JP2010504102A5 - - Google Patents
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- JP2010504102A5 JP2010504102A5 JP2009529373A JP2009529373A JP2010504102A5 JP 2010504102 A5 JP2010504102 A5 JP 2010504102A5 JP 2009529373 A JP2009529373 A JP 2009529373A JP 2009529373 A JP2009529373 A JP 2009529373A JP 2010504102 A5 JP2010504102 A5 JP 2010504102A5
- Authority
- JP
- Japan
- Prior art keywords
- hsa
- mir
- mirna
- expression
- pancreatic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 238000000034 method Methods 0.000 claims description 63
- 230000014509 gene expression Effects 0.000 claims description 42
- 239000000523 sample Substances 0.000 claims description 31
- 108091070501 miRNA Proteins 0.000 claims description 25
- 239000002679 microRNA Substances 0.000 claims description 24
- 201000008129 pancreatic ductal adenocarcinoma Diseases 0.000 claims description 15
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims description 14
- 238000003556 assay Methods 0.000 claims description 14
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims description 14
- 201000002528 pancreatic cancer Diseases 0.000 claims description 14
- 208000008443 pancreatic carcinoma Diseases 0.000 claims description 14
- 238000009396 hybridization Methods 0.000 claims description 11
- 230000003321 amplification Effects 0.000 claims description 10
- 238000003199 nucleic acid amplification method Methods 0.000 claims description 10
- 210000001519 tissue Anatomy 0.000 claims description 9
- 206010033645 Pancreatitis Diseases 0.000 claims description 7
- 230000003247 decreasing effect Effects 0.000 claims description 3
- 239000011324 bead Substances 0.000 claims description 2
- 210000004369 blood Anatomy 0.000 claims description 2
- 239000008280 blood Substances 0.000 claims description 2
- 239000011521 glass Substances 0.000 claims description 2
- 239000004816 latex Substances 0.000 claims description 2
- 229920000126 latex Polymers 0.000 claims description 2
- 239000002184 metal Substances 0.000 claims description 2
- 210000001819 pancreatic juice Anatomy 0.000 claims description 2
- 210000002381 plasma Anatomy 0.000 claims description 2
- 239000004033 plastic Substances 0.000 claims description 2
- 210000002966 serum Anatomy 0.000 claims description 2
- -1 hsa-let-7f Proteins 0.000 claims 4
- 108091067465 Homo sapiens miR-217 stem-loop Proteins 0.000 claims 3
- 108091070365 Homo sapiens miR-30a stem-loop Proteins 0.000 claims 2
- 108091065436 Homo sapiens miR-30e stem-loop Proteins 0.000 claims 2
- 108091070514 Homo sapiens let-7b stem-loop Proteins 0.000 claims 1
- 108091070511 Homo sapiens let-7c stem-loop Proteins 0.000 claims 1
- 108091070512 Homo sapiens let-7d stem-loop Proteins 0.000 claims 1
- 108091069046 Homo sapiens let-7g stem-loop Proteins 0.000 claims 1
- 108091069047 Homo sapiens let-7i stem-loop Proteins 0.000 claims 1
- 108091068853 Homo sapiens miR-100 stem-loop Proteins 0.000 claims 1
- 108091068928 Homo sapiens miR-107 stem-loop Proteins 0.000 claims 1
- 108091069094 Homo sapiens miR-134 stem-loop Proteins 0.000 claims 1
- 108091069017 Homo sapiens miR-140 stem-loop Proteins 0.000 claims 1
- 108091068991 Homo sapiens miR-141 stem-loop Proteins 0.000 claims 1
- 108091068992 Homo sapiens miR-143 stem-loop Proteins 0.000 claims 1
- 108091069002 Homo sapiens miR-145 stem-loop Proteins 0.000 claims 1
- 108091069088 Homo sapiens miR-150 stem-loop Proteins 0.000 claims 1
- 108091068955 Homo sapiens miR-154 stem-loop Proteins 0.000 claims 1
- 108091065981 Homo sapiens miR-155 stem-loop Proteins 0.000 claims 1
- 108091067627 Homo sapiens miR-182 stem-loop Proteins 0.000 claims 1
- 108091068956 Homo sapiens miR-186 stem-loop Proteins 0.000 claims 1
- 108091070493 Homo sapiens miR-21 stem-loop Proteins 0.000 claims 1
- 108091067468 Homo sapiens miR-210 stem-loop Proteins 0.000 claims 1
- 108091067580 Homo sapiens miR-214 stem-loop Proteins 0.000 claims 1
