KR950026862A - 벤조일 우레아 유도체 - Google Patents

벤조일 우레아 유도체 Download PDF

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Publication number
KR950026862A
KR950026862A KR1019950004499A KR19950004499A KR950026862A KR 950026862 A KR950026862 A KR 950026862A KR 1019950004499 A KR1019950004499 A KR 1019950004499A KR 19950004499 A KR19950004499 A KR 19950004499A KR 950026862 A KR950026862 A KR 950026862A
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KR
South Korea
Prior art keywords
group
linear
structural formula
hydrogen atom
following structural
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KR1019950004499A
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English (en)
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황기준
박경호
이정옥
최상운
Original Assignee
강박광
재단법인 한국화학연구소
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Publication of KR950026862A publication Critical patent/KR950026862A/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/18—One oxygen or sulfur atom
    • C07D231/20—One oxygen atom attached in position 3 or 5
    • C07D231/22—One oxygen atom attached in position 3 or 5 with aryl radicals attached to ring nitrogen atoms
    • C07D231/26—1-Phenyl-3-methyl-5- pyrazolones, unsubstituted or substituted on the phenyl ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/18—One oxygen or sulfur atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/18—One oxygen or sulfur atom
    • C07D231/20—One oxygen atom attached in position 3 or 5
    • C07D231/22—One oxygen atom attached in position 3 or 5 with aryl radicals attached to ring nitrogen atoms

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

본 발명은 항종양제로서 암세포의 성장 억제효과를 갖는 다음 구조식(I)로 표시되는 피라졸을 함유한 벤조일 우레아 유도체에 관한 것이다.
상기식에서, R과 R2는 서로 같거나 다른 것으로서, 각각 수소원자; 플루오르, 클로로 및 브로모 중에서 선택되는 한개 이상의 할로겐 원자; C1~C6의 직쇄상 또는 분쇄상의 알콕시가; 또는 니트로기이며, R1은 수소원자; 또는 C1~C6의 직쇄 또는 분쇄상의 알킬기이고, W, X 및 Y는 서로 같거나 다른 것으로서, 각각 수소원자; 할로겐원자; 할로알킬기; C1~C6의 직쇄 또는 분쇄상의 알킬기; 또는 페닐기 또는 할로겐원자, 알킬기 또는 할로알킬기로 치환된 페닐기이고, Z는 산소 또는 황원자이다.

Description

벤조일 우레아 유도체
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (3)

  1. 항종양제로 유용한 다음 구조식(I)로 표시되는 벤조일 우레아 유도체.
    상기식에서, R과 R2는 서로 같거나 다른 것으로서, 각각 수소원자; 플루오르, 클로로 및 브로모 중에서 선택되는 한개 이상의 할로겐 원자; C1~C6의 직쇄상 또는 분쇄상의 알콕시기; 또는 니트로기이며, R1은 수소원자; 또는 C1~C6의 직쇄 또는 분쇄상의 알킬기이고, W, X 및 Y는 서로 같거나 다른 것으로서, 각각 수소원자; 할로겐원자; 할로알킬기; C1~C6의 직쇄 또는 분쇄상의 알킬기; 또는 페닐기 또는 할로겐원자, 알킬기 또는 할로알킬기로 치환된 페닐기이고, Z는 산소 또는 황원자이다.
  2. 다음 구조식(I)로 표시되는 벤조일 우레아 유도체의 도입기로 유용한 다음 구조식(IV-b)로 표시되는 아닐린 유도체.
    상기식에서, R,R1,R2,W,X,Y 및 Z는 각각 상기 청구범위 1항에서 정의한 바와 같다.
  3. 다음 구조식(I)로 표시되는 벤조일 우레아 유도체의 도입기로 유용한 다음 구조식(IV-c)로 표시되는 아닐린 유도체.
    상기식에서, R,R1,R2,W,X,Y 및 Z는 각각 상기 청구범위 1항에서 정의한 바와 같다.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019950004499A 1994-03-15 1995-03-06 벤조일 우레아 유도체 KR950026862A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR94-5089 1994-03-15
KR19940005089 1994-03-15

Publications (1)

Publication Number Publication Date
KR950026862A true KR950026862A (ko) 1995-10-16

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ID=19378898

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019950004499A KR950026862A (ko) 1994-03-15 1995-03-06 벤조일 우레아 유도체

Country Status (3)

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KR (1) KR950026862A (ko)
AU (1) AU1961895A (ko)
WO (1) WO1995025096A1 (ko)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE488232T1 (de) 2006-09-04 2010-12-15 Univ Dundee P53 aktivierende benzoylharnstoff- und benzoylthioharnstoff-verbindungen
GB0909912D0 (en) 2009-06-09 2009-07-22 Univ Dundee Compounds

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0262560A3 (en) * 1986-09-29 1989-07-05 Ishihara Sangyo Kaisha, Ltd. Benzoyl urea compound
NZ234551A (en) * 1989-07-28 1991-10-25 Ishihara Sangyo Kaisha Benzoylurea derivatives and antitumour compositions
JPH05247001A (ja) * 1991-12-05 1993-09-24 Ishihara Sangyo Kaisha Ltd 置換ベンゾイルウレア誘導体又はその塩、それらの製造方法及びそれらを含有する抗癌剤

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WO1995025096A1 (en) 1995-09-21
AU1961895A (en) 1995-10-03

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