JP2010506910A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2010506910A5 JP2010506910A5 JP2009533278A JP2009533278A JP2010506910A5 JP 2010506910 A5 JP2010506910 A5 JP 2010506910A5 JP 2009533278 A JP2009533278 A JP 2009533278A JP 2009533278 A JP2009533278 A JP 2009533278A JP 2010506910 A5 JP2010506910 A5 JP 2010506910A5
- Authority
- JP
- Japan
- Prior art keywords
- methyl
- quinolin
- ylidene
- piperidin
- benzamide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 claims description 9
- 238000000034 method Methods 0.000 claims description 8
- 208000019901 Anxiety disease Diseases 0.000 claims description 2
- 230000036506 anxiety Effects 0.000 claims description 2
- 239000008194 pharmaceutical composition Substances 0.000 claims description 2
- UIUHRTMSQIPPSU-UHFFFAOYSA-N n-(2-hydroxyethyl)-n-methyl-4-[piperidin-4-ylidene(quinolin-8-yl)methyl]benzamide Chemical compound C1=CC(C(=O)N(CCO)C)=CC=C1C(C=1C2=NC=CC=C2C=CC=1)=C1CCNCC1 UIUHRTMSQIPPSU-UHFFFAOYSA-N 0.000 claims 10
- YHZOSVOJWLWTLC-UHFFFAOYSA-N 4-[bromo(piperidin-4-ylidene)methyl]-n-(2-hydroxyethyl)-n-methylbenzamide Chemical compound C1=CC(C(=O)N(CCO)C)=CC=C1C(Br)=C1CCNCC1 YHZOSVOJWLWTLC-UHFFFAOYSA-N 0.000 claims 5
- 238000004519 manufacturing process Methods 0.000 claims 5
- 239000003814 drug Substances 0.000 claims 4
- KXJJSKYICDAICD-UHFFFAOYSA-N quinolin-8-ylboronic acid Chemical compound C1=CN=C2C(B(O)O)=CC=CC2=C1 KXJJSKYICDAICD-UHFFFAOYSA-N 0.000 claims 4
- -1 (4- (N- (2-hydroxyethyl) -N-methylcarbamoyl) phenyl) (quinolin-8-yl) methylene Chemical group 0.000 claims 3
- 125000000954 2-hydroxyethyl group Chemical group [H]C([*])([H])C([H])([H])O[H] 0.000 claims 3
- ZJKUETLEJYCOBO-UHFFFAOYSA-N n-(2-hydroxyethyl)-n-methyl-4-[quinolin-8-yl-[1-(1,3-thiazol-4-ylmethyl)piperidin-4-ylidene]methyl]benzamide Chemical compound C1=CC(C(=O)N(CCO)C)=CC=C1C(C=1C2=NC=CC=C2C=CC=1)=C1CCN(CC=2N=CSC=2)CC1 ZJKUETLEJYCOBO-UHFFFAOYSA-N 0.000 claims 3
- WRFKSVINLIQRKF-UHFFFAOYSA-N 1,3-thiazole-4-carbaldehyde Chemical compound O=CC1=CSC=N1 WRFKSVINLIQRKF-UHFFFAOYSA-N 0.000 claims 2
- VXFBDZNSWXGHHU-UHFFFAOYSA-N 4-[bromo(piperidin-4-ylidene)methyl]benzoic acid Chemical compound C1=CC(C(=O)O)=CC=C1C(Br)=C1CCNCC1 VXFBDZNSWXGHHU-UHFFFAOYSA-N 0.000 claims 2
- KXDAEFPNCMNJSK-UHFFFAOYSA-N Benzamide Chemical compound NC(=O)C1=CC=CC=C1 KXDAEFPNCMNJSK-UHFFFAOYSA-N 0.000 claims 2
- OPKOKAMJFNKNAS-UHFFFAOYSA-N N-methylethanolamine Chemical compound CNCCO OPKOKAMJFNKNAS-UHFFFAOYSA-N 0.000 claims 2
- KWSAVZDIBRTUEI-UHFFFAOYSA-N tert-butyl 4-[[4-[2-hydroxyethyl(methyl)carbamoyl]phenyl]-quinolin-8-ylmethylidene]piperidine-1-carboxylate Chemical compound C1=CC(C(=O)N(CCO)C)=CC=C1C(C=1C2=NC=CC=C2C=CC=1)=C1CCN(C(=O)OC(C)(C)C)CC1 KWSAVZDIBRTUEI-UHFFFAOYSA-N 0.000 claims 2
