JP2010507681A

JP2010507681A - カテプシンプロテアーゼ阻害剤

カテプシンプロテアーゼ阻害剤 Download PDF

Info

Publication number: JP2010507681A
Authority: JP; Japan
Prior art keywords: compound; optionally substituted; cathepsin; alkyl; pharmaceutically acceptable
Prior art date: 2006-10-23
Legal status : Pending

Application number

JP2009534774A

Other languages

English (en)

Japanese (ja)

Inventor

ロベルト・エップレ

ロス・ルッソ

Current Assignee

IRM LLC

Original Assignee

IRM LLC

Priority date

2006-10-23

Filing date

2007-10-17

Publication date

2010-03-11

2007-10-17 Application filed by IRM LLC filed Critical IRM LLC

2010-03-11 Publication of JP2010507681A publication Critical patent/JP2010507681A/ja

Status Pending legal-status Critical Current

Links

108010084457 Cathepsins Proteins 0.000 title claims abstract description 35
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239000000137 peptide hydrolase inhibitor Substances 0.000 title description 2
229940124158 Protease/peptidase inhibitor Drugs 0.000 title 1
150000001875 compounds Chemical class 0.000 claims abstract description 70
150000003839 salts Chemical class 0.000 claims abstract description 22
125000000217 alkyl group Chemical group 0.000 claims abstract description 14
239000008194 pharmaceutical composition Substances 0.000 claims abstract description 13
125000000304 alkynyl group Chemical group 0.000 claims abstract description 12
125000000882 C2-C6 alkenyl group Chemical group 0.000 claims abstract description 9
125000002837 carbocyclic group Chemical group 0.000 claims abstract description 9
125000000623 heterocyclic group Chemical group 0.000 claims abstract description 9
125000001072 heteroaryl group Chemical group 0.000 claims abstract description 8
229910052717 sulfur Inorganic materials 0.000 claims abstract description 8
229910052760 oxygen Inorganic materials 0.000 claims abstract description 6
229940124530 sulfonamide Drugs 0.000 claims abstract description 6
125000003107 substituted aryl group Chemical group 0.000 claims abstract description 5
BFZWDYZNSLLKKO-UHFFFAOYSA-N N#CNN[N+]([O-])=O Chemical compound N#CNN[N+]([O-])=O BFZWDYZNSLLKKO-UHFFFAOYSA-N 0.000 claims abstract description 4
150000003456 sulfonamides Chemical class 0.000 claims abstract description 4
125000001475 halogen functional group Chemical group 0.000 claims abstract 3
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 12
201000010099 disease Diseases 0.000 claims description 10
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230000009400 cancer invasion Effects 0.000 claims description 4
238000004519 manufacturing process Methods 0.000 claims description 4
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125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 4
208000006386 Bone Resorption Diseases 0.000 claims description 3
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