JP2013543850A5 - - Google Patents
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- Publication number
- JP2013543850A5 JP2013543850A5 JP2013538047A JP2013538047A JP2013543850A5 JP 2013543850 A5 JP2013543850 A5 JP 2013543850A5 JP 2013538047 A JP2013538047 A JP 2013538047A JP 2013538047 A JP2013538047 A JP 2013538047A JP 2013543850 A5 JP2013543850 A5 JP 2013543850A5
- Authority
- JP
- Japan
- Prior art keywords
- prolyl
- group
- methyl
- leucyl
- amidinophenyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 0 C*(C([C@](CCC1)*1C(O*(*)*)=O)=O)N Chemical compound C*(C([C@](CCC1)*1C(O*(*)*)=O)=O)N 0.000 description 7
- UZEKTDVGUQCDBI-UHFFFAOYSA-N CC(C)NC(N)=N Chemical compound CC(C)NC(N)=N UZEKTDVGUQCDBI-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201010535094.4A CN102464701B (zh) | 2010-11-08 | 2010-11-08 | 一类新型化合物、其制备方法及用途 |
| CN201010535094.4 | 2010-11-08 | ||
| PCT/CN2011/081811 WO2012062187A1 (zh) | 2010-11-08 | 2011-11-04 | 作为凝血酶抑制剂的脯氨酰胺衍生物、其制备方法及应用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013543850A JP2013543850A (ja) | 2013-12-09 |
| JP2013543850A5 true JP2013543850A5 (https=) | 2014-12-11 |
| JP6219720B2 JP6219720B2 (ja) | 2017-10-25 |
Family
ID=46050404
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013538047A Active JP6219720B2 (ja) | 2010-11-08 | 2011-11-04 | 新規な化合物、その製造方法および用途 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US9434760B2 (https=) |
| EP (3) | EP3466961B1 (https=) |
| JP (1) | JP6219720B2 (https=) |
| CN (1) | CN102464701B (https=) |
| WO (1) | WO2012062187A1 (https=) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103833827B (zh) * | 2012-11-27 | 2016-08-03 | 上海医药工业研究院 | 一种酰胺类化合物、其药物组合物、制备方法及应用 |
| HUE061437T2 (hu) | 2015-10-23 | 2023-06-28 | Navitor Pharm Inc | A Sestrin-GATOR2 kölcsönhatás modulátorai és ezek alkalmazásai |
| US10912750B2 (en) | 2017-04-26 | 2021-02-09 | Navitor Pharmaceuticals, Inc. | Modulators of Sestrin-GATOR2 interaction and uses thereof |
| CN112041328B (zh) * | 2018-04-26 | 2024-06-21 | 志瑞亚新药工业株式会社 | 二肽和含有该二肽的药物组合物 |
| CN113164414A (zh) | 2018-10-24 | 2021-07-23 | 纳维托制药有限公司 | 多晶型化合物和其用途 |
| EP3873916B8 (en) * | 2018-10-29 | 2025-03-26 | Shanghai Synergy Pharmaceutical Sciences, Ltd. | Novel dipeptide compounds and uses thereof |
| JP7693644B2 (ja) * | 2019-07-08 | 2025-06-17 | リゾルート，インコーポレイティド | 血漿カリクレイン阻害薬の調製プロセス |
| TN2022000028A1 (en) | 2019-08-06 | 2023-10-09 | Biocryst Pharm Inc | Process-scale synthesis of a plasma kallikrein inhibitor |
| CA3156436A1 (en) | 2019-11-01 | 2021-05-06 | Steven LEVENTER | Methods of treatment using an mtorc1 modulator |
| WO2024169765A1 (zh) * | 2023-02-16 | 2024-08-22 | 上海华汇拓医药科技有限公司 | 一种二肽类化合物的盐、其制备方法和用途 |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4101653A (en) | 1974-11-08 | 1978-07-18 | Mitsubishi Chemical Industries Limited | N2 -arylsulfonyl-argininamides and the pharmaceutically acceptable salts thereof |
| CA1161431A (en) * | 1979-05-11 | 1984-01-31 | Lars G. Svendsen | Tripeptide derivatives |
| HU178398B (en) | 1979-06-12 | 1982-04-28 | Gyogyszerkutato Intezet | Process for producing new agmatine derivatives of activity against haemagglutination |
| SE9103612D0 (sv) | 1991-12-04 | 1991-12-04 | Astra Ab | New peptide derivatives |
| US5583146A (en) * | 1992-12-02 | 1996-12-10 | Bristol-Myers Squibb Company | Heterocyclic thrombin inhibitors |
| SE9301916D0 (sv) * | 1993-06-03 | 1993-06-03 | Ab Astra | New peptides derivatives |
| AU1025795A (en) | 1994-01-27 | 1995-08-03 | Mitsubishi Chemical Corporation | Prolineamide derivatives |
| JP3840668B2 (ja) * | 1994-01-27 | 2006-11-01 | 三菱化学株式会社 | プロリンアミド誘導体 |
| ZA951617B (en) | 1994-03-04 | 1997-02-27 | Lilly Co Eli | Antithrombotic agents. |
| US5510369A (en) | 1994-07-22 | 1996-04-23 | Merck & Co., Inc. | Pyrrolidine thrombin inhibitors |
| CZ245797A3 (cs) * | 1995-02-17 | 1998-06-17 | Basf Aktiengesellschaft | Derivát amidinu dipeptidu jako inhibitor thrombinu |
| AU709088B2 (en) | 1995-10-24 | 1999-08-19 | Merck & Co., Inc. | Thrombin inhibitors |
| FI105274B (fi) | 1996-03-15 | 2000-07-14 | Upm Kymmene Oy | Menetelmä ei-hormonivaikutteisten, tyydyttymättömien kasvisteroidien hydraamiseksi ja käytetyn katalyytin regenerointi |
| EP1051431A1 (de) * | 1998-01-26 | 2000-11-15 | Basf Aktiengesellschaft | Thrombininhibitoren |
| CZ20013577A3 (cs) * | 1999-04-09 | 2002-07-17 | Basf Aktiengesellschaft | Inhibitory komplementních proteáz s nízkou molekulovou hmotností |
| DE10064797A1 (de) * | 2000-12-22 | 2002-06-27 | Knoll Ag | Orale und parenterale pharmazeutische Formulierung, umfassend eine niedermolekulare Thrombininhibitor-Pro-Pharmakon |
| HUP0304058A2 (hu) * | 2001-01-30 | 2004-04-28 | Bristol-Myers Squibb Company | Xa faktor szulfonamid-laktám inhibitorok és alkalmazásuk és ezeket tartalmazó gyógyszerkészítmények |
| WO2008076415A1 (en) * | 2006-12-14 | 2008-06-26 | Exelixis, Inc. | Methods of using mek inhibitors |
-
2010
- 2010-11-08 CN CN201010535094.4A patent/CN102464701B/zh active Active
-
2011
- 2011-11-04 JP JP2013538047A patent/JP6219720B2/ja active Active
- 2011-11-04 EP EP18208270.1A patent/EP3466961B1/en active Active
- 2011-11-04 WO PCT/CN2011/081811 patent/WO2012062187A1/zh not_active Ceased
- 2011-11-04 EP EP11839747.0A patent/EP2639230A4/en active Pending
- 2011-11-04 EP EP14183844.1A patent/EP2824097A1/en not_active Withdrawn
- 2011-11-04 US US13/884,196 patent/US9434760B2/en active Active
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