- LRCHQJMBFAIMEU-UHFFFAOYSA-N tert-butyl 4-[bromo-[4-[2-hydroxyethyl(methyl)carbamoyl]phenyl]methylidene]piperidine-1-carboxylate Chemical compound C1=CC(C(=O)N(CCO)C)=CC=C1C(Br)=C1CCN(C(=O)OC(C)(C)C)CC1 LRCHQJMBFAIMEU-UHFFFAOYSA-N 0.000 claims 2
- ZXAPQWICZVMRRE-UHFFFAOYSA-N 4-[bromo-[1-[(2-methylpropan-2-yl)oxycarbonyl]piperidin-4-ylidene]methyl]benzoic acid Chemical compound C1CN(C(=O)OC(C)(C)C)CCC1=C(Br)C1=CC=C(C(O)=O)C=C1 ZXAPQWICZVMRRE-UHFFFAOYSA-N 0.000 claims 1
- 208000020401 Depressive disease Diseases 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- DNUTZBZXLPWRJG-UHFFFAOYSA-M piperidine-1-carboxylate Chemical compound [O-]C(=O)N1CCCCC1 DNUTZBZXLPWRJG-UHFFFAOYSA-M 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 claims 1
- 239000000543 intermediate Substances 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US86232706P | 2006-10-20 | 2006-10-20 | |
| PCT/SE2007/000924 WO2008048171A1 (en) | 2006-10-20 | 2007-10-19 | N- (2 -hydroxyethyl) -n-methyl- 4- (quinolin- 8-yl (1- (thiazol-4- ylmethyl) piperidin- 4 -ylidene) methyl) benzamide, the process of making it as well as its use for the treatment of pain, anxiety and depression. |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010506910A JP2010506910A (ja) | 2010-03-04 |
| JP2010506910A5 true JP2010506910A5 (https=) | 2010-07-15 |
| JP4668346B2 JP4668346B2 (ja) | 2011-04-13 |
Family
ID=39314285
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009533278A Expired - Fee Related JP4668346B2 (ja) | 2006-10-20 | 2007-10-19 | Ｎ−（２−ヒドロキシエチル）−ｎ−メチル−４−（キノリン−８−イル（１−（チアゾール−４−イルメチル）ピペリジン−４−イリデン）メチル）ベンズアミド、その製造方法、並びに疼痛、不安及びうつ病の治療のためのその使用 |
Country Status (32)
| Country | Link |
|---|---|
| US (2) | US7659286B2 (https=) |
| EP (1) | EP2079735B1 (https=) |
| JP (1) | JP4668346B2 (https=) |
| KR (1) | KR20090065534A (https=) |
| CN (1) | CN101528739B (https=) |
| AR (1) | AR063345A1 (https=) |
| AT (1) | ATE543818T1 (https=) |
| AU (2) | AU2007313515B2 (https=) |
| BR (1) | BRPI0717631A2 (https=) |
| CA (1) | CA2667041C (https=) |
| CL (1) | CL2007003009A1 (https=) |
| CO (1) | CO6180450A2 (https=) |
| CY (1) | CY1112718T1 (https=) |
| DK (1) | DK2079735T3 (https=) |
| ES (1) | ES2379519T3 (https=) |
| HR (1) | HRP20120344T1 (https=) |
| IL (1) | IL197876A0 (https=) |
| MX (1) | MX2009003974A (https=) |
| MY (1) | MY148880A (https=) |
| NO (1) | NO20091969L (https=) |
| NZ (1) | NZ577060A (https=) |
| PE (2) | PE20080892A1 (https=) |
| PL (1) | PL2079735T3 (https=) |
| PT (1) | PT2079735E (https=) |
| RS (1) | RS52260B (https=) |
| RU (1) | RU2454414C2 (https=) |
| SA (1) | SA07280549B1 (https=) |
| SI (1) | SI2079735T1 (https=) |
| TW (1) | TW200826939A (https=) |
| UA (1) | UA97648C2 (https=) |
| UY (1) | UY30652A1 (https=) |
