JP2010507567A - 併用療法 - Google Patents
併用療法 Download PDFInfo
- Publication number
- JP2010507567A JP2010507567A JP2009523960A JP2009523960A JP2010507567A JP 2010507567 A JP2010507567 A JP 2010507567A JP 2009523960 A JP2009523960 A JP 2009523960A JP 2009523960 A JP2009523960 A JP 2009523960A JP 2010507567 A JP2010507567 A JP 2010507567A
- Authority
- JP
- Japan
- Prior art keywords
- pyridinylmethyl
- benzenedimethanamine
- tetrahydro
- bis
- quinolinyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 238000002648 combination therapy Methods 0.000 title description 4
- 210000000130 stem cell Anatomy 0.000 claims abstract description 94
- 102000004269 Granulocyte Colony-Stimulating Factor Human genes 0.000 claims abstract description 53
- 108010017080 Granulocyte Colony-Stimulating Factor Proteins 0.000 claims abstract description 52
- 108010018951 Interleukin-8B Receptors Proteins 0.000 claims abstract description 36
- 102100031650 C-X-C chemokine receptor type 4 Human genes 0.000 claims abstract description 35
- 101000922348 Homo sapiens C-X-C chemokine receptor type 4 Proteins 0.000 claims abstract description 35
- 239000000556 agonist Substances 0.000 claims abstract description 32
- 239000003112 inhibitor Substances 0.000 claims abstract description 31
- 102100028989 C-X-C chemokine receptor type 2 Human genes 0.000 claims abstract 10
- 238000000034 method Methods 0.000 claims description 53
- 210000004027 cell Anatomy 0.000 claims description 50
- 101000889128 Homo sapiens C-X-C motif chemokine 2 Proteins 0.000 claims description 46
- 102100039398 C-X-C motif chemokine 2 Human genes 0.000 claims description 45
- YIQPUIGJQJDJOS-UHFFFAOYSA-N plerixafor Chemical group C=1C=C(CN2CCNCCCNCCNCCC2)C=CC=1CN1CCCNCCNCCCNCC1 YIQPUIGJQJDJOS-UHFFFAOYSA-N 0.000 claims description 26
- 229960002169 plerixafor Drugs 0.000 claims description 25
- 238000002512 chemotherapy Methods 0.000 claims description 18
- 239000000203 mixture Substances 0.000 claims description 16
- 206010035226 Plasma cell myeloma Diseases 0.000 claims description 12
- 206010028980 Neoplasm Diseases 0.000 claims description 11
- 230000001483 mobilizing effect Effects 0.000 claims description 10
- 201000000050 myeloid neoplasm Diseases 0.000 claims description 10
- 238000001959 radiotherapy Methods 0.000 claims description 10
- 239000003814 drug Substances 0.000 claims description 9
- 238000003306 harvesting Methods 0.000 claims description 8
- 241001465754 Metazoa Species 0.000 claims description 7
- 230000000694 effects Effects 0.000 claims description 7
- 229940079593 drug Drugs 0.000 claims description 5
- 208000032839 leukemia Diseases 0.000 claims description 5
- 208000002250 Hematologic Neoplasms Diseases 0.000 claims description 4
- 230000003394 haemopoietic effect Effects 0.000 claims description 4
- 239000002243 precursor Substances 0.000 claims description 4
- 206010025323 Lymphomas Diseases 0.000 claims description 3
- 239000004480 active ingredient Substances 0.000 claims description 3
- 238000000338 in vitro Methods 0.000 claims description 3
- 238000004519 manufacturing process Methods 0.000 claims description 3
- 238000012258 culturing Methods 0.000 claims 1
- -1 AMD3100 Chemical class 0.000 description 244
- 229910052757 nitrogen Inorganic materials 0.000 description 137
- 125000000325 methylidene group Chemical group [H]C([H])=* 0.000 description 113
- 150000001875 compounds Chemical class 0.000 description 71
- 125000003118 aryl group Chemical group 0.000 description 67
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 61
- 125000000623 heterocyclic group Chemical group 0.000 description 54
- 125000000217 alkyl group Chemical group 0.000 description 52
- RAXXELZNTBOGNW-UHFFFAOYSA-N imidazole Natural products C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 description 43
- JUJWROOIHBZHMG-UHFFFAOYSA-N pyridine Substances C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 description 36
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 34
- 229910052760 oxygen Inorganic materials 0.000 description 34
- 125000005842 heteroatom Chemical group 0.000 description 32
- 125000004122 cyclic group Chemical group 0.000 description 29
- 229910052717 sulfur Inorganic materials 0.000 description 29
- 125000004432 carbon atom Chemical group C* 0.000 description 27
- 102000002791 Interleukin-8B Receptors Human genes 0.000 description 26
- 125000001072 heteroaryl group Chemical group 0.000 description 26
- 229940121384 cxc chemokine receptor type 4 (cxcr4) antagonist Drugs 0.000 description 25
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 24
- 150000003839 salts Chemical class 0.000 description 24
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 23
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 23
- LBUJPTNKIBCYBY-UHFFFAOYSA-N 1,2,3,4-tetrahydroquinoline Chemical compound C1=CC=C2CCCNC2=C1 LBUJPTNKIBCYBY-UHFFFAOYSA-N 0.000 description 22
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 description 22
- NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical compound C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 description 22
- 239000002576 chemokine receptor CXCR4 antagonist Substances 0.000 description 22
- 241000699670 Mus sp. Species 0.000 description 21
- RWRDLPDLKQPQOW-UHFFFAOYSA-N Pyrrolidine Chemical compound C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 description 21
- AMNPXXIGUOKIPP-UHFFFAOYSA-N [4-(carbamothioylamino)phenyl]thiourea Chemical compound NC(=S)NC1=CC=C(NC(N)=S)C=C1 AMNPXXIGUOKIPP-UHFFFAOYSA-N 0.000 description 21
- 125000003342 alkenyl group Chemical group 0.000 description 20
- 239000008280 blood Substances 0.000 description 20
- 125000005843 halogen group Chemical group 0.000 description 20
- 210000004369 blood Anatomy 0.000 description 19
- IOJUPLGTWVMSFF-UHFFFAOYSA-N benzothiazole Chemical compound C1=CC=C2SC=NC2=C1 IOJUPLGTWVMSFF-UHFFFAOYSA-N 0.000 description 18
- 210000001185 bone marrow Anatomy 0.000 description 18
- SIKJAQJRHWYJAI-UHFFFAOYSA-N Indole Chemical compound C1=CC=C2NC=CC2=C1 SIKJAQJRHWYJAI-UHFFFAOYSA-N 0.000 description 17
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 description 17
- 229920006395 saturated elastomer Polymers 0.000 description 17
- 125000001424 substituent group Chemical group 0.000 description 17
- YLQBMQCUIZJEEH-UHFFFAOYSA-N Furan Chemical compound C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 16
- GLUUGHFHXGJENI-UHFFFAOYSA-N Piperazine Chemical compound C1CNCCN1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 description 16
- 238000002054 transplantation Methods 0.000 description 15
- HYZJCKYKOHLVJF-UHFFFAOYSA-N 1H-benzimidazole Chemical compound C1=CC=C2NC=NC2=C1 HYZJCKYKOHLVJF-UHFFFAOYSA-N 0.000 description 14
- SMWDFEZZVXVKRB-UHFFFAOYSA-N Quinoline Chemical compound N1=CC=CC2=CC=CC=C21 SMWDFEZZVXVKRB-UHFFFAOYSA-N 0.000 description 14
- YTPLMLYBLZKORZ-UHFFFAOYSA-N Thiophene Chemical compound C=1C=CSC=1 YTPLMLYBLZKORZ-UHFFFAOYSA-N 0.000 description 14
- 229910052739 hydrogen Inorganic materials 0.000 description 14
- AWJUIBRHMBBTKR-UHFFFAOYSA-N isoquinoline Chemical compound C1=NC=CC2=CC=CC=C21 AWJUIBRHMBBTKR-UHFFFAOYSA-N 0.000 description 14
- 229940002612 prodrug Drugs 0.000 description 14
- 239000000651 prodrug Substances 0.000 description 14
- UWYZHKAOTLEWKK-UHFFFAOYSA-N 1,2,3,4-tetrahydroisoquinoline Chemical compound C1=CC=C2CNCCC2=C1 UWYZHKAOTLEWKK-UHFFFAOYSA-N 0.000 description 12
- KYQCOXFCLRTKLS-UHFFFAOYSA-N Pyrazine Chemical compound C1=CN=CC=N1 KYQCOXFCLRTKLS-UHFFFAOYSA-N 0.000 description 12
- KAESVJOAVNADME-UHFFFAOYSA-N Pyrrole Chemical compound C=1C=CNC=1 KAESVJOAVNADME-UHFFFAOYSA-N 0.000 description 12
- 125000002947 alkylene group Chemical group 0.000 description 12
- 238000002617 apheresis Methods 0.000 description 12
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 description 12
- 239000001257 hydrogen Substances 0.000 description 12
- 229920000768 polyamine Polymers 0.000 description 12
- 230000002194 synthesizing effect Effects 0.000 description 12
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 description 11
- KFRQQIJWOPSAAH-UHFFFAOYSA-N [4-(aminomethyl)-3-(pyridin-2-ylmethyl)phenyl]methanamine Chemical compound NCC1=CC=C(CN)C(CC=2N=CC=CC=2)=C1 KFRQQIJWOPSAAH-UHFFFAOYSA-N 0.000 description 11
- 229910052799 carbon Inorganic materials 0.000 description 11
- 229910052736 halogen Inorganic materials 0.000 description 11
- 150000002367 halogens Chemical class 0.000 description 11
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 11
- 230000003211 malignant effect Effects 0.000 description 11
- 125000004076 pyridyl group Chemical group 0.000 description 11
- YNAVUWVOSKDBBP-UHFFFAOYSA-N Morpholine Chemical compound C1COCCN1 YNAVUWVOSKDBBP-UHFFFAOYSA-N 0.000 description 10
- UFWIBTONFRDIAS-UHFFFAOYSA-N Naphthalene Chemical compound C1=CC=CC2=CC=CC=C21 UFWIBTONFRDIAS-UHFFFAOYSA-N 0.000 description 10
- FZWLAAWBMGSTSO-UHFFFAOYSA-N Thiazole Chemical compound C1=CSC=N1 FZWLAAWBMGSTSO-UHFFFAOYSA-N 0.000 description 10
- 239000002253 acid Substances 0.000 description 10
- 125000002950 monocyclic group Chemical group 0.000 description 10
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 10
- 125000000547 substituted alkyl group Chemical group 0.000 description 10
- 238000011282 treatment Methods 0.000 description 10
- 102400000500 GRO-beta(5-73) Human genes 0.000 description 9
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 9
- WTKZEGDFNFYCGP-UHFFFAOYSA-N Pyrazole Chemical compound C=1C=NNC=1 WTKZEGDFNFYCGP-UHFFFAOYSA-N 0.000 description 9
- CZPWVGJYEJSRLH-UHFFFAOYSA-N Pyrimidine Chemical compound C1=CN=CN=C1 CZPWVGJYEJSRLH-UHFFFAOYSA-N 0.000 description 9
- 108010077140 SB251353 Proteins 0.000 description 9
- 125000002252 acyl group Chemical group 0.000 description 9
- 125000003710 aryl alkyl group Chemical group 0.000 description 9
- 210000003958 hematopoietic stem cell Anatomy 0.000 description 9
- 210000000265 leukocyte Anatomy 0.000 description 9
- 125000004433 nitrogen atom Chemical group N* 0.000 description 9
- BCMCBBGGLRIHSE-UHFFFAOYSA-N 1,3-benzoxazole Chemical compound C1=CC=C2OC=NC2=C1 BCMCBBGGLRIHSE-UHFFFAOYSA-N 0.000 description 8
- ZCQWOFVYLHDMMC-UHFFFAOYSA-N Oxazole Chemical compound C1=COC=N1 ZCQWOFVYLHDMMC-UHFFFAOYSA-N 0.000 description 8
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 description 8
- 125000003545 alkoxy group Chemical group 0.000 description 8
- 125000000304 alkynyl group Chemical group 0.000 description 8
- 150000001413 amino acids Chemical group 0.000 description 8
- 150000003857 carboxamides Chemical class 0.000 description 8
- 230000004087 circulation Effects 0.000 description 8
- 125000004093 cyano group Chemical group *C#N 0.000 description 8
- 125000000753 cycloalkyl group Chemical group 0.000 description 8
- 108010002386 Interleukin-3 Proteins 0.000 description 7
- 102000000646 Interleukin-3 Human genes 0.000 description 7
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 description 7
- 201000011510 cancer Diseases 0.000 description 7
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 description 7
- 238000009472 formulation Methods 0.000 description 7
- PZOUSPYUWWUPPK-UHFFFAOYSA-N indole Natural products CC1=CC=CC2=C1C=CN2 PZOUSPYUWWUPPK-UHFFFAOYSA-N 0.000 description 7
- RKJUIXBNRJVNHR-UHFFFAOYSA-N indolenine Natural products C1=CC=C2CC=NC2=C1 RKJUIXBNRJVNHR-UHFFFAOYSA-N 0.000 description 7
- 229940076264 interleukin-3 Drugs 0.000 description 7
- 125000005647 linker group Chemical group 0.000 description 7
- 229930192474 thiophene Natural products 0.000 description 7
- 150000003852 triazoles Chemical class 0.000 description 7
- 108010017213 Granulocyte-Macrophage Colony-Stimulating Factor Proteins 0.000 description 6
- 102100039620 Granulocyte-macrophage colony-stimulating factor Human genes 0.000 description 6
- 102000004890 Interleukin-8 Human genes 0.000 description 6
- 108090001007 Interleukin-8 Proteins 0.000 description 6
- PCNDJXKNXGMECE-UHFFFAOYSA-N Phenazine Natural products C1=CC=CC2=NC3=CC=CC=C3N=C21 PCNDJXKNXGMECE-UHFFFAOYSA-N 0.000 description 6
- 102100021669 Stromal cell-derived factor 1 Human genes 0.000 description 6
- 150000001412 amines Chemical class 0.000 description 6
- QRUDEWIWKLJBPS-UHFFFAOYSA-N benzotriazole Chemical compound C1=CC=C2N[N][N]C2=C1 QRUDEWIWKLJBPS-UHFFFAOYSA-N 0.000 description 6
- 125000005518 carboxamido group Chemical group 0.000 description 6
- 125000000592 heterocycloalkyl group Chemical group 0.000 description 6
- 125000002883 imidazolyl group Chemical group 0.000 description 6
- 210000000987 immune system Anatomy 0.000 description 6
- 238000002347 injection Methods 0.000 description 6
- 239000007924 injection Substances 0.000 description 6
- XKTZWUACRZHVAN-VADRZIEHSA-N interleukin-8 Chemical compound C([C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@@H](NC(C)=O)CCSC)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](CCSC)C(=O)N1[C@H](CCC1)C(=O)N1[C@H](CCC1)C(=O)N[C@@H](C)C(=O)N[C@H](CC(O)=O)C(=O)N[C@H](CCC(O)=O)C(=O)N[C@H](CC(O)=O)C(=O)N[C@H](CC=1C=CC(O)=CC=1)C(=O)N[C@H](CO)C(=O)N1[C@H](CCC1)C(N)=O)C1=CC=CC=C1 XKTZWUACRZHVAN-VADRZIEHSA-N 0.000 description 6
- 229940096397 interleukin-8 Drugs 0.000 description 6
- ZLTPDFXIESTBQG-UHFFFAOYSA-N isothiazole Chemical compound C=1C=NSC=1 ZLTPDFXIESTBQG-UHFFFAOYSA-N 0.000 description 6
- CTAPFRYPJLPFDF-UHFFFAOYSA-N isoxazole Chemical compound C=1C=NOC=1 CTAPFRYPJLPFDF-UHFFFAOYSA-N 0.000 description 6
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 description 6
- WCPAKWJPBJAGKN-UHFFFAOYSA-N oxadiazole Chemical compound C1=CON=N1 WCPAKWJPBJAGKN-UHFFFAOYSA-N 0.000 description 6
- 210000005259 peripheral blood Anatomy 0.000 description 6
- 239000011886 peripheral blood Substances 0.000 description 6
- 150000003536 tetrazoles Chemical class 0.000 description 6
- KEIFWROAQVVDBN-UHFFFAOYSA-N 1,2-dihydronaphthalene Chemical compound C1=CC=C2C=CCCC2=C1 KEIFWROAQVVDBN-UHFFFAOYSA-N 0.000 description 5
