JP2010507578A5 - - Google Patents
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- Publication number
- JP2010507578A5 JP2010507578A5 JP2009533541A JP2009533541A JP2010507578A5 JP 2010507578 A5 JP2010507578 A5 JP 2010507578A5 JP 2009533541 A JP2009533541 A JP 2009533541A JP 2009533541 A JP2009533541 A JP 2009533541A JP 2010507578 A5 JP2010507578 A5 JP 2010507578A5
- Authority
- JP
- Japan
- Prior art keywords
- cancer
- receptor tyrosine
- tyrosine kinase
- kinase
- leukemia
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 108091008598 receptor tyrosine kinases Proteins 0.000 claims 4
- 102000027426 receptor tyrosine kinases Human genes 0.000 claims 4
- 102000001253 Protein Kinase Human genes 0.000 claims 3
- 208000032839 leukemia Diseases 0.000 claims 3
- 108060006633 protein kinase Proteins 0.000 claims 3
- 101000916644 Homo sapiens Macrophage colony-stimulating factor 1 receptor Proteins 0.000 claims 2
- 102100028198 Macrophage colony-stimulating factor 1 receptor Human genes 0.000 claims 2
- 206010028980 Neoplasm Diseases 0.000 claims 2
- 102000008022 Proto-Oncogene Proteins c-met Human genes 0.000 claims 2
- 108010089836 Proto-Oncogene Proteins c-met Proteins 0.000 claims 2
- 150000001875 compounds Chemical class 0.000 claims 2
- 201000001441 melanoma Diseases 0.000 claims 2
- 102100033793 ALK tyrosine kinase receptor Human genes 0.000 claims 1
- 208000024893 Acute lymphoblastic leukemia Diseases 0.000 claims 1
- 208000014697 Acute lymphocytic leukaemia Diseases 0.000 claims 1
- 208000032791 BCR-ABL1 positive chronic myelogenous leukemia Diseases 0.000 claims 1
- 206010005003 Bladder cancer Diseases 0.000 claims 1
- 206010006187 Breast cancer Diseases 0.000 claims 1
- 208000026310 Breast neoplasm Diseases 0.000 claims 1
- 201000009030 Carcinoma Diseases 0.000 claims 1
- 208000010833 Chronic myeloid leukaemia Diseases 0.000 claims 1
- 206010009944 Colon cancer Diseases 0.000 claims 1
- 208000001333 Colorectal Neoplasms Diseases 0.000 claims 1
- 208000017604 Hodgkin disease Diseases 0.000 claims 1
- 208000010747 Hodgkins lymphoma Diseases 0.000 claims 1
- 101000779641 Homo sapiens ALK tyrosine kinase receptor Proteins 0.000 claims 1
- 101000606129 Homo sapiens Tyrosine-protein kinase receptor TYRO3 Proteins 0.000 claims 1
- 208000008839 Kidney Neoplasms Diseases 0.000 claims 1
- 208000018142 Leiomyosarcoma Diseases 0.000 claims 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 1
- 208000031422 Lymphocytic Chronic B-Cell Leukemia Diseases 0.000 claims 1
- 208000034578 Multiple myelomas Diseases 0.000 claims 1
- 208000033761 Myelogenous Chronic BCR-ABL Positive Leukemia Diseases 0.000 claims 1
- 206010033128 Ovarian cancer Diseases 0.000 claims 1
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 1
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 1
- 206010035226 Plasma cell myeloma Diseases 0.000 claims 1
- 208000006664 Precursor Cell Lymphoblastic Leukemia-Lymphoma Diseases 0.000 claims 1
- 206010060862 Prostate cancer Diseases 0.000 claims 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 1