- 108091067572 Homo sapiens miR-221 stem-loop Proteins 0.000 claims 1
- 108091067573 Homo sapiens miR-222 stem-loop Proteins 0.000 claims 1
- 108091069527 Homo sapiens miR-223 stem-loop Proteins 0.000 claims 1
- 108091069517 Homo sapiens miR-224 stem-loop Proteins 0.000 claims 1
- 108091070395 Homo sapiens miR-31 stem-loop Proteins 0.000 claims 1
- 108091066896 Homo sapiens miR-331 stem-loop Proteins 0.000 claims 1
- 108091066985 Homo sapiens miR-335 stem-loop Proteins 0.000 claims 1
- 108091067535 Homo sapiens miR-375 stem-loop Proteins 0.000 claims 1
- 108091067243 Homo sapiens miR-377 stem-loop Proteins 0.000 claims 1
- 108091067552 Homo sapiens miR-379 stem-loop Proteins 0.000 claims 1
- 108091032930 Homo sapiens miR-429 stem-loop Proteins 0.000 claims 1
- 108091032542 Homo sapiens miR-452 stem-loop Proteins 0.000 claims 1
- 108091092307 Homo sapiens miR-494 stem-loop Proteins 0.000 claims 1
- 108091092303 Homo sapiens miR-497 stem-loop Proteins 0.000 claims 1
- 108091070377 Homo sapiens miR-93 stem-loop Proteins 0.000 claims 1
- 108091070375 Homo sapiens miR-95 stem-loop Proteins 0.000 claims 1
- 108091070376 Homo sapiens miR-96 stem-loop Proteins 0.000 claims 1
- 108091007773 MIR100 Proteins 0.000 claims 1
- 108091008065 MIR21 Proteins 0.000 claims 1
- 108091007772 MIRLET7C Proteins 0.000 claims 1
- 108091028141 MiR-203 Proteins 0.000 claims 1
- 108091062154 Mir-205 Proteins 0.000 claims 1
- 108091064378 miR-196b stem-loop Proteins 0.000 claims 1
- 150000007523 nucleic acids Chemical class 0.000 description 15
- 208000000668 Chronic Pancreatitis Diseases 0.000 description 11
- 206010033649 Pancreatitis chronic Diseases 0.000 description 11
- 210000004923 pancreatic tissue Anatomy 0.000 description 11
- 108091054189 miR-196a stem-loop Proteins 0.000 description 10
- 230000001575 pathological effect Effects 0.000 description 10
- 108091035328 miR-217 stem-loop Proteins 0.000 description 8
- 108091039135 miR-217-1 stem-loop Proteins 0.000 description 8
- 108091029206 miR-217-2 stem-loop Proteins 0.000 description 8
- 108020004707 nucleic acids Proteins 0.000 description 8
- 102000039446 nucleic acids Human genes 0.000 description 8
- 238000003762 quantitative reverse transcription PCR Methods 0.000 description 8
- 108091032973 (ribonucleotides)n+m Proteins 0.000 description 7
- 108091028043 Nucleic acid sequence Proteins 0.000 description 7
- 238000006243 chemical reaction Methods 0.000 description 7
- 239000003153 chemical reaction reagent Substances 0.000 description 7
- 239000003112 inhibitor Substances 0.000 description 4
- 238000002372 labelling Methods 0.000 description 4
- 210000000496 pancreas Anatomy 0.000 description 4
- 108090000623 proteins and genes Proteins 0.000 description 4
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 description 3
- 102100031181 Glyceraldehyde-3-phosphate dehydrogenase Human genes 0.000 description 3
- 108020004445 glyceraldehyde-3-phosphate dehydrogenase Proteins 0.000 description 3
- 230000037452 priming Effects 0.000 description 3
- 238000003753 real-time PCR Methods 0.000 description 3
- 238000000926 separation method Methods 0.000 description 3
- 239000013598 vector Substances 0.000 description 3
- 101710124239 Poly(A) polymerase Proteins 0.000 description 2
- 238000004458 analytical method Methods 0.000 description 2
- 108020004999 messenger RNA Proteins 0.000 description 2
- 108091092825 miR-24 stem-loop Proteins 0.000 description 2
- 108091032978 miR-24-3 stem-loop Proteins 0.000 description 2
- 108091064025 miR-24-4 stem-loop Proteins 0.000 description 2
- 239000013610 patient sample Substances 0.000 description 2
- 238000000513 principal component analysis Methods 0.000 description 2
- 108020005075 5S Ribosomal RNA Proteins 0.000 description 1
- 206010052747 Adenocarcinoma pancreas Diseases 0.000 description 1
- 102100021663 Baculoviral IAP repeat-containing protein 5 Human genes 0.000 description 1