- 125000001140 1,4-phenylene group Chemical group [H]C1=C([H])C([*:2])=C([H])C([H])=C1[*:1] 0.000 description 5
- BAXOFTOLAUCFNW-UHFFFAOYSA-N 1H-indazole Chemical compound C1=CC=C2C=NNC2=C1 BAXOFTOLAUCFNW-UHFFFAOYSA-N 0.000 description 5
- GAMYYCRTACQSBR-UHFFFAOYSA-N 4-azabenzimidazole Chemical compound C1=CC=C2NC=NC2=N1 GAMYYCRTACQSBR-UHFFFAOYSA-N 0.000 description 5
- 208000031261 Acute myeloid leukaemia Diseases 0.000 description 5
- KYNSBQPICQTCGU-UHFFFAOYSA-N Benzopyrane Chemical compound C1=CC=C2C=CCOC2=C1 KYNSBQPICQTCGU-UHFFFAOYSA-N 0.000 description 5
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 5
- 108010008951 Chemokine CXCL12 Proteins 0.000 description 5
- CMSMOCZEIVJLDB-UHFFFAOYSA-N Cyclophosphamide Chemical compound ClCCN(CCCl)P1(=O)NCCCO1 CMSMOCZEIVJLDB-UHFFFAOYSA-N 0.000 description 5
- 102100031573 Hematopoietic progenitor cell antigen CD34 Human genes 0.000 description 5
- 101000777663 Homo sapiens Hematopoietic progenitor cell antigen CD34 Proteins 0.000 description 5
- 102000000589 Interleukin-1 Human genes 0.000 description 5
- 108010002352 Interleukin-1 Proteins 0.000 description 5
- DFPAKSUCGFBDDF-UHFFFAOYSA-N Nicotinamide Chemical compound NC(=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-UHFFFAOYSA-N 0.000 description 5
- 150000001408 amides Chemical class 0.000 description 5
- RFRXIWQYSOIBDI-UHFFFAOYSA-N benzarone Chemical compound CCC=1OC2=CC=CC=C2C=1C(=O)C1=CC=C(O)C=C1 RFRXIWQYSOIBDI-UHFFFAOYSA-N 0.000 description 5
- 239000012964 benzotriazole Substances 0.000 description 5
- 125000002619 bicyclic group Chemical group 0.000 description 5
- 229910002091 carbon monoxide Inorganic materials 0.000 description 5
- 125000006297 carbonyl amino group Chemical group [H]N([*:2])C([*:1])=O 0.000 description 5
- 150000007942 carboxylates Chemical class 0.000 description 5
- MTNDZQHUAFNZQY-UHFFFAOYSA-N imidazoline Chemical compound C1CN=CN1 MTNDZQHUAFNZQY-UHFFFAOYSA-N 0.000 description 5
- MGQNMYSRDBFUIR-UHFFFAOYSA-N nitro cyanoformate Chemical compound [O-][N+](=O)OC(=O)C#N MGQNMYSRDBFUIR-UHFFFAOYSA-N 0.000 description 5
- 238000011476 stem cell transplantation Methods 0.000 description 5
- CXWXQJXEFPUFDZ-UHFFFAOYSA-N tetralin Chemical compound C1=CC=C2CCCCC2=C1 CXWXQJXEFPUFDZ-UHFFFAOYSA-N 0.000 description 5
- VLLMWSRANPNYQX-UHFFFAOYSA-N thiadiazole Chemical compound C1=CSN=N1.C1=CSN=N1 VLLMWSRANPNYQX-UHFFFAOYSA-N 0.000 description 5
- BRNULMACUQOKMR-UHFFFAOYSA-N thiomorpholine Chemical compound C1CSCCN1 BRNULMACUQOKMR-UHFFFAOYSA-N 0.000 description 5
- 230000017423 tissue regeneration Effects 0.000 description 5
- CXWGKAYMVASWDQ-UHFFFAOYSA-N 1,2-dithiane Chemical compound C1CCSSC1 CXWGKAYMVASWDQ-UHFFFAOYSA-N 0.000 description 4
- RYHBNJHYFVUHQT-UHFFFAOYSA-N 1,4-Dioxane Chemical compound C1COCCO1 RYHBNJHYFVUHQT-UHFFFAOYSA-N 0.000 description 4
- FQUYSHZXSKYCSY-UHFFFAOYSA-N 1,4-diazepane Chemical compound C1CNCCNC1 FQUYSHZXSKYCSY-UHFFFAOYSA-N 0.000 description 4
- OXBLVCZKDOZZOJ-UHFFFAOYSA-N 2,3-Dihydrothiophene Chemical compound C1CC=CS1 OXBLVCZKDOZZOJ-UHFFFAOYSA-N 0.000 description 4
- JKTCBAGSMQIFNL-UHFFFAOYSA-N 2,3-dihydrofuran Chemical compound C1CC=CO1 JKTCBAGSMQIFNL-UHFFFAOYSA-N 0.000 description 4
- RSEBUVRVKCANEP-UHFFFAOYSA-N 2-pyrroline Chemical compound C1CC=CN1 RSEBUVRVKCANEP-UHFFFAOYSA-N 0.000 description 4
- KDCGOANMDULRCW-UHFFFAOYSA-N 7H-purine Chemical compound N1=CNC2=NC=NC2=C1 KDCGOANMDULRCW-UHFFFAOYSA-N 0.000 description 4
- KXDAEFPNCMNJSK-UHFFFAOYSA-N Benzamide Chemical compound NC(=O)C1=CC=CC=C1 KXDAEFPNCMNJSK-UHFFFAOYSA-N 0.000 description 4
- 102000019034 Chemokines Human genes 0.000 description 4
- 108010012236 Chemokines Proteins 0.000 description 4
- BUDQDWGNQVEFAC-UHFFFAOYSA-N Dihydropyran Chemical compound C1COC=CC1 BUDQDWGNQVEFAC-UHFFFAOYSA-N 0.000 description 4
- WRYCSMQKUKOKBP-UHFFFAOYSA-N Imidazolidine Chemical compound C1CNCN1 WRYCSMQKUKOKBP-UHFFFAOYSA-N 0.000 description 4
- 208000034578 Multiple myelomas Diseases 0.000 description 4
- 208000033776 Myeloid Acute Leukemia Diseases 0.000 description 4
- DHXVGJBLRPWPCS-UHFFFAOYSA-N Tetrahydropyran Chemical compound C1CCOCC1 DHXVGJBLRPWPCS-UHFFFAOYSA-N 0.000 description 4
- 230000000735 allogeneic effect Effects 0.000 description 4
- 125000004202 aminomethyl group Chemical group [H]N([H])C([H])([H])* 0.000 description 4
- 125000004429 atom Chemical group 0.000 description 4
- 125000005605 benzo group Chemical group 0.000 description 4
- 210000002798 bone marrow cell Anatomy 0.000 description 4
- 230000000973 chemotherapeutic effect Effects 0.000 description 4
- 239000000460 chlorine Substances 0.000 description 4
- 229910052801 chlorine Inorganic materials 0.000 description 4
- 230000001332 colony forming effect Effects 0.000 description 4
- LOZWAPSEEHRYPG-UHFFFAOYSA-N dithiane Natural products C1CSCCS1 LOZWAPSEEHRYPG-UHFFFAOYSA-N 0.000 description 4
- 229910052731 fluorine Inorganic materials 0.000 description 4
- 125000004435 hydrogen atom Chemical group [H]* 0.000 description 4
- 229910052751 metal Inorganic materials 0.000 description 4
- 239000002184 metal Substances 0.000 description 4
- 230000002107 myocardial effect Effects 0.000 description 4
- 210000000440 neutrophil Anatomy 0.000 description 4
- 210000003819 peripheral blood mononuclear cell Anatomy 0.000 description 4
- 108090000623 proteins and genes Proteins 0.000 description 4
- 102000004169 proteins and genes Human genes 0.000 description 4
- USPWKWBDZOARPV-UHFFFAOYSA-N pyrazolidine Chemical compound C1CNNC1 USPWKWBDZOARPV-UHFFFAOYSA-N 0.000 description 4
- PBMFSQRYOILNGV-UHFFFAOYSA-N pyridazine Chemical compound C1=CC=NN=C1 PBMFSQRYOILNGV-UHFFFAOYSA-N 0.000 description 4
- 125000005551 pyridylene group Chemical group 0.000 description 4
- HNJBEVLQSNELDL-UHFFFAOYSA-N pyrrolidin-2-one Chemical compound O=C1CCCN1 HNJBEVLQSNELDL-UHFFFAOYSA-N 0.000 description 4
- ZVJHJDDKYZXRJI-UHFFFAOYSA-N pyrroline Natural products C1CC=NC1 ZVJHJDDKYZXRJI-UHFFFAOYSA-N 0.000 description 4
- 230000007115 recruitment Effects 0.000 description 4
- 230000008439 repair process Effects 0.000 description 4
- 125000000565 sulfonamide group Chemical group 0.000 description 4
- 125000003396 thiol group Chemical group [H]S* 0.000 description 4
- 150000003573 thiols Chemical group 0.000 description 4
- 229960001124 trientine Drugs 0.000 description 4
- 229910052720 vanadium Inorganic materials 0.000 description 4
- JYEUMXHLPRZUAT-UHFFFAOYSA-N 1,2,3-triazine Chemical compound C1=CN=NN=C1 JYEUMXHLPRZUAT-UHFFFAOYSA-N 0.000 description 3
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
- LSNNMFCWUKXFEE-UHFFFAOYSA-M Bisulfite Chemical compound OS([O-])=O LSNNMFCWUKXFEE-UHFFFAOYSA-M 0.000 description 3
- YPDMXXRNCBSNNS-UHFFFAOYSA-N C(C(CC)N1CCNCCCNCCNCCC1)N1CCNCCCNCCNCCC1.C(C(C)N1CCNCCCNCCNCCC1)N1CCNCCCNCCNCCC1.C(CN1CCNCCCNCCNCCC1)N1CCNCCCNCCNCCC1 Chemical compound C(C(CC)N1CCNCCCNCCNCCC1)N1CCNCCCNCCNCCC1.C(C(C)N1CCNCCCNCCNCCC1)N1CCNCCCNCCNCCC1.C(CN1CCNCCCNCCNCCC1)N1CCNCCCNCCNCCC1 YPDMXXRNCBSNNS-UHFFFAOYSA-N 0.000 description 3
- 108010061299 CXCR4 Receptors Proteins 0.000 description 3
- 102000012000 CXCR4 Receptors Human genes 0.000 description 3
- 102000016950 Chemokine CXCL1 Human genes 0.000 description 3
- 108010014419 Chemokine CXCL1 Proteins 0.000 description 3
- RGSFGYAAUTVSQA-UHFFFAOYSA-N Cyclopentane Chemical compound C1CCCC1 RGSFGYAAUTVSQA-UHFFFAOYSA-N 0.000 description 3
- UHDGCWIWMRVCDJ-CCXZUQQUSA-N Cytarabine Chemical compound O=C1N=C(N)C=CN1[C@H]1[C@@H](O)[C@H](O)[C@@H](CO)O1 UHDGCWIWMRVCDJ-CCXZUQQUSA-N 0.000 description 3
- 108010029961 Filgrastim Proteins 0.000 description 3
- 239000005517 L01XE01 - Imatinib Substances 0.000 description 3
- 108010009474 Macrophage Inflammatory Proteins Proteins 0.000 description 3
- 102000009571 Macrophage Inflammatory Proteins Human genes 0.000 description 3
- 229910004013 NO 2 Inorganic materials 0.000 description 3
- MUBZPKHOEPUJKR-UHFFFAOYSA-N Oxalic acid Chemical compound OC(=O)C(O)=O MUBZPKHOEPUJKR-UHFFFAOYSA-N 0.000 description 3
- 108010041111 Thrombopoietin Proteins 0.000 description 3
- 102000036693 Thrombopoietin Human genes 0.000 description 3
- DGEZNRSVGBDHLK-UHFFFAOYSA-N [1,10]phenanthroline Chemical compound C1=CN=C2C3=NC=CC=C3C=CC2=C1 DGEZNRSVGBDHLK-UHFFFAOYSA-N 0.000 description 3
- KMLHDSULFOYCCK-UHFFFAOYSA-N [3-(aminomethyl)-2-(pyridin-2-ylmethyl)phenyl]methanamine Chemical compound NCC1=CC=CC(CN)=C1CC1=CC=CC=N1 KMLHDSULFOYCCK-UHFFFAOYSA-N 0.000 description 3
- 125000003277 amino group Chemical group 0.000 description 3
- 239000003242 anti bacterial agent Substances 0.000 description 3
- 229940088710 antibiotic agent Drugs 0.000 description 3
- 239000002246 antineoplastic agent Substances 0.000 description 3
- 125000005018 aryl alkenyl group Chemical group 0.000 description 3
- 125000005015 aryl alkynyl group Chemical group 0.000 description 3
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 3
- 230000008901 benefit Effects 0.000 description 3
- 230000037396 body weight Effects 0.000 description 3
- 229910052794 bromium Inorganic materials 0.000 description 3
- 150000001721 carbon Chemical group 0.000 description 3
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 3
- 239000003795 chemical substances by application Substances 0.000 description 3
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 description 3
- 229960004397 cyclophosphamide Drugs 0.000 description 3
- 125000005044 dihydroquinolinyl group Chemical group N1(CC=CC2=CC=CC=C12)* 0.000 description 3
- 238000005516 engineering process Methods 0.000 description 3
- 150000002148 esters Chemical class 0.000 description 3
- 108020001507 fusion proteins Proteins 0.000 description 3
- 102000037865 fusion proteins Human genes 0.000 description 3
- DMEGYFMYUHOHGS-UHFFFAOYSA-N heptamethylene Natural products C1CCCCCC1 DMEGYFMYUHOHGS-UHFFFAOYSA-N 0.000 description 3
- 238000001727 in vivo Methods 0.000 description 3
- 208000015181 infectious disease Diseases 0.000 description 3
- 238000001990 intravenous administration Methods 0.000 description 3
- CWJJHESJXJQCJA-UHFFFAOYSA-N n-(pyridin-2-ylmethyl)-1-[4-(1,4,8,11-tetrazacyclotetradec-1-ylmethyl)phenyl]methanamine Chemical compound C=1C=C(CN2CCNCCCNCCNCCC2)C=CC=1CNCC1=CC=CC=N1 CWJJHESJXJQCJA-UHFFFAOYSA-N 0.000 description 3
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 description 3
- 150000002923 oximes Chemical class 0.000 description 3
- 239000001301 oxygen Chemical group 0.000 description 3
- 125000000843 phenylene group Chemical group C1(=C(C=CC=C1)*)* 0.000 description 3
- 125000003386 piperidinyl group Chemical group 0.000 description 3
- 125000000714 pyrimidinyl group Chemical group 0.000 description 3
- XSCHRSMBECNVNS-UHFFFAOYSA-N quinoxaline Chemical compound N1=CC=NC2=CC=CC=C21 XSCHRSMBECNVNS-UHFFFAOYSA-N 0.000 description 3
- 230000004044 response Effects 0.000 description 3
- 230000000638 stimulation Effects 0.000 description 3
- BUUPQKDIAURBJP-UHFFFAOYSA-N sulfinic acid Chemical compound OS=O BUUPQKDIAURBJP-UHFFFAOYSA-N 0.000 description 3
- 125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 description 3
- 239000011593 sulfur Chemical group 0.000 description 3
- 210000001519 tissue Anatomy 0.000 description 3
- FOSDRKVGBZLRRC-QMMNWOAZSA-N (1r,2r)-1-n-[[4-[(pyridin-2-ylmethylamino)methyl]phenyl]methyl]-1-n-(5,6,7,8-tetrahydroquinolin-8-yl)cyclopentane-1,2-diamine Chemical compound N[C@@H]1CCC[C@H]1N(C1C2=NC=CC=C2CCC1)CC(C=C1)=CC=C1CNCC1=CC=CC=N1 FOSDRKVGBZLRRC-QMMNWOAZSA-N 0.000 description 2
- DEPCBODWMCNAKO-GORYFVAVSA-N (1r,2r)-2-n-[[4-[(pyridin-2-ylmethylamino)methyl]phenyl]methyl]-2-n-(5,6,7,8-tetrahydroquinolin-8-yl)cyclohexane-1,2-diamine Chemical compound N[C@@H]1CCCC[C@H]1N(C1C2=NC=CC=C2CCC1)CC(C=C1)=CC=C1CNCC1=CC=CC=N1 DEPCBODWMCNAKO-GORYFVAVSA-N 0.000 description 2
- UPXZXNQWHQWURB-UXMRNZNESA-N (2S)-2-amino-N-[[4-[(pyridin-2-ylmethylamino)methyl]phenyl]methyl]-N-(5,6,7,8-tetrahydroquinolin-8-yl)butanediamide Chemical compound C1CCC2=CC=CN=C2C1N(C(=O)[C@H](CC(N)=O)N)CC(C=C1)=CC=C1CNCC1=CC=CC=N1 UPXZXNQWHQWURB-UXMRNZNESA-N 0.000 description 2
- FDIAHPIZYUHCDZ-QBHOUYDASA-N (2s)-2,6-diamino-n-[[4-[(pyridin-2-ylmethylamino)methyl]phenyl]methyl]-n-(5,6,7,8-tetrahydroquinolin-8-yl)hexanamide Chemical compound C1CCC2=CC=CN=C2C1N(C(=O)[C@@H](N)CCCCN)CC(C=C1)=CC=C1CNCC1=CC=CC=N1 FDIAHPIZYUHCDZ-QBHOUYDASA-N 0.000 description 2
- RSGZLNITLGQDQL-XGLRFROISA-N (2s)-2-amino-n-[[4-[(pyridin-2-ylmethylamino)methyl]phenyl]methyl]-n-(5,6,7,8-tetrahydroquinolin-8-yl)propanamide Chemical compound C1CCC2=CC=CN=C2C1N(C(=O)[C@@H](N)C)CC(C=C1)=CC=C1CNCC1=CC=CC=N1 RSGZLNITLGQDQL-XGLRFROISA-N 0.000 description 2
- XBTRYWRVOBZSGM-UHFFFAOYSA-N (4-methylphenyl)methanediamine Chemical compound CC1=CC=C(C(N)N)C=C1 XBTRYWRVOBZSGM-UHFFFAOYSA-N 0.000 description 2
- 125000004890 (C1-C6) alkylamino group Chemical group 0.000 description 2
- 125000006569 (C5-C6) heterocyclic group Chemical group 0.000 description 2
- ZCZVGQCBSJLDDS-UHFFFAOYSA-N 1,2,3,4-tetrahydro-1,8-naphthyridine Chemical compound C1=CC=C2CCCNC2=N1 ZCZVGQCBSJLDDS-UHFFFAOYSA-N 0.000 description 2
- XEYKWYIXHMEQGM-UHFFFAOYSA-N 1,2-dihydro-1,8-naphthyridine Chemical compound C1=CC=C2C=CCNC2=N1 XEYKWYIXHMEQGM-UHFFFAOYSA-N 0.000 description 2
- LXUJUJYVZSBOKU-UHFFFAOYSA-N 1,4,7-triazacyclotetradecane Chemical compound C1CCCNCCNCCNCCC1 LXUJUJYVZSBOKU-UHFFFAOYSA-N 0.000 description 2
- KBKWSBZLRBYERS-UHFFFAOYSA-N 1-[4-(1,2,3,4,4a,5,7,7a-octahydropyrrolo[3,4-b]pyrazin-6-ylmethyl)phenyl]-n-(pyridin-2-ylmethyl)methanamine Chemical compound C=1C=C(CN2CC3NCCNC3C2)C=CC=1CNCC1=CC=CC=N1 KBKWSBZLRBYERS-UHFFFAOYSA-N 0.000 description 2
- PMGQWFFOFZQXSJ-UHFFFAOYSA-N 1-[4-(1,7-diazacyclotetradec-4-ylmethyl)phenyl]-n-(pyridin-2-ylmethyl)methanamine Chemical compound C=1C=C(CC2CCNCCCCCCCNCC2)C=CC=1CNCC1=CC=CC=N1 PMGQWFFOFZQXSJ-UHFFFAOYSA-N 0.000 description 2
- GKJYLJLZQLRHLX-UHFFFAOYSA-N 1-[4-[(11,11-difluoro-1,4,7-triazacyclotetradec-4-yl)methyl]phenyl]-n-(pyridin-2-ylmethyl)methanamine Chemical compound C1CNCCCC(F)(F)CCCNCCN1CC(C=C1)=CC=C1CNCC1=CC=CC=N1 GKJYLJLZQLRHLX-UHFFFAOYSA-N 0.000 description 2
