JP2010509220A - 眼瞼スクラブ用組成物 - Google Patents
眼瞼スクラブ用組成物 Download PDFInfo
- Publication number
- JP2010509220A JP2010509220A JP2009535335A JP2009535335A JP2010509220A JP 2010509220 A JP2010509220 A JP 2010509220A JP 2009535335 A JP2009535335 A JP 2009535335A JP 2009535335 A JP2009535335 A JP 2009535335A JP 2010509220 A JP2010509220 A JP 2010509220A
- Authority
- JP
- Japan
- Prior art keywords
- composition
- eyelid
- weight
- octanediol
- hexanediol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 158
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- 239000004094 surface-active agent Substances 0.000 claims abstract description 65
- 229920002413 Polyhexanide Polymers 0.000 claims abstract description 39
- 239000000243 solution Substances 0.000 claims abstract description 39
- AEIJTFQOBWATKX-UHFFFAOYSA-N octane-1,2-diol Chemical compound CCCCCCC(O)CO AEIJTFQOBWATKX-UHFFFAOYSA-N 0.000 claims abstract description 30
- 229940031723 1,2-octanediol Drugs 0.000 claims abstract description 29
- 229940015975 1,2-hexanediol Drugs 0.000 claims abstract description 28
- FHKSXSQHXQEMOK-UHFFFAOYSA-N hexane-1,2-diol Chemical compound CCCCC(O)CO FHKSXSQHXQEMOK-UHFFFAOYSA-N 0.000 claims abstract description 28
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims abstract description 27
- 239000012891 Ringer solution Substances 0.000 claims abstract description 26
- VAZJLPXFVQHDFB-UHFFFAOYSA-N 1-(diaminomethylidene)-2-hexylguanidine Polymers CCCCCCN=C(N)N=C(N)N VAZJLPXFVQHDFB-UHFFFAOYSA-N 0.000 claims abstract description 23
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- 239000006260 foam Substances 0.000 claims abstract description 19
- 230000000087 stabilizing effect Effects 0.000 claims abstract description 15
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- ZORQXIQZAOLNGE-UHFFFAOYSA-N 1,1-difluorocyclohexane Chemical compound FC1(F)CCCCC1 ZORQXIQZAOLNGE-UHFFFAOYSA-N 0.000 claims description 15
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- 125000002704 decyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 claims description 7
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- 229930182470 glycoside Chemical class 0.000 claims description 5
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- 150000003893 lactate salts Chemical class 0.000 claims description 5
- 229940044591 methyl glucose dioleate Drugs 0.000 claims description 5
