JP2019510811A - 眼瞼衛生を維持するための組成物、キット及び方法 - Google Patents
眼瞼衛生を維持するための組成物、キット及び方法 Download PDFInfo
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Abstract
Description
試験結果
本発明の第1の眼科用組成物は、抗菌作用を有し、他の抗菌組成物より刺激が低レベルである。本発明の組成物の特徴を確認するため、組成物の刺激及び抗菌作用の両方を試験した。9匹の白色ウサギ各々の片眼に試験材料を滴下し、3眼は洗い落とさず、3眼は曝露後3〜4秒に洗い落とし、3眼は30秒の接触期間後に洗い落とした。ウサギの眼にサンプルを滴下して洗い落とさないと、眼刺激は軽微であった。平均最高刺激スコアは、1時間の観察で3.33/110.0、すべての刺激は、48時間の観察までになくなった。ウサギの眼にサンプルを滴下して4秒で洗い落とすと、眼刺激は軽微であった。平均最高刺激スコアは、1時間の観察で4.0/110.0であり、すべての刺激は、48時間の観察までになくなった。ウサギの眼にサンプルを滴下して30秒で洗い落とすと、眼刺激は軽微であった。平均最高刺激スコアは、1時間の観察で4.01/110.0であり、すべての刺激は、48時間の観察までになくなった。試験の結果に基づくと、本材料は、洗い落とさない眼と洗い落とした眼を問わず、眼刺激物ではないと考えられよう。
Claims (20)
- 第1の眼科用組成物において、
ポリアミノプロピルビグアニド、1,2−グリコール及びスフィンゴイド脂質の混合物から本質的になる防腐剤ブレンドと、
界面活性剤溶液と、
保湿剤と
を含有する、第1の眼科用組成物。 - 前記1,2−グリコールは、1,2−ヘキサンジオール、カプリリルグリコール、ペンチレングリコール及びそれらの混合物からなる群から選択される、請求項1に記載の第1の眼科用組成物。
- 前記スフィンゴイド脂質は、サリチロイルフィトスフィンゴシンを含んでなる、請求項1に記載の第1の眼科用組成物。
- 前記サリチロイルフィトスフィンゴシンは、前記組成物の総重量に対して0.01〜1重量%の範囲の濃度で存在する、請求項3に記載の第1の眼科用組成物。
- 前記界面活性剤溶液は、非イオン界面活性剤と両性界面活性剤又はアニオン性界面活性剤の少なくとも1つとの水性混合物を含む、請求項1に記載の第1の眼科用組成物。
- 前記界面活性剤溶液は本質的に、水、塩化ナトリウム、塩化カリウム、塩化カルシウム、ココアンホジ酢酸二ナトリウム、ラウリン酸PEG−80ソルビタン及びデシルグルコシドからなる、請求項5に記載の第1の眼科用組成物。
- 前記保湿剤は、メチルグルセス−20、ソルビタール、グリセリン、プロピレングリコール、パンテノール、D−パンテノール及びD,L−パンテノールならびにそれらの混合物からなる群から選択される、請求項1に記載の第1の眼科用組成物。
- 気泡安定剤をさらに含有する、請求項1に記載の第1の眼科用組成物。
- 前記気泡安定剤は、ジオレイン酸PEG−120メチルグルコースを含んでなる、請求項1に記載の第1の眼科用組成物。
- 前記第1の眼科用組成物は泡状である、請求項1に記載の第1の眼科用組成物。
- 本質的に、水、ラウリン酸PEG−80ソルビタン、メチルグルセス−20、ジオレイン酸PEG−120メチルグルコース、サリチロイルフィトスフィンゴシン、デシルグルコシド、1,2−ヘキサンジオール、カプリリルグリコール、ココアンホジ酢酸二ナトリウム、パンテノール、ポリアミノプロピルビグアニド、塩化ナトリウム、塩化カリウム及び塩化カルシウムからなる、請求項1に記載の第1の眼科用組成物。
- 眼瞼衛生を維持するための方法において、
第1の眼科用組成物で眼瞼を洗浄する工程と、
洗い落とさずに前記眼瞼上で前記第1の眼科用組成物を放置する工程とを備え、
前記第1の眼科用組成物は本質的に、水、ラウリン酸PEG−80ソルビタン、メチルグルセス−20、ジオレイン酸PEG−120メチルグルコース、サリチロイルフィトスフィンゴシン、デシルグルコシド、1,2−ヘキサンジオール、カプリリルグリコール、ココアンホジ酢酸二ナトリウム、パンテノール、ポリアミノプロピルビグアニド、塩化ナトリウム、塩化カリウム及び塩化カルシウムからなる、方法。 - 眼状態を処置するための方法において、