- KCIMFODBVYVAJW-UHFFFAOYSA-N 1-[4-[(11-fluoro-1,4,7-triazacyclotetradec-4-yl)methyl]phenyl]-n-(pyridin-2-ylmethyl)methanamine Chemical compound C1CNCCCC(F)CCCNCCN1CC(C=C1)=CC=C1CNCC1=CC=CC=N1 KCIMFODBVYVAJW-UHFFFAOYSA-N 0.000 description 2
- NBCDGKOOYGZODJ-UHFFFAOYSA-N 1-[4-[[1h-imidazol-2-ylmethyl(pyridin-2-ylmethyl)amino]methyl]phenyl]-n-(pyridin-2-ylmethyl)methanamine Chemical compound C=1C=C(CN(CC=2NC=CN=2)CC=2N=CC=CC=2)C=CC=1CNCC1=CC=CC=N1 NBCDGKOOYGZODJ-UHFFFAOYSA-N 0.000 description 2
- CGBPRRHXVCXIKY-UHFFFAOYSA-N 1-[[2-bromo-4-(1,4,8,11-tetrazacyclotetradec-1-ylmethyl)phenyl]methyl]-1,4,8,11-tetrazacyclotetradecane Chemical compound C=1C=C(CN2CCNCCCNCCNCCC2)C(Br)=CC=1CN1CCCNCCNCCCNCC1 CGBPRRHXVCXIKY-UHFFFAOYSA-N 0.000 description 2
- BKJDPXSXCZMISN-UHFFFAOYSA-N 1-[[6-(1,4,8,11-tetrazacyclotetradec-1-ylmethyl)pyridin-2-yl]methyl]-1,4,8,11-tetrazacyclotetradecane Chemical compound C=1C=CC(CN2CCNCCCNCCNCCC2)=NC=1CN1CCCNCCNCCCNCC1 BKJDPXSXCZMISN-UHFFFAOYSA-N 0.000 description 2
- LSTOTGFDCJUTLM-UHFFFAOYSA-N 1-benzyl-n-(2-pyridin-2-ylethyl)-n-[[3-[(pyridin-2-ylmethylamino)methyl]phenyl]methyl]pyrrolidin-3-amine Chemical compound C=1C=CC(CNCC=2N=CC=CC=2)=CC=1CN(C1CN(CC=2C=CC=CC=2)CC1)CCC1=CC=CC=N1 LSTOTGFDCJUTLM-UHFFFAOYSA-N 0.000 description 2
- MJHXLZLPZMMAIK-UHFFFAOYSA-N 1-benzyl-n-(2-pyridin-2-ylethyl)-n-[[4-[(pyridin-2-ylmethylamino)methyl]phenyl]methyl]piperidin-4-amine Chemical compound C=1C=C(CNCC=2N=CC=CC=2)C=CC=1CN(C1CCN(CC=2C=CC=CC=2)CC1)CCC1=CC=CC=N1 MJHXLZLPZMMAIK-UHFFFAOYSA-N 0.000 description 2
- VHUNAUGRQAADNH-UHFFFAOYSA-N 1-benzyl-n-(pyridin-2-ylmethyl)-n-[[3-[(pyridin-2-ylmethylamino)methyl]phenyl]methyl]pyrrolidin-3-amine Chemical compound C=1C=CC(CN(CC=2N=CC=CC=2)C2CN(CC=3C=CC=CC=3)CC2)=CC=1CNCC1=CC=CC=N1 VHUNAUGRQAADNH-UHFFFAOYSA-N 0.000 description 2
- IWFUTXGNXCUDCF-UHFFFAOYSA-N 1-butyl-n-(2-pyridin-2-ylethyl)-n-[[3-[(pyridin-2-ylmethylamino)methyl]phenyl]methyl]piperidin-4-amine Chemical compound C1CN(CCCC)CCC1N(CC=1C=C(CNCC=2N=CC=CC=2)C=CC=1)CCC1=CC=CC=N1 IWFUTXGNXCUDCF-UHFFFAOYSA-N 0.000 description 2
- BJXXQCURPZWADT-UHFFFAOYSA-N 1-methyl-n-[[4-[(pyridin-2-ylmethylamino)methyl]phenyl]methyl]-1,2,3,4-tetrahydronaphthalen-2-amine Chemical compound C1CC2=CC=CC=C2C(C)C1NCC(C=C1)=CC=C1CNCC1=CC=CC=N1 BJXXQCURPZWADT-UHFFFAOYSA-N 0.000 description 2
- RQVLBXNLNVOMQX-UHFFFAOYSA-N 1-phenyl-3-[2-[[4-[(pyridin-2-ylmethylamino)methyl]phenyl]methyl-(5,6,7,8-tetrahydroquinolin-8-yl)amino]ethyl]urea Chemical compound C=1C=CC=CC=1NC(=O)NCCN(C1C2=NC=CC=C2CCC1)CC(C=C1)=CC=C1CNCC1=CC=CC=N1 RQVLBXNLNVOMQX-UHFFFAOYSA-N 0.000 description 2
- YRMKTQNDPSHONR-UHFFFAOYSA-N 1-phenyl-n-[[4-(1,4,8,11-tetrazacyclotetradec-1-ylmethyl)phenyl]methyl]methanamine Chemical compound C=1C=CC=CC=1CNCC(C=C1)=CC=C1CN1CCCNCCNCCCNCC1 YRMKTQNDPSHONR-UHFFFAOYSA-N 0.000 description 2
- GCBXAQLZTBLSGE-UHFFFAOYSA-N 1-phenylcyclopropane-1-carboxamide Chemical compound C=1C=CC=CC=1C1(C(=O)N)CC1 GCBXAQLZTBLSGE-UHFFFAOYSA-N 0.000 description 2
- IAGWLDWQRRSAIK-UHFFFAOYSA-N 11-[[4-(1,4,7,11-tetrazacyclotetradec-11-ylmethyl)phenyl]methyl]-1,4,7,11-tetrazacyclotetradecane Chemical compound C=1C=C(CN2CCCNCCNCCNCCC2)C=CC=1CN1CCCNCCNCCNCCC1 IAGWLDWQRRSAIK-UHFFFAOYSA-N 0.000 description 2
- 125000001617 2,3-dimethoxy phenyl group Chemical group [H]C1=C([H])C(*)=C(OC([H])([H])[H])C(OC([H])([H])[H])=C1[H] 0.000 description 2
- UEJJHQNACJXSKW-UHFFFAOYSA-N 2-(2,6-dioxopiperidin-3-yl)-1H-isoindole-1,3(2H)-dione Chemical compound O=C1C2=CC=CC=C2C(=O)N1C1CCC(=O)NC1=O UEJJHQNACJXSKW-UHFFFAOYSA-N 0.000 description 2
- NRYHPSFCBKKDJE-UHFFFAOYSA-N 2-[1-benzyl-4-[pyridin-2-ylmethyl-[[3-[(pyridin-2-ylmethylamino)methyl]phenyl]methyl]amino]piperidin-3-yl]acetic acid Chemical compound C1CC(N(CC=2C=C(CNCC=3N=CC=CC=3)C=CC=2)CC=2N=CC=CC=2)C(CC(=O)O)CN1CC1=CC=CC=C1 NRYHPSFCBKKDJE-UHFFFAOYSA-N 0.000 description 2
- YGRKCIJFPKKQKJ-UHFFFAOYSA-N 2-[2-[[4-[(pyridin-2-ylmethylamino)methyl]phenyl]methyl-(5,6,7,8-tetrahydroquinolin-8-yl)amino]ethyl]guanidine Chemical compound C1CCC2=CC=CN=C2C1N(CCNC(=N)N)CC(C=C1)=CC=C1CNCC1=CC=CC=N1 YGRKCIJFPKKQKJ-UHFFFAOYSA-N 0.000 description 2
- VTSJNUHXDBTHAG-UHFFFAOYSA-N 2-[[4-[(pyridin-2-ylmethylamino)methyl]phenyl]methyl-(5,6,7,8-tetrahydroquinolin-8-yl)amino]acetic acid Chemical compound C1CCC2=CC=CN=C2C1N(CC(=O)O)CC(C=C1)=CC=C1CNCC1=CC=CC=N1 VTSJNUHXDBTHAG-UHFFFAOYSA-N 0.000 description 2
- UQJUPEBNPXJTGH-UHFFFAOYSA-N 2-[[[4-(1,4,8,11-tetrazacyclotetradec-1-ylmethyl)phenyl]methylamino]methyl]aniline Chemical compound NC1=CC=CC=C1CNCC(C=C1)=CC=C1CN1CCNCCCNCCNCCC1 UQJUPEBNPXJTGH-UHFFFAOYSA-N 0.000 description 2
- FBFOFFQQFBONCW-UHFFFAOYSA-N 2-[[[4-[(pyridin-2-ylmethylamino)methyl]phenyl]methyl-(5,6,7,8-tetrahydroquinolin-8-yl)amino]methyl]phenol Chemical compound OC1=CC=CC=C1CN(C1C2=NC=CC=C2CCC1)CC(C=C1)=CC=C1CNCC1=CC=CC=N1 FBFOFFQQFBONCW-UHFFFAOYSA-N 0.000 description 2
- XPWUCLRKBVXLAK-UHFFFAOYSA-N 2-[[[4-[(pyridin-2-ylmethylamino)methyl]phenyl]methyl-(6,7,8,9-tetrahydro-5h-cyclohepta[b]pyridin-9-yl)amino]methyl]quinolin-8-ol Chemical compound N1=C2C(O)=CC=CC2=CC=C1CN(C1C2=NC=CC=C2CCCC1)CC(C=C1)=CC=C1CNCC1=CC=CC=N1 XPWUCLRKBVXLAK-UHFFFAOYSA-N 0.000 description 2
- VRRHGRADXKUDHV-UHFFFAOYSA-N 2-amino-n-[[4-[(pyridin-2-ylmethylamino)methyl]phenyl]methyl]-n-(5,6,7,8-tetrahydroquinolin-8-yl)acetamide Chemical compound C1CCC2=CC=CN=C2C1N(C(=O)CN)CC(C=C1)=CC=C1CNCC1=CC=CC=N1 VRRHGRADXKUDHV-UHFFFAOYSA-N 0.000 description 2
- 125000004182 2-chlorophenyl group Chemical group [H]C1=C([H])C(Cl)=C(*)C([H])=C1[H] 0.000 description 2
- 125000004200 2-methoxyethyl group Chemical group [H]C([H])([H])OC([H])([H])C([H])([H])* 0.000 description 2
- JWJNUFDEINAFJW-UHFFFAOYSA-N 2-phenyl-n-[[4-[(pyridin-2-ylmethylamino)methyl]phenyl]methyl]-5,6,7,8-tetrahydroquinolin-8-amine Chemical compound C=1C=C(CNC2C3=NC(=CC=C3CCC2)C=2C=CC=CC=2)C=CC=1CNCC1=CC=CC=N1 JWJNUFDEINAFJW-UHFFFAOYSA-N 0.000 description 2
- 125000000094 2-phenylethyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])* 0.000 description 2
- 125000000175 2-thienyl group Chemical group S1C([*])=C([H])C([H])=C1[H] 0.000 description 2
- FEAVXMPFTQROEI-UHFFFAOYSA-N 2h-pyrano[3,2-b]pyridine Chemical group C1=CN=C2C=CCOC2=C1 FEAVXMPFTQROEI-UHFFFAOYSA-N 0.000 description 2
- XNARZJQXBMWIQU-UHFFFAOYSA-N 3,4-dihydro-2h-pyrano[3,2-b]pyridine Chemical group C1=CN=C2CCCOC2=C1 XNARZJQXBMWIQU-UHFFFAOYSA-N 0.000 description 2
- OZFANALXKZFARG-UHFFFAOYSA-N 3-(2-chlorophenyl)-5-methyl-1,2-oxazole-4-carboxamide Chemical compound NC(=O)C1=C(C)ON=C1C1=CC=CC=C1Cl OZFANALXKZFARG-UHFFFAOYSA-N 0.000 description 2
- SELQQIVKCRNKIT-UHFFFAOYSA-N 3-benzyl-1-[[4-[(pyridin-2-ylmethylamino)methyl]phenyl]methyl]-1-(5,6,7,8-tetrahydroquinolin-8-yl)urea Chemical compound C=1C=C(CNCC=2N=CC=CC=2)C=CC=1CN(C1C2=NC=CC=C2CCC1)C(=O)NCC1=CC=CC=C1 SELQQIVKCRNKIT-UHFFFAOYSA-N 0.000 description 2
- WVAWOUKVAOMCPU-UHFFFAOYSA-N 3-phenyl-1-[[4-[(pyridin-2-ylmethylamino)methyl]phenyl]methyl]-1-(5,6,7,8-tetrahydroquinolin-8-yl)urea Chemical compound C=1C=C(CNCC=2N=CC=CC=2)C=CC=1CN(C1C2=NC=CC=C2CCC1)C(=O)NC1=CC=CC=C1 WVAWOUKVAOMCPU-UHFFFAOYSA-N 0.000 description 2
- WRXILBMKDNKDQT-UHFFFAOYSA-N 4-[[[4-(1,4,8,11-tetrazacyclotetradec-1-ylmethyl)phenyl]methylamino]methyl]aniline Chemical compound C1=CC(N)=CC=C1CNCC(C=C1)=CC=C1CN1CCNCCCNCCNCCC1 WRXILBMKDNKDQT-UHFFFAOYSA-N 0.000 description 2
- 125000004801 4-cyanophenyl group Chemical group [H]C1=C([H])C(C#N)=C([H])C([H])=C1* 0.000 description 2
- 125000004172 4-methoxyphenyl group Chemical group [H]C1=C([H])C(OC([H])([H])[H])=C([H])C([H])=C1* 0.000 description 2
- OGWKCGZFUXNPDA-CFWMRBGOSA-N 5j49q6b70f Chemical compound C([C@H](C[C@]1(C(=O)OC)C=2C(=CC3=C([C@]45[C@H]([C@@]([C@H](OC(C)=O)[C@]6(CC)C=CCN([C@H]56)CC4)(O)C(=O)OC)N3C=O)C=2)OC)C[C@@](C2)(O)CC)N2CCC2=C1NC1=CC=CC=C21 OGWKCGZFUXNPDA-CFWMRBGOSA-N 0.000 description 2
- BGNKBUMUVFZBAZ-UHFFFAOYSA-N 7-[1h-imidazol-2-ylmethyl-[[4-[(pyridin-2-ylmethylamino)methyl]phenyl]methyl]amino]-5,6,7,8-tetrahydronaphthalen-1-ol Chemical compound C1C=2C(O)=CC=CC=2CCC1N(CC=1C=CC(CNCC=2N=CC=CC=2)=CC=1)CC1=NC=CN1 BGNKBUMUVFZBAZ-UHFFFAOYSA-N 0.000 description 2
- DKDLSEPIAWSONV-UHFFFAOYSA-N 7-[[4-[(pyridin-2-ylmethylamino)methyl]phenyl]methylamino]-5,6,7,8-tetrahydronaphthalen-1-ol Chemical compound C1C=2C(O)=CC=CC=2CCC1NCC(C=C1)=CC=C1CNCC1=CC=CC=N1 DKDLSEPIAWSONV-UHFFFAOYSA-N 0.000 description 2
- OTLMPGFPWPEXIK-UHFFFAOYSA-N 8-fluoro-n-(1h-imidazol-2-ylmethyl)-n-[[4-[(pyridin-2-ylmethylamino)methyl]phenyl]methyl]-1,2,3,4-tetrahydronaphthalen-2-amine Chemical compound C1C=2C(F)=CC=CC=2CCC1N(CC=1C=CC(CNCC=2N=CC=CC=2)=CC=1)CC1=NC=CN1 OTLMPGFPWPEXIK-UHFFFAOYSA-N 0.000 description 2
- XUQNFXXFHDZHNO-UHFFFAOYSA-N 8-fluoro-n-[[4-[(pyridin-2-ylmethylamino)methyl]phenyl]methyl]-1,2,3,4-tetrahydronaphthalen-2-amine Chemical compound C1C=2C(F)=CC=CC=2CCC1NCC(C=C1)=CC=C1CNCC1=CC=CC=N1 XUQNFXXFHDZHNO-UHFFFAOYSA-N 0.000 description 2
- DLFVBJFMPXGRIB-UHFFFAOYSA-N Acetamide Chemical compound CC(N)=O DLFVBJFMPXGRIB-UHFFFAOYSA-N 0.000 description 2
- 102100030009 Azurocidin Human genes 0.000 description 2
- 101710154607 Azurocidin Proteins 0.000 description 2
- KAKZBPTYRLMSJV-UHFFFAOYSA-N Butadiene Chemical group C=CC=C KAKZBPTYRLMSJV-UHFFFAOYSA-N 0.000 description 2
- FERIUCNNQQJTOY-UHFFFAOYSA-N Butyric acid Chemical compound CCCC(O)=O FERIUCNNQQJTOY-UHFFFAOYSA-N 0.000 description 2
- 102100036153 C-X-C motif chemokine 6 Human genes 0.000 description 2
- 108010014423 Chemokine CXCL6 Proteins 0.000 description 2
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 description 2
- XZMCDFZZKTWFGF-UHFFFAOYSA-N Cyanamide Chemical compound NC#N XZMCDFZZKTWFGF-UHFFFAOYSA-N 0.000 description 2
- AOJJSUZBOXZQNB-TZSSRYMLSA-N Doxorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(=O)CO)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 AOJJSUZBOXZQNB-TZSSRYMLSA-N 0.000 description 2
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 2
- QUSNBJAOOMFDIB-UHFFFAOYSA-N Ethylamine Chemical compound CCN QUSNBJAOOMFDIB-UHFFFAOYSA-N 0.000 description 2
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 description 2
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 2
- 102100039619 Granulocyte colony-stimulating factor Human genes 0.000 description 2
- ZRALSGWEFCBTJO-UHFFFAOYSA-N Guanidine Chemical compound NC(N)=N ZRALSGWEFCBTJO-UHFFFAOYSA-N 0.000 description 2
- CPELXLSAUQHCOX-UHFFFAOYSA-N Hydrogen bromide Chemical compound Br CPELXLSAUQHCOX-UHFFFAOYSA-N 0.000 description 2
- AVXURJPOCDRRFD-UHFFFAOYSA-N Hydroxylamine Chemical class ON AVXURJPOCDRRFD-UHFFFAOYSA-N 0.000 description 2
- 108010062867 Lenograstim Proteins 0.000 description 2
- LSDPWZHWYPCBBB-UHFFFAOYSA-N Methanethiol Chemical compound SC LSDPWZHWYPCBBB-UHFFFAOYSA-N 0.000 description 2
- KUUFFMDRRZLVNA-LHEWISCISA-N O=C([C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)C)N(CC1)CCC1N(CC=1C=C(CNCC=2N=CC=CC=2)C=CC=1)CCC1=CC=CC=N1 Chemical compound O=C([C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)C)N(CC1)CCC1N(CC=1C=C(CNCC=2N=CC=CC=2)C=CC=1)CCC1=CC=CC=N1 KUUFFMDRRZLVNA-LHEWISCISA-N 0.000 description 2
- 108700020796 Oncogene Proteins 0.000 description 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 2
- 102100036154 Platelet basic protein Human genes 0.000 description 2
- 208000008691 Precursor B-Cell Lymphoblastic Leukemia-Lymphoma Diseases 0.000 description 2
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 2
- WNLRTRBMVRJNCN-UHFFFAOYSA-N adipic acid Chemical compound OC(=O)CCCCC(O)=O WNLRTRBMVRJNCN-UHFFFAOYSA-N 0.000 description 2
- 125000004390 alkyl sulfonyl group Chemical group 0.000 description 2
- 229940035676 analgesics Drugs 0.000 description 2
- 239000005557 antagonist Substances 0.000 description 2
- 239000000730 antalgic agent Substances 0.000 description 2
- 229940124599 anti-inflammatory drug Drugs 0.000 description 2
- 125000004391 aryl sulfonyl group Chemical group 0.000 description 2
- ZSIQJIWKELUFRJ-UHFFFAOYSA-N azepane Chemical compound C1CCCNCC1 ZSIQJIWKELUFRJ-UHFFFAOYSA-N 0.000 description 2
- HONIICLYMWZJFZ-UHFFFAOYSA-N azetidine Chemical compound C1CNC1 HONIICLYMWZJFZ-UHFFFAOYSA-N 0.000 description 2
- 125000003785 benzimidazolyl group Chemical group N1=C(NC2=C1C=CC=C2)* 0.000 description 2
- 210000002960 bfu-e Anatomy 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 210000000601 blood cell Anatomy 0.000 description 2
- RYYVLZVUVIJVGH-UHFFFAOYSA-N caffeine Chemical compound CN1C(=O)N(C)C(=O)C2=C1N=CN2C RYYVLZVUVIJVGH-UHFFFAOYSA-N 0.000 description 2
- 150000001733 carboxylic acid esters Chemical class 0.000 description 2
- 238000003776 cleavage reaction Methods 0.000 description 2
- 108010035886 connective tissue-activating peptide Proteins 0.000 description 2
- 125000006310 cycloalkyl amino group Chemical group 0.000 description 2
- 125000001162 cycloheptenyl group Chemical group C1(=CCCCCC1)* 0.000 description 2
- 125000000582 cycloheptyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 description 2
- HGCIXCUEYOPUTN-UHFFFAOYSA-N cyclohexene Chemical compound C1CCC=CC1 HGCIXCUEYOPUTN-UHFFFAOYSA-N 0.000 description 2
- 125000000596 cyclohexenyl group Chemical group C1(=CCCCC1)* 0.000 description 2
- LPIQUOYDBNQMRZ-UHFFFAOYSA-N cyclopentene Chemical compound C1CC=CC1 LPIQUOYDBNQMRZ-UHFFFAOYSA-N 0.000 description 2
- 125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 description 2
- AIMMVWOEOZMVMS-UHFFFAOYSA-N cyclopropanecarboxamide Chemical compound NC(=O)C1CC1 AIMMVWOEOZMVMS-UHFFFAOYSA-N 0.000 description 2
- 229960000684 cytarabine Drugs 0.000 description 2
- 230000006378 damage Effects 0.000 description 2
- 230000004069 differentiation Effects 0.000 description 2
- XBDQKXXYIPTUBI-UHFFFAOYSA-N dimethylselenoniopropionate Natural products CCC(O)=O XBDQKXXYIPTUBI-UHFFFAOYSA-N 0.000 description 2
- 125000006575 electron-withdrawing group Chemical group 0.000 description 2
- QQLSDQQQTYRPOD-UHFFFAOYSA-N ethyl 4-[[4-[(pyridin-2-ylmethylamino)methyl]phenyl]methyl-(5,6,7,8-tetrahydroquinolin-8-yl)amino]piperidine-1-carboxylate Chemical compound C1CN(C(=O)OCC)CCC1N(C1C2=NC=CC=C2CCC1)CC(C=C1)=CC=C1CNCC1=CC=CC=N1 QQLSDQQQTYRPOD-UHFFFAOYSA-N 0.000 description 2
