ES2122288T3 - Antiinfeccioso. - Google Patents

Antiinfeccioso.

Info

Publication number
ES2122288T3
ES2122288T3 ES94918330T ES94918330T ES2122288T3 ES 2122288 T3 ES2122288 T3 ES 2122288T3 ES 94918330 T ES94918330 T ES 94918330T ES 94918330 T ES94918330 T ES 94918330T ES 2122288 T3 ES2122288 T3 ES 2122288T3
Authority
ES
Spain
Prior art keywords
wound
hexamethylene
poly
biguanide
suitably
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES94918330T
Other languages
English (en)
Inventor
Ulrich Kirschner
Frank Jethon
Frank Rauch
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fresenius SE and Co KGaA
Original Assignee
Fresenius SE and Co KGaA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fresenius SE and Co KGaA filed Critical Fresenius SE and Co KGaA
Application granted granted Critical
Publication of ES2122288T3 publication Critical patent/ES2122288T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N47/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
    • A01N47/40—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having a double or triple bond to nitrogen, e.g. cyanates, cyanamides
    • A01N47/42—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having a double or triple bond to nitrogen, e.g. cyanates, cyanamides containing —N=CX2 groups, e.g. isothiourea
    • A01N47/44—Guanidine; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L12/00—Methods or apparatus for disinfecting or sterilising contact lenses; Accessories therefor
    • A61L12/08—Methods or apparatus for disinfecting or sterilising contact lenses; Accessories therefor using chemical substances
    • A61L12/14—Organic compounds not covered by groups A61L12/10 or A61L12/12
    • A61L12/141—Biguanides, e.g. chlorhexidine
    • A61L12/142—Polymeric biguanides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/10—Anthelmintics

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Agronomy & Crop Science (AREA)
  • Wood Science & Technology (AREA)
  • Communicable Diseases (AREA)
  • Environmental Sciences (AREA)
  • Oncology (AREA)
  • Pest Control & Pesticides (AREA)
  • Plant Pathology (AREA)
  • Engineering & Computer Science (AREA)
  • Dentistry (AREA)
  • Zoology (AREA)
  • Virology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Saccharide Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

EL OBJETIVO DE LA INVENCION SON AGENTES ANTIINFECCION COMO MEDIOS ANTIMICROBIALES SOBRE LA BASE DE POLI(HEXAMETILENO) BIGUANIDA CON UN PESO MOLECULAR MEDIO M{SUB, W} DESDE 2.900 HASTA 15.000, CON PREFERENCIA 3.000 HASTA 8.000, EN PARTICULAR 3.200 HASTA 5.000, QUE PUEDEN SER UTILIZADOS CON PREFERENCIA EN FORMA DE UN ANTISEPTICO DE HERIDAS Y/O DE UN MEDIO DE TRATAMIENTO DE HERIDAS O DE UN MEDIO PARA TRATAMIENTO ANTIMICROBIAL, ANTIVIRAL Y/O ANTIPARASITARIO, CON PREFERENCIA MEDIANTE ADMINISTRACION INTRAVENOSA. LA CONCENTRACION DE UTILIZACION DEL POLI(HEXAMETILENO)BIGUANIDA COMO ANTISEPTICO DE HERIDAS Y/O MEDIO DE TRATAMIENTO DE HERIDAS SE ENCUENTRA DE MANERA MAS APROPIADA DESDE 0,001 HASTA 0,05 % EN PESO, EN PARTICULAR 0,005 HASTA 0,012 % EN PESO. EN CONTRA DE LOS MEDIOS DE DESINFECCION CONOCIDOS SOBRE LA BASE DE POLI(HEXAMETILENO)BIGUANIDA, QUE PUEDEN SER UTILIZADOS COMO ANTISEPTICO DE HERIDAS Y MEDIO DE TRATAMIENTO DE HERIDAS, EL POLI(HEXAMETILENO)BIGUANIDA UTILIZADO DE ACUERDO CON LA INVENCION POSEE UN PESO MOLECULAR MEDIO M{SUB, W} MAS ALTO Y MUESTRA UNA ACTIVIDAD MICROBICIDA ELEVADA CON AL MISMO TIEMPO TOXICIDAD REDUCIDA Y ESTA LIBRE DE EFECTOS SECUNDARIOS SOBRE EL SISTEMA NERVIOSO CENTRAL.
ES94918330T 1993-05-26 1994-05-17 Antiinfeccioso. Expired - Lifetime ES2122288T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4317477 1993-05-26

