JP2010500978A5 - - Google Patents

Info

Publication number

JP2010500978A5

JP2010500978A5 JP2009524051A JP2009524051A JP2010500978A5 JP 2010500978 A5 JP2010500978 A5 JP 2010500978A5 JP 2009524051 A JP2009524051 A JP 2009524051A JP 2009524051 A JP2009524051 A JP 2009524051A JP 2010500978 A5 JP2010500978 A5 JP 2010500978A5

Authority

JP

Japan

Prior art keywords

alkyl

cycloalkyl

het

independently

alkylene

Prior art date

2007-08-06

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

• Espacenet
• Global Dossier
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• 125000000217 alkyl group Chemical group 0.000 claims 69
• 125000000753 cycloalkyl group Chemical group 0.000 claims 26
• 125000005843 halogen group Chemical group 0.000 claims 12
• 150000001875 compounds Chemical class 0.000 claims 11
• 125000003118 aryl group Chemical group 0.000 claims 9
• 125000001424 substituent group Chemical group 0.000 claims 9
• 125000000171 (C1-C6) haloalkyl group Chemical group 0.000 claims 7
• 125000005842 heteroatom Chemical group 0.000 claims 6
• 125000004093 cyano group Chemical group *C#N 