CA2659337A1

CA2659337A1 - Combination therapy

Combination therapy Download PDF

Info

Publication number: CA2659337A1
Authority: CA; Canada
Prior art keywords: pyridinylmethyl; benzenedimethanamine; tetrahydro; bis; quinolinyl
Prior art date: 2006-08-07
Legal status : Abandoned

Application number

CA002659337A

Other languages

English (en)

French (fr)

Inventor

Gary Bridger

Louis M. Pelus

Current Assignee

Genzyme Corp

Original Assignee

Individual

Priority date

2006-08-07

Filing date

2007-08-07

Publication date

2008-02-14

2007-08-07 Application filed by Individual filed Critical Individual

2008-02-14 Publication of CA2659337A1 publication Critical patent/CA2659337A1/en

Status Abandoned legal-status Critical Current

Links

238000002648 combination therapy Methods 0.000 title description 3
210000000130 stem cell Anatomy 0.000 claims abstract description 104
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102100031650 C-X-C chemokine receptor type 4 Human genes 0.000 claims abstract description 41
101000922348 Homo sapiens C-X-C chemokine receptor type 4 Proteins 0.000 claims abstract description 41
108010018951 Interleukin-8B Receptors Proteins 0.000 claims abstract description 32
239000000556 agonist Substances 0.000 claims abstract description 32
239000003112 inhibitor Substances 0.000 claims abstract description 31
238000001959 radiotherapy Methods 0.000 claims abstract description 9
208000002250 Hematologic Neoplasms Diseases 0.000 claims abstract description 5
102100028989 C-X-C chemokine receptor type 2 Human genes 0.000 claims abstract 6
210000004027 cell Anatomy 0.000 claims description 55
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239000000203 mixture Substances 0.000 claims description 16
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238000011282 treatment Methods 0.000 claims description 11
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238000003306 harvesting Methods 0.000 claims description 10
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