JP2010507392A5 - - Google Patents
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- JP2010507392A5 JP2010507392A5 JP2009534633A JP2009534633A JP2010507392A5 JP 2010507392 A5 JP2010507392 A5 JP 2010507392A5 JP 2009534633 A JP2009534633 A JP 2009534633A JP 2009534633 A JP2009534633 A JP 2009534633A JP 2010507392 A5 JP2010507392 A5 JP 2010507392A5
- Authority
- JP
- Japan
- Prior art keywords
- stem cells
- pharmaceutical composition
- composition according
- placental stem
- cancer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 239000008194 pharmaceutical composition Substances 0.000 claims 32
- 210000004991 placental stem cell Anatomy 0.000 claims 26
- 239000000203 mixture Substances 0.000 claims 15
- 210000000130 stem cell Anatomy 0.000 claims 13
- 102100031573 Hematopoietic progenitor cell antigen CD34 Human genes 0.000 claims 10
- 101000777663 Homo sapiens Hematopoietic progenitor cell antigen CD34 Proteins 0.000 claims 10
- 206010028980 Neoplasm Diseases 0.000 claims 10
- 210000000988 bone and bone Anatomy 0.000 claims 10
- 201000011510 cancer Diseases 0.000 claims 10
- 239000011159 matrix material Substances 0.000 claims 10
- 230000007547 defect Effects 0.000 claims 8
- 208000034578 Multiple myelomas Diseases 0.000 claims 7
- 206010035226 Plasma cell myeloma Diseases 0.000 claims 7
- 230000001464 adherent effect Effects 0.000 claims 7
- 238000000034 method Methods 0.000 claims 7
- 239000000758 substrate Substances 0.000 claims 7
- 206010005949 Bone cancer Diseases 0.000 claims 5
- 208000018084 Bone neoplasm Diseases 0.000 claims 5
- 102100032912 CD44 antigen Human genes 0.000 claims 5
- 102100028967 HLA class I histocompatibility antigen, alpha chain G Human genes 0.000 claims 5
- 108010024164 HLA-G Antigens Proteins 0.000 claims 5
- 101000868273 Homo sapiens CD44 antigen Proteins 0.000 claims 5
- 102000003729 Neprilysin Human genes 0.000 claims 5
- 108090000028 Neprilysin Proteins 0.000 claims 5
- 210000004027 cell Anatomy 0.000 claims 5
- 229920001436 collagen Polymers 0.000 claims 5
- 102100022464 5'-nucleotidase Human genes 0.000 claims 4
- 102000008186 Collagen Human genes 0.000 claims 4
- 108010035532 Collagen Proteins 0.000 claims 4
- 101000678236 Homo sapiens 5'-nucleotidase Proteins 0.000 claims 4
- 102000008100 Human Serum Albumin Human genes 0.000 claims 4
- 108091006905 Human Serum Albumin Proteins 0.000 claims 4
- 208000003076 Osteolysis Diseases 0.000 claims 4
- 208000029791 lytic metastatic bone lesion Diseases 0.000 claims 4
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims 3
- 101000738771 Homo sapiens Receptor-type tyrosine-protein phosphatase C Proteins 0.000 claims 3
- 102100037422 Receptor-type tyrosine-protein phosphatase C Human genes 0.000 claims 3
- 229920002674 hyaluronan Polymers 0.000 claims 3
- 229960003160 hyaluronic acid Drugs 0.000 claims 3
- 208000037819 metastatic cancer Diseases 0.000 claims 3
- 208000011575 metastatic malignant neoplasm Diseases 0.000 claims 3
- 210000005009 osteogenic cell Anatomy 0.000 claims 3
- 102100031585 ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 Human genes 0.000 claims 2
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims 2
- 208000005243 Chondrosarcoma Diseases 0.000 claims 2
- 201000009047 Chordoma Diseases 0.000 claims 2
- 208000006168 Ewing Sarcoma Diseases 0.000 claims 2
- 101000777636 Homo sapiens ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 Proteins 0.000 claims 2
- 206010029260 Neuroblastoma Diseases 0.000 claims 2
- 208000018420 bone fibrosarcoma Diseases 0.000 claims 2
- 238000002513 implantation Methods 0.000 claims 2
- 239000007972 injectable composition Substances 0.000 claims 2
- 238000001990 intravenous administration Methods 0.000 claims 2
- FZWBNHMXJMCXLU-BLAUPYHCSA-N isomaltotriose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)[C@@H](OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C=O)O1 FZWBNHMXJMCXLU-BLAUPYHCSA-N 0.000 claims 2
- 239000007788 liquid Substances 0.000 claims 2