- 239000011737 fluorine Substances 0.000 description 2
- CHPZKNULDCNCBW-UHFFFAOYSA-N gallium nitrate Chemical compound [Ga+3].[O-][N+]([O-])=O.[O-][N+]([O-])=O.[O-][N+]([O-])=O CHPZKNULDCNCBW-UHFFFAOYSA-N 0.000 description 2
- 229950001987 garnocestim Drugs 0.000 description 2
- 238000001415 gene therapy Methods 0.000 description 2
- 239000008103 glucose Substances 0.000 description 2
- 230000012010 growth Effects 0.000 description 2
- 201000009277 hairy cell leukemia Diseases 0.000 description 2
- 230000009033 hematopoietic malignancy Effects 0.000 description 2
- 239000012676 herbal extract Substances 0.000 description 2
- 230000002631 hypothermal effect Effects 0.000 description 2
- KTUFNOKKBVMGRW-UHFFFAOYSA-N imatinib Chemical compound C1CN(C)CCN1CC1=CC=C(C(=O)NC=2C=C(NC=3N=C(C=CN=3)C=3C=NC=CC=3)C(C)=CC=2)C=C1 KTUFNOKKBVMGRW-UHFFFAOYSA-N 0.000 description 2
- 150000002460 imidazoles Chemical class 0.000 description 2
- 210000002865 immune cell Anatomy 0.000 description 2
- 230000001976 improved effect Effects 0.000 description 2
- 230000003993 interaction Effects 0.000 description 2
- 238000010253 intravenous injection Methods 0.000 description 2
- 230000007774 longterm Effects 0.000 description 2
- 230000036210 malignancy Effects 0.000 description 2
- 239000003550 marker Substances 0.000 description 2
- YORNHNMWEWVKTM-UHFFFAOYSA-N n'-(1-methyl-3,4-dihydro-2h-quinolin-8-yl)-n-(pyridin-2-ylmethyl)-n'-[[4-[(pyridin-2-ylmethylamino)methyl]phenyl]methyl]ethane-1,2-diamine Chemical compound C=12N(C)CCCC2=CC=CC=1N(CC=1C=CC(CNCC=2N=CC=CC=2)=CC=1)CCNCC1=CC=CC=N1 YORNHNMWEWVKTM-UHFFFAOYSA-N 0.000 description 2
- OBCGVCHGTISUSB-UHFFFAOYSA-N n'-[[4-[(pyridin-2-ylmethylamino)methyl]phenyl]methyl]-n'-(5,6,7,8-tetrahydroquinolin-8-yl)ethane-1,2-diamine Chemical compound C1CCC2=CC=CN=C2C1N(CCN)CC(C=C1)=CC=C1CNCC1=CC=CC=N1 OBCGVCHGTISUSB-UHFFFAOYSA-N 0.000 description 2
- TWAJZSBBOJFYRN-UHFFFAOYSA-N n,n-bis[(2-methoxyphenyl)methyl]-n'-[[4-[(pyridin-2-ylmethylamino)methyl]phenyl]methyl]-n'-(5,6,7,8-tetrahydroquinolin-8-yl)ethane-1,2-diamine Chemical compound COC1=CC=CC=C1CN(CC=1C(=CC=CC=1)OC)CCN(C1C2=NC=CC=C2CCC1)CC(C=C1)=CC=C1CNCC1=CC=CC=N1 TWAJZSBBOJFYRN-UHFFFAOYSA-N 0.000 description 2
- ODIMBPKBZOUTLX-UHFFFAOYSA-N n-(1,3-benzodioxol-5-ylmethyl)-n-[[4-[(pyridin-2-ylmethylamino)methyl]phenyl]methyl]-6,7,8,9-tetrahydro-5h-cyclohepta[b]pyridin-9-amine Chemical compound C=1C=C(CN(CC=2C=C3OCOC3=CC=2)C2C3=NC=CC=C3CCCC2)C=CC=1CNCC1=CC=CC=N1 ODIMBPKBZOUTLX-UHFFFAOYSA-N 0.000 description 2
- YPTODVXKEJXEET-UHFFFAOYSA-N n-(1h-benzimidazol-2-ylmethyl)-n-[[4-[(pyridin-2-ylmethylamino)methyl]phenyl]methyl]-5,6,7,8-tetrahydroquinolin-8-amine Chemical compound C=1C=C(CN(CC=2NC3=CC=CC=C3N=2)C2C3=NC=CC=C3CCC2)C=CC=1CNCC1=CC=CC=N1 YPTODVXKEJXEET-UHFFFAOYSA-N 0.000 description 2
- RDVFBUBHPDUNRW-UHFFFAOYSA-N n-(1h-imidazol-2-ylmethyl)-7-methoxy-n-[[4-[(pyridin-2-ylmethylamino)methyl]phenyl]methyl]-1,2,3,4-tetrahydronaphthalen-2-amine Chemical compound C1C2=CC(OC)=CC=C2CCC1N(CC=1C=CC(CNCC=2N=CC=CC=2)=CC=1)CC1=NC=CN1 RDVFBUBHPDUNRW-UHFFFAOYSA-N 0.000 description 2
- CVCOZIAFFAJQFJ-UHFFFAOYSA-N n-(1h-imidazol-2-ylmethyl)-n'-(1-methyl-3,4-dihydro-2h-quinolin-8-yl)-n'-[[4-[(pyridin-2-ylmethylamino)methyl]phenyl]methyl]ethane-1,2-diamine Chemical compound C=12N(C)CCCC2=CC=CC=1N(CC=1C=CC(CNCC=2N=CC=CC=2)=CC=1)CCNCC1=NC=CN1 CVCOZIAFFAJQFJ-UHFFFAOYSA-N 0.000 description 2
- JNSXPMQONUZISJ-UHFFFAOYSA-N n-(1h-imidazol-2-ylmethyl)-n'-[[4-[(pyridin-2-ylmethylamino)methyl]phenyl]methyl]-n'-(1,2,3,4-tetrahydronaphthalen-1-yl)ethane-1,2-diamine Chemical compound N=1C=CNC=1CNCCN(C1C2=CC=CC=C2CCC1)CC(C=C1)=CC=C1CNCC1=CC=CC=N1 JNSXPMQONUZISJ-UHFFFAOYSA-N 0.000 description 2
- AAEQSVMSSUKQLP-UHFFFAOYSA-N n-(1h-imidazol-2-ylmethyl)-n-[[4-[(pyridin-2-ylmethylamino)methyl]phenyl]methyl]-5,6,7,8-tetrahydroquinolin-5-amine Chemical compound C=1C=C(CN(CC=2NC=CN=2)C2C3=CC=CN=C3CCC2)C=CC=1CNCC1=CC=CC=N1 AAEQSVMSSUKQLP-UHFFFAOYSA-N 0.000 description 2
- CFZVQPIGMZCPFB-UHFFFAOYSA-N n-(1h-imidazol-2-ylmethyl)-n-[[4-[(pyridin-2-ylmethylamino)methyl]phenyl]methyl]-5,6,7,8-tetrahydroquinolin-7-amine Chemical compound C=1C=C(CN(CC=2NC=CN=2)C2CC3=NC=CC=C3CC2)C=CC=1CNCC1=CC=CC=N1 CFZVQPIGMZCPFB-UHFFFAOYSA-N 0.000 description 2
- UWDNZPLJAOUFIF-UHFFFAOYSA-N n-(1h-imidazol-2-ylmethyl)-n-[[4-[(pyridin-2-ylmethylamino)methyl]phenyl]methyl]-5,6,7,8-tetrahydroquinolin-8-amine Chemical compound C=1C=C(CN(CC=2NC=CN=2)C2C3=NC=CC=C3CCC2)C=CC=1CNCC1=CC=CC=N1 UWDNZPLJAOUFIF-UHFFFAOYSA-N 0.000 description 2
- WOCZPNMRMRTPNS-UHFFFAOYSA-N n-(1h-imidazol-5-ylmethyl)-2-pyridin-2-yl-n-[[3-[(pyridin-2-ylmethylamino)methyl]phenyl]methyl]ethanamine Chemical compound C=1NC=NC=1CN(CC=1C=C(CNCC=2N=CC=CC=2)C=CC=1)CCC1=CC=CC=N1 WOCZPNMRMRTPNS-UHFFFAOYSA-N 0.000 description 2
- HUQUYFJWQMETSC-UHFFFAOYSA-N n-(1h-imidazol-5-ylmethyl)-n'-[[4-[(pyridin-2-ylmethylamino)methyl]phenyl]methyl]-n'-(5,6,7,8-tetrahydroquinolin-8-yl)ethane-1,2-diamine Chemical compound C=1NC=NC=1CNCCN(C1C2=NC=CC=C2CCC1)CC(C=C1)=CC=C1CNCC1=CC=CC=N1 HUQUYFJWQMETSC-UHFFFAOYSA-N 0.000 description 2
- IKTGDJUQIPTXPP-UHFFFAOYSA-N n-(1h-pyrazol-5-ylmethyl)-n-[[4-[(pyridin-2-ylmethylamino)methyl]phenyl]methyl]-5,6,7,8-tetrahydroquinolin-8-amine Chemical compound C=1C=C(CN(CC2=NNC=C2)C2C3=NC=CC=C3CCC2)C=CC=1CNCC1=CC=CC=N1 IKTGDJUQIPTXPP-UHFFFAOYSA-N 0.000 description 2
- GVCLHOJGDIBACL-UHFFFAOYSA-N n-(2-methylpropyl)-n'-[[4-[(pyridin-2-ylmethylamino)methyl]phenyl]methyl]-n'-(5,6,7,8-tetrahydroquinolin-8-yl)ethane-1,2-diamine Chemical compound C1CCC2=CC=CN=C2C1N(CCNCC(C)C)CC(C=C1)=CC=C1CNCC1=CC=CC=N1 GVCLHOJGDIBACL-UHFFFAOYSA-N 0.000 description 2
- PMNHJMNUXJHRCG-UHFFFAOYSA-N n-(2-phenylethyl)-n-[[4-[(pyridin-2-ylmethylamino)methyl]phenyl]methyl]-5,6,7,8-tetrahydroquinolin-8-amine Chemical compound C=1C=C(CNCC=2N=CC=CC=2)C=CC=1CN(C1C2=NC=CC=C2CCC1)CCC1=CC=CC=C1 PMNHJMNUXJHRCG-UHFFFAOYSA-N 0.000 description 2
- QYISGBVHZGPVRO-UHFFFAOYSA-N n-(2-phenylmethoxyethyl)-n-[[3-[(pyridin-2-ylmethylamino)methyl]phenyl]methyl]-5,6,7,8-tetrahydroquinolin-8-amine Chemical compound C=1C=CC=CC=1COCCN(C1C2=NC=CC=C2CCC1)CC(C=1)=CC=CC=1CNCC1=CC=CC=N1 QYISGBVHZGPVRO-UHFFFAOYSA-N 0.000 description 2
- MXYQOQASCBNUDZ-UHFFFAOYSA-N n-(2-pyridin-2-ylethyl)-n-[[4-[(pyridin-2-ylmethylamino)methyl]phenyl]methyl]-5,6,7,8-tetrahydroquinolin-8-amine Chemical compound C=1C=C(CNCC=2N=CC=CC=2)C=CC=1CN(C1C2=NC=CC=C2CCC1)CCC1=CC=CC=N1 MXYQOQASCBNUDZ-UHFFFAOYSA-N 0.000 description 2
- VFVPTCKHUQJLLP-UHFFFAOYSA-N n-(3-phenylpropyl)-n-[[4-[(pyridin-2-ylmethylamino)methyl]phenyl]methyl]-5,6,7,8-tetrahydroquinolin-8-amine Chemical compound C=1C=CC=CC=1CCCN(C1C2=NC=CC=C2CCC1)CC(C=C1)=CC=C1CNCC1=CC=CC=N1 VFVPTCKHUQJLLP-UHFFFAOYSA-N 0.000 description 2
- JDLVDJOZOJUSKB-UHFFFAOYSA-N n-(furan-2-ylmethyl)-n'-[[4-[(pyridin-2-ylmethylamino)methyl]phenyl]methyl]-n'-(5,6,7,8-tetrahydroquinolin-8-yl)ethane-1,2-diamine Chemical compound C=1C=COC=1CNCCN(C1C2=NC=CC=C2CCC1)CC(C=C1)=CC=C1CNCC1=CC=CC=N1 JDLVDJOZOJUSKB-UHFFFAOYSA-N 0.000 description 2
- IIBURQNHZQCMKA-UHFFFAOYSA-N n-(furan-2-ylmethyl)-n-[[4-[(pyridin-2-ylmethylamino)methyl]phenyl]methyl]-5,6,7,8-tetrahydroquinolin-8-amine Chemical compound C=1C=C(CN(CC=2OC=CC=2)C2C3=NC=CC=C3CCC2)C=CC=1CNCC1=CC=CC=N1 IIBURQNHZQCMKA-UHFFFAOYSA-N 0.000 description 2
- DTLFISKHFHZEGV-UHFFFAOYSA-N n-(pyridin-2-ylmethyl)-n'-[[4-[(pyridin-2-ylmethylamino)methyl]phenyl]methyl]-n'-(5,6,7,8-tetrahydroquinolin-8-yl)ethane-1,2-diamine Chemical compound C=1C=CC=NC=1CNCCN(C1C2=NC=CC=C2CCC1)CC(C=C1)=CC=C1CNCC1=CC=CC=N1 DTLFISKHFHZEGV-UHFFFAOYSA-N 0.000 description 2
- UUAATDVFOQOPPY-UHFFFAOYSA-N n-(pyridin-2-ylmethyl)-n-[[4-[(pyridin-2-ylmethylamino)methyl]phenyl]methyl]-1,2,3,4-tetrahydronaphthalen-1-amine Chemical compound C=1C=C(CN(CC=2N=CC=CC=2)C2C3=CC=CC=C3CCC2)C=CC=1CNCC1=CC=CC=N1 UUAATDVFOQOPPY-UHFFFAOYSA-N 0.000 description 2
- ZOEJTQLRFVTEMH-UHFFFAOYSA-N n-(pyridin-2-ylmethyl)-n-[[4-[(pyridin-2-ylmethylamino)methyl]phenyl]methyl]-1-(5,6,7,8-tetrahydroquinolin-8-yl)methanamine Chemical compound C=1C=C(CN(CC2C3=NC=CC=C3CCC2)CC=2N=CC=CC=2)C=CC=1CNCC1=CC=CC=N1 ZOEJTQLRFVTEMH-UHFFFAOYSA-N 0.000 description 2
- FFNBWWNCOBAIHU-UHFFFAOYSA-N n-(pyridin-3-ylmethyl)-n-[[4-[(pyridin-2-ylmethylamino)methyl]phenyl]methyl]-5,6,7,8-tetrahydroquinolin-8-amine Chemical compound C=1C=C(CN(CC=2C=NC=CC=2)C2C3=NC=CC=C3CCC2)C=CC=1CNCC1=CC=CC=N1 FFNBWWNCOBAIHU-UHFFFAOYSA-N 0.000 description 2
- RTHCDPLDSUOFCC-UHFFFAOYSA-N n-(pyridin-4-ylmethyl)-1-[4-(1,4,8,11-tetrazacyclotetradec-1-ylmethyl)phenyl]methanamine Chemical compound C=1C=NC=CC=1CNCC(C=C1)=CC=C1CN1CCCNCCNCCCNCC1 RTHCDPLDSUOFCC-UHFFFAOYSA-N 0.000 description 2
- IMOJNKRLXGTIIV-UHFFFAOYSA-N n-(pyridin-4-ylmethyl)-n-[[4-[(pyridin-2-ylmethylamino)methyl]phenyl]methyl]-5,6,7,8-tetrahydroquinolin-8-amine Chemical compound C=1C=C(CN(CC=2C=CN=CC=2)C2C3=NC=CC=C3CCC2)C=CC=1CNCC1=CC=CC=N1 IMOJNKRLXGTIIV-UHFFFAOYSA-N 0.000 description 2
- MAFZBZUSYWGNLM-UHFFFAOYSA-N n-[(1-methylbenzimidazol-2-yl)methyl]-2-pyridin-2-yl-n-[[4-[(pyridin-2-ylmethylamino)methyl]phenyl]methyl]ethanamine Chemical compound N=1C2=CC=CC=C2N(C)C=1CN(CC=1C=CC(CNCC=2N=CC=CC=2)=CC=1)CCC1=CC=CC=N1 MAFZBZUSYWGNLM-UHFFFAOYSA-N 0.000 description 2
- WWCSYVUBGHAPBM-UHFFFAOYSA-N n-[(1-methylbenzimidazol-2-yl)methyl]-n-[[4-[(pyridin-2-ylmethylamino)methyl]phenyl]methyl]-5,6,7,8-tetrahydroquinolin-8-amine Chemical compound N=1C2=CC=CC=C2N(C)C=1CN(C1C2=NC=CC=C2CCC1)CC(C=C1)=CC=C1CNCC1=CC=CC=N1 WWCSYVUBGHAPBM-UHFFFAOYSA-N 0.000 description 2
- PGPVOBTXVGCPBN-UHFFFAOYSA-N n-[(1-methylbenzimidazol-2-yl)methyl]-n-[[4-[(pyridin-2-ylmethylamino)methyl]phenyl]methyl]-6,7,8,9-tetrahydro-5h-cyclohepta[b]pyridin-9-amine Chemical compound N=1C2=CC=CC=C2N(C)C=1CN(C1C2=NC=CC=C2CCCC1)CC(C=C1)=CC=C1CNCC1=CC=CC=N1 PGPVOBTXVGCPBN-UHFFFAOYSA-N 0.000 description 2
- FGQINHRQJRJTAG-UHFFFAOYSA-N n-[(1-methylindol-3-yl)methyl]-2-pyridin-2-yl-n-[[3-[(pyridin-2-ylmethylamino)methyl]phenyl]methyl]ethanamine Chemical compound C12=CC=CC=C2N(C)C=C1CN(CC=1C=C(CNCC=2N=CC=CC=2)C=CC=1)CCC1=CC=CC=N1 FGQINHRQJRJTAG-UHFFFAOYSA-N 0.000 description 2
- NZQJPPFVFICWOR-UHFFFAOYSA-N n-[(1-methylpyrrol-2-yl)methyl]-n-[[4-[(pyridin-2-ylmethylamino)methyl]phenyl]methyl]-5,6,7,8-tetrahydroquinolin-8-amine Chemical compound CN1C=CC=C1CN(C1C2=NC=CC=C2CCC1)CC(C=C1)=CC=C1CNCC1=CC=CC=N1 NZQJPPFVFICWOR-UHFFFAOYSA-N 0.000 description 2
- GQCANGSJLVHDAO-UHFFFAOYSA-N n-[(2-ethoxynaphthalen-1-yl)methyl]-n-[[3-[(pyridin-2-ylmethylamino)methyl]phenyl]methyl]-5,6,7,8-tetrahydroquinolin-8-amine Chemical compound CCOC1=CC=C2C=CC=CC2=C1CN(C1C2=NC=CC=C2CCC1)CC(C=1)=CC=CC=1CNCC1=CC=CC=N1 GQCANGSJLVHDAO-UHFFFAOYSA-N 0.000 description 2
- BMMFYDSMCVZFMW-UHFFFAOYSA-N n-[(2-ethoxyphenyl)methyl]-n-[[3-[(pyridin-2-ylmethylamino)methyl]phenyl]methyl]-6,7,8,9-tetrahydro-5h-cyclohepta[b]pyridin-9-amine Chemical compound CCOC1=CC=CC=C1CN(C1C2=NC=CC=C2CCCC1)CC1=CC=CC(CNCC=2N=CC=CC=2)=C1 BMMFYDSMCVZFMW-UHFFFAOYSA-N 0.000 description 2
- JSQYNPNXPHQYDW-UHFFFAOYSA-N n-[(2-methoxyphenyl)methyl]-n-[[3-[(pyridin-2-ylmethylamino)methyl]phenyl]methyl]-5,6,7,8-tetrahydroquinolin-8-amine Chemical compound COC1=CC=CC=C1CN(C1C2=NC=CC=C2CCC1)CC1=CC=CC(CNCC=2N=CC=CC=2)=C1 JSQYNPNXPHQYDW-UHFFFAOYSA-N 0.000 description 2
- SNAPQAHESGUMBX-UHFFFAOYSA-N n-[(2-phenyl-1h-indol-3-yl)methyl]-2-pyridin-2-yl-n-[[4-[(pyridin-2-ylmethylamino)methyl]phenyl]methyl]ethanamine Chemical compound C=1C=CC=CC=1C=1NC2=CC=CC=C2C=1CN(CC=1C=CC(CNCC=2N=CC=CC=2)=CC=1)CCC1=CC=CC=N1 SNAPQAHESGUMBX-UHFFFAOYSA-N 0.000 description 2
- PUPNXLZCDGNKTF-UHFFFAOYSA-N n-[(4-methoxy-3-phenylmethoxyphenyl)methyl]-n-[[4-[(pyridin-2-ylmethylamino)methyl]phenyl]methyl]-6,7,8,9-tetrahydro-5h-cyclohepta[b]pyridin-9-amine Chemical compound C1=C(OCC=2C=CC=CC=2)C(OC)=CC=C1CN(C1C2=NC=CC=C2CCCC1)CC(C=C1)=CC=C1CNCC1=CC=CC=N1 PUPNXLZCDGNKTF-UHFFFAOYSA-N 0.000 description 2
- CKLHJTZOTREWRN-UHFFFAOYSA-N n-[(5,6-dimethyl-1h-benzimidazol-2-yl)methyl]-n-[[4-[(pyridin-2-ylmethylamino)methyl]phenyl]methyl]-5,6,7,8-tetrahydroquinolin-8-amine Chemical compound N1C=2C=C(C)C(C)=CC=2N=C1CN(C1C2=NC=CC=C2CCC1)CC(C=C1)=CC=C1CNCC1=CC=CC=N1 CKLHJTZOTREWRN-UHFFFAOYSA-N 0.000 description 2
- YFYZCQQXITUSEF-UHFFFAOYSA-N n-[(6-chloro-1,3-benzodioxol-5-yl)methyl]-n-[[4-[(pyridin-2-ylmethylamino)methyl]phenyl]methyl]-5,6,7,8-tetrahydroquinolin-8-amine Chemical compound ClC1=CC=2OCOC=2C=C1CN(C1C2=NC=CC=C2CCC1)CC(C=C1)=CC=C1CNCC1=CC=CC=N1 YFYZCQQXITUSEF-UHFFFAOYSA-N 0.000 description 2
- QSQHWRVQHDVQKG-UHFFFAOYSA-N n-[(7-methoxy-1,3-benzodioxol-5-yl)methyl]-n-[[4-[(pyridin-2-ylmethylamino)methyl]phenyl]methyl]-5,6,7,8-tetrahydroquinolin-8-amine Chemical compound C=1C=2OCOC=2C(OC)=CC=1CN(C1C2=NC=CC=C2CCC1)CC(C=C1)=CC=C1CNCC1=CC=CC=N1 QSQHWRVQHDVQKG-UHFFFAOYSA-N 0.000 description 2
- JXPSYJDUAHOGQX-UHFFFAOYSA-N n-[2-[[4-[(pyridin-2-ylmethylamino)methyl]phenyl]methyl-(5,6,7,8-tetrahydroquinolin-8-yl)amino]ethyl]naphthalene-2-carboxamide Chemical compound C=1C=C2C=CC=CC2=CC=1C(=O)NCCN(C1C2=NC=CC=C2CCC1)CC(C=C1)=CC=C1CNCC1=CC=CC=N1 JXPSYJDUAHOGQX-UHFFFAOYSA-N 0.000 description 2
- SKZLIWLJXMQJGM-UHFFFAOYSA-N n-[3-(1-methylpyrazol-3-yl)propyl]-n-[[4-[(pyridin-2-ylmethylamino)methyl]phenyl]methyl]-5,6,7,8-tetrahydroquinolin-8-amine Chemical compound CN1C=CC(CCCN(CC=2C=CC(CNCC=3N=CC=CC=3)=CC=2)C2C3=NC=CC=C3CCC2)=N1 SKZLIWLJXMQJGM-UHFFFAOYSA-N 0.000 description 2
- XPMDBFDZSFFEKB-UHFFFAOYSA-N n-[4-[[[4-[(pyridin-2-ylmethylamino)methyl]phenyl]methyl-(5,6,7,8-tetrahydroquinolin-8-yl)amino]methyl]phenyl]acetamide Chemical compound C1=CC(NC(=O)C)=CC=C1CN(C1C2=NC=CC=C2CCC1)CC(C=C1)=CC=C1CNCC1=CC=CC=N1 XPMDBFDZSFFEKB-UHFFFAOYSA-N 0.000 description 2
- SQUVPSMZPTVSQB-UHFFFAOYSA-N n-[4-[[[4-[(pyridin-2-ylmethylamino)methyl]phenyl]methyl-(6,7,8,9-tetrahydro-5h-cyclohepta[b]pyridin-9-yl)amino]methyl]phenyl]acetamide Chemical compound C1=CC(NC(=O)C)=CC=C1CN(C1C2=NC=CC=C2CCCC1)CC(C=C1)=CC=C1CNCC1=CC=CC=N1 SQUVPSMZPTVSQB-UHFFFAOYSA-N 0.000 description 2
