JP2010502582A5 - - Google Patents

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Publication number
JP2010502582A5
JP2010502582A5 JP2009526177A JP2009526177A JP2010502582A5 JP 2010502582 A5 JP2010502582 A5 JP 2010502582A5 JP 2009526177 A JP2009526177 A JP 2009526177A JP 2009526177 A JP2009526177 A JP 2009526177A JP 2010502582 A5 JP2010502582 A5 JP 2010502582A5
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JP
Japan
Prior art keywords
alkyl
substituted
aryl
alkynyl
alkenyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2009526177A
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English (en)
Japanese (ja)
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JP2010502582A (ja
JP5506386B2 (ja
Filing date
Publication date
Priority claimed from GB0617278A external-priority patent/GB0617278D0/en
Priority claimed from GB0625929A external-priority patent/GB0625929D0/en
Application filed filed Critical
Priority claimed from PCT/GB2007/003302 external-priority patent/WO2008029096A2/en
Publication of JP2010502582A publication Critical patent/JP2010502582A/ja
Publication of JP2010502582A5 publication Critical patent/JP2010502582A5/ja
Application granted granted Critical
Publication of JP5506386B2 publication Critical patent/JP5506386B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

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JP2009526177A 2006-09-04 2007-09-04 Ｐ５３活性化化合物 Expired - Fee Related JP5506386B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GB0617278A GB0617278D0 (en) 2006-09-04 2006-09-04 P53 activating compounds
GB0617278.7 2006-09-04
GB0625929A GB0625929D0 (en) 2006-12-23 2006-12-23 P53 activating compounds
GB0625929.5 2006-12-23
PCT/GB2007/003302 WO2008029096A2 (en) 2006-09-04 2007-09-04 P53 activating benzoyl urea and benzoyl thiourea compounds

Publications (3)

Publication Number Publication Date
JP2010502582A JP2010502582A (ja) 2010-01-28
JP2010502582A5 true JP2010502582A5 (cg-RX-API-DMAC10.html) 2010-10-21
JP5506386B2 JP5506386B2 (ja) 2014-05-28

Family

ID=38819391

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2009526177A Expired - Fee Related JP5506386B2 (ja) 2006-09-04 2007-09-04 Ｐ５３活性化化合物

Country Status (6)