Publications (1)

Publication Number Publication Date
ES2122288T3 true ES2122288T3 (es) 1998-12-16

Family

ID=6488934

Family Applications (1)

Application Number Title Priority Date Filing Date
ES94918330T Expired - Lifetime ES2122288T3 (es) 1993-05-26 1994-05-17 Antiinfeccioso.

Country Status (8)

Country Link
US (1) US5942218A (es)
EP (1) EP0700249B1 (es)
JP (1) JPH08510454A (es)
AT (1) ATE168530T1 (es)
CA (1) CA2163791C (es)
DE (1) DE59406509D1 (es)
ES (1) ES2122288T3 (es)
WO (1) WO1994027440A1 (es)

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GB9506841D0 (en) * 1995-04-03 1995-05-24 Unilever Plc Deodorant compositions
GB9512290D0 (en) * 1995-06-16 1995-08-16 Moorfields Eye Hospital Uses of polyhexanide
DE19604475A1 (de) * 1996-02-08 1997-08-14 Fresenius Ag Verwendung von PHMB zur Behandlung von durch sich intrazellulär vermehrende Erreger verursachten Infektionen
GB9606868D0 (en) * 1996-04-01 1996-06-05 Waverley Pharma Ltd Disinfectant solutions
JP3698832B2 (ja) * 1996-10-08 2005-09-21 株式会社メニコン コンタクトレンズ用液剤
GB9705740D0 (en) 1997-03-20 1997-05-07 Medeva Europ Ltd A method of preservation
NL1005658C2 (nl) * 1997-03-27 1998-09-29 Jon Holding B V Vloeistof voor het bewaren van contactlenzen en werkwijze voor het reinigen en spoelen van een contactlens.
US20030147925A1 (en) * 1998-09-11 2003-08-07 Samuel P. Sawan Topical dermal antimicrobial compositions, methods for generating same, and monitoring methods utilizing same
WO2000033829A1 (de) * 1998-12-05 2000-06-15 Fresenius Kabi Deutschland Gmbh Verwendung von poly (hexamethylen) biguanid zur herstellung eines mittels zur förderung der heilung von infektionsfreien wunden
US7678836B2 (en) * 1999-11-04 2010-03-16 Fxs Ventures, Llc Method for rendering a contact lens wettable
DE10012026B4 (de) * 2000-03-11 2004-01-08 Prontomed Gmbh Verwendung eines Gels
US8557868B2 (en) * 2000-11-04 2013-10-15 Fxs Ventures, Llc Ophthalmic and contact lens solutions using low molecular weight amines
US20070110782A1 (en) * 2000-11-08 2007-05-17 Fxs Ventures, Llc L-histidine in ophthalmic solutions
US9492582B2 (en) * 2000-11-08 2016-11-15 Fxs Ventures, Llc Ophthalmic and contact lens solutions containing simple saccharides as preservative enhancers
EP1339418B1 (en) * 2000-11-08 2009-09-23 FXS Ventures, LLC Improved ophthalmic and contact lens solutions containing simple saccharides as preservative enhancers
US20070104744A1 (en) * 2000-11-08 2007-05-10 Fxs Ventures, Llc Ophthalmic and contact lens solutions containing forms of vitamin b
EP3045168A1 (en) * 2000-11-08 2016-07-20 FXS Ventures, LLC Improved ophthalmic and contact lens solution
US20060127496A1 (en) * 2000-11-08 2006-06-15 Bioconcept Laboratories L-histidine in ophthalmic solutions
US20060148665A1 (en) * 2000-11-08 2006-07-06 Bioconcept Laboratories Ophthalmic and contact lens solutions containing forms of vitamin b
US20070098813A1 (en) * 2000-11-08 2007-05-03 Fxs Ventures, Llc Ophthalmic and contact lens solutions with a peroxide source and a preservative
US9308264B2 (en) 2000-11-08 2016-04-12 Fxs Ventures, Llc Ophthalmic contact lens solutions containing forms of vitamin B
DE10132817A1 (de) * 2001-07-06 2003-01-30 Prontomed Gmbh Wundbehandlungsmittel
DE10140361B4 (de) * 2001-08-17 2009-07-16 Rüdiger Bode Verwendung einer Biguanide enthaltenden Zubereitung zur Hufpflege
GB0202494D0 (en) * 2002-02-02 2002-03-20 Avecia Ltd Process
US20030203013A1 (en) * 2002-04-26 2003-10-30 Xylos Corporation Microbial cellulose wound dressing for treating chronic wounds
US20050019380A1 (en) * 2002-04-26 2005-01-27 Xylos Corporation Microbial cellulose wound dressing for treating chronic wounds
US7704523B2 (en) * 2002-04-26 2010-04-27 Lohmann & Rauscher Gmbh Microbial cellulose wound dressing for treating chronic wounds
US7390499B2 (en) * 2002-04-26 2008-06-24 Lohmann & Rauscher Gmbh Microbial cellulose wound dressing for treating chronic wounds