- 108010091528 Proto-Oncogene Proteins B-raf Proteins 0.000 claims 1
- 102000018471 Proto-Oncogene Proteins B-raf Human genes 0.000 claims 1
- 102000001788 Proto-Oncogene Proteins c-raf Human genes 0.000 claims 1
- 108010029869 Proto-Oncogene Proteins c-raf Proteins 0.000 claims 1
- 206010038389 Renal cancer Diseases 0.000 claims 1
- 208000005718 Stomach Neoplasms Diseases 0.000 claims 1
- 101150098329 Tyro3 gene Proteins 0.000 claims 1
- 102100039127 Tyrosine-protein kinase receptor TYRO3 Human genes 0.000 claims 1
- 102100037236 Tyrosine-protein kinase receptor UFO Human genes 0.000 claims 1
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 claims 1
- 108010023337 axl receptor tyrosine kinase Proteins 0.000 claims 1
- 210000001185 bone marrow Anatomy 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 239000012830 cancer therapeutic Substances 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 206010017758 gastric cancer Diseases 0.000 claims 1
- 208000005017 glioblastoma Diseases 0.000 claims 1
- 201000010536 head and neck cancer Diseases 0.000 claims 1
- 208000014829 head and neck neoplasm Diseases 0.000 claims 1
- 230000002489 hematologic effect Effects 0.000 claims 1
- 201000010982 kidney cancer Diseases 0.000 claims 1
- 210000003292 kidney cell Anatomy 0.000 claims 1
- 201000007270 liver cancer Diseases 0.000 claims 1
- 208000014018 liver neoplasm Diseases 0.000 claims 1
- 201000005202 lung cancer Diseases 0.000 claims 1
- 208000020816 lung neoplasm Diseases 0.000 claims 1
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 1
- 239000003607 modifier Substances 0.000 claims 1
- 201000002528 pancreatic cancer Diseases 0.000 claims 1
- 208000008443 pancreatic carcinoma Diseases 0.000 claims 1
- 206010041823 squamous cell carcinoma Diseases 0.000 claims 1
- 201000011549 stomach cancer Diseases 0.000 claims 1
- 229940124597 therapeutic agent Drugs 0.000 claims 1
- 102000047459 trkC Receptor Human genes 0.000 claims 1
- 108010064892 trkC Receptor Proteins 0.000 claims 1
- 201000005112 urinary bladder cancer Diseases 0.000 claims 1
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US86255206P | 2006-10-23 | 2006-10-23 | |
| US60/862,552 | 2006-10-23 | ||
| US87030906P | 2006-12-15 | 2006-12-15 | |
| US60/870,309 | 2006-12-15 | ||
| US91376607P | 2007-04-24 | 2007-04-24 | |
| US60/913,766 | 2007-04-24 | ||
| US95284007P | 2007-07-30 | 2007-07-30 | |
| US60/952,840 | 2007-07-30 | ||
| PCT/US2007/081841 WO2008051808A2 (en) | 2006-10-23 | 2007-10-18 | Bicyclic triazoles as protein kinase modulators |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010507578A JP2010507578A (ja) | 2010-03-11 |
| JP2010507578A5 true JP2010507578A5 (OSRAM) | 2010-12-02 |
| JP5378222B2 JP5378222B2 (ja) | 2013-12-25 |
Family
ID=38956385
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009533541A Expired - Fee Related JP5378222B2 (ja) | 2006-10-23 | 2007-10-18 | タンパク質キナーゼ調節物質としての二環式トリアゾール |
Country Status (25)
| Country | Link |
|---|---|
| US (1) | US8507489B2 (OSRAM) |
| EP (1) | EP2084162B1 (OSRAM) |
| JP (1) | JP5378222B2 (OSRAM) |