- 201000008968 osteosarcoma Diseases 0.000 claims 2
- 239000000725 suspension Substances 0.000 claims 2
- 238000007910 systemic administration Methods 0.000 claims 2
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 claims 2
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims 1
- 229920002307 Dextran Polymers 0.000 claims 1
- 101000800116 Homo sapiens Thy-1 membrane glycoprotein Proteins 0.000 claims 1
- 208000006644 Malignant Fibrous Histiocytoma Diseases 0.000 claims 1
- 206010025557 Malignant fibrous histiocytoma of bone Diseases 0.000 claims 1
- 229910019142 PO4 Inorganic materials 0.000 claims 1
- 102100033523 Thy-1 membrane glycoprotein Human genes 0.000 claims 1
- 208000015778 Undifferentiated pleomorphic sarcoma Diseases 0.000 claims 1
- 229960005070 ascorbic acid Drugs 0.000 claims 1
- 235000010323 ascorbic acid Nutrition 0.000 claims 1
- 239000011668 ascorbic acid Substances 0.000 claims 1
- 239000011575 calcium Substances 0.000 claims 1
- 229910052791 calcium Inorganic materials 0.000 claims 1
- 229910000389 calcium phosphate Inorganic materials 0.000 claims 1
- 239000001506 calcium phosphate Substances 0.000 claims 1
- 235000011010 calcium phosphates Nutrition 0.000 claims 1
- 239000000919 ceramic Substances 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- UREBDLICKHMUKA-CXSFZGCWSA-N dexamethasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@@H](C)[C@@](C(=O)CO)(O)[C@@]1(C)C[C@@H]2O UREBDLICKHMUKA-CXSFZGCWSA-N 0.000 claims 1
- 229960003957 dexamethasone Drugs 0.000 claims 1
- 229940119744 dextran 40 Drugs 0.000 claims 1
- 201000008825 fibrosarcoma of bone Diseases 0.000 claims 1
- 229910052500 inorganic mineral Inorganic materials 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000011707 mineral Substances 0.000 claims 1
- 239000010452 phosphate Substances 0.000 claims 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims 1
- 230000003169 placental effect Effects 0.000 claims 1
- 208000018417 undifferentiated high grade pleomorphic sarcoma of bone Diseases 0.000 claims 1
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US85397106P | 2006-10-23 | 2006-10-23 | |
| US85562906P | 2006-10-30 | 2006-10-30 | |
| US99702207P | 2007-09-28 | 2007-09-28 | |
| PCT/US2007/022545 WO2008051568A2 (en) | 2006-10-23 | 2007-10-23 | Methods and compositions for treatment of bone defects with placental cell populations |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013110672A Division JP2013216661A (ja) | 2006-10-23 | 2013-05-27 | 胎盤細胞集団で骨欠損を治療するための方法及び組成物 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2010507392A JP2010507392A (ja) | 2010-03-11 |
| JP2010507392A5 true JP2010507392A5 (https=) | 2010-12-16 |
Family
ID=39325178
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009534633A Pending JP2010507392A (ja) | 2006-10-23 | 2007-10-23 | 胎盤細胞集団で骨欠損を治療するための方法及び組成物 |
| JP2013110672A Pending JP2013216661A (ja) | 2006-10-23 | 2013-05-27 | 胎盤細胞集団で骨欠損を治療するための方法及び組成物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013110672A Pending JP2013216661A (ja) | 2006-10-23 | 2013-05-27 | 胎盤細胞集団で骨欠損を治療するための方法及び組成物 |
Country Status (16)
| Country | Link |
|---|---|
| US (5) | US8562972B2 (https=) |
| EP (5) | EP2084268B1 (https=) |
| JP (2) | JP2010507392A (https=) |
| KR (1) | KR20090076989A (https=) |
| CN (3) | CN101631852A (https=) |
| AU (1) | AU2007309447B2 (https=) |
| CA (2) | CA2667359C (https=) |
| DK (1) | DK2084268T3 (https=) |
| ES (1) | ES2709205T3 (https=) |
| IL (1) | IL198008A (https=) |
| MX (1) | MX2009004238A (https=) |
| NZ (3) | NZ576194A (https=) |
| PL (1) | PL2084268T3 (https=) |
| PT (1) | PT2084268T (https=) |
| WO (1) | WO2008051568A2 (https=) |
| ZA (1) | ZA200902233B (https=) |
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-
2018
- 2018-09-21 US US16/138,962 patent/US20190262406A1/en not_active Abandoned
-
2021
- 2021-05-13 US US17/302,855 patent/US20220096564A1/en not_active Abandoned
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