- 108010067225 Cell Adhesion Molecules Proteins 0.000 description 1
- 108010008699 Mucin-4 Proteins 0.000 description 1
- 102000007270 Mucin-4 Human genes 0.000 description 1
- 208000016222 Pancreatic disease Diseases 0.000 description 1
- 108010002687 Survivin Proteins 0.000 description 1
- 102000004504 Urokinase Plasminogen Activator Receptors Human genes 0.000 description 1
- 108010042352 Urokinase Plasminogen Activator Receptors Proteins 0.000 description 1
- 239000011543 agarose gel Substances 0.000 description 1
- 150000001412 amines Chemical class 0.000 description 1
- 239000000427 antigen Substances 0.000 description 1
- 108091007433 antigens Proteins 0.000 description 1
- 102000036639 antigens Human genes 0.000 description 1
- 102000008395 cell adhesion mediator activity proteins Human genes 0.000 description 1
- 238000002512 chemotherapy Methods 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- ZMMJGEGLRURXTF-UHFFFAOYSA-N ethidium bromide Chemical compound [Br-].C12=CC(N)=CC=C2C2=CC=C(N)C=C2[N+](CC)=C1C1=CC=CC=C1 ZMMJGEGLRURXTF-UHFFFAOYSA-N 0.000 description 1
- 229960005542 ethidium bromide Drugs 0.000 description 1
- 238000003633 gene expression assay Methods 0.000 description 1
- 238000009169 immunotherapy Methods 0.000 description 1
- 210000004153 islets of langerhan Anatomy 0.000 description 1
- 238000003253 miRNA assay Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000010606 normalization Methods 0.000 description 1
- 125000003729 nucleotide group Chemical group 0.000 description 1
- 201000002094 pancreatic adenocarcinoma Diseases 0.000 description 1
- 239000013600 plasmid vector Substances 0.000 description 1
- 238000004393 prognosis Methods 0.000 description 1
- 238000001959 radiotherapy Methods 0.000 description 1
- 239000000985 reactive dye Substances 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 238000003757 reverse transcription PCR Methods 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 230000008685 targeting Effects 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 239000013603 viral vector Substances 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US82617306P | 2006-09-19 | 2006-09-19 | |
| US60/826,173 | 2006-09-19 | ||
| PCT/US2007/078936 WO2008036765A2 (en) | 2006-09-19 | 2007-09-19 | Micrornas differentially expressed in pancreatic diseases and uses thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010504102A JP2010504102A (ja) | 2010-02-12 |
| JP2010504102A5 true JP2010504102A5 (https=) | 2011-11-24 |
| JP5520605B2 JP5520605B2 (ja) | 2014-06-11 |
Family
ID=38947406
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009529373A Active JP5520605B2 (ja) | 2006-09-19 | 2007-09-19 | 膵臓疾患で差次的に発現されるマイクロｒｎａおよびその使用 |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US20090131348A1 (https=) |
| EP (2) | EP2487240B1 (https=) |
| JP (1) | JP5520605B2 (https=) |
| AU (1) | AU2007299828C1 (https=) |
| CA (1) | CA2664383C (https=) |
| IL (1) | IL197690A0 (https=) |
| WO (1) | WO2008036765A2 (https=) |
Families Citing this family (132)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2290073A3 (en) | 2004-05-28 | 2011-08-31 | Asuragen, Inc. | Methods and compositions involving microRNA |
| EP2302055B1 (en) | 2004-11-12 | 2014-08-27 | Asuragen, Inc. | Methods and compositions involving miRNA and miRNA inhibitor molecules |
| CN103820562B (zh) * | 2005-08-01 | 2015-05-13 | 俄亥俄州立大学研究基金会 | 用于乳腺癌的诊断、预后和治疗的基于MicroRNA的方法和组合物 |
| JP2009507918A (ja) * | 2005-09-12 | 2009-02-26 | ジ・オハイオ・ステイト・ユニバーシティ・リサーチ・ファウンデイション | Ｂｃｌ２関連癌の診断及び療法のための組成物及び方法 |
| US20090270484A1 (en) * | 2005-10-05 | 2009-10-29 | The Ohio State University Research Foundation | WWOX Vectors and Uses in Treatment of Cancer |
| EP1969147B1 (en) | 2006-01-05 | 2014-07-30 | The Ohio State University Research Foundation | microRNA-based methods for the diagnosis of stomach cancer |