Country Link
US (2) US8501991B2 (cg-RX-API-DMAC10.html)
EP (1) EP2099445B1 (cg-RX-API-DMAC10.html)
JP (1) JP5506386B2 (cg-RX-API-DMAC10.html)
AT (1) ATE488232T1 (cg-RX-API-DMAC10.html)
DE (1) DE602007010664D1 (cg-RX-API-DMAC10.html)
WO (1) WO2008029096A2 (cg-RX-API-DMAC10.html)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8889632B2 (en) 2007-01-31 2014-11-18 Dana-Farber Cancer Institute, Inc. Stabilized p53 peptides and uses thereof
US8580488B2 (en) * 2007-02-05 2013-11-12 City Of Hope Cell culture model for acquired chemoresistance of chronic myelogenous leukemia and related methods for identifying agents to overcome resistance
US8952028B2 (en) 2007-02-05 2015-02-10 City Of Hope Methods of treating chemoresistance and relapse in cancer cells
EP2508531B1 (en) 2007-03-28 2016-10-19 President and Fellows of Harvard College Stitched polypeptides
WO2008138943A2 (en) * 2007-05-14 2008-11-20 Universite Libre De Bruxelles Prophylactic and therapeutic use of sirtuin inhibitors in tnf-alpha mediated pathologies
FR2930552B1 (fr) * 2008-04-24 2012-10-12 Centre Nat Rech Scient N-acylthiourees et n-acylurees inhibiteurs de la voie de signalisation des proteines hedgehog
WO2011022028A2 (en) * 2009-05-18 2011-02-24 Tufts University Small molecule antagonists of phosphatidylinositol-3, 4, 5-triphosphate (pip3) and uses thereof
GB0909912D0 (en) 2009-06-09 2009-07-22 Univ Dundee Compounds
US9233087B2 (en) 2010-02-19 2016-01-12 Siga Technologies, Inc Inhibitors and methods of inhibiting bacterial and viral pathogens
SI2603600T1 (sl) 2010-08-13 2019-04-30 Aileron Therapeutics, Inc. Peptidomimetični makrocikli
WO2012065182A2 (en) 2010-11-12 2012-05-18 University Of Massachusetts Modulation of ubiquitination of synaptic proteins for the treatment of neurodegenerative and psychiatric disorders
FR2980477B1 (fr) * 2011-09-23 2013-10-18 Centre Nat Rech Scient Nouveaux composes modulateurs de la voie de signalisation des proteines hedgehog, leurs formes marquees, et applications
TW201806968A (zh) 2011-10-18 2018-03-01 艾利倫治療公司 擬肽巨環化合物
HK1205454A1 (en) 2012-02-15 2015-12-18 Aileron Therapeutics, Inc. Triazole-crosslinked and thioether-crosslinked peptidomimetic macrocycles
KR102112373B1 (ko) 2012-02-15 2020-05-18 에일러론 테라퓨틱스 인코포레이티드 펩티드모방체 마크로사이클
WO2014071241A1 (en) 2012-11-01 2014-05-08 Aileron Therapeutics, Inc. Disubstituted amino acids and methods of preparation and use thereof
JP6376707B2 (ja) 2013-05-13 2018-08-22 グラクソスミスクライン・リミテッド・ライアビリティ・カンパニーＧｌａｘｏＳｍｉｔｈＫｌｉｎｅ ＬＬＣ サーチュイン調節剤としての置換架橋尿素類似体
BR112017005598A2 (pt) 2014-09-24 2017-12-12 Aileron Therapeutics Inc macrociclos peptidomiméticos e usos dos mesmos
JP2018503595A (ja) 2014-09-24 2018-02-08 エルロン・セラピューティクス・インコーポレイテッドＡｉｌｅｒｏｎ Ｔｈｅｒａｐｅｕｔｉｃｓ，Ｉｎｃ． ペプチド模倣大環状分子およびその製剤
WO2016154058A1 (en) 2015-03-20 2016-09-29 Aileron Therapeutics, Inc. Peptidomimetic macrocycles and uses thereof
US10023613B2 (en) 2015-09-10 2018-07-17 Aileron Therapeutics, Inc. Peptidomimetic macrocycles as modulators of MCL-1
CN115724780B (zh) * 2022-11-17 2024-04-26 武汉大学 一种基于疏水标签的酰基硫脲类化合物及其制备方法与抗甲型流感病毒的应用
CN117069631A (zh) * 2023-08-15 2023-11-17 北京中医药大学 一种具有抗肿瘤活性的新型硫脲类化合物及其制备方法与应用

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0117320B1 (en) * 1983-01-24 1987-03-04 Duphar International Research B.V Benzoylurea compounds, and pesticidal compositions comprising same
EP0116728B1 (en) * 1983-01-24 1987-08-12 Duphar International Research B.V Composition active against mites, whitefly and thrips, pharmaceutical composition, and new benzoylureau compounds
ATE43788T1 (de) 1983-09-01 1989-06-15 Duphar Int Res Benzoylharnstoffe mit antitumoraler wirkung.
ES8801896A1 (es) 1985-03-01 1988-03-01 Duphar Int Res Procedimiento para preparar derivados de urea
AU642524B2 (en) 1990-09-10 1993-10-21 Duphar International Research B.V. Pharmaceutical formulation containing a benzoyl urea derivative
JPH05247001A (ja) * 1991-12-05 1993-09-24 Ishihara Sangyo Kaisha Ltd 置換ベンゾイルウレア誘導体又はその塩、それらの製造方法及びそれらを含有する抗癌剤
KR950026862A (ko) * 1994-03-15 1995-10-16 강박광 벤조일 우레아 유도체
JPH07285952A (ja) * 1994-04-08 1995-10-31 Fujisawa Pharmaceut Co Ltd 新規複素環誘導体
US20060004085A1 (en) * 2002-03-29 2006-01-05 University Of Maryland , Baltimore Inhibitors of the S100-p53 protein-protein interaction and method of inhibiting cancer employing the same
WO2004014885A1 (en) 2002-08-07 2004-02-19 Neuraxon Inc. Amino benzothiazole compounds with nos inhibitory activity
US7087761B2 (en) * 2003-01-07 2006-08-08 Hoffmann-La Roche Inc. Cyclization process for substituted benzothiazole derivatives
TW200600492A (en) * 2004-05-18 2006-01-01 Achillion Pharmaceuticals Inc Substituted aryl acylthioureas and related compounds; inhibitors of viral replication
US20090081636A1 (en) 2005-04-11 2009-03-26 Mingjun Huang Pharmaceutical compositions for and methods of inhibiting HCV replication

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