JP2010502582A5 - - Google Patents

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Publication number
JP2010502582A5
JP2010502582A5 JP2009526177A JP2009526177A JP2010502582A5 JP 2010502582 A5 JP2010502582 A5 JP 2010502582A5 JP 2009526177 A JP2009526177 A JP 2009526177A JP 2009526177 A JP2009526177 A JP 2009526177A JP 2010502582 A5 JP2010502582 A5 JP 2010502582A5
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JP
Japan
Prior art keywords
alkyl
substituted
aryl
alkynyl
alkenyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2009526177A
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English (en)
Japanese (ja)
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JP2010502582A (ja
JP5506386B2 (ja
Filing date
Publication date
Priority claimed from GB0617278A external-priority patent/GB0617278D0/en
Priority claimed from GB0625929A external-priority patent/GB0625929D0/en
Application filed filed Critical
Priority claimed from PCT/GB2007/003302 external-priority patent/WO2008029096A2/en
Publication of JP2010502582A publication Critical patent/JP2010502582A/ja
Publication of JP2010502582A5 publication Critical patent/JP2010502582A5/ja
Application granted granted Critical
Publication of JP5506386B2 publication Critical patent/JP5506386B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

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JP2009526177A 2006-09-04 2007-09-04 Ｐ５３活性化化合物 Expired - Fee Related JP5506386B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GB0617278.7 2006-09-04
GB0617278A GB0617278D0 (en) 2006-09-04 2006-09-04 P53 activating compounds
GB0625929A GB0625929D0 (en) 2006-12-23 2006-12-23 P53 activating compounds
GB0625929.5 2006-12-23
PCT/GB2007/003302 WO2008029096A2 (en) 2006-09-04 2007-09-04 P53 activating benzoyl urea and benzoyl thiourea compounds

Publications (3)

Publication Number Publication Date
JP2010502582A JP2010502582A (ja) 2010-01-28
JP2010502582A5 true JP2010502582A5 (https=) 2010-10-21
JP5506386B2 JP5506386B2 (ja) 2014-05-28

Family

ID=38819391

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2009526177A Expired - Fee Related JP5506386B2 (ja) 2006-09-04 2007-09-04 Ｐ５３活性化化合物

Country Status (6)