- 150000003751 zinc Chemical class 0.000 claims description 5
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims description 4
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical class OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 claims description 4
- GHVNFZFCNZKVNT-UHFFFAOYSA-N decanoic acid Chemical compound CCCCCCCCCC(O)=O GHVNFZFCNZKVNT-UHFFFAOYSA-N 0.000 claims description 4
- POULHZVOKOAJMA-UHFFFAOYSA-N dodecanoic acid Chemical compound CCCCCCCCCCCC(O)=O POULHZVOKOAJMA-UHFFFAOYSA-N 0.000 claims description 4
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- 150000002334 glycols Chemical class 0.000 claims description 4
- WWZKQHOCKIZLMA-UHFFFAOYSA-N octanoic acid Chemical compound CCCCCCCC(O)=O WWZKQHOCKIZLMA-UHFFFAOYSA-N 0.000 claims description 4
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- JNYAEWCLZODPBN-JGWLITMVSA-N (2r,3r,4s)-2-[(1r)-1,2-dihydroxyethyl]oxolane-3,4-diol Chemical class OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O JNYAEWCLZODPBN-JGWLITMVSA-N 0.000 claims description 3
- PDNLXUROKBBMBE-BYOHNYAZSA-N (Z)-octadec-9-enoic acid (3R,4S,5R,6R)-3,4,5,6,7-pentahydroxyheptan-2-one Chemical compound CC(=O)[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO.CCCCCCCC\C=C/CCCCCCCC(O)=O.CCCCCCCC\C=C/CCCCCCCC(O)=O PDNLXUROKBBMBE-BYOHNYAZSA-N 0.000 claims description 3
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- 150000005690 diesters Chemical class 0.000 claims description 3
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- ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 claims description 3
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- 235000020957 pantothenol Nutrition 0.000 claims description 3
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- 239000008213 purified water Substances 0.000 claims description 3
- WRIDQFICGBMAFQ-UHFFFAOYSA-N (E)-8-Octadecenoic acid Natural products CCCCCCCCCC=CCCCCCCC(O)=O WRIDQFICGBMAFQ-UHFFFAOYSA-N 0.000 claims description 2
- LQJBNNIYVWPHFW-UHFFFAOYSA-N 20:1omega9c fatty acid Natural products CCCCCCCCCCC=CCCCCCCCC(O)=O LQJBNNIYVWPHFW-UHFFFAOYSA-N 0.000 claims description 2
- QSBYPNXLFMSGKH-UHFFFAOYSA-N 9-Heptadecensaeure Natural products CCCCCCCC=CCCCCCCCC(O)=O QSBYPNXLFMSGKH-UHFFFAOYSA-N 0.000 claims description 2
- 239000005632 Capric acid (CAS 334-48-5) Substances 0.000 claims description 2
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- 239000005639 Lauric acid Substances 0.000 claims description 2