| WO (1) | WO2008048171A1 (https=) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BRPI0410347A (pt) * | 2003-05-16 | 2006-05-30 | Astrazeneca Ab | composto, uso de um composto, composição farmacêutica, métodos para as terapias da dor e de distúrbios gostrointestinais funcionais em animal de sangue quente, e, processo para preparação de um composto |
| MY148880A (en) * | 2006-10-20 | 2013-06-14 | Astrazeneca Ab | N-(2-hydroxyethyl)-n-methyl-4-(quinolin-8-yl(1-(thiazol-4-ylmethyl)piperidin-4-ylidene)methyl)benzamide, the process of making it as well as its use for the treatment of pain, anxiety and depression |
| EA201001644A1 (ru) * | 2008-05-20 | 2011-06-30 | Астразенека Аб | Способ лечения тревожного большого депрессивного расстройства |
| CN101906078B (zh) * | 2009-06-08 | 2012-02-01 | 上海威智医药科技有限公司 | 噻唑衍生物的合成方法 |
| CN102106807B (zh) * | 2009-12-29 | 2013-03-27 | 上海中西制药有限公司 | 一种固体制剂的制备方法及所得固体制剂 |
| EP3233825B1 (en) * | 2014-12-19 | 2020-04-29 | Pharmnovo AB | Diarylmethylidene piperidine derivatives and their use as delta opioid receptor agonists |
| EP3853435B1 (en) | 2018-09-21 | 2024-08-21 | Garland Industries, Inc. | Helical hardbanding |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2898339A (en) * | 1957-07-29 | 1959-08-04 | Wm S Merrell Co | N-substituted benzhydrol, benzhydryl, and benzhydrylidene piperidine |
| US4581171A (en) * | 1983-07-27 | 1986-04-08 | Janssen Pharmaceutica, N.V. | [[Bis(aryl)methylene]-1-piperidinyl]alkyl-pyrimidinones useful for treating psychotropic disorders |
| TW548271B (en) * | 1996-12-20 | 2003-08-21 | Astra Pharma Inc | Novel piperidine derivatives having an exocyclic double bond with analgesic effects |
| WO1999033806A1 (en) * | 1997-12-24 | 1999-07-08 | Ortho-Mcneil Pharmaceutical, Inc. | 4-[aryl(piperidin-4-yl)] aminobenzamides which bind to the delta-opioid receptor |
| US6492375B2 (en) * | 1998-06-30 | 2002-12-10 | Neuromed Technologies, Inc. | Partially saturated calcium channel blockers |
| SE9904673D0 (sv) | 1999-12-20 | 1999-12-20 | Astra Pharma Inc | Novel compounds |
| MXPA02006137A (es) | 1999-12-20 | 2002-12-05 | Neuromed Tech Inc | Bloqueadores del canal de calcio parcialmente saturados. |
| EP1263758A2 (en) * | 2000-03-03 | 2002-12-11 | Ortho-McNeil Pharmaceutical, Inc. | 3-(diarylmethylene)-8-azabicyclo[3.2.1]octane derivatives |
| SE0001208D0 (sv) * | 2000-04-04 | 2000-04-04 | Astrazeneca Canada Inc | Novel compounds |
| SE0101768D0 (sv) * | 2001-05-18 | 2001-05-18 | Astrazeneca Ab | Novel compounds |
| US20040204404A1 (en) * | 2002-09-30 | 2004-10-14 | Robert Zelle | Human N-type calcium channel blockers |
| SE0300105D0 (sv) * | 2003-01-16 | 2003-01-16 | Astrazeneca Ab | Diarylmethylidene piperdine derivatives, preparations thereof and uses thereof |