- LEAHSUUCRLJLTN-UHFFFAOYSA-N n-[[4-(dimethylamino)phenyl]methyl]-n-[[4-[(pyridin-2-ylmethylamino)methyl]phenyl]methyl]-6,7,8,9-tetrahydro-5h-cyclohepta[b]pyridin-9-amine Chemical compound C1=CC(N(C)C)=CC=C1CN(C1C2=NC=CC=C2CCCC1)CC(C=C1)=CC=C1CNCC1=CC=CC=N1 LEAHSUUCRLJLTN-UHFFFAOYSA-N 0.000 description 2
- UMQKDDXFDPRWKQ-UHFFFAOYSA-N n-[[4-[(pyridin-2-ylmethylamino)methyl]phenyl]methyl]-1,2,3,4-tetrahydroquinolin-8-amine Chemical compound C=1C=C(CNC=2C=3NCCCC=3C=CC=2)C=CC=1CNCC1=CC=CC=N1 UMQKDDXFDPRWKQ-UHFFFAOYSA-N 0.000 description 2
- OWQFWPLLANSQQV-UHFFFAOYSA-N n-[[4-[(pyridin-2-ylmethylamino)methyl]phenyl]methyl]-5,6,7,8-tetrahydroquinolin-7-amine Chemical compound C=1C=C(CNC2CC3=NC=CC=C3CC2)C=CC=1CNCC1=CC=CC=N1 OWQFWPLLANSQQV-UHFFFAOYSA-N 0.000 description 2
- MQVBXWKLLOZAJE-UHFFFAOYSA-N n-[[4-[(pyridin-2-ylmethylamino)methyl]phenyl]methyl]-n-(1,3-thiazol-2-ylmethyl)-5,6,7,8-tetrahydroquinolin-8-amine Chemical compound C=1C=C(CN(CC=2SC=CN=2)C2C3=NC=CC=C3CCC2)C=CC=1CNCC1=CC=CC=N1 MQVBXWKLLOZAJE-UHFFFAOYSA-N 0.000 description 2
- PNDMWKHXWDAICF-UHFFFAOYSA-N n-[[4-[(pyridin-2-ylmethylamino)methyl]phenyl]methyl]-n-(1h-pyrrol-2-ylmethyl)-5,6,7,8-tetrahydroquinolin-8-amine Chemical compound C=1C=C(CN(CC=2NC=CC=2)C2C3=NC=CC=C3CCC2)C=CC=1CNCC1=CC=CC=N1 PNDMWKHXWDAICF-UHFFFAOYSA-N 0.000 description 2
- RKEIPHNVBYPWQO-UHFFFAOYSA-N n-[[4-[(pyridin-2-ylmethylamino)methyl]phenyl]methyl]-n-(5,6,7,8-tetrahydroquinolin-8-yl)-1,3-benzoxazol-2-amine Chemical compound C=1C=C(CN(C2C3=NC=CC=C3CCC2)C=2OC3=CC=CC=C3N=2)C=CC=1CNCC1=CC=CC=N1 RKEIPHNVBYPWQO-UHFFFAOYSA-N 0.000 description 2
- QAGAPIORZOUMSX-UHFFFAOYSA-N n-[[4-[(pyridin-2-ylmethylamino)methyl]phenyl]methyl]-n-(5,6,7,8-tetrahydroquinolin-8-yl)benzamide Chemical compound C=1C=CC=CC=1C(=O)N(C1C2=NC=CC=C2CCC1)CC(C=C1)=CC=C1CNCC1=CC=CC=N1 QAGAPIORZOUMSX-UHFFFAOYSA-N 0.000 description 2
- UWAKJWARIZWAPY-UHFFFAOYSA-N n-[[4-[(pyridin-2-ylmethylamino)methyl]phenyl]methyl]-n-(5,6,7,8-tetrahydroquinolin-8-yl)pyrazine-2-carboxamide Chemical compound C=1N=CC=NC=1C(=O)N(C1C2=NC=CC=C2CCC1)CC(C=C1)=CC=C1CNCC1=CC=CC=N1 UWAKJWARIZWAPY-UHFFFAOYSA-N 0.000 description 2
- KNFODAPPVSMDKV-UHFFFAOYSA-N n-[[4-[(pyridin-2-ylmethylamino)methyl]phenyl]methyl]-n-(5,6,7,8-tetrahydroquinolin-8-yl)pyridine-2-carboxamide Chemical compound C=1C=CC=NC=1C(=O)N(C1C2=NC=CC=C2CCC1)CC(C=C1)=CC=C1CNCC1=CC=CC=N1 KNFODAPPVSMDKV-UHFFFAOYSA-N 0.000 description 2
- JIDPWUUAOHRSGW-UHFFFAOYSA-N n-[[4-[(pyridin-2-ylmethylamino)methyl]phenyl]methyl]-n-(quinolin-2-ylmethyl)-5,6,7,8-tetrahydroquinolin-8-amine Chemical compound C=1C=C(CN(CC=2N=C3C=CC=CC3=CC=2)C2C3=NC=CC=C3CCC2)C=CC=1CNCC1=CC=CC=N1 JIDPWUUAOHRSGW-UHFFFAOYSA-N 0.000 description 2
- LHLSXJIWISDKGG-UHFFFAOYSA-N n-[[4-[(pyridin-2-ylmethylamino)methyl]phenyl]methyl]-n-(quinolin-3-ylmethyl)-5,6,7,8-tetrahydroquinolin-8-amine Chemical compound C=1C=C(CN(CC=2C=C3C=CC=CC3=NC=2)C2C3=NC=CC=C3CCC2)C=CC=1CNCC1=CC=CC=N1 LHLSXJIWISDKGG-UHFFFAOYSA-N 0.000 description 2
- SUXWTBAOYVYILW-UHFFFAOYSA-N n-[[4-[(pyridin-2-ylmethylamino)methyl]phenyl]methyl]-n-(thiophen-2-ylmethyl)-5,6,7,8-tetrahydroquinolin-8-amine Chemical compound C=1C=C(CN(CC=2SC=CC=2)C2C3=NC=CC=C3CCC2)C=CC=1CNCC1=CC=CC=N1 SUXWTBAOYVYILW-UHFFFAOYSA-N 0.000 description 2
- YYXOXWVEQUZBAX-UHFFFAOYSA-N n-[[4-[(pyridin-2-ylmethylamino)methyl]phenyl]methyl]-n-pyrrolidin-3-yl-5,6,7,8-tetrahydroquinolin-8-amine Chemical compound C=1C=C(CN(C2CNCC2)C2C3=NC=CC=C3CCC2)C=CC=1CNCC1=CC=CC=N1 YYXOXWVEQUZBAX-UHFFFAOYSA-N 0.000 description 2
- DIRVCOZGHSWRJP-UHFFFAOYSA-N n-[[4-[(pyridin-2-ylmethylamino)methyl]phenyl]methyl]quinolin-8-amine Chemical compound C=1C=C(CNC=2C3=NC=CC=C3C=CC=2)C=CC=1CNCC1=CC=CC=N1 DIRVCOZGHSWRJP-UHFFFAOYSA-N 0.000 description 2
- TUMGQCHXRWOHMH-UHFFFAOYSA-N n-phenyl-n'-[[4-[(pyridin-2-ylmethylamino)methyl]phenyl]methyl]-n'-(5,6,7,8-tetrahydroquinolin-8-yl)ethane-1,2-diamine Chemical compound C=1C=CC=CC=1NCCN(C1C2=NC=CC=C2CCC1)CC(C=C1)=CC=C1CNCC1=CC=CC=N1 TUMGQCHXRWOHMH-UHFFFAOYSA-N 0.000 description 2
- JDUKCSJDLQKSCH-UHFFFAOYSA-N n-piperidin-4-yl-n-[[4-[(pyridin-2-ylmethylamino)methyl]phenyl]methyl]-5,6,7,8-tetrahydroquinolin-8-amine Chemical compound C=1C=C(CN(C2CCNCC2)C2C3=NC=CC=C3CCC2)C=CC=1CNCC1=CC=CC=N1 JDUKCSJDLQKSCH-UHFFFAOYSA-N 0.000 description 2
- 125000001624 naphthyl group Chemical group 0.000 description 2
- 229940029345 neupogen Drugs 0.000 description 2
- 239000011570 nicotinamide Substances 0.000 description 2
- 229960003966 nicotinamide Drugs 0.000 description 2
- 235000005152 nicotinamide Nutrition 0.000 description 2
- 150000002829 nitrogen Chemical group 0.000 description 2
- 125000003261 o-tolyl group Chemical group [H]C1=C([H])C(*)=C(C([H])=C1[H])C([H])([H])[H] 0.000 description 2
- 150000007530 organic bases Chemical class 0.000 description 2
- 210000002997 osteoclast Anatomy 0.000 description 2
- 108010044644 pegfilgrastim Proteins 0.000 description 2
- UEMDJZHLMSDWCP-UHFFFAOYSA-N phenyl-[4-[2-pyridin-2-ylethyl-[[3-[(pyridin-2-ylmethylamino)methyl]phenyl]methyl]amino]piperidin-1-yl]methanone Chemical compound C=1C=CC=CC=1C(=O)N(CC1)CCC1N(CC=1C=C(CNCC=2N=CC=CC=2)C=CC=1)CCC1=CC=CC=N1 UEMDJZHLMSDWCP-UHFFFAOYSA-N 0.000 description 2
- 210000004180 plasmocyte Anatomy 0.000 description 2
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 125000004289 pyrazol-3-yl group Chemical group [H]N1N=C(*)C([H])=C1[H] 0.000 description 2
- 125000006513 pyridinyl methyl group Chemical group 0.000 description 2
- 239000012217 radiopharmaceutical Substances 0.000 description 2
- 239000000018 receptor agonist Substances 0.000 description 2
- 229940044601 receptor agonist Drugs 0.000 description 2
- 238000011084 recovery Methods 0.000 description 2
- 230000007017 scission Effects 0.000 description 2
- 238000010254 subcutaneous injection Methods 0.000 description 2
- 239000007929 subcutaneous injection Substances 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 229940124530 sulfonamide Drugs 0.000 description 2
- 150000003456 sulfonamides Chemical class 0.000 description 2
- XTQHKBHJIVJGKJ-UHFFFAOYSA-N sulfur monoxide Chemical class S=O XTQHKBHJIVJGKJ-UHFFFAOYSA-N 0.000 description 2
- 229910052815 sulfur oxide Inorganic materials 0.000 description 2
- 230000002195 synergetic effect Effects 0.000 description 2
- RAOIDOHSFRTOEL-UHFFFAOYSA-N tetrahydrothiophene Chemical compound C1CCSC1 RAOIDOHSFRTOEL-UHFFFAOYSA-N 0.000 description 2
- 229960003433 thalidomide Drugs 0.000 description 2
- 238000002560 therapeutic procedure Methods 0.000 description 2
- 125000001544 thienyl group Chemical group 0.000 description 2
- 239000011782 vitamin Substances 0.000 description 2
- 229940088594 vitamin Drugs 0.000 description 2
- 229930003231 vitamin Natural products 0.000 description 2
- 235000013343 vitamin Nutrition 0.000 description 2
- LGLVVVCSQBZONM-HCCLCSBVSA-N (2r)-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-acetamido-5-(diaminomethylideneamino)pentanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]-5-(diaminomethylideneamino)pentano Chemical compound NC(N)=NCCC[C@@H](NC(=O)C)C(=O)N[C@H](CCCN=C(N)N)C(=O)N[C@H](CCCN=C(N)N)C(=O)N[C@H](CCCN=C(N)N)C(=O)N[C@H](CCCN=C(N)N)C(=O)N[C@H](CCCN=C(N)N)C(=O)N[C@H](CCCN=C(N)N)C(=O)N[C@H](CCCN=C(N)N)C(=O)N[C@H](CCCN=C(N)N)C(N)=O LGLVVVCSQBZONM-HCCLCSBVSA-N 0.000 description 1
- DAXHOHUIVFZEPB-KIYNQFGBSA-N (2s)-1-(5,6,7,8-tetrahydroquinolin-8-yl)pyrrolidine-2-carboxamide Chemical compound NC(=O)[C@@H]1CCCN1C1C2=NC=CC=C2CCC1 DAXHOHUIVFZEPB-KIYNQFGBSA-N 0.000 description 1
- JMISKXGBLMKCBE-PMCHYTPCSA-N (2s)-n-[[4-[(pyridin-2-ylmethylamino)methyl]phenyl]methyl]-n-(5,6,7,8-tetrahydroquinolin-8-yl)pyrrolidine-2-carboxamide Chemical compound C=1C=C(CNCC=2N=CC=CC=2)C=CC=1CN(C1C2=NC=CC=C2CCC1)C(=O)[C@@H]1CCCN1 JMISKXGBLMKCBE-PMCHYTPCSA-N 0.000 description 1
- 125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 description 1
- 0 *C(CCCC1)C1NCc1ccccc1 Chemical compound *C(CCCC1)C1NCc1ccccc1 0.000 description 1
- QMDFHZOGAYONLN-UHFFFAOYSA-N 1,2,3,4-tetrahydropyridine-3-carboxylic acid Chemical compound OC(=O)C1CNC=CC1 QMDFHZOGAYONLN-UHFFFAOYSA-N 0.000 description 1
- OWQPOVKKUWUEKE-UHFFFAOYSA-N 1,2,3-benzotriazine Chemical compound N1=NN=CC2=CC=CC=C21 OWQPOVKKUWUEKE-UHFFFAOYSA-N 0.000 description 1
- UGUHFDPGDQDVGX-UHFFFAOYSA-N 1,2,3-thiadiazole Chemical compound C1=CSN=N1 UGUHFDPGDQDVGX-UHFFFAOYSA-N 0.000 description 1
- HTJMXYRLEDBSLT-UHFFFAOYSA-N 1,2,4,5-tetrazine Chemical compound C1=NN=CN=N1 HTJMXYRLEDBSLT-UHFFFAOYSA-N 0.000 description 1
- GDAXJBDYNVDMDF-UHFFFAOYSA-N 1,2,4-benzotriazine Chemical compound N1=NC=NC2=CC=CC=C21 GDAXJBDYNVDMDF-UHFFFAOYSA-N 0.000 description 1
- FYADHXFMURLYQI-UHFFFAOYSA-N 1,2,4-triazine Chemical compound C1=CN=NC=N1 FYADHXFMURLYQI-UHFFFAOYSA-N 0.000 description 1
- CSNIZNHTOVFARY-UHFFFAOYSA-N 1,2-benzothiazole Chemical compound C1=CC=C2C=NSC2=C1 CSNIZNHTOVFARY-UHFFFAOYSA-N 0.000 description 1
- KTZQTRPPVKQPFO-UHFFFAOYSA-N 1,2-benzoxazole Chemical compound C1=CC=C2C=NOC2=C1 KTZQTRPPVKQPFO-UHFFFAOYSA-N 0.000 description 1
- IRFSXVIRXMYULF-UHFFFAOYSA-N 1,2-dihydroquinoline Chemical compound C1=CC=C2C=CCNC2=C1 IRFSXVIRXMYULF-UHFFFAOYSA-N 0.000 description 1
- FKASFBLJDCHBNZ-UHFFFAOYSA-N 1,3,4-oxadiazole Chemical compound C1=NN=CO1 FKASFBLJDCHBNZ-UHFFFAOYSA-N 0.000 description 1
- MBIZXFATKUQOOA-UHFFFAOYSA-N 1,3,4-thiadiazole Chemical compound C1=NN=CS1 MBIZXFATKUQOOA-UHFFFAOYSA-N 0.000 description 1
- JIHQDMXYYFUGFV-UHFFFAOYSA-N 1,3,5-triazine Chemical compound C1=NC=NC=N1 JIHQDMXYYFUGFV-UHFFFAOYSA-N 0.000 description 1
- 125000001989 1,3-phenylene group Chemical group [H]C1=C([H])C([*:1])=C([H])C([*:2])=C1[H] 0.000 description 1
- NAPSAMRUCLUKEP-UHFFFAOYSA-N 1,4,7,10,13-pentazacyclohexadecane Chemical compound C1CNCCNCCNCCNCCNC1 NAPSAMRUCLUKEP-UHFFFAOYSA-N 0.000 description 1
- QBPPRVHXOZRESW-UHFFFAOYSA-N 1,4,7,10-tetraazacyclododecane Chemical compound C1CNCCNCCNCCN1 QBPPRVHXOZRESW-UHFFFAOYSA-N 0.000 description 1
- HLRWRACNIJFYEO-UHFFFAOYSA-N 1,4,7,10-tetrazacyclotetradecane Chemical compound C1CCNCCNCCNCCNC1 HLRWRACNIJFYEO-UHFFFAOYSA-N 0.000 description 1
- NLOPAGUJRJHUDJ-UHFFFAOYSA-N 1,4,7-triazacyclotetradecan-2-one Chemical compound O=C1CNCCNCCCCCCCN1 NLOPAGUJRJHUDJ-UHFFFAOYSA-N 0.000 description 1
- HGEJJHMFSDZCRJ-UHFFFAOYSA-N 1,4,7-triazacyclotetradecan-3-one Chemical compound O=C1CNCCCCCCCNCCN1 HGEJJHMFSDZCRJ-UHFFFAOYSA-N 0.000 description 1
- YXPRJLINFVQPDT-UHFFFAOYSA-N 1,5,9,13-tetrazacyclohexadecane Chemical compound C1CNCCCNCCCNCCCNC1 YXPRJLINFVQPDT-UHFFFAOYSA-N 0.000 description 1
- VQFZKDXSJZVGDA-UHFFFAOYSA-N 1,5,9-triazacyclododecane Chemical compound C1CNCCCNCCCNC1 VQFZKDXSJZVGDA-UHFFFAOYSA-N 0.000 description 1
- QPFUQMRWZANCBG-UHFFFAOYSA-N 1-[1-(1,4,8,11-tetrazacyclotetradec-1-yl)hexan-2-yl]-1,4,8,11-tetrazacyclotetradecane Chemical compound C1CCNCCNCCCNCCN1C(CCCC)CN1CCCNCCNCCCNCC1 QPFUQMRWZANCBG-UHFFFAOYSA-N 0.000 description 1
- VEEDYUPGPMCQTN-UHFFFAOYSA-N 1-[1-(1,4,8,11-tetrazacyclotetradec-1-yl)pentan-2-yl]-1,4,8,11-tetrazacyclotetradecane Chemical compound C1CCNCCNCCCNCCN1C(CCC)CN1CCCNCCNCCCNCC1 VEEDYUPGPMCQTN-UHFFFAOYSA-N 0.000 description 1
- YUEOTDBNBGFZSZ-UHFFFAOYSA-N 1-[1-(1,4,8,11-tetrazacyclotetradec-1-yl)propan-2-yl]-1,4,8,11-tetrazacyclotetradecane Chemical compound C1CCNCCNCCCNCCN1C(C)CN1CCCNCCNCCCNCC1 YUEOTDBNBGFZSZ-UHFFFAOYSA-N 0.000 description 1
- UEINORGHTABAFL-UHFFFAOYSA-N 1-[3-[[1h-imidazol-5-ylmethyl(pyridin-2-ylmethyl)amino]methyl]phenyl]-n-(pyridin-2-ylmethyl)methanamine Chemical compound C=1C=CC(CN(CC=2N=CNC=2)CC=2N=CC=CC=2)=CC=1CNCC1=CC=CC=N1 UEINORGHTABAFL-UHFFFAOYSA-N 0.000 description 1
- HBJFVMZNYLAQNK-UHFFFAOYSA-N 1-[4-[[(5-methyl-1h-imidazol-4-yl)methyl-(pyridin-2-ylmethyl)amino]methyl]phenyl]-n-(pyridin-2-ylmethyl)methanamine Chemical compound N1=CNC(CN(CC=2C=CC(CNCC=3N=CC=CC=3)=CC=2)CC=2N=CC=CC=2)=C1C HBJFVMZNYLAQNK-UHFFFAOYSA-N 0.000 description 1
- SEFLKOOVNJZTFY-UHFFFAOYSA-N 1-[[2,3,5,6-tetrafluoro-4-(1,4,8,11-tetrazacyclotetradec-1-ylmethyl)phenyl]methyl]-1,4,8,11-tetrazacyclotetradecane Chemical compound FC=1C(F)=C(CN2CCNCCCNCCNCCC2)C(F)=C(F)C=1CN1CCCNCCNCCCNCC1 SEFLKOOVNJZTFY-UHFFFAOYSA-N 0.000 description 1
- PEVCHIZAJILPKB-UHFFFAOYSA-N 1-[[3-nitro-5-(1,4,8,11-tetrazacyclotetradec-1-ylmethyl)phenyl]methyl]-1,4,8,11-tetrazacyclotetradecane Chemical compound C=1C(CN2CCNCCCNCCNCCC2)=CC([N+](=O)[O-])=CC=1CN1CCCNCCNCCCNCC1 PEVCHIZAJILPKB-UHFFFAOYSA-N 0.000 description 1
- QNIZOKGSHPITQD-UHFFFAOYSA-N 1-[[4-(1,4,7,11-tetrazacyclotetradec-11-ylmethyl)phenyl]methyl]-1,4,8,11-tetrazacyclotetradecane Chemical compound C=1C=C(CN2CCNCCCNCCNCCC2)C=CC=1CN1CCCNCCNCCNCCC1 QNIZOKGSHPITQD-UHFFFAOYSA-N 0.000 description 1
- YOOLUGFXVSTJRL-UHFFFAOYSA-N 1-benzyl-n-(pyridin-2-ylmethyl)-n-[[4-[(pyridin-2-ylmethylamino)methyl]phenyl]methyl]pyrrolidin-3-amine Chemical compound C=1C=C(CN(CC=2N=CC=CC=2)C2CN(CC=3C=CC=CC=3)CC2)C=CC=1CNCC1=CC=CC=N1 YOOLUGFXVSTJRL-UHFFFAOYSA-N 0.000 description 1
- RTBFRGCFXZNCOE-UHFFFAOYSA-N 1-methylsulfonylpiperidin-4-one Chemical compound CS(=O)(=O)N1CCC(=O)CC1 RTBFRGCFXZNCOE-UHFFFAOYSA-N 0.000 description 1
- VSNHCAURESNICA-NJFSPNSNSA-N 1-oxidanylurea Chemical compound N[14C](=O)NO VSNHCAURESNICA-NJFSPNSNSA-N 0.000 description 1
- HOXGWRSXHJHFMF-UHFFFAOYSA-N 1-phenyl-n-(pyridin-2-ylmethyl)-n-[[3-[(pyridin-2-ylmethylamino)methyl]phenyl]methyl]ethanamine Chemical compound C=1C=CC=CC=1C(C)N(CC=1N=CC=CC=1)CC(C=1)=CC=CC=1CNCC1=CC=CC=N1 HOXGWRSXHJHFMF-UHFFFAOYSA-N 0.000 description 1
- QWENRTYMTSOGBR-UHFFFAOYSA-N 1H-1,2,3-Triazole Chemical compound C=1C=NNN=1 QWENRTYMTSOGBR-UHFFFAOYSA-N 0.000 description 1
- 125000003287 1H-imidazol-4-ylmethyl group Chemical group [H]N1C([H])=NC(C([H])([H])[*])=C1[H] 0.000 description 1
- KJUGUADJHNHALS-UHFFFAOYSA-N 1H-tetrazole Chemical group C=1N=NNN=1 KJUGUADJHNHALS-UHFFFAOYSA-N 0.000 description 1
- YHCUZRJTNSWYCY-UHFFFAOYSA-N 2,3,4,7-tetrahydro-1h-azepine Chemical compound C1CNCC=CC1 YHCUZRJTNSWYCY-UHFFFAOYSA-N 0.000 description 1
- SMOHMDMTVAYPAI-UHFFFAOYSA-N 2,3,6,7-tetrahydro-1h-azepine Chemical compound C1CC=CCCN1 SMOHMDMTVAYPAI-UHFFFAOYSA-N 0.000 description 1
- NHBKXEKEPDILRR-UHFFFAOYSA-N 2,3-bis(butanoylsulfanyl)propyl butanoate Chemical compound CCCC(=O)OCC(SC(=O)CCC)CSC(=O)CCC NHBKXEKEPDILRR-UHFFFAOYSA-N 0.000 description 1