| KR (1) | KR20090071612A (OSRAM) |
| AR (1) | AR063520A1 (OSRAM) |
| AU (1) | AU2007309149C1 (OSRAM) |
| BR (1) | BRPI0717320A2 (OSRAM) |
| CA (1) | CA2667428A1 (OSRAM) |
| CO (1) | CO6190620A2 (OSRAM) |
| CR (1) | CR10803A (OSRAM) |
| DK (1) | DK2084162T3 (OSRAM) |
| EA (1) | EA200970403A1 (OSRAM) |
| ES (1) | ES2393130T3 (OSRAM) |
| IL (1) | IL197958A0 (OSRAM) |
| MA (1) | MA30871B1 (OSRAM) |
| MX (1) | MX2009004059A (OSRAM) |
| NO (1) | NO20091618L (OSRAM) |
| NZ (1) | NZ575336A (OSRAM) |
| PE (1) | PE20080893A1 (OSRAM) |
| PL (1) | PL2084162T3 (OSRAM) |
| PT (1) | PT2084162E (OSRAM) |
| SV (1) | SV2009003235A (OSRAM) |
| TN (1) | TN2009000142A1 (OSRAM) |
| TW (1) | TW200835492A (OSRAM) |
| WO (1) | WO2008051808A2 (OSRAM) |
Families Citing this family (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PA8792501A1 (es) * | 2007-08-09 | 2009-04-23 | Sanofi Aventis | Nuevos derivados de 6-triazolopiridacina-sulfanil benzotiazol y bencimidazol,su procedimiento de preparación,su aplicación como medicamentos,composiciones farmacéuticas y nueva utilización principalmente como inhibidores de met. |
| TWI365185B (en) | 2008-07-24 | 2012-06-01 | Lilly Co Eli | Amidophenoxyindazoles useful as inhibitors of c-met |
| UY32049A (es) | 2008-08-14 | 2010-03-26 | Takeda Pharmaceutical | Inhibidores de cmet |
| EP2165710A1 (en) * | 2008-09-19 | 2010-03-24 | Institut Curie | Tyrosine kinase receptor Tyro3 as a therapeutic target in the treatment of a bladder tumor |
| US8592448B2 (en) | 2008-11-20 | 2013-11-26 | OSI Pharmaceuticals, LLC | Substituted pyrrolo[2,3-b]-pyridines and -pyrazines |
| FR2941951B1 (fr) * | 2009-02-06 | 2011-04-01 | Sanofi Aventis | Derives de 6-(6-nh-substitue-triazolopyridazine-sulfanyl) benzothiazoles et benzimidazoles : preparation, application comme medicaments et utilisation comme inhibiteurs de met. |
| FR2941950B1 (fr) * | 2009-02-06 | 2011-04-01 | Sanofi Aventis | Derives de 6-(6-o-substitue-triazolopyridazine-sulfanyl) benzothiazoles et benzimidazoles : preparation, application comme medicaments et utilisation comme inhibiteurs de met. |
| FR2941949B1 (fr) * | 2009-02-06 | 2011-04-01 | Sanofi Aventis | Derives de 6-(6-o-cycloalkyl ou 6-nh-cycloalkyl- triazolopyridazine-sulfanyl)benzothiazoles et benzimidazoles preparation, application comme medicaments et utilisation comme inhibiteurs de met. |
| FR2941952B1 (fr) * | 2009-02-06 | 2011-04-01 | Sanofi Aventis | Derives de 6-(6-substitue-triazolopyridazine-sulfanyl) 5-fluoro-benzothiazoles et 5-fluoro-benzimidazoles : preparation, application comme medicaments et utilisation comme inhibiteurs de met. |
| EA201200260A1 (ru) | 2009-08-12 | 2012-09-28 | Новартис Аг | Гетероциклические гидразоны и их применение для лечения рака и воспаления |
| IN2012DN01453A (OSRAM) | 2009-08-20 | 2015-06-05 | Novartis Ag | |
| PL2719699T3 (pl) | 2009-12-31 | 2016-01-29 | Hutchison Medipharma Ltd | Pewne triazolopirazyny, ich kompozycje i sposoby ich stosowania |
| AR081039A1 (es) | 2010-05-14 | 2012-05-30 | Osi Pharmaceuticals Llc | Inhibidores biciclicos fusionados de quinasa |