| SE0301445D0 (sv) * | 2003-05-16 | 2003-05-16 | Astrazeneca Ab | Diarylmethylidene piperidine derivatives, preparations thereof and uses thereof |
| SE0301444D0 (sv) * | 2003-05-16 | 2003-05-16 | Astrazeneca Ab | Diarylmethylidene piperidine derivatives, preparations thereof and uses thereof |
| SE0301442D0 (sv) | 2003-05-16 | 2003-05-16 | Astrazeneca Ab | Diarylmethylidene piperidine derivatives, preparations therof and uses thereof |
| SE0301441D0 (sv) * | 2003-05-16 | 2003-05-16 | Astrazeneca Ab | Diarylmethylidene piperidine derivatives, preparations thereof and uses thereof |
| BRPI0410347A (pt) * | 2003-05-16 | 2006-05-30 | Astrazeneca Ab | composto, uso de um composto, composição farmacêutica, métodos para as terapias da dor e de distúrbios gostrointestinais funcionais em animal de sangue quente, e, processo para preparação de um composto |
| SE0400025D0 (sv) * | 2004-01-09 | 2004-01-09 | Astrazeneca Ab | Diarylmethylidene piperidine derivatives, preparations thereof and uses thereof |
| WO2005087742A1 (en) | 2004-03-08 | 2005-09-22 | Exelixis, Inc. | Metabolic kinase modulators and methods of use as pesticides |
| MY148880A (en) | 2006-10-20 | 2013-06-14 | Astrazeneca Ab | N-(2-hydroxyethyl)-n-methyl-4-(quinolin-8-yl(1-(thiazol-4-ylmethyl)piperidin-4-ylidene)methyl)benzamide, the process of making it as well as its use for the treatment of pain, anxiety and depression |
-
2007
- 2007-10-09 MY MYPI20091593A patent/MY148880A/en unknown
- 2007-10-18 TW TW096139052A patent/TW200826939A/zh unknown
- 2007-10-19 UY UY30652A patent/UY30652A1/es not_active Application Discontinuation
- 2007-10-19 US US11/875,014 patent/US7659286B2/en not_active Expired - Fee Related
- 2007-10-19 UA UAA200903085A patent/UA97648C2/ru unknown
- 2007-10-19 HR HRP20120344TT patent/HRP20120344T1/hr unknown
- 2007-10-19 BR BRPI0717631-7A patent/BRPI0717631A2/pt not_active IP Right Cessation
- 2007-10-19 CN CN2007800390975A patent/CN101528739B/zh not_active Expired - Fee Related
- 2007-10-19 PE PE2007001423A patent/PE20080892A1/es not_active Application Discontinuation
- 2007-10-19 CA CA2667041A patent/CA2667041C/en not_active Expired - Fee Related
- 2007-10-19 CL CL200703009A patent/CL2007003009A1/es unknown
- 2007-10-19 AR ARP070104641A patent/AR063345A1/es not_active Application Discontinuation
- 2007-10-19 MX MX2009003974A patent/MX2009003974A/es active IP Right Grant
- 2007-10-19 PL PL07835125T patent/PL2079735T3/pl unknown
- 2007-10-19 KR KR1020097007893A patent/KR20090065534A/ko not_active Ceased
- 2007-10-19 ES ES07835125T patent/ES2379519T3/es active Active
- 2007-10-19 DK DK07835125.1T patent/DK2079735T3/da active
- 2007-10-19 EP EP07835125A patent/EP2079735B1/en active Active
- 2007-10-19 JP JP2009533278A patent/JP4668346B2/ja not_active Expired - Fee Related