- RTQWWZBSTRGEAV-PKHIMPSTSA-N 2-[[(2s)-2-[bis(carboxymethyl)amino]-3-[4-(methylcarbamoylamino)phenyl]propyl]-[2-[bis(carboxymethyl)amino]propyl]amino]acetic acid Chemical compound CNC(=O)NC1=CC=C(C[C@@H](CN(CC(C)N(CC(O)=O)CC(O)=O)CC(O)=O)N(CC(O)=O)CC(O)=O)C=C1 RTQWWZBSTRGEAV-PKHIMPSTSA-N 0.000 description 1
- FZZMTSNZRBFGGU-UHFFFAOYSA-N 2-chloro-7-fluoroquinazolin-4-amine Chemical compound FC1=CC=C2C(N)=NC(Cl)=NC2=C1 FZZMTSNZRBFGGU-UHFFFAOYSA-N 0.000 description 1
- CJQNJRRDTPULTL-UHFFFAOYSA-N 3-azabicyclo[3.2.1]octane Chemical compound C1C2CCC1CNC2 CJQNJRRDTPULTL-UHFFFAOYSA-N 0.000 description 1
- FTAHXMZRJCZXDL-UHFFFAOYSA-N 3-piperideine Chemical compound C1CC=CCN1 FTAHXMZRJCZXDL-UHFFFAOYSA-N 0.000 description 1
- JVQIKJMSUIMUDI-UHFFFAOYSA-N 3-pyrroline Chemical compound C1NCC=C1 JVQIKJMSUIMUDI-UHFFFAOYSA-N 0.000 description 1
- HRVGVJXJUIVOPJ-UHFFFAOYSA-N 4-oxopiperidine-3,5-dicarboxylic acid Chemical compound OC(=O)C1CNCC(C(O)=O)C1=O HRVGVJXJUIVOPJ-UHFFFAOYSA-N 0.000 description 1
- NSPMIYGKQJPBQR-UHFFFAOYSA-N 4H-1,2,4-triazole Chemical compound C=1N=CNN=1 NSPMIYGKQJPBQR-UHFFFAOYSA-N 0.000 description 1
- YQDGQEKUTLYWJU-UHFFFAOYSA-N 5,6,7,8-tetrahydroquinoline Chemical group C1=CC=C2CCCCC2=N1 YQDGQEKUTLYWJU-UHFFFAOYSA-N 0.000 description 1
- STQGQHZAVUOBTE-UHFFFAOYSA-N 7-Cyan-hept-2t-en-4,6-diinsaeure Natural products C1=2C(O)=C3C(=O)C=4C(OC)=CC=CC=4C(=O)C3=C(O)C=2CC(O)(C(C)=O)CC1OC1CC(N)C(O)C(C)O1 STQGQHZAVUOBTE-UHFFFAOYSA-N 0.000 description 1
- DGGKXQQCVPAUEA-UHFFFAOYSA-N 8-azabicyclo[3.2.1]octane Chemical compound C1CCC2CCC1N2 DGGKXQQCVPAUEA-UHFFFAOYSA-N 0.000 description 1
- 208000024893 Acute lymphoblastic leukemia Diseases 0.000 description 1
- 229920001817 Agar Polymers 0.000 description 1
- 206010003497 Asphyxia Diseases 0.000 description 1
- 241000271566 Aves Species 0.000 description 1
- 208000025324 B-cell acute lymphoblastic leukemia Diseases 0.000 description 1
- 208000032791 BCR-ABL1 positive chronic myelogenous leukemia Diseases 0.000 description 1
- 108010006654 Bleomycin Proteins 0.000 description 1
- 206010006002 Bone pain Diseases 0.000 description 1
- 108091003079 Bovine Serum Albumin Proteins 0.000 description 1
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 description 1
- COVZYZSDYWQREU-UHFFFAOYSA-N Busulfan Chemical compound CS(=O)(=O)OCCCCOS(C)(=O)=O COVZYZSDYWQREU-UHFFFAOYSA-N 0.000 description 1
- IYIUQXSYBROSSY-UHFFFAOYSA-N C(=O)(NN([N+](=O)[O-])O)O Chemical compound C(=O)(NN([N+](=O)[O-])O)O IYIUQXSYBROSSY-UHFFFAOYSA-N 0.000 description 1
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 description 1
- 241000282472 Canis lupus familiaris Species 0.000 description 1
- KXDHJXZQYSOELW-UHFFFAOYSA-M Carbamate Chemical compound NC([O-])=O KXDHJXZQYSOELW-UHFFFAOYSA-M 0.000 description 1
- KXDHJXZQYSOELW-UHFFFAOYSA-N Carbamic acid Chemical class NC(O)=O KXDHJXZQYSOELW-UHFFFAOYSA-N 0.000 description 1
- DLGOEMSEDOSKAD-UHFFFAOYSA-N Carmustine Chemical compound ClCCNC(=O)N(N=O)CCCl DLGOEMSEDOSKAD-UHFFFAOYSA-N 0.000 description 1
- 102000009410 Chemokine receptor Human genes 0.000 description 1
- 108050000299 Chemokine receptor Proteins 0.000 description 1
- 206010053138 Congenital aplastic anaemia Diseases 0.000 description 1
- 102000001189 Cyclic Peptides Human genes 0.000 description 1
- 108010069514 Cyclic Peptides Proteins 0.000 description 1
- PMPVIKIVABFJJI-UHFFFAOYSA-N Cyclobutane Chemical compound C1CCC1 PMPVIKIVABFJJI-UHFFFAOYSA-N 0.000 description 1
- XDTMQSROBMDMFD-UHFFFAOYSA-N Cyclohexane Chemical compound C1CCCCC1 XDTMQSROBMDMFD-UHFFFAOYSA-N 0.000 description 1
- PMATZTZNYRCHOR-CGLBZJNRSA-N Cyclosporin A Chemical compound CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 description 1
- 108010036949 Cyclosporine Proteins 0.000 description 1
- 206010011732 Cyst Diseases 0.000 description 1
- 102000004127 Cytokines Human genes 0.000 description 1
- 108090000695 Cytokines Proteins 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical compound C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 description 1
- 239000005977 Ethylene Substances 0.000 description 1
- 208000009386 Experimental Arthritis Diseases 0.000 description 1
- 201000004939 Fanconi anemia Diseases 0.000 description 1
- 208000002633 Febrile Neutropenia Diseases 0.000 description 1
- 241000282326 Felis catus Species 0.000 description 1
- 241000287828 Gallus gallus Species 0.000 description 1
- 239000012981 Hank's balanced salt solution Substances 0.000 description 1
- 101000746367 Homo sapiens Granulocyte colony-stimulating factor Proteins 0.000 description 1
- 101000617130 Homo sapiens Stromal cell-derived factor 1 Proteins 0.000 description 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- 108010008212 Integrin alpha4beta1 Proteins 0.000 description 1
- LPHGQDQBBGAPDZ-UHFFFAOYSA-N Isocaffeine Natural products CN1C(=O)N(C)C(=O)C2=C1N(C)C=N2 LPHGQDQBBGAPDZ-UHFFFAOYSA-N 0.000 description 1
- 208000028018 Lymphocytic leukaemia Diseases 0.000 description 1
- 241000699666 Mus <mouse, genus> Species 0.000 description 1
- 101100335081 Mus musculus Flt3 gene Proteins 0.000 description 1
- 101000746372 Mus musculus Granulocyte-macrophage colony-stimulating factor Proteins 0.000 description 1
- 108010056642 N-alpha-acetyl-nona-D-arginine amide acetate Proteins 0.000 description 1
- CHJJGSNFBQVOTG-UHFFFAOYSA-N N-methyl-guanidine Natural products CNC(N)=N CHJJGSNFBQVOTG-UHFFFAOYSA-N 0.000 description 1
- 206010067482 No adverse event Diseases 0.000 description 1
- 102000043276 Oncogene Human genes 0.000 description 1
- 208000003076 Osteolysis Diseases 0.000 description 1
- 229910019142 PO4 Inorganic materials 0.000 description 1
- 108010025037 T140 peptide Proteins 0.000 description 1
- YPWFISCTZQNZAU-UHFFFAOYSA-N Thiane Chemical compound C1CCSCC1 YPWFISCTZQNZAU-UHFFFAOYSA-N 0.000 description 1
- FOCVUCIESVLUNU-UHFFFAOYSA-N Thiotepa Chemical compound C1CN1P(N1CC1)(=S)N1CC1 FOCVUCIESVLUNU-UHFFFAOYSA-N 0.000 description 1
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 1
- 238000010817 Wright-Giemsa staining Methods 0.000 description 1
- FKCMADOPPWWGNZ-YUMQZZPRSA-N [(2r)-1-[(2s)-2-amino-3-methylbutanoyl]pyrrolidin-2-yl]boronic acid Chemical compound CC(C)[C@H](N)C(=O)N1CCC[C@H]1B(O)O FKCMADOPPWWGNZ-YUMQZZPRSA-N 0.000 description 1
- IBXPAFBDJCXCDW-MHFPCNPESA-A [Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].Cc1cn([C@H]2C[C@H](O)[C@@H](COP([S-])(=O)O[C@H]3C[C@@H](O[C@@H]3COP([O-])(=S)O[C@H]3C[C@@H](O[C@@H]3COP([O-])(=S)O[C@H]3C[C@@H](O[C@@H]3COP([O-])(=S)O[C@H]3C[C@@H](O[C@@H]3COP([O-])(=S)O[C@H]3C[C@@H](O[C@@H]3COP([O-])(=S)O[C@H]3C[C@@H](O[C@@H]3COP([O-])(=S)O[C@H]3C[C@@H](O[C@@H]3COP([O-])(=S)O[C@H]3C[C@@H](O[C@@H]3COP([O-])(=S)O[C@H]3C[C@@H](O[C@@H]3COP([O-])(=S)O[C@H]3C[C@@H](O[C@@H]3COP([O-])(=S)O[C@H]3C[C@@H](O[C@@H]3COP([O-])(=S)O[C@H]3C[C@@H](O[C@@H]3COP([O-])(=S)O[C@H]3C[C@@H](O[C@@H]3COP([O-])(=S)O[C@H]3C[C@@H](O[C@@H]3COP([O-])(=S)O[C@H]3C[C@@H](O[C@@H]3COP([O-])(=S)O[C@H]3C[C@@H](O[C@@H]3COP([O-])(=S)O[C@H]3C[C@@H](O[C@@H]3CO)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c3nc(N)[nH]c4=O)n3ccc(N)nc3=O)n3cnc4c3nc(N)[nH]c4=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3ccc(N)nc3=O)n3cnc4c3nc(N)[nH]c4=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O Chemical compound [Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].Cc1cn([C@H]2C[C@H](O)[C@@H](COP([S-])(=O)O[C@H]3C[C@@H](O[C@@H]3COP([O-])(=S)O[C@H]3C[C@@H](O[C@@H]3COP([O-])(=S)O[C@H]3C[C@@H](O[C@@H]3COP([O-])(=S)O[C@H]3C[C@@H](O[C@@H]3COP([O-])(=S)O[C@H]3C[C@@H](O[C@@H]3COP([O-])(=S)O[C@H]3C[C@@H](O[C@@H]3COP([O-])(=S)O[C@H]3C[C@@H](O[C@@H]3COP([O-])(=S)O[C@H]3C[C@@H](O[C@@H]3COP([O-])(=S)O[C@H]3C[C@@H](O[C@@H]3COP([O-])(=S)O[C@H]3C[C@@H](O[C@@H]3COP([O-])(=S)O[C@H]3C[C@@H](O[C@@H]3COP([O-])(=S)O[C@H]3C[C@@H](O[C@@H]3COP([O-])(=S)O[C@H]3C[C@@H](O[C@@H]3COP([O-])(=S)O[C@H]3C[C@@H](O[C@@H]3COP([O-])(=S)O[C@H]3C[C@@H](O[C@@H]3COP([O-])(=S)O[C@H]3C[C@@H](O[C@@H]3COP([O-])(=S)O[C@H]3C[C@@H](O[C@@H]3CO)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c3nc(N)[nH]c4=O)n3ccc(N)nc3=O)n3cnc4c3nc(N)[nH]c4=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3ccc(N)nc3=O)n3cnc4c3nc(N)[nH]c4=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O IBXPAFBDJCXCDW-MHFPCNPESA-A 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- 230000002378 acidificating effect Effects 0.000 description 1
- 150000007513 acids Chemical class 0.000 description 1
- 230000003213 activating effect Effects 0.000 description 1
- 239000001361 adipic acid Substances 0.000 description 1
- 235000011037 adipic acid Nutrition 0.000 description 1
- 239000008272 agar Substances 0.000 description 1
- 150000001298 alcohols Chemical class 0.000 description 1
- 125000005137 alkenylsulfonyl group Chemical group 0.000 description 1
- 125000003282 alkyl amino group Chemical group 0.000 description 1
- 125000005139 alkynylsulfonyl group Chemical group 0.000 description 1
- 238000011316 allogeneic transplantation Methods 0.000 description 1
- 229910000147 aluminium phosphate Inorganic materials 0.000 description 1
- 108700024685 ancestim Proteins 0.000 description 1
- JFCQEDHGNNZCLN-UHFFFAOYSA-N anhydrous glutaric acid Natural products OC(=O)CCCC(O)=O JFCQEDHGNNZCLN-UHFFFAOYSA-N 0.000 description 1
- 230000001028 anti-proliverative effect Effects 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- 125000003435 aroyl group Chemical group 0.000 description 1
- 125000005251 aryl acyl group Chemical group 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- QXNDZONIWRINJR-UHFFFAOYSA-N azocane Chemical compound C1CCCNCCC1 QXNDZONIWRINJR-UHFFFAOYSA-N 0.000 description 1
- 210000003719 b-lymphocyte Anatomy 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 150000001555 benzenes Chemical class 0.000 description 1
- 125000001164 benzothiazolyl group Chemical group S1C(=NC2=C1C=CC=C2)* 0.000 description 1
- 125000004541 benzoxazolyl group Chemical group O1C(=NC2=C1C=CC=C2)* 0.000 description 1
- 230000003115 biocidal effect Effects 0.000 description 1
- 229960001561 bleomycin Drugs 0.000 description 1
- OYVAGSVQBOHSSS-UAPAGMARSA-O bleomycin A2 Chemical compound N([C@H](C(=O)N[C@H](C)[C@@H](O)[C@H](C)C(=O)N[C@@H]([C@H](O)C)C(=O)NCCC=1SC=C(N=1)C=1SC=C(N=1)C(=O)NCCC[S+](C)C)[C@@H](O[C@H]1[C@H]([C@@H](O)[C@H](O)[C@H](CO)O1)O[C@@H]1[C@H]([C@@H](OC(N)=O)[C@H](O)[C@@H](CO)O1)O)C=1N=CNC=1)C(=O)C1=NC([C@H](CC(N)=O)NC[C@H](N)C(N)=O)=NC(N)=C1C OYVAGSVQBOHSSS-UAPAGMARSA-O 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 238000004820 blood count Methods 0.000 description 1
- 238000010241 blood sampling Methods 0.000 description 1
- 210000001124 body fluid Anatomy 0.000 description 1
- 239000010839 body fluid Substances 0.000 description 1
- 210000000988 bone and bone Anatomy 0.000 description 1
- GXJABQQUPOEUTA-RDJZCZTQSA-N bortezomib Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)B(O)O)NC(=O)C=1N=CC=NC=1)C1=CC=CC=C1 GXJABQQUPOEUTA-RDJZCZTQSA-N 0.000 description 1
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 description 1
- 229960002092 busulfan Drugs 0.000 description 1
- 210000004899 c-terminal region Anatomy 0.000 description 1
- 229960001948 caffeine Drugs 0.000 description 1
- VJEONQKOZGKCAK-UHFFFAOYSA-N caffeine Natural products CN1C(=O)N(C)C(=O)C2=C1C=CN2C VJEONQKOZGKCAK-UHFFFAOYSA-N 0.000 description 1
- 159000000007 calcium salts Chemical class 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 239000004202 carbamide Substances 0.000 description 1
- 125000003739 carbamimidoyl group Chemical group C(N)(=N)* 0.000 description 1
- OWIUPIRUAQMTTK-UHFFFAOYSA-N carbazic acid Chemical compound NNC(O)=O OWIUPIRUAQMTTK-UHFFFAOYSA-N 0.000 description 1
- 125000002837 carbocyclic group Chemical group 0.000 description 1
- KPUFNLPDWGSMGZ-UHFFFAOYSA-N carboxy(nitro)azanide Chemical group OC(=O)[N-][N+]([O-])=O KPUFNLPDWGSMGZ-UHFFFAOYSA-N 0.000 description 1
- 150000001732 carboxylic acid derivatives Chemical class 0.000 description 1
- 150000001735 carboxylic acids Chemical class 0.000 description 1
- 238000012754 cardiac puncture Methods 0.000 description 1
- 229960005243 carmustine Drugs 0.000 description 1
- 239000000969 carrier Substances 0.000 description 1
- 230000006041 cell recruitment Effects 0.000 description 1
- 230000035605 chemotaxis Effects 0.000 description 1
- 229940044683 chemotherapy drug Drugs 0.000 description 1
- 235000013330 chicken meat Nutrition 0.000 description 1
- 229960001265 ciclosporin Drugs 0.000 description 1
- WCZVZNOTHYJIEI-UHFFFAOYSA-N cinnoline Chemical compound N1=NC=CC2=CC=CC=C21 WCZVZNOTHYJIEI-UHFFFAOYSA-N 0.000 description 1
- DQLATGHUWYMOKM-UHFFFAOYSA-L cisplatin Chemical compound N[Pt](N)(Cl)Cl DQLATGHUWYMOKM-UHFFFAOYSA-L 0.000 description 1
- 229960004316 cisplatin Drugs 0.000 description 1
- WDDPHFBMKLOVOX-AYQXTPAHSA-N clofarabine Chemical compound C1=NC=2C(N)=NC(Cl)=NC=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@@H]1F WDDPHFBMKLOVOX-AYQXTPAHSA-N 0.000 description 1
- 229960000928 clofarabine Drugs 0.000 description 1
- 238000011260 co-administration Methods 0.000 description 1
- 230000001276 controlling effect Effects 0.000 description 1
- 150000004696 coordination complex Chemical class 0.000 description 1
- ZXIJMRYMVAMXQP-UHFFFAOYSA-N cycloheptene Chemical compound C1CCC=CCC1 ZXIJMRYMVAMXQP-UHFFFAOYSA-N 0.000 description 1
- WJTCGQSWYFHTAC-UHFFFAOYSA-N cyclooctane Chemical compound C1CCCCCCC1 WJTCGQSWYFHTAC-UHFFFAOYSA-N 0.000 description 1
- 239000004914 cyclooctane Substances 0.000 description 1
- URYYVOIYTNXXBN-UPHRSURJSA-N cyclooctene Chemical compound C1CCC\C=C/CC1 URYYVOIYTNXXBN-UPHRSURJSA-N 0.000 description 1
- 239000004913 cyclooctene Substances 0.000 description 1
- 229930182912 cyclosporin Natural products 0.000 description 1
- 208000031513 cyst Diseases 0.000 description 1
- 231100000433 cytotoxic Toxicity 0.000 description 1
- 229940127089 cytotoxic agent Drugs 0.000 description 1
- 230000001472 cytotoxic effect Effects 0.000 description 1