- 239000005642 Oleic acid Substances 0.000 claims description 2
- ZQPPMHVWECSIRJ-UHFFFAOYSA-N Oleic acid Natural products CCCCCCCCC=CCCCCCCCC(O)=O ZQPPMHVWECSIRJ-UHFFFAOYSA-N 0.000 claims description 2
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- ULUAUXLGCMPNKK-UHFFFAOYSA-N Sulfobutanedioic acid Chemical class OC(=O)CC(C(O)=O)S(O)(=O)=O ULUAUXLGCMPNKK-UHFFFAOYSA-N 0.000 claims description 2
- 150000001298 alcohols Chemical class 0.000 claims description 2
- SNPLKNRPJHDVJA-UHFFFAOYSA-N dl-panthenol Chemical compound OCC(C)(C)C(O)C(=O)NCCCO SNPLKNRPJHDVJA-UHFFFAOYSA-N 0.000 claims description 2
- MTNDZQHUAFNZQY-UHFFFAOYSA-N imidazoline Chemical compound C1CN=CN1 MTNDZQHUAFNZQY-UHFFFAOYSA-N 0.000 claims description 2
- QXJSBBXBKPUZAA-UHFFFAOYSA-N isooleic acid Natural products CCCCCCCC=CCCCCCCCCC(O)=O QXJSBBXBKPUZAA-UHFFFAOYSA-N 0.000 claims description 2
- 238000004519 manufacturing process Methods 0.000 claims description 2
- SBOJXQVPLKSXOG-UHFFFAOYSA-N o-amino-hydroxylamine Chemical class NON SBOJXQVPLKSXOG-UHFFFAOYSA-N 0.000 claims description 2
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- QVLTXCYWHPZMCA-UHFFFAOYSA-N po4-po4 Chemical class OP(O)(O)=O.OP(O)(O)=O QVLTXCYWHPZMCA-UHFFFAOYSA-N 0.000 description 1
- 229940093424 polyaminopropyl biguanide Drugs 0.000 description 1
- 239000002516 radical scavenger Substances 0.000 description 1
- 201000004700 rosacea Diseases 0.000 description 1
- 210000004761 scalp Anatomy 0.000 description 1
- 238000005201 scrubbing Methods 0.000 description 1
- 230000003248 secreting effect Effects 0.000 description 1
- 230000037307 sensitive skin Effects 0.000 description 1
- 230000036558 skin tension Effects 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 229940083542 sodium Drugs 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229960002668 sodium chloride Drugs 0.000 description 1
- 229940102544 sodium laureth-13 carboxylate Drugs 0.000 description 1
- 229960001922 sodium perborate Drugs 0.000 description 1
- 229940102541 sodium trideceth sulfate Drugs 0.000 description 1
- KLYDBHUQNXKACI-UHFFFAOYSA-M sodium;2-[2-(2-tridecoxyethoxy)ethoxy]ethyl sulfate Chemical compound [Na+].CCCCCCCCCCCCCOCCOCCOCCOS([O-])(=O)=O KLYDBHUQNXKACI-UHFFFAOYSA-M 0.000 description 1