| JP2013526570A (ja) | 2010-05-14 | 2013-06-24 | オーエスアイ・ファーマシューティカルズ，エルエルシー | 縮合二環式キナーゼ阻害剤 |
| AR085183A1 (es) * | 2010-07-30 | 2013-09-18 | Lilly Co Eli | Compuesto 6-(1-metil-1h-pirazol-4-il)-3-(2-metil-2h-indazol-5-iltio)-[1,2,4]triazol[4,3-b]piridazina, composicion farmaceutica que lo comprende y uso para preparar un medicamento util para tratar cancer |
| UY33549A (es) * | 2010-08-10 | 2012-01-31 | Glaxo Group Ltd | Quinolil aminas como agentes inhibidores de las quinasas |
| WO2012042421A1 (en) | 2010-09-29 | 2012-04-05 | Pfizer Inc. | Method of treating abnormal cell growth |
| CN102532141A (zh) | 2010-12-08 | 2012-07-04 | 中国科学院上海药物研究所 | [1，2，4]三唑并[4，3-b][1，2，4]三嗪类化合物、其制备方法和用途 |
| US8765760B2 (en) | 2011-01-11 | 2014-07-01 | Sunovion Pharmaceuticals, Inc. | [1,2,4] triazol [1,5-a] pyrazines useful as inhibitors of phosphodiesterases |
| EP2673277A1 (en) * | 2011-02-10 | 2013-12-18 | Novartis AG | [1, 2, 4]triazolo [4, 3 -b]pyridazine compounds as inhibitors of the c-met tyrosine kinase |
| CN103459396B (zh) * | 2011-02-10 | 2015-08-19 | 诺瓦提斯公司 | 作为c-Met酪氨酸激酶抑制剂的[1,2,4]三唑并[4,3-b]哒嗪化合物 |
| US20140088114A1 (en) | 2011-05-16 | 2014-03-27 | OSI Pharmaceuticals ,LLC | Fused bicyclic kinase inhibitors |
| CN103958509B (zh) * | 2011-09-15 | 2015-12-23 | 诺华股份有限公司 | 作为酪氨酸激酶抑制剂的6-取代的3-(喹啉-6-基硫代)-[1,2,4]三唑并[4,3-a]吡啶化合物 |
| EP2755976B1 (en) * | 2011-09-15 | 2018-07-18 | Novartis AG | 6-substituted 3-(quinolin-6-ylthio)-[1,2,4]triazolo[4,3-a]pyridines as c-met tyrosine kinase inhibitors |
| WO2013151913A1 (en) | 2012-04-03 | 2013-10-10 | Novartis Ag | Tyrosine kinase inhibitor combinations and their use |
| CN110507654A (zh) | 2012-04-03 | 2019-11-29 | 诺华有限公司 | 有酪氨酸激酶抑制剂的组合产品和其应用 |
| CN103122000B (zh) * | 2012-09-03 | 2013-12-25 | 中美冠科生物技术（太仓）有限公司 | 用作抗肿瘤药物的高选择性的c-Met激酶抑制剂 |
| WO2014089904A1 (en) | 2012-12-10 | 2014-06-19 | Abbvie Inc. | Triazinone compounds |
| WO2014158943A1 (en) * | 2013-03-13 | 2014-10-02 | Avon Products, Inc | Tyrosinase inhibitors |
| US20150174034A1 (en) | 2013-03-13 | 2015-06-25 | Avon Products, Inc. | Tyrosinase inhibitors |
| WO2014164195A1 (en) | 2013-03-13 | 2014-10-09 | Avon Products, Inc | Tyrosinase inhibitors |
| EP3404032B1 (en) * | 2013-03-13 | 2025-07-02 | F. Hoffmann-La Roche AG | Process for making benzoxazepin compounds |
| WO2014174478A1 (en) | 2013-04-26 | 2014-10-30 | Novartis Ag | Pharmaceutical combinations of a pkc inhibitor and a c-met receptor tyrosine kinase inhibitor |
| EP2995618B1 (en) * | 2013-05-10 | 2019-01-09 | Jiangsu Hansoh Pharmaceutical Group Co., Ltd. | [1,2,4]triazol [4,3-a]pyridine derivate, preparation method therefor or medical application thereof |
| US10301325B2 (en) | 2015-09-24 | 2019-05-28 | Shanghai Haiju Biological Technology Co., Ltd. | Quinoline derivative, and pharmaceutical composition, preparation method and use thereof |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5604091A (en) | 1984-03-01 | 1997-02-18 | Microgenics Corporation | Methods for protein binding enzyme complementation |
| JPS60194443A (ja) * | 1984-03-16 | 1985-10-02 | Fuji Photo Film Co Ltd | ハロゲン化銀写真感光材料 |