- STQGQHZAVUOBTE-VGBVRHCVSA-N daunorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(C)=O)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 STQGQHZAVUOBTE-VGBVRHCVSA-N 0.000 description 1
- 229960000975 daunorubicin Drugs 0.000 description 1
- 238000012217 deletion Methods 0.000 description 1
- 230000037430 deletion Effects 0.000 description 1
- 108010017271 denileukin diftitox Proteins 0.000 description 1
- UREBDLICKHMUKA-CXSFZGCWSA-N dexamethasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@@H](C)[C@@](C(=O)CO)(O)[C@@]1(C)C[C@@H]2O UREBDLICKHMUKA-CXSFZGCWSA-N 0.000 description 1
- 229960003957 dexamethasone Drugs 0.000 description 1
- 239000000539 dimer Substances 0.000 description 1
- SWSQBOPZIKWTGO-UHFFFAOYSA-N dimethylaminoamidine Natural products CN(C)C(N)=N SWSQBOPZIKWTGO-UHFFFAOYSA-N 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 239000003534 dna topoisomerase inhibitor Substances 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 229960004679 doxorubicin Drugs 0.000 description 1
- 238000009510 drug design Methods 0.000 description 1
- 210000002889 endothelial cell Anatomy 0.000 description 1
- 210000002919 epithelial cell Anatomy 0.000 description 1
- VJJPUSNTGOMMGY-MRVIYFEKSA-N etoposide Chemical compound COC1=C(O)C(OC)=CC([C@@H]2C3=CC=4OCOC=4C=C3[C@@H](O[C@H]3[C@@H]([C@@H](O)[C@@H]4O[C@H](C)OC[C@H]4O3)O)[C@@H]3[C@@H]2C(OC3)=O)=C1 VJJPUSNTGOMMGY-MRVIYFEKSA-N 0.000 description 1
- 229960005420 etoposide Drugs 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000012091 fetal bovine serum Substances 0.000 description 1
- 229960004177 filgrastim Drugs 0.000 description 1
- 238000001943 fluorescence-activated cell sorting Methods 0.000 description 1
- 125000001153 fluoro group Chemical group F* 0.000 description 1
- 229940044658 gallium nitrate Drugs 0.000 description 1
- 108700017752 gamma-Glu-S-BzCys-PhGly diethyl ester Proteins 0.000 description 1
- 229940080856 gleevec Drugs 0.000 description 1
- 210000003714 granulocyte Anatomy 0.000 description 1
- 239000003102 growth factor Substances 0.000 description 1
- 210000005003 heart tissue Anatomy 0.000 description 1
- 201000005787 hematologic cancer Diseases 0.000 description 1
- 208000024200 hematopoietic and lymphoid system neoplasm Diseases 0.000 description 1
- 210000000777 hematopoietic system Anatomy 0.000 description 1
- 230000011132 hemopoiesis Effects 0.000 description 1
- 125000004404 heteroalkyl group Chemical group 0.000 description 1
- 125000005343 heterocyclic alkyl group Chemical group 0.000 description 1
- 210000003630 histaminocyte Anatomy 0.000 description 1
- 102000046353 human CXCL2 Human genes 0.000 description 1
- 150000002431 hydrogen Chemical group 0.000 description 1
- IXCSERBJSXMMFS-UHFFFAOYSA-N hydrogen chloride Substances Cl.Cl IXCSERBJSXMMFS-UHFFFAOYSA-N 0.000 description 1
- 150000002443 hydroxylamines Chemical class 0.000 description 1
- 229960001001 ibritumomab tiuxetan Drugs 0.000 description 1
- 229960002411 imatinib Drugs 0.000 description 1
- YLMAHDNUQAMNNX-UHFFFAOYSA-N imatinib methanesulfonate Chemical compound CS(O)(=O)=O.C1CN(C)CCN1CC1=CC=C(C(=O)NC=2C=C(NC=3N=C(C=CN=3)C=3C=NC=CC=3)C(C)=CC=2)C=C1 YLMAHDNUQAMNNX-UHFFFAOYSA-N 0.000 description 1
- YAMHXTCMCPHKLN-UHFFFAOYSA-N imidazolidin-2-one Chemical compound O=C1NCCN1 YAMHXTCMCPHKLN-UHFFFAOYSA-N 0.000 description 1
- 125000001841 imino group Chemical group [H]N=* 0.000 description 1
- 238000001802 infusion Methods 0.000 description 1
- 150000007529 inorganic bases Chemical class 0.000 description 1
- 238000003780 insertion Methods 0.000 description 1
- 230000037431 insertion Effects 0.000 description 1
- 238000007918 intramuscular administration Methods 0.000 description 1
- 239000007928 intraperitoneal injection Substances 0.000 description 1
- PNDPGZBMCMUPRI-UHFFFAOYSA-N iodine Chemical compound II PNDPGZBMCMUPRI-UHFFFAOYSA-N 0.000 description 1
- GWVMLCQWXVFZCN-UHFFFAOYSA-N isoindoline Chemical compound C1=CC=C2CNCC2=C1 GWVMLCQWXVFZCN-UHFFFAOYSA-N 0.000 description 1
- 125000000468 ketone group Chemical group 0.000 description 1
- GOTYRUGSSMKFNF-UHFFFAOYSA-N lenalidomide Chemical compound C1C=2C(N)=CC=CC=2C(=O)N1C1CCC(=O)NC1=O GOTYRUGSSMKFNF-UHFFFAOYSA-N 0.000 description 1
- 229960002618 lenograstim Drugs 0.000 description 1
- 229940087875 leukine Drugs 0.000 description 1
- 239000002502 liposome Substances 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 244000144972 livestock Species 0.000 description 1
- 208000003747 lymphoid leukemia Diseases 0.000 description 1
- 208000029791 lytic metastatic bone lesion Diseases 0.000 description 1
- 210000002540 macrophage Anatomy 0.000 description 1
- 159000000003 magnesium salts Chemical class 0.000 description 1
- SGDBTWWWUNNDEQ-LBPRGKRZSA-N melphalan Chemical compound OC(=O)[C@@H](N)CC1=CC=C(N(CCCl)CCCl)C=C1 SGDBTWWWUNNDEQ-LBPRGKRZSA-N 0.000 description 1
- 229960001924 melphalan Drugs 0.000 description 1
- 150000007522 mineralic acids Chemical class 0.000 description 1
- 108010032806 molgramostim Proteins 0.000 description 1
- 210000004877 mucosa Anatomy 0.000 description 1
- 208000025113 myeloid leukemia Diseases 0.000 description 1
- 210000003643 myeloid progenitor cell Anatomy 0.000 description 1
- 108010059631 myelopoietin Proteins 0.000 description 1
- WEZLIYLAGMXZGO-UHFFFAOYSA-N n-(1h-imidazol-2-ylmethyl)-n'-[[4-[(pyridin-2-ylmethylamino)methyl]phenyl]methyl]-n'-(5,6,7,8-tetrahydroquinolin-8-yl)ethane-1,2-diamine Chemical compound N=1C=CNC=1CNCCN(C1C2=NC=CC=C2CCC1)CC(C=C1)=CC=C1CNCC1=CC=CC=N1 WEZLIYLAGMXZGO-UHFFFAOYSA-N 0.000 description 1
- ABWLCCXVRITGNR-UHFFFAOYSA-N n-(1h-imidazol-5-ylmethyl)-n-[[4-[(pyridin-2-ylmethylamino)methyl]phenyl]methyl]-5,6,7,8-tetrahydroquinolin-8-amine Chemical compound C=1C=C(CN(CC=2N=CNC=2)C2C3=NC=CC=C3CCC2)C=CC=1CNCC1=CC=CC=N1 ABWLCCXVRITGNR-UHFFFAOYSA-N 0.000 description 1
- IAKOZGHZGQFGTL-UHFFFAOYSA-N n-(naphthalen-2-ylmethyl)-n'-[[4-[(pyridin-2-ylmethylamino)methyl]phenyl]methyl]-n'-(5,6,7,8-tetrahydroquinolin-8-yl)ethane-1,2-diamine Chemical compound C=1C=C2C=CC=CC2=CC=1CNCCN(C1C2=NC=CC=C2CCC1)CC(C=C1)=CC=C1CNCC1=CC=CC=N1 IAKOZGHZGQFGTL-UHFFFAOYSA-N 0.000 description 1
- TWTLJZJKDUYSON-UHFFFAOYSA-N n-(pyridin-3-ylmethyl)-1-[4-(1,4,8,11-tetrazacyclotetradec-1-ylmethyl)phenyl]methanamine Chemical compound C=1C=C(CN2CCNCCCNCCNCCC2)C=CC=1CNCC1=CC=CN=C1 TWTLJZJKDUYSON-UHFFFAOYSA-N 0.000 description 1
- RIQPBQKUXWVZKM-UHFFFAOYSA-N n-[(2,4-difluorophenyl)methyl]-n-[[4-[(pyridin-2-ylmethylamino)methyl]phenyl]methyl]-5,6,7,8-tetrahydroquinolin-8-amine Chemical compound FC1=CC(F)=CC=C1CN(C1C2=NC=CC=C2CCC1)CC(C=C1)=CC=C1CNCC1=CC=CC=N1 RIQPBQKUXWVZKM-UHFFFAOYSA-N 0.000 description 1
- VKDHBCBGBPBMJS-BHVANESWSA-N n-[(2s)-3-methyl-1-oxo-1-[4-[2-pyridin-2-ylethyl-[[3-[(pyridin-2-ylmethylamino)methyl]phenyl]methyl]amino]piperidin-1-yl]butan-2-yl]benzamide Chemical compound N([C@@H](C(C)C)C(=O)N1CCC(CC1)N(CCC=1N=CC=CC=1)CC=1C=C(CNCC=2N=CC=CC=2)C=CC=1)C(=O)C1=CC=CC=C1 VKDHBCBGBPBMJS-BHVANESWSA-N 0.000 description 1
- UYMDKKVILQGGBT-ZTOMLWHTSA-N n-[(2s)-5-(diaminomethylideneamino)-1-[[(1s)-1-naphthalen-1-ylethyl]amino]-1-oxopentan-2-yl]-4-[(pyridin-2-ylmethylamino)methyl]benzamide Chemical compound N([C@@H](CCCN=C(N)N)C(=O)N[C@@H](C)C=1C2=CC=CC=C2C=CC=1)C(=O)C(C=C1)=CC=C1CNCC1=CC=CC=N1 UYMDKKVILQGGBT-ZTOMLWHTSA-N 0.000 description 1
- HBQUSQLYWUYSNZ-UHFFFAOYSA-N n-[(3,5-dimethyl-2-phenyl-1,3-dihydropyrazol-4-yl)methyl]-n-[[4-[(pyridin-2-ylmethylamino)methyl]phenyl]methyl]-5,6,7,8-tetrahydroquinolin-8-amine Chemical compound CC1N(C=2C=CC=CC=2)NC(C)=C1CN(C1C2=NC=CC=C2CCC1)CC(C=C1)=CC=C1CNCC1=CC=CC=N1 HBQUSQLYWUYSNZ-UHFFFAOYSA-N 0.000 description 1
- TULISIMBRMEOGK-UHFFFAOYSA-N n-[(7-methoxy-1,3-benzodioxol-5-yl)methyl]-n-[[4-[(pyridin-2-ylmethylamino)methyl]phenyl]methyl]-6,7,8,9-tetrahydro-5h-cyclohepta[b]pyridin-9-amine Chemical compound C=1C=2OCOC=2C(OC)=CC=1CN(C1C2=NC=CC=C2CCCC1)CC(C=C1)=CC=C1CNCC1=CC=CC=N1 TULISIMBRMEOGK-UHFFFAOYSA-N 0.000 description 1
- VKBJDOBPGVLLTB-UHFFFAOYSA-N n-[[4-[(pyridin-2-ylmethylamino)methyl]phenyl]methyl]naphthalen-1-amine Chemical compound C=1C=C(CNC=2C3=CC=CC=C3C=CC=2)C=CC=1CNCC1=CC=CC=N1 VKBJDOBPGVLLTB-UHFFFAOYSA-N 0.000 description 1
- NJDVDIVVFUXOHL-UHFFFAOYSA-N n-benzyl-n-[[4-[(pyridin-2-ylmethylamino)methyl]phenyl]methyl]-5,6,7,8-tetrahydroquinolin-8-amine Chemical compound C=1C=C(CN(CC=2C=CC=CC=2)C2C3=NC=CC=C3CCC2)C=CC=1CNCC1=CC=CC=N1 NJDVDIVVFUXOHL-UHFFFAOYSA-N 0.000 description 1
- 239000007922 nasal spray Substances 0.000 description 1
- IXOXBSCIXZEQEQ-UHTZMRCNSA-N nelarabine Chemical compound C1=NC=2C(OC)=NC(N)=NC=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@@H]1O IXOXBSCIXZEQEQ-UHTZMRCNSA-N 0.000 description 1
- 229960000801 nelarabine Drugs 0.000 description 1
- 229940071846 neulasta Drugs 0.000 description 1
- 150000002825 nitriles Chemical group 0.000 description 1
- MWUXSHHQAYIFBG-UHFFFAOYSA-N nitrogen oxide Inorganic materials O=[N] MWUXSHHQAYIFBG-UHFFFAOYSA-N 0.000 description 1
- 125000006574 non-aromatic ring group Chemical group 0.000 description 1
- 235000016709 nutrition Nutrition 0.000 description 1
- 229960000435 oblimersen Drugs 0.000 description 1
- 238000011275 oncology therapy Methods 0.000 description 1
- 229940100027 ontak Drugs 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
- 238000005457 optimization Methods 0.000 description 1
- 150000007524 organic acids Chemical class 0.000 description 1
- 235000005985 organic acids Nutrition 0.000 description 1
- 230000001599 osteoclastic effect Effects 0.000 description 1
- 235000006408 oxalic acid Nutrition 0.000 description 1
- 125000002971 oxazolyl group Chemical group 0.000 description 1
- UHHKSVZZTYJVEG-UHFFFAOYSA-N oxepane Chemical compound C1CCCOCC1 UHHKSVZZTYJVEG-UHFFFAOYSA-N 0.000 description 1
- 125000004430 oxygen atom Chemical group O* 0.000 description 1
- 125000001037 p-tolyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1*)C([H])([H])[H] 0.000 description 1
- 238000007911 parenteral administration Methods 0.000 description 1
- HQQSBEDKMRHYME-UHFFFAOYSA-N pefloxacin mesylate Chemical compound [H+].CS([O-])(=O)=O.C1=C2N(CC)C=C(C(O)=O)C(=O)C2=CC(F)=C1N1CCN(C)CC1 HQQSBEDKMRHYME-UHFFFAOYSA-N 0.000 description 1
- 229960001373 pegfilgrastim Drugs 0.000 description 1
- 230000000149 penetrating effect Effects 0.000 description 1
- 239000000816 peptidomimetic Chemical class 0.000 description 1
- 230000002093 peripheral effect Effects 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- LFSXCDWNBUNEEM-UHFFFAOYSA-N phthalazine Chemical compound C1=NN=CC2=CC=CC=C21 LFSXCDWNBUNEEM-UHFFFAOYSA-N 0.000 description 1
- 125000004193 piperazinyl group Chemical group 0.000 description 1
- 229960004403 pixantrone Drugs 0.000 description 1
- PEZPMAYDXJQYRV-UHFFFAOYSA-N pixantrone Chemical compound O=C1C2=CN=CC=C2C(=O)C2=C1C(NCCN)=CC=C2NCCN PEZPMAYDXJQYRV-UHFFFAOYSA-N 0.000 description 1
- 229910052697 platinum Inorganic materials 0.000 description 1
- 229920001184 polypeptide Polymers 0.000 description 1
- XAEFZNCEHLXOMS-UHFFFAOYSA-M potassium benzoate Chemical compound [K+].[O-]C(=O)C1=CC=CC=C1 XAEFZNCEHLXOMS-UHFFFAOYSA-M 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- 230000002062 proliferating effect Effects 0.000 description 1
- 235000019260 propionic acid Nutrition 0.000 description 1
- 125000006239 protecting group Chemical group 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 125000003373 pyrazinyl group Chemical group 0.000 description 1
- 125000005576 pyrimidinylene group Chemical group 0.000 description 1
- 125000000719 pyrrolidinyl group Chemical group 0.000 description 1
- JWVCLYRUEFBMGU-UHFFFAOYSA-N quinazoline Chemical compound N1=CN=CC2=CC=CC=C21 JWVCLYRUEFBMGU-UHFFFAOYSA-N 0.000 description 1
- IUVKMZGDUIUOCP-BTNSXGMBSA-N quinbolone Chemical compound O([C@H]1CC[C@H]2[C@H]3[C@@H]([C@]4(C=CC(=O)C=C4CC3)C)CC[C@@]21C)C1=CCCC1 IUVKMZGDUIUOCP-BTNSXGMBSA-N 0.000 description 1
- 125000002943 quinolinyl group Chemical group N1=C(C=CC2=CC=CC=C12)* 0.000 description 1
- 229940121896 radiopharmaceutical Drugs 0.000 description 1
- 230000002799 radiopharmaceutical effect Effects 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 229940120975 revlimid Drugs 0.000 description 1
- 238000007363 ring formation reaction Methods 0.000 description 1
- 229960004641 rituximab Drugs 0.000 description 1
- 108010038379 sargramostim Proteins 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 210000004927 skin cell Anatomy 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 159000000000 sodium salts Chemical class 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 239000012453 solvate Substances 0.000 description 1
- 210000004989 spleen cell Anatomy 0.000 description 1
- 238000010561 standard procedure Methods 0.000 description 1
- 125000005415 substituted alkoxy group Chemical group 0.000 description 1
- 125000003107 substituted aryl group Chemical group 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- NVBFHJWHLNUMCV-UHFFFAOYSA-N sulfamide Chemical compound NS(N)(=O)=O NVBFHJWHLNUMCV-UHFFFAOYSA-N 0.000 description 1
- BDHFUVZGWQCTTF-UHFFFAOYSA-M sulfonate Chemical class [O-]S(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-M 0.000 description 1
- 150000003457 sulfones Chemical group 0.000 description 1
- 125000004434 sulfur atom Chemical group 0.000 description 1
- 230000003319 supportive effect Effects 0.000 description 1
- 239000000829 suppository Substances 0.000 description 1
- 230000002459 sustained effect Effects 0.000 description 1
- 238000001308 synthesis method Methods 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 235000020357 syrup Nutrition 0.000 description 1
- 239000006188 syrup Substances 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- MUTNCGKQJGXKEM-UHFFFAOYSA-N tamibarotene Chemical compound C=1C=C2C(C)(C)CCC(C)(C)C2=CC=1NC(=O)C1=CC=C(C(O)=O)C=C1 MUTNCGKQJGXKEM-UHFFFAOYSA-N 0.000 description 1
- 229950010130 tamibarotene Drugs 0.000 description 1
- 150000003530 tetrahydroquinolines Chemical class 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 125000000335 thiazolyl group Chemical group 0.000 description 1