Country Link
US (2) US8501991B2 (https=)
EP (1) EP2099445B1 (https=)
JP (1) JP5506386B2 (https=)
AT (1) ATE488232T1 (https=)
DE (1) DE602007010664D1 (https=)
WO (1) WO2008029096A2 (https=)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK2118123T3 (en) * 2007-01-31 2016-01-25 Dana Farber Cancer Inst Inc Stabilized p53 peptides and uses thereof
US8580488B2 (en) * 2007-02-05 2013-11-12 City Of Hope Cell culture model for acquired chemoresistance of chronic myelogenous leukemia and related methods for identifying agents to overcome resistance
US8952028B2 (en) 2007-02-05 2015-02-10 City Of Hope Methods of treating chemoresistance and relapse in cancer cells
US8592377B2 (en) 2007-03-28 2013-11-26 President And Fellows Of Harvard College Stitched polypeptides
US20100137345A1 (en) * 2007-05-14 2010-06-03 Universite Libre De Bruxelles Prophylactic and therapeutic use of sirtuin inhibitors in tnf-alpha mediated pathologies
FR2930552B1 (fr) * 2008-04-24 2012-10-12 Centre Nat Rech Scient N-acylthiourees et n-acylurees inhibiteurs de la voie de signalisation des proteines hedgehog
WO2011022028A2 (en) * 2009-05-18 2011-02-24 Tufts University Small molecule antagonists of phosphatidylinositol-3, 4, 5-triphosphate (pip3) and uses thereof
GB0909912D0 (en) 2009-06-09 2009-07-22 Univ Dundee Compounds
US9233087B2 (en) 2010-02-19 2016-01-12 Siga Technologies, Inc Inhibitors and methods of inhibiting bacterial and viral pathogens
ES2711526T3 (es) 2010-08-13 2019-05-06 Aileron Therapeutics Inc Macrociclos peptidomiméticos
US10016414B2 (en) 2010-11-12 2018-07-10 University Of Massachusetts Modulation of ubiquitination of synaptic proteins for the treatment of neurodegenerative and psychiatric disorders
FR2980477B1 (fr) * 2011-09-23 2013-10-18 Centre Nat Rech Scient Nouveaux composes modulateurs de la voie de signalisation des proteines hedgehog, leurs formes marquees, et applications
TW201806968A (zh) 2011-10-18 2018-03-01 艾利倫治療公司 擬肽巨環化合物
BR112014020103A2 (pt) 2012-02-15 2018-10-09 Aileron Therapeutics, Inc. macrociclos peptidomiméticos
EP2819688A4 (en) 2012-02-15 2015-10-28 Aileron Therapeutics Inc TRIAZOL AND THIOETHER-COUPLED PEPTIDOMIMETIC MACROCYCLES
WO2014071241A1 (en) 2012-11-01 2014-05-08 Aileron Therapeutics, Inc. Disubstituted amino acids and methods of preparation and use thereof
CN105392788B (zh) 2013-05-13 2018-10-23 葛兰素史密斯克莱有限责任公司 用作沉默调节蛋白调节剂的取代的桥连脲类似物
EP3197478A4 (en) 2014-09-24 2018-05-30 Aileron Therapeutics, Inc. Peptidomimetic macrocycles and uses thereof
AU2015320545C1 (en) 2014-09-24 2020-05-14 Aileron Therapeutics, Inc. Peptidomimetic macrocycles and formulations thereof
WO2016154058A1 (en) 2015-03-20 2016-09-29 Aileron Therapeutics, Inc. Peptidomimetic macrocycles and uses thereof
WO2017044633A1 (en) 2015-09-10 2017-03-16 Aileron Therapeutics, Inc. Peptidomimetic macrocycles as modulators of mcl-1
CN115724780B (zh) * 2022-11-17 2024-04-26 武汉大学 一种基于疏水标签的酰基硫脲类化合物及其制备方法与抗甲型流感病毒的应用
CN117069631A (zh) * 2023-08-15 2023-11-17 北京中医药大学 一种具有抗肿瘤活性的新型硫脲类化合物及其制备方法与应用

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3369979D1 (en) * 1983-01-24 1987-04-09 Duphar Int Res Benzoylurea compounds, and pesticidal compositions comprising same
EP0116728B1 (en) * 1983-01-24 1987-08-12 Duphar International Research B.V Composition active against mites, whitefly and thrips, pharmaceutical composition, and new benzoylureau compounds
ATE43788T1 (de) * 1983-09-01 1989-06-15 Duphar Int Res Benzoylharnstoffe mit antitumoraler wirkung.
IE860511L (en) * 1985-03-01 1986-09-01 Alfa Farmaceutici Spa "Benzoyl urea derivatives having anti-tumor activity"
AU642524B2 (en) 1990-09-10 1993-10-21 Duphar International Research B.V. Pharmaceutical formulation containing a benzoyl urea derivative
JPH05247001A (ja) * 1991-12-05 1993-09-24 Ishihara Sangyo Kaisha Ltd 置換ベンゾイルウレア誘導体又はその塩、それらの製造方法及びそれらを含有する抗癌剤
KR950026862A (ko) * 1994-03-15 1995-10-16 강박광 벤조일 우레아 유도체
JPH07285952A (ja) * 1994-04-08 1995-10-31 Fujisawa Pharmaceut Co Ltd 新規複素環誘導体
US20060004085A1 (en) 2002-03-29 2006-01-05 University Of Maryland , Baltimore Inhibitors of the S100-p53 protein-protein interaction and method of inhibiting cancer employing the same
AU2003257300B2 (en) * 2002-08-07 2010-01-21 Neuraxon Inc. Amino benzothiazole compounds with NOS inhibitory activity
US7087761B2 (en) * 2003-01-07 2006-08-08 Hoffmann-La Roche Inc. Cyclization process for substituted benzothiazole derivatives
TW200600492A (en) 2004-05-18 2006-01-01 Achillion Pharmaceuticals Inc Substituted aryl acylthioureas and related compounds; inhibitors of viral replication
WO2006110762A2 (en) * 2005-04-11 2006-10-19 Achillion Pharmaceutical compositions for and methods of inhibiting hcv replication

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