- QOCMGIRPKVJJKN-UHFFFAOYSA-M sodium;2-[4-(2-acetyloxyethyl)piperazin-1-yl]ethanesulfonate Chemical compound [Na+].CC(=O)OCCN1CCN(CCS([O-])(=O)=O)CC1 QOCMGIRPKVJJKN-UHFFFAOYSA-M 0.000 description 1
- YKLJGMBLPUQQOI-UHFFFAOYSA-M sodium;oxidooxy(oxo)borane Chemical compound [Na+].[O-]OB=O YKLJGMBLPUQQOI-UHFFFAOYSA-M 0.000 description 1
- 229950006451 sorbitan laurate Drugs 0.000 description 1
- 229940035044 sorbitan monolaurate Drugs 0.000 description 1
- 235000011067 sorbitan monolaureate Nutrition 0.000 description 1
- 229940021506 stye Drugs 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 239000010677 tea tree oil Substances 0.000 description 1
- 229940111630 tea tree oil Drugs 0.000 description 1
- 230000036572 transepidermal water loss Effects 0.000 description 1
- WGIWBXUNRXCYRA-UHFFFAOYSA-H trizinc;2-hydroxypropane-1,2,3-tricarboxylate Chemical compound [Zn+2].[Zn+2].[Zn+2].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O.[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O WGIWBXUNRXCYRA-UHFFFAOYSA-H 0.000 description 1
- 239000011701 zinc Substances 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
- 239000004246 zinc acetate Substances 0.000 description 1
- 229960000314 zinc acetate Drugs 0.000 description 1
- 235000013904 zinc acetate Nutrition 0.000 description 1
- 239000011746 zinc citrate Substances 0.000 description 1
- 235000006076 zinc citrate Nutrition 0.000 description 1
- 229940068475 zinc citrate Drugs 0.000 description 1
- 239000011670 zinc gluconate Substances 0.000 description 1
- 235000011478 zinc gluconate Nutrition 0.000 description 1
- 229960000306 zinc gluconate Drugs 0.000 description 1
- 239000011576 zinc lactate Substances 0.000 description 1
- 235000000193 zinc lactate Nutrition 0.000 description 1
- 229940050168 zinc lactate Drugs 0.000 description 1
- WDHVIZKSFZNHJB-UHFFFAOYSA-L zinc;butanoate Chemical compound [Zn+2].CCCC([O-])=O.CCCC([O-])=O WDHVIZKSFZNHJB-UHFFFAOYSA-L 0.000 description 1
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Abstract
【選択図】図1
Description
亜鉛塩は、皮膚を引き締める収斂剤である。眼の周囲の領域の皮膚は、その他の領域の皮膚よりも敏感である。亜鉛塩の含有物は、その収斂特性によって組成物が眼瞼により刺激を与えるようになるので、望ましくない組成物である。それ故に、ある実施例では、組成物は、PHMBと、1,2−ヘキサンジオールと、1,2−オクタンジオールと、pH安定化界面活性剤溶液とを含んでいるが、実質的に亜鉛塩を含んでいない。亜鉛塩の例には、酢酸亜鉛、乳酸亜鉛、グルコン酸亜鉛、クエン酸亜鉛、酪酸亜鉛、及び ステアリン酸亜鉛(zinc sterate)が含まれる。
本発明の組成物を生成するために、修正リンガー溶液が、水に電解質を混合することで作られる。シムジオール、つまり、1,2−ヘキサンジオールと1,2−オクタンジオールの混合物が、界面活性剤を伴った修正リンガー溶液と混合される。界面活性剤を伴ったこの修正リンガー溶液は、pH安定化界面活性剤溶液を構成する。その後、混合物が加熱されて、溶液に固体が溶解する。その後、塩酸ポリへキサニドが加えられる前に、混合物は冷却されてよい。この方法のある形態では、混合物は、約60℃に加熱される。別の形態では、混合物は、約40度に達するまで冷却されてよい。