| US7670840B2 (en) | 2006-01-05 | 2010-03-02 | The Ohio State University Research Foundation | Micro-RNA expression abnormalities of pancreatic, endocrine and acinar tumors |
| ES2553442T3 (es) | 2006-01-05 | 2015-12-09 | The Ohio State University Research Foundation | Procedimientos basados en los microARN para el diagnóstico, pronóstico y tratamiento del cáncer de pulmón |
| EP2369011A1 (en) | 2006-03-20 | 2011-09-28 | The Ohio State University Research Foundation | Microrna fingerprints during human megakaryocytopoiesis |
| EP2041317A4 (en) | 2006-07-13 | 2009-10-14 | Univ Ohio State Res Found | METHODS AND COMPOSITIONS BASED ON MICRO-RNA FOR THE DIAGNOSIS AND TREATMENT OF COLON CANCER RELATED DISEASES |
| EP2061907B1 (en) | 2006-09-19 | 2011-11-23 | The Ohio State University Research Foundation | Tcl1 expression in chronic lymphocytic leukemia (cll) regulated by mir-29 and mir-181 |
| US8252538B2 (en) | 2006-11-01 | 2012-08-28 | The Ohio State University | MicroRNA expression signature for predicting survival and metastases in hepatocellular carcinoma |
| US20080131878A1 (en) * | 2006-12-05 | 2008-06-05 | Asuragen, Inc. | Compositions and Methods for the Detection of Small RNA |
| CA2671270A1 (en) * | 2006-12-29 | 2008-07-17 | Asuragen, Inc. | Mir-16 regulated genes and pathways as targets for therapeutic intervention |
| WO2008094545A2 (en) * | 2007-01-31 | 2008-08-07 | The Ohio State University Research Foundation | Mic orna-based methods and compositions for the treatment of acute myeloid leukemia |
| AU2008248319B2 (en) * | 2007-04-30 | 2013-09-05 | The Ohio State University Research Foundation | Methods for differentiating pancreatic cancer from normal pancreatic function and/or chronic pancreatitis |
| US20090232893A1 (en) * | 2007-05-22 | 2009-09-17 | Bader Andreas G | miR-143 REGULATED GENES AND PATHWAYS AS TARGETS FOR THERAPEUTIC INTERVENTION |
| WO2008147974A1 (en) | 2007-05-23 | 2008-12-04 | University Of South Florida | Micro-rnas modulating immunity and inflammation |
| US20090099034A1 (en) * | 2007-06-07 | 2009-04-16 | Wisconsin Alumni Research Foundation | Reagents and Methods for miRNA Expression Analysis and Identification of Cancer Biomarkers |
| ES2537349T3 (es) * | 2007-06-08 | 2015-06-05 | The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Métodos para determinar un subtipo de carcinoma hepatocelular |
| CN101918424A (zh) | 2007-06-15 | 2010-12-15 | 俄亥俄州立大学研究基金会 | 用于靶向由Drosha介导的微小RNA加工的致癌ALL-1融合蛋白 |
| CN101809169B (zh) * | 2007-07-31 | 2013-07-17 | 俄亥俄州立大学研究基金会 | 通过靶向dnmt3a和dnmt3b恢复甲基化的方法 |
| EP2653561B1 (en) * | 2007-08-03 | 2016-03-02 | The Ohio State University Research Foundation | Ultraconserved regions encoding ncRNAs |
| EP3028708A1 (en) * | 2007-08-22 | 2016-06-08 | The Ohio State University Research Foundation | Methods and compositions for inducing deregulation of epha7 and erk phosphorylation in human acute leukemias |
| EP2212440A4 (en) * | 2007-10-11 | 2011-04-06 | Univ Ohio State Res Found | METHOD AND COMPOSITIONS FOR DIAGNOSIS AND TREATMENT OF ADENOCARCINOMES OF DISHES |
| CA2703707A1 (en) | 2007-10-26 | 2009-04-30 | The Ohio State University Research Foundation | Methods for identifying fragile histidine triad (fhit) interaction and uses thereof |
| US8895525B2 (en) * | 2007-10-29 | 2014-11-25 | University Of Southern California | Preventing hyaluronan-mediated tumorigenetic mechanisms using intronic RNAs |
| CN101918594A (zh) * | 2007-11-30 | 2010-12-15 | 俄亥俄州立大学研究基金会 | 肺癌中外周血中的微rna表达特征谱和靶向 |
| CA2717026A1 (en) * | 2008-02-28 | 2009-09-03 | The Ohio State University Research Foundation | Microrna signatures associated with human chronic lymphocytic leukemia (ccl) and uses thereof |
| CN102027129B (zh) * | 2008-02-28 | 2014-03-12 | 俄亥俄州立大学研究基金会 | 用于前列腺相关病症的诊断、预后和治疗的基于微rna的方法和组合物 |
| US20110143360A1 (en) | 2008-04-30 | 2011-06-16 | Nec Corporation | Cancer marker, method for evaluation of cancer by using the cancer marker, and evaluation reagent |