| JPS62228086A (ja) * | 1985-12-23 | 1987-10-06 | Takeda Chem Ind Ltd | セフエム化合物 |
| EP0228061A3 (en) * | 1985-12-23 | 1988-12-14 | Takeda Chemical Industries, Ltd. | Cephem compounds |
| GB9918035D0 (en) | 1999-07-30 | 1999-09-29 | Novartis Ag | Organic compounds |
| AU2002251266A1 (en) * | 2001-04-10 | 2002-10-28 | Merck Sharp And Dohme Limited | Inhibitors of akt activity |
| WO2002083139A1 (en) * | 2001-04-10 | 2002-10-24 | Merck & Co., Inc. | Inhibitors of akt activity |
| US20030229453A1 (en) | 2002-04-09 | 2003-12-11 | Antonysamy Stephen Suresh | Crystals and structures of PAK4KD kinase PAK4KD |
| KR101075812B1 (ko) * | 2002-12-18 | 2011-10-25 | 버텍스 파마슈티칼스 인코포레이티드 | 단백질 키나제 억제제로서의 트리아졸로피리다진 |
| US7122548B2 (en) * | 2003-07-02 | 2006-10-17 | Sugen, Inc. | Triazolotriazine compounds and uses thereof |
| AU2005269387A1 (en) * | 2004-07-27 | 2006-02-09 | Sgx Pharmaceuticals, Inc. | Fused ring heterocycle kinase modulators |
| ATE492544T1 (de) | 2004-08-26 | 2011-01-15 | Pfizer | Pyrazol-substituierte aminoheteroarylverbindungen als proteinkinasehemmer |
| JP2008525453A (ja) | 2004-12-27 | 2008-07-17 | アルコン，インコーポレイティド | 緑内障と、ｒｈｏキナーゼを媒介とした他の疾患および症状を治療するためのアミノピラジン・アナログ |
-
2007
- 2007-10-18 NZ NZ575336A patent/NZ575336A/en not_active IP Right Cessation
- 2007-10-18 PT PT07844414T patent/PT2084162E/pt unknown
- 2007-10-18 ES ES07844414T patent/ES2393130T3/es active Active
- 2007-10-18 WO PCT/US2007/081841 patent/WO2008051808A2/en not_active Ceased
- 2007-10-18 BR BRPI0717320-2A2A patent/BRPI0717320A2/pt not_active IP Right Cessation
- 2007-10-18 PL PL07844414T patent/PL2084162T3/pl unknown
- 2007-10-18 EP EP07844414A patent/EP2084162B1/en active Active
- 2007-10-18 KR KR1020097008200A patent/KR20090071612A/ko not_active Abandoned
- 2007-10-18 MX MX2009004059A patent/MX2009004059A/es active IP Right Grant
- 2007-10-18 JP JP2009533541A patent/JP5378222B2/ja not_active Expired - Fee Related
- 2007-10-18 DK DK07844414.8T patent/DK2084162T3/da active
- 2007-10-18 EA EA200970403A patent/EA200970403A1/ru unknown
- 2007-10-18 AU AU2007309149A patent/AU2007309149C1/en not_active Ceased
- 2007-10-18 US US12/442,566 patent/US8507489B2/en not_active Expired - Fee Related
- 2007-10-18 CA CA002667428A patent/CA2667428A1/en not_active Abandoned
- 2007-10-22 TW TW096139480A patent/TW200835492A/zh unknown
- 2007-10-23 PE PE2007001437A patent/PE20080893A1/es not_active Application Discontinuation
- 2007-10-23 AR ARP070104680A patent/AR063520A1/es not_active Application Discontinuation
-
2009
- 2009-04-05 IL IL197958A patent/IL197958A0/en unknown
- 2009-04-15 TN TNP2009000142A patent/TN2009000142A1/fr unknown
- 2009-04-22 CO CO09040677A patent/CO6190620A2/es not_active Application Discontinuation
- 2009-04-23 NO NO20091618A patent/NO20091618L/no not_active Application Discontinuation
- 2009-04-23 SV SV2009003235A patent/SV2009003235A/es not_active Application Discontinuation
- 2009-05-07 MA MA31849A patent/MA30871B1/fr unknown
- 2009-05-19 CR CR10803A patent/CR10803A/es not_active Application Discontinuation
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