第1の眼科用組成物で眼瞼を洗浄する工程と、
洗い落とさずに前記眼瞼上で前記第1の眼科用組成物を放置する工程とを備え、
前記第1の眼科用組成物は本質的に、水、ラウリン酸PEG−80ソルビタン、メチルグルセス−20、ジオレイン酸PEG−120メチルグルコース、サリチロイルフィトスフィンゴシン、デシルグルコシド、1,2−ヘキサンジオール、カプリリルグリコール、ココアンホジ酢酸二ナトリウム、パンテノール、ポリアミノプロピルビグアニド、塩化ナトリウム、塩化カリウム及び塩化カルシウムからなる、方法。 - 治療有効量の第2の眼科用組成物を前記眼瞼の縁に投与する、請求項13に記載の方法。
- 前記第2の眼科用組成物は本質的に、水及び次亜塩素酸を含んでなる、請求項14に記載の方法。
- 前記第2の眼科用組成物は本質的に、≧99%の水及び≦0.02%の次亜塩素酸を含んでなる、請求項14に記載の方法。
- 前記第2の眼科用組成物は、水性ゲル又はスプレー剤である、請求項14に記載の方法。
- 眼瞼衛生を維持するためのキットにおいて、
本質的に、水、ラウリン酸PEG−80ソルビタン、メチルグルセス−20、ジオレイン酸PEG−120メチルグルコース、サリチロイルフィトスフィンゴシン、デシルグルコシド、1,2−ヘキサンジオール、カプリリルグリコール、ココアンホジ酢酸二ナトリウム、パンテノール、ポリアミノプロピルビグアニド、塩化ナトリウム、塩化カリウム及び塩化カルシウムからなる第1の眼科用組成物と、
前記第1の眼科用組成物を入れるための薬学的に許容される容器と、
前記第1の眼科用組成物を眼瞼に投与するためのアプリケータと、
から本質的になる、キット。 - 前記第1の眼科用組成物は、25ml〜100mlの体積を有する、請求項18に記載のキット。
- 前記アプリケータは、複数の布パッドを有する、請求項18に記載のキット。
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PCT/US2016/025908 WO2017176246A1 (en) | 2016-04-04 | 2016-04-04 | Compositions, kits and methods for maintaining eyelid hygiene |
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GB2564797A (en) | 2019-01-23 |
CN109195592B (zh) | 2021-11-09 |
GB201817389D0 (en) | 2018-12-12 |
GB2564797B (en) | 2020-01-15 |
AU2016401656A1 (en) | 2018-11-01 |
PT3439641T (pt) | 2021-03-10 |
KR20190126944A (ko) | 2019-11-12 |
KR20180125171A (ko) | 2018-11-22 |
DK3439641T3 (da) | 2021-04-06 |
MX2018012072A (es) | 2019-01-14 |
EP3439641A4 (en) | 2020-01-08 |
SG11201808486YA (en) | 2018-10-30 |
CN109195592A (zh) | 2019-01-11 |
AU2016401656B2 (en) | 2019-02-14 |
EP3439641B1 (en) | 2021-01-20 |
EP3439641A1 (en) | 2019-02-13 |
JP6559914B2 (ja) | 2019-08-14 |
CA3017841A1 (en) | 2017-10-12 |
WO2017176246A1 (en) | 2017-10-12 |
ECSP18082081A (es) | 2018-11-30 |
MX370824B (es) | 2020-01-08 |
ES2862418T3 (es) | 2021-10-07 |
HUE054600T2 (hu) | 2021-09-28 |
CA3017841C (en) | 2019-01-22 |
HRP20210515T1 (hr) | 2021-05-14 |
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