJNR-ATOGVRKGSA-N somatostatin Chemical compound C([C@H]1C(=O)N[C@H](C(N[C@@H](CO)C(=O)N[C@@H](CSSC[C@@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CC=2C3=CC=CC=C3NC=2)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N1)[C@@H](C)O)NC(=O)CNC(=O)[C@H](C)N)C(O)=O)=O)[C@H](O)C)C1=CC=CC=C1 NHXLMOGPVYXJNR-ATOGVRKGSA-N 0.000 claims 1
• 229960000553 somatostatin Drugs 0.000 claims 1
• 230000002459 sustained effect Effects 0.000 claims 1