図1を参照すると、本発明の組成物が繊維性パッド(1)と組み合わされて、眼瞼を洗浄する器具が形成されてもよい。第1実施例では、その器具は、眼瞼スクラブ用組成物で予め湿らされた繊維性パッド(1)を備えている。眼瞼スクラブ用組成物は、塩酸ポリへキサニドと、1,2−ヘキサンジオールと、1,2−オクタンジオールと、組成物のpHレベルを5.5と7.5の間で制御するのに効果的な量で存在するpH安定化界面活性剤溶液とを含んでいる。ある形態では、繊維性パッド(1)は、レーヨンとポリプロピレンの混紡織物(fabric blend)である。別の形態では、繊維性パッドは、織目の写った表面(textured surface)(2)を備えている。
本発明の組成物は、抗菌効果を有しているが、他の抗菌性組成物よりも、刺激のレベルが低い。本発明の組成物の特性を確かめるために、組成物の刺激効果と抗菌効果の両方が試験された。これらの結果は、一般的に入手できる別の組成物であるステリリッド(Sterilid)(登録商標)と比較された。
Claims (49)
- 塩酸ポリへキサニドと、
1,2−ヘキサンジオールと、
1,2−オクタンジオールと、
組成物のpHレベルを5.5と7.5の間で制御するのに効果的な量で存在するpH安定化界面活性剤溶液と、
を含んでいる組成物。 - pH安定化界面活性剤溶液は、両性界面活性剤、アニオン性界面活性剤、及び非イオン性界面活性剤から成る群から選択される1種又は2種以上の界面活性剤である、請求項1の組成物。
- 両性界面活性剤は、アルキルジメチルベタイン類、アルキルアミノベタイン類、スルホベタイン類、及びイミダゾリン両性化合物から成る群から選択される、請求項2の組成物。
- アニオン性界面活性剤は、高級アルコール硫酸類、アルファオレインスルホン酸塩類、スルホコハク酸塩類、サルコシン類、リン酸エステル類、及びカルボン酸類から成る群から選択される、請求項2の組成物。
- 非イオン性界面活性剤は、アルカノールアミド類、エトキシ化アミド類、エステル類、アルキル化アルコール類、アルキルポリグルコシド類、アミノオキシド類、 ソルビタンエステル類、及びエトキシレート類から成る群から選択される、請求項2の組成物。
- pH安定化界面活性剤溶液は、
ココアンホジ酢酸2Naと、
ポリオキシエチレン80ソルビタンモノオレエートと、
デシルポリグルコシドと、
修正リンガー溶液と、
を含んでいる、請求項1の組成物。 - 0.1乃至25重量%のココアンホジ酢酸2Naと、
0.1乃至10重量%のポリオキシエチレン80ソルビタンモノオレエートと、
0.2乃至10重量%のデシルポリグルコシドと、
60乃至98重量%の修正リンガー溶液と、
を含んでいる、請求項6の組成物。 - 修正リンガー溶液は、
塩化ナトリウムと、
塩化カリウムと、
塩化カルシウムと、
水と、
を含んでいる、請求項6に記載の組成物。 - 修正リンガー溶液は、
0.05乃至1.2重量%の塩化ナトリウムと、
0.005乃至0.5重量%の塩化カリウムと、
0.005乃至0.5重量%の塩化カルシウムと、
水と、
を含んでいる、請求項8に記載の組成物。 - 修正リンガー溶液は、
0.7重量%の塩化ナトリウムと、
0.03重量%の塩化カリウムと、
0.033重量%の塩化カルシウムと、
精製水と、
を含んでいる、請求項8に記載の組成物。 - D−パンテノールと、
メチルグルセス−20と、
ジオレイン酸PEG−120メチルグルコースと、
を更に含んでいる、請求項1に記載の組成物。 - 1種又は2種以上の保湿剤を更に含んでいる、請求項1に記載の組成物。
- 1種又は2種以上の保湿剤は、メチルグルセス−20、ソルビトール、グリセリン、グリコール類、プロピレングリコール、カルボン酸類、アミノ酸類、グリコシド誘導体、尿素、乳酸塩類、及びパントテン酸誘導体から成る群から選択される、請求項12の組成物。
- パントテン酸誘導体は、パンテノール、D−パンテノール、D,L−パンテノール、及びそれらの組合せから成る群から選択される、請求項13の組成物。
- 気泡安定剤を更に含んでいる、請求項1の組成物。
- 気泡安定剤は、メチルグルコースのポリエチレングルコールジエステル及び脂肪酸である、請求項15の組成物。
- 脂肪酸は、オレイン酸、ステアリン酸、ラウリン酸、カプリル酸、及びカプリン酸から成る群から選択される、請求項16の組成物。
- 塩酸ポリへキサニドと、
1,2−ヘキサンジオールと、
1,2−オクタンジオールと、
組成物のpHレベルを5.5と7.5の間で制御するのに効果的な量で存在するpH安定化界面活性剤溶液と、
を含んでおり、実質的に亜鉛塩を含んでいない組成物。 - pH安定化界面活性剤溶液は、両性界面活性剤、アニオン性界面活性剤、及び非イオン性界面活性剤から成る群から選択される1種又は2種以上の界面活性剤である、請求項19の組成物。
- 1種又は2種以上の保湿剤を更に含んでいる、請求項17に記載の組成物。
- 1種又は2種以上の保湿剤は、メチルグルセス−20、ソルビトール、グリセリン、グリコール類、プロピレングリコール、カルボン酸類、アミノ酸類、グリコシド誘導体、尿素、乳酸塩類、及びパントテン酸誘導体から成る群から選択される、請求項20の組成物。
- 気泡安定剤を更に含んでいる、請求項18の組成物。
- 気泡安定剤は、メチルグルコースのポリエチレングルコールジエステル及び脂肪酸である、請求項22の組成物。