- JWCVYQRPINPYQJ-UHFFFAOYSA-N thiepane Chemical compound C1CCCSCC1 JWCVYQRPINPYQJ-UHFFFAOYSA-N 0.000 description 1
- 125000004001 thioalkyl group Chemical group 0.000 description 1
- 229960001196 thiotepa Drugs 0.000 description 1
- 229940044693 topoisomerase inhibitor Drugs 0.000 description 1
- 229960005267 tositumomab Drugs 0.000 description 1
- 230000026683 transduction Effects 0.000 description 1
- 238000010361 transduction Methods 0.000 description 1
- 239000013638 trimer Substances 0.000 description 1
- 210000005166 vasculature Anatomy 0.000 description 1
- 229940099039 velcade Drugs 0.000 description 1
- 229960004528 vincristine Drugs 0.000 description 1
- OGWKCGZFUXNPDA-UHFFFAOYSA-N vincristine Natural products C1C(CC)(O)CC(CC2(C(=O)OC)C=3C(=CC4=C(C56C(C(C(OC(C)=O)C7(CC)C=CCN(C67)CC5)(O)C(=O)OC)N4C=O)C=3)OC)CN1CCC1=C2NC2=CC=CC=C12 OGWKCGZFUXNPDA-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/195—Chemokines, e.g. RANTES
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/193—Colony stimulating factors [CSF]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Gastroenterology & Hepatology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Zoology (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US83640906P | 2006-08-07 | 2006-08-07 | |
| PCT/US2007/075376 WO2008019371A1 (en) | 2006-08-07 | 2007-08-07 | Combination therapy |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2010507567A true JP2010507567A (ja) | 2010-03-11 |
| JP2010507567A5 JP2010507567A5 (enExample) | 2010-09-30 |
Family
ID=39033325
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009523960A Withdrawn JP2010507567A (ja) | 2006-08-07 | 2007-08-07 | 併用療法 |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US20100178271A1 (enExample) |
| EP (1) | EP2056853A1 (enExample) |
| JP (1) | JP2010507567A (enExample) |
| CN (1) | CN101500595A (enExample) |
| AR (1) | AR062271A1 (enExample) |
| AU (1) | AU2007281677A1 (enExample) |
| BR (1) | BRPI0715393A2 (enExample) |
| CA (1) | CA2659337A1 (enExample) |
| IL (1) | IL196559A0 (enExample) |
| MX (1) | MX2009001445A (enExample) |
| RU (1) | RU2009108289A (enExample) |
| WO (1) | WO2008019371A1 (enExample) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2016516672A (ja) * | 2013-02-28 | 2016-06-09 | プレジデント アンド フェローズ オブ ハーバード カレッジ | 幹細胞を動員するための方法および組成物 |
| JP2019532654A (ja) * | 2016-10-24 | 2019-11-14 | イェール ユニバーシティーＹａｌｅ Ｕｎｉｖｅｒｓｉｔｙ | 吸引デバイス |
| JP2021505172A (ja) * | 2017-12-06 | 2021-02-18 | マジェンタ セラピューティクス インコーポレイテッドＭａｇｅｎｔａ Ｔｈｅｒａｐｅｕｔｉｃｓ， Ｉｎｃ． | 造血幹細胞及び前駆細胞を動員させるための投薬レジメン |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101631850B (zh) * | 2007-01-09 | 2013-12-04 | 克里夫兰生物实验室公司 | 增加和转移造血干细胞的方法 |
| EP2262494A2 (en) * | 2008-02-29 | 2010-12-22 | The Board Of Trustees Of The Leland Stanford Junior University | Inhibition of post-radiation tumor growth by an inhibitor of vasculogenesis |
| US10813917B2 (en) * | 2009-12-11 | 2020-10-27 | Medregen, Llc | Treatment methods utilizing stem cell mobilizers and immunosuppressive agents |
| WO2011119738A2 (en) | 2010-03-23 | 2011-09-29 | The Johns Hopkins University | Methods of treatment using stem cell mobilizers |
| US8546353B2 (en) | 2010-05-06 | 2013-10-01 | Glykos Finland Oy | Compounds and combinations |
| EP2384759A1 (en) | 2010-05-06 | 2011-11-09 | Suomen Punainen Risti Veripalvelu | Sulphated hyaluronic acid in combination with G-CSF for use in mobilising blood stem cells |
| ES2370986B1 (es) * | 2010-06-08 | 2012-11-16 | Institut Quimic De Sarria Cets | Nuevos inhibidores de cxcr4 como agentes anti-vih |
| WO2012047339A2 (en) | 2010-06-28 | 2012-04-12 | The General Hospital Corporation | Anti-cxcr4 as a sensitizer to cancer therapeutics |
| CA2807552A1 (en) | 2010-08-06 | 2012-02-09 | Moderna Therapeutics, Inc. | Engineered nucleic acids and methods of use thereof |
| SI3590949T1 (sl) | 2010-10-01 | 2022-09-30 | Modernatx, Inc. | Ribonukleinske kisline, ki vsebujejo N1-metil-psevdouracil, in njihove uporabe |
| WO2012129073A2 (en) | 2011-03-18 | 2012-09-27 | University Of Virginia Patent Foundation | Compositions and methods for tissue engineering and cell based therapies |
| JP2014511687A (ja) | 2011-03-31 | 2014-05-19 | モデルナ セラピューティクス インコーポレイテッド | 工学操作された核酸の送達および製剤 |
| PL2709991T3 (pl) | 2011-05-16 | 2021-04-06 | Genzyme Corporation | Zastosowanie antagonistów CXCR4 w leczeniu zespołu WHIM, mielokateksji, neutropenii i limfocytopenii |
| WO2012174522A1 (en) * | 2011-06-16 | 2012-12-20 | Children's Medical Center Corporation | Combined chemical modification of sphingosine-1-phosphate (s1p) and cxcr4 signalling pathways for hematopoietic stem cell (hsc) mobilization and engraftment |
| US9464124B2 (en) | 2011-09-12 | 2016-10-11 | Moderna Therapeutics, Inc. | Engineered nucleic acids and methods of use thereof |
| EP2763701B1 (en) | 2011-10-03 | 2018-12-19 | Moderna Therapeutics, Inc. | Modified nucleosides, nucleotides, and nucleic acids, and uses thereof |
| RU2649364C2 (ru) | 2011-12-16 | 2018-04-02 | Модерна Терапьютикс, Инк. | Составы на основе модифицированного нуклеозида, нуклеотида и нуклеиновой кислоты |
| US9572897B2 (en) | 2012-04-02 | 2017-02-21 | Modernatx, Inc. | Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins |
| EP3520821A1 (en) | 2012-04-02 | 2019-08-07 | Moderna Therapeutics, Inc. | Modified polynucleotides for the production of biologics and proteins associated with human disease |
| US9283287B2 (en) | 2012-04-02 | 2016-03-15 | Moderna Therapeutics, Inc. | Modified polynucleotides for the production of nuclear proteins |
| US9878056B2 (en) | 2012-04-02 | 2018-01-30 | Modernatx, Inc. | Modified polynucleotides for the production of cosmetic proteins and peptides |
| SI2922554T1 (sl) | 2012-11-26 | 2022-06-30 | Modernatx, Inc. | Terminalno modificirana RNA |
| US8980864B2 (en) | 2013-03-15 | 2015-03-17 | Moderna Therapeutics, Inc. | Compositions and methods of altering cholesterol levels |
| US10023626B2 (en) | 2013-09-30 | 2018-07-17 | Modernatx, Inc. | Polynucleotides encoding immune modulating polypeptides |
| KR20160067219A (ko) | 2013-10-03 | 2016-06-13 | 모더나 세라퓨틱스, 인코포레이티드 | 저밀도 지단백질 수용체를 암호화하는 폴리뉴클레오타이드 |
| WO2016191811A1 (en) * | 2015-06-03 | 2016-12-08 | The University Of Queensland | Mobilizing agents and uses therefor |
| EP3389720A1 (en) | 2015-12-18 | 2018-10-24 | The General Hospital Corporation | Polyacetal polymers, conjugates, particles and uses thereof |
| WO2018106738A1 (en) | 2016-12-05 | 2018-06-14 | Massachusetts Institute Of Technology | Brush-arm star polymers, conjugates and particles, and uses thereof |
| SG11202003795YA (en) | 2017-11-03 | 2020-05-28 | Roemer & Heigl Gmbh | Extraction of stem cells from bone marrow niches |
| US10058573B1 (en) | 2017-12-06 | 2018-08-28 | Magenta Therapeutics, Inc. | Dosing regimens for the mobilization of hematopoietic stem cells |
| US11260079B2 (en) | 2017-12-06 | 2022-03-01 | Magenta Therapeutics, Inc. | Dosing regimens for the mobilization of hematopoietic stem and progenitor cells |
| EP4146797A1 (en) | 2020-05-06 | 2023-03-15 | Orchard Therapeutics (Europe) Limited | Treatment for neurodegenerative diseases |
| WO2022101359A1 (en) | 2020-11-12 | 2022-05-19 | Roemer & Heigl Gmbh | Reversible release of stem cells from bone marrow niches |
| WO2025224720A1 (en) | 2024-04-24 | 2025-10-30 | Biolinerx Ltd. | Methods of selecting treatment regimen against solid tumors |
Family Cites Families (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4810643A (en) * | 1985-08-23 | 1989-03-07 | Kirin- Amgen Inc. | Production of pluripotent granulocyte colony-stimulating factor |
| US5194596A (en) * | 1989-07-27 | 1993-03-16 | California Biotechnology Inc. | Production of vascular endothelial cell growth factor |
| US5350836A (en) * | 1989-10-12 | 1994-09-27 | Ohio University | Growth hormone antagonists |
| US6001826A (en) * | 1989-12-21 | 1999-12-14 | Anormed, Inc. | Chemical compounds |
| US5021409A (en) * | 1989-12-21 | 1991-06-04 | Johnson Matthey Plc | Antiviral cyclic polyamines |
| GB9126677D0 (en) * | 1991-12-16 | 1992-02-12 | Johnson Matthey Plc | Improvements in chemical compounds |
| US6447766B1 (en) * | 1993-06-08 | 2002-09-10 | Smithkline Beecham Corporation | Method of mobilizing hematopoietic stem cells |
| EP0713495B1 (en) * | 1993-06-08 | 2003-11-05 | Smithkline Beecham Corporation | Methods of enhancing bioactivity of chemokines |
| DE4320478B4 (de) * | 1993-06-21 | 2007-11-15 | Robert Bosch Gmbh | Fahrstabilitätsregler |
| GB9400411D0 (en) * | 1994-01-11 | 1994-03-09 | Johnson Matthey Plc | Improvements in chemical compounds |
| GB9511357D0 (en) * | 1995-06-06 | 1995-08-02 | Johnson Matthey Plc | Improved antiviral compounds |
| US6506770B1 (en) * | 1996-06-06 | 2003-01-14 | Anormed, Inc. | Antiviral compounds |
| US6713052B1 (en) * | 1995-10-24 | 2004-03-30 | Human Genome Sciences, Inc. | Method of mobilizing stem cells with chemokine β-8 |
| US6365583B1 (en) * | 1999-02-02 | 2002-04-02 | Anormed, Inc. | Methods to enhance white blood cell count |
| US6750348B1 (en) * | 1999-03-24 | 2004-06-15 | Anormed, Inc. | Chemokine receptor binding heterocyclic compounds |
| CN100335478C (zh) * | 1999-12-17 | 2007-09-05 | 阿诺麦德股份有限公司 | 结合趋化因子受体的杂环化合物 |
| DE60137944D1 (de) * | 2000-09-15 | 2009-04-23 | Anormed Inc | Chemokin rezeptor bindenden heterozyklische verbindungen |
| DK1317451T3 (da) * | 2000-09-15 | 2006-12-18 | Anormed Inc | Kemokinreceptorbindende heterocykliske forbindelser |
| EP1322626B1 (en) * | 2000-09-29 | 2008-11-05 | Anormed Inc. | Process for preparation of n-1 protected n ring nitrogen containing cyclic polyamines and products thereof |
| US6853731B1 (en) * | 2000-09-30 | 2005-02-08 | Keen Personal Technologies, Inc. | Digital video recorder employing a unique ID to interlock with encrypted video programs stored on a storage device |
| WO2002081727A2 (en) * | 2001-04-03 | 2002-10-17 | Pe Corporation (Ny) | Isolated human kinase proteins, nucleic acid molecules encoding human kinase proteins, and uses thereof |
| US7169750B2 (en) * | 2001-07-31 | 2007-01-30 | Anormed, Inc. | Methods to mobilize progenitor/stem cells |
| EP2371361B1 (en) * | 2001-07-31 | 2019-08-07 | Genzyme Corporation | Methods to mobilize progenitor/stem cells |
| WO2003048345A1 (en) * | 2001-12-07 | 2003-06-12 | Toolgen, Inc. | Phenotypic screen of chimeric proteins |
| WO2004091518A2 (en) * | 2003-04-11 | 2004-10-28 | Anormed Inc. | Cxcr4 chemokine receptor binding compounds |
| EP2374804A1 (en) * | 2003-04-22 | 2011-10-12 | Genzyme Corporation | Chemokine receptor binding heterocyclic compounds with enhanced efficacy |
| EP1708703A4 (en) * | 2003-12-11 | 2008-04-09 | Anormed Inc | CHEMOKIN RECEPTOR BINDING COMPOUNDS |
-
2007
- 2007-08-07 AR ARP070103484A patent/AR062271A1/es unknown
- 2007-08-07 AU AU2007281677A patent/AU2007281677A1/en not_active Abandoned
- 2007-08-07 MX MX2009001445A patent/MX2009001445A/es unknown
- 2007-08-07 US US12/376,591 patent/US20100178271A1/en not_active Abandoned
- 2007-08-07 RU RU2009108289/15A patent/RU2009108289A/ru not_active Application Discontinuation
- 2007-08-07 EP EP07813853A patent/EP2056853A1/en active Pending
- 2007-08-07 WO PCT/US2007/075376 patent/WO2008019371A1/en not_active Ceased
- 2007-08-07 CA CA002659337A patent/CA2659337A1/en not_active Abandoned
- 2007-08-07 JP JP2009523960A patent/JP2010507567A/ja not_active Withdrawn
- 2007-08-07 BR BRPI0715393-7A patent/BRPI0715393A2/pt not_active Application Discontinuation
- 2007-08-07 CN CNA2007800295078A patent/CN101500595A/zh active Pending
-
2009
- 2009-01-15 IL IL196559A patent/IL196559A0/en unknown
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2016516672A (ja) * | 2013-02-28 | 2016-06-09 | プレジデント アンド フェローズ オブ ハーバード カレッジ | 幹細胞を動員するための方法および組成物 |
| JP2020073589A (ja) * | 2013-02-28 | 2020-05-14 | プレジデント アンド フェローズ オブ ハーバード カレッジ | 幹細胞を動員するための方法および組成物 |
| JP2021165306A (ja) * | 2013-02-28 | 2021-10-14 | プレジデント アンド フェローズ オブ ハーバード カレッジ | 幹細胞を動員するための方法および組成物 |
| KR20210132751A (ko) * | 2013-02-28 | 2021-11-04 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | 줄기세포를 동원하기 위한 방법 및 조성물 |
| KR102503695B1 (ko) * | 2013-02-28 | 2023-02-23 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | 줄기세포를 동원하기 위한 방법 및 조성물 |
| JP2019532654A (ja) * | 2016-10-24 | 2019-11-14 | イェール ユニバーシティーＹａｌｅ Ｕｎｉｖｅｒｓｉｔｙ | 吸引デバイス |
| US12419619B2 (en) | 2016-10-24 | 2025-09-23 | Yale University | Aspiration device |
| JP2021505172A (ja) * | 2017-12-06 | 2021-02-18 | マジェンタ セラピューティクス インコーポレイテッドＭａｇｅｎｔａ Ｔｈｅｒａｐｅｕｔｉｃｓ， Ｉｎｃ． | 造血幹細胞及び前駆細胞を動員させるための投薬レジメン |
| JP2024023226A (ja) * | 2017-12-06 | 2024-02-21 | マジェンタ セラピューティクス インコーポレイテッド | 造血幹細胞及び前駆細胞を動員させるための投薬レジメン |
Also Published As
| Publication number | Publication date |
|---|---|
| AU2007281677A1 (en) | 2008-02-14 |
| AR062271A1 (es) | 2008-10-29 |
| BRPI0715393A2 (pt) | 2013-06-25 |
| CN101500595A (zh) | 2009-08-05 |
| US20100178271A1 (en) | 2010-07-15 |
| EP2056853A1 (en) | 2009-05-13 |
| CA2659337A1 (en) | 2008-02-14 |
| MX2009001445A (es) | 2009-02-18 |
| RU2009108289A (ru) | 2010-09-20 |
| WO2008019371A1 (en) | 2008-02-14 |
| IL196559A0 (en) | 2011-08-01 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2010507567A (ja) | 併用療法 | |
| RU2309741C2 (ru) | Способы активации клеток-предшественников/стволовых клеток | |
| US20100003224A1 (en) | Combination Therapy | |
| US20060035829A1 (en) | Chemokine combinations to mobilize progenitor/stem cells | |
| AU2002318927A1 (en) | Methods to mobilize progenitor/stem cells | |
| EP1991221B1 (en) | Methods for increasing blood flow and/or promoting tissue regeneration | |
| HK40026817A (en) | Methods to mobilize progenitor/stem cells | |
| MX2007001802A (en) | Chemokine combinations to mobilize progenitor/stem cells |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20100720 |
|
| A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20100720 |
|
| A761 | Written withdrawal of application |
Free format text: JAPANESE INTERMEDIATE CODE: A761 Effective date: 20100805 |