FR2849383B1 (fr) * 2002-12-26 2005-09-30 Jean Noel Thorel Composition trophique en milieu aqueux, et ses applications, notamment en ophtalmologie
US20040142019A1 (en) * 2003-01-16 2004-07-22 Xylos Corporation Microbial-derived cellulose amorphous hydrogel wound dressing
WO2004091438A2 (en) * 2003-04-15 2004-10-28 Fxs Ventures, Llc Improved ophthalmic and contact lens solutions containing peptides as representative enhancers
DE10332680A1 (de) * 2003-07-18 2005-02-17 Biomet Deutschland Gmbh Verwendung von antiseptischen Wirkstoffen in PMMA-Knochenzementen
NZ546032A (en) * 2003-08-22 2009-07-31 Synthes Gmbh Dura substitute and a process for producing the same using Acetobacter xylinum
US8198261B2 (en) * 2003-08-22 2012-06-12 Xylos Corporation Thermally modified microbial-derived cellulose for in vivo implantation
US20050058673A1 (en) 2003-09-09 2005-03-17 3M Innovative Properties Company Antimicrobial compositions and methods
US6936640B2 (en) * 2003-12-04 2005-08-30 Alcon, Inc. Biguanide/quaternary ammonium containing copolymeric biocides and use thereof in pharmaceutical compositions
EP1755624A4 (en) * 2004-05-03 2009-04-29 Neosil Inc POLYCENTRIC ANTIMICROBIAL THERAPEUTIC
DE102004024140A1 (de) * 2004-05-14 2005-12-08 Fresenius Medical Care Deutschland Gmbh Konservierungsmittel für medizinische Vorrichtungen
US9028852B2 (en) 2004-09-07 2015-05-12 3M Innovative Properties Company Cationic antiseptic compositions and methods of use
EP3025704B1 (en) 2005-03-10 2019-01-16 3M Innovative Properties Company Methods of reducing microbial contamination
WO2006099358A2 (en) 2005-03-10 2006-09-21 3M Innovative Properties Company Antimicrobial compositions comprising esters of hydroxycarboxylic acids
DE502005009924D1 (de) * 2005-09-15 2010-08-26 Aesculap Ag Bioverträgliches antimikrobielles nahtmaterial
US9629361B2 (en) 2006-02-09 2017-04-25 Gojo Industries, Inc. Composition and method for pre-surgical skin disinfection
US8450378B2 (en) 2006-02-09 2013-05-28 Gojo Industries, Inc. Antiviral method
US8119115B2 (en) * 2006-02-09 2012-02-21 Gojo Industries, Inc. Antiviral method
US20070185216A1 (en) * 2006-02-09 2007-08-09 Marcia Snyder Antiviral method
US7709631B2 (en) 2006-03-13 2010-05-04 Xylos Corporation Oxidized microbial cellulose and use thereof
WO2007135163A1 (de) * 2006-05-23 2007-11-29 Sanitized Ag Verwendung von poly- (hexamethylenb iguanid) hydrochlorid als antivirales mittel
US20070286884A1 (en) * 2006-06-13 2007-12-13 Xylos Corporation Implantable microbial cellulose materials for hard tissue repair and regeneration
BRPI0716325A2 (pt) 2006-10-27 2014-03-04 3M Innovative Properties Co Composição antimicrobianas
US8281445B2 (en) * 2006-11-03 2012-10-09 Ocusoft, Inc. Heated eyelid cleanser
US7951387B2 (en) * 2006-11-03 2011-05-31 Ocusoft, Inc. Eyelid scrub composition
BRPI0819567A2 (pt) 2007-12-31 2015-05-05 3M Innovative Properties Co "composições antimicrobianas, método para aprimorar a adesão molhada do artigo adesivo médico e método para evitar ou tratar uma condição da pele de um mamífero
DE102008005193A1 (de) * 2008-01-18 2009-07-23 Dahlen, Neithard Bakteriophagenpräparation und Verwendung
US20100324516A1 (en) 2009-06-18 2010-12-23 Tyco Healthcare Group Lp Apparatus for Vacuum Bridging and/or Exudate Collection
US8821848B1 (en) 2010-08-10 2014-09-02 Biolife, L.L.C. Ferrate and povidone iodine (PI) composition
DE102012007212A1 (de) 2012-04-11 2013-10-17 Merz Pharma Gmbh & Co. Kgaa Zubereitung zur topischen Anwendung auf Schleimhäuten mit Polyhexanid als Wirkstoff
US9278079B2 (en) 2013-07-12 2016-03-08 Ocusoft, Inc. Ocular composition and kits thereof
EP2857025A1 (en) 2013-10-02 2015-04-08 Special Water Patents B.V. Wound treatment composition
WO2015161860A1 (en) * 2014-04-25 2015-10-29 Frank Flechsig Improved biocide compositions based on calcium fluoride as well as uses thereof
US9848604B2 (en) 2014-07-11 2017-12-26 Medtronic Xomed, Inc. Antimicrobial wash
US20170290789A1 (en) 2016-04-11 2017-10-12 Frank DiCosmo Wound irrigation solutions