- 塩酸ポリへキサニドと、
1,2−ヘキサンジオールと、
1,2−オクタンジオールと、
ココアンホジ酢酸2Naと、
ポリオキシエチレン80ソルビタンモノオレエートと、
デシルポリグルコシドと、
修正リンガー溶液と、
を含んでいる組成物。 - 1種又は2種以上の保湿剤を更に含んでいる、請求項24の組成物。
- 保湿剤は、メチルグルセス−20、ソルビトール、グリセリン、グリコール類、プロピレングリコール、カルボン酸類、アミノ酸類、グリコシド誘導体、尿素、乳酸塩類、及びパントテン酸誘導体から成る群から選択される、請求項25の組成物。
- D−パンテノールと、
メチルグルセス−20と、
ジオレイン酸PEG−120メチルグルコースと、
を更に含んでいる、請求項24の組成物。 - 塩酸ポリへキサニドと、
1,2−ヘキサンジオールと、
1,2−オクタンジオールと、
D−パンテノールと、
ココアンホジ酢酸2Naと、
ポリオキシエチレン80ソルビタンモノオレエートと、
デシルポリグルコシドと、
メチルグルセス−20と、
PEG−120メチルグルコースと、
を含んでいる組成物。 - 0.02重量%乃至0.3重量%の塩酸ポリへキサニドと、
0.05重量%乃至2.0重量%の1,2−ヘキサンジオールと、
0.05重量%乃至2.0重量%の1,2−オクタンジオールと、
0.1重量%乃至25重量%のココアンホジ酢酸2Naと、
0.1重量%乃至10重量%のポリオキシエチレン80ソルビタンモノオレエートと、
0.2重量%乃至10重量%のデシルポリグルコシドと、
60重量%乃至98重量%の修正リンガー溶液と、
を含んでいる組成物。 - 0.05重量%乃至5.0重量%のD−パンテノールと、
1.0重量%乃至20重量%のメチルグルセス−20と、
0.1重量%乃至5重量%のジオレイン酸PEG−120メチルグルコースと、
を更に含んでいる、請求項29の組成物。 - 0.04重量%の塩酸ポリへキサニドと、
0.2重量%の1,2−ヘキサンジオールと、
0.2重量%の1,2−オクタンジオールと、
0.2重量%のD−パンテノールと、
0.215重量%のココアンホジ酢酸2Naと、
4.032重量%のポリオキシエチレン80ソルビタンモノオレエートと、
0.275重量%のデシルポリグルコシドと、
4.3重量%のメチルグルセス−20と、
0.6重量%のジオレイン酸PEG−120メチルグルコースと、
87.985重量%の修正リンガー溶液と、
1.953重量%の水と、
を含んでいる組成物。 - 眼瞼スクラブ用組成物を製造する方法において、
a)水で電解質を混合して修正リンガー溶液を生成する工程と、
b)1,2−ヘキサンジオールと、1,2−オクタンジオールと、効果的な量の1種又は2種以上のpH安定化界面活性剤とを、修正リンガー溶液と混合する工程と、
c)混合物を加熱する工程と、
d)混合物を冷却する工程と、
e)冷却した混合物に塩酸ポリへキサニドを加える工程と、
を含む方法。 - 工程(a)は、塩化ナトリウム、塩化カリウム、及び塩化カルシウムを水と混合する工程を含む、請求項32に記載の方法。
- 工程(b)は、1種又は2種以上の保湿剤を修正リンガー溶液と混合する工程を更に含む、請求項32に記載の方法。
- pH安定化界面活性剤は、塩酸ポリへキサニド、ポリオキシエチレン80ソルビタンモノオレエート、デシルポリグルコシド、及びそれらの組合せからなる群から選択される、請求項32の方法。
- 工程(c)は、混合物を60℃に加熱する工程を含む、請求項32の方法。
- 混合物を冷却する工程の前に、固体を溶解させる工程を更に含む、請求項36の方法。
- 工程(d)は、混合物を40℃に冷却する工程を含む、請求項32の方法。
- 請求項42の方法で作製された眼瞼スクラブ用組成物。
- 眼瞼スクラブを用いて眼瞼を洗浄する方法において、
効果的な量の眼瞼スクラブを眼瞼に付ける工程を含んでおり、
眼瞼スクラブは、塩酸ポリへキサニドと、1,2−ヘキサンジオールと、1,2−オクタンジオールと、組成物のpHレベルを5.5と7.5の間で制御するのに効果的な量で存在するpH安定化界面活性剤溶液とを含んでいる方法。 - 眼瞼スクラブは、繊維性パッドから眼瞼に付けられる、請求項40の方法。
- 眼瞼スクラブは、眼瞼上で擦られて、泡が生成される、請求項40の方法。
- 眼瞼スクラブは、繊維性パッドを用いて眼瞼上で擦られる、請求項42の方法。
- 眼瞼スクラブは、濯がれることなく眼瞼上に残されたままにされる、請求項40の方法。
- 眼瞼を洗浄する器具において、
眼瞼スクラブ用組成物で予め湿らされた繊維性パッドを備えており、
眼瞼スクラブ用組成物は、塩酸ポリへキサニドと、1,2−ヘキサンジオールと、
1,2−オクタンジオールと、組成物のpHレベルを5.5と7.5の間で制御するのに効果的な量で存在するpH安定化界面活性剤溶液とを含んでいる器具。 - 繊維性パッドは、レーヨンとポリプロピレンの混紡織物である、請求項45の器具。
- 繊維性パッドは、織目の写った表面を備えている、請求項45の器具。
- 予め湿らされた繊維性パッドを入れる密閉容器を更に備える、請求項45の器具。
- 1.3グラム乃至1.5グラムの眼瞼スクラブ用組成物を備える、請求項45の器具。
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WO2008057442A3 (en) | 2008-07-03 |
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