| US20110160290A1 (en) * | 2008-05-21 | 2011-06-30 | Muneesh Tewari | Use of extracellular rna to measure disease |
| EP2294218A2 (en) * | 2008-06-02 | 2011-03-16 | New York University | Compositions and methods for diagnosis, prognosis and treatment of mesothelioma |
| EP2307028B1 (en) | 2008-06-11 | 2013-10-02 | The Government of the United States of America as represented by The Secretary of the Department of Health and Human Services | Use of mir-26 family as a predictive marker of hepatocellular carcinoma and responsiveness to therapy |
| KR101043433B1 (ko) * | 2008-07-18 | 2011-06-22 | 국립암센터 | 마이크로ｒｎａ분자를 포함하는 항암 조성물 |
| US9347089B2 (en) | 2008-09-19 | 2016-05-24 | Children's Medical Center Corporation | Therapeutic and diagnostic strategies |
| EP2191834A1 (en) * | 2008-11-26 | 2010-06-02 | Centre National De La Recherche Scientifique (Cnrs) | Compositions and methods for treating retrovirus infections |
| CN101475984A (zh) | 2008-12-15 | 2009-07-08 | 江苏命码生物科技有限公司 | 一种非小细胞肺癌检测标记物及其检测方法、相关生物芯片和试剂盒 |
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| EP2910650A1 (en) | 2009-08-24 | 2015-08-26 | National University Corporation Kanazawa University | Detection of colorectal cancer by gene expression profiling |
| JPWO2011024918A1 (ja) * | 2009-08-26 | 2013-01-31 | 国立大学法人大阪大学 | 血管新生抑制剤及び血管新生抑制方法 |
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| AU2010321555B2 (en) | 2009-11-23 | 2015-10-15 | The Ohio State University | Materials and methods useful for affecting tumor cell growth, migration and invasion |
| DK3150721T3 (da) | 2009-12-24 | 2019-07-01 | Micromedmark Biotech Co Ltd | Pankreascancermarkører og detekteringsfremgangsmåder |
| WO2011106104A2 (en) * | 2010-02-26 | 2011-09-01 | Memorial Sloan-Kettering Cancer Center | Methods and compositions for the detection and treatment of cancer involving mirnas and mirna inhibitors and targets |
| EP3181692A1 (en) * | 2010-05-07 | 2017-06-21 | Centre National De La Recherche Scientifique | Ucp1 (thermogenin) - inducing agents for use in the treatment of a disorder of the energy homeostasis |
| WO2012020308A2 (en) * | 2010-08-13 | 2012-02-16 | The University Court Of The University Of Glasgow | Cellular and molecular therapies |
| EP2627766B1 (en) | 2010-10-17 | 2016-05-25 | Yeda Research and Development Co. Ltd. | Methods and compositions for the treatment of insulin-associated medical conditions |
| ES2606146T3 (es) | 2010-11-12 | 2017-03-22 | The Ohio State University Research Foundation | Métodos relacionados con microARN-21 y reparación de desapareamiento en cáncer colorrectal |
| CN103313706A (zh) | 2010-11-15 | 2013-09-18 | 俄亥俄州立大学研究基金会 | 控制释放粘膜粘合系统 |
| BR112013012265A2 (pt) | 2010-11-17 | 2016-08-02 | Asuragen Inc | mirnas como biomarcadores para distinguir neoplasmas de tireoide benignos de malignos |
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| US8664192B2 (en) | 2011-03-07 | 2014-03-04 | The Ohio State University | Mutator activity induced by microRNA-155 (miR-155) links inflammation and cancer |
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2007
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- 2007-09-19 WO PCT/US2007/078936 patent/WO2008036765A2/en not_active Ceased
- 2007-09-19 EP EP12159733.0A patent/EP2487240B1/en not_active Not-in-force
- 2007-09-19 CA CA2664383A patent/CA2664383C/en not_active Expired - Fee Related
- 2007-09-19 JP JP2009529373A patent/JP5520605B2/ja active Active
- 2007-09-19 EP EP07842816A patent/EP2115138A2/en not_active Withdrawn
- 2007-09-19 AU AU2007299828A patent/AU2007299828C1/en not_active Ceased
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2009
- 2009-03-19 IL IL197690A patent/IL197690A0/en unknown
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2018
- 2018-03-12 US US15/917,935 patent/US20190330623A1/en not_active Abandoned
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