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GB702268A (en) * 1949-08-22 1954-01-13 Francis Leslie Rose Polymeric diguanides
GB1152243A (en) * 1965-11-26 1969-05-14 Ici Ltd Process for the Manufacture of Polymeric Diguanides
US4654208A (en) * 1983-03-01 1987-03-31 Stockel Richard F Anti-microbial compositions comprising an aqueous solution of a germicidal polymeric nitrogen compound and a potentiating oxidizing agent
US4758595A (en) * 1984-12-11 1988-07-19 Bausch & Lomb Incorporated Disinfecting and preserving systems and methods of use
CA1259542A (en) * 1984-09-28 1989-09-19 Francis X. Smith Disinfecting and preserving solutions for contact lenses and methods of use
DE3537627C2 (de) * 1984-11-03 1995-01-26 Infectless S A Desinfektionsmittel und seine Verwendung
US5183664A (en) * 1986-09-20 1993-02-02 Smith And Nephew Associated Companies P.L.C. Thin film adhesive dressings preparation and use
US4891423A (en) * 1989-03-20 1990-01-02 Stockel Richard F Polymeric biguanides
EP0450117A1 (de) * 1990-04-02 1991-10-09 Infectless S.A. Ringerlösung und dessen Anwendung als bakterizid wirkendes lokales Wundbehandlungsmedikament

Also Published As

Publication number Publication date
US5942218A (en) 1999-08-24
EP0700249B1 (de) 1998-07-22
DE59406509D1 (de) 1998-08-27
CA2163791C (en) 2003-12-30
ATE168530T1 (de) 1998-08-15
WO1994027440A1 (de) 1994-12-08
EP0700249A1 (de) 1996-03-13
JPH08510454A (ja) 1996-11-05
CA2163791A1 (en) 1994-12-08

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