- 2007-10-19 AT AT07835125T patent/ATE543818T1/de active
- 2007-10-19 WO PCT/SE2007/000924 patent/WO2008048171A1/en not_active Ceased
- 2007-10-19 SI SI200730905T patent/SI2079735T1/sl unknown
- 2007-10-19 RU RU2009111337/04A patent/RU2454414C2/ru not_active IP Right Cessation
- 2007-10-19 NZ NZ577060A patent/NZ577060A/en not_active IP Right Cessation
- 2007-10-19 PT PT07835125T patent/PT2079735E/pt unknown
- 2007-10-19 AU AU2007313515A patent/AU2007313515B2/en not_active Ceased
- 2007-10-19 RS RS20120166A patent/RS52260B/sr unknown
- 2007-10-20 SA SA7280549A patent/SA07280549B1/ar unknown
-
2009
- 2009-03-26 IL IL197876A patent/IL197876A0/en unknown
- 2009-03-31 CO CO0903310009033100A patent/CO6180450A2/es not_active Application Discontinuation
- 2009-05-20 NO NO20091969A patent/NO20091969L/no not_active Application Discontinuation
- 2009-12-21 US US12/643,202 patent/US7977355B2/en not_active Expired - Fee Related
-
2010
- 2010-10-06 AU AU2010226996A patent/AU2010226996A1/en not_active Abandoned
-
2012
- 2012-04-25 CY CY20121100389T patent/CY1112718T1/el unknown
- 2012-07-24 PE PE2012001060A patent/PE20140634A1/es not_active Application Discontinuation
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2010506910A5 (https=) | ||
| JP4187274B2 (ja) | 新規化合物、それらの使用および調製 | |
| CA2725355C (en) | N-piperidinyl acetamide derivatives as calcium channel blockers | |
| JPWO2004046110A1 (ja) | メラニン凝集ホルモン受容体拮抗剤 | |
| JP2010538076A5 (https=) | ||
| JP2008500337A5 (https=) | ||
| JP2004503549A (ja) | 生体等配電子性ベンズアミド誘導体およびそのアポｂ−１００分泌阻害剤としての使用 | |
| AU2005272389B2 (en) | Novel cyclic aminobenzoic acid derivative | |
| JP2007519754A5 (https=) | ||
| JP3897594B2 (ja) | ミクロソームトリグリセリド輸送タンパク質およびアポリポタンパク質分泌の阻害剤として有用なカルボキサミド | |
| JP2005514373A5 (https=) | ||
| CA2417638A1 (en) | Carboxamide compounds and their use as antagonists of a human 11cby receptor | |
| FR2842804A1 (fr) | Derives de n-[phenyl(piperidin-2-yl)methyl]benzamide, leur preparation et leur application en therapeutique | |
| JPWO2008059854A1 (ja) | ピペリジン誘導体またはその塩 | |
| CA2667041A1 (en) | N-(2-hydroxyethyl)-n-methyl-4-(quinolin-8-yl(1-(thiazol-4-ylmethyl)piperidin-4-ylidene)methyl)benzamide, the process of making it as well as its use for the treatment of pain, anxiety and depression | |
| JP2013543850A5 (https=) | ||
| JP2008512470A5 (https=) | ||
| CA2909400A1 (en) | Dicarboxylic acid compound | |
| KR20130044240A (ko) | 페닐 카바메이트 화합물 및 이를 포함하는 근육 이완제 | |
| US20100179118A1 (en) | Cyclic aminoalkylcarboxamide derivative | |
| JP2005518363A5 (https=) | ||
| WO2008089436A3 (en) | Crystalline forms of histone deacetylase inhibitors | |
| JP2007520466A5 (https=) | ||
| CN108218947B (zh) | 一种含噻唑杂环的甾体衍生物及其制备方法与应用 | |
| JP2006516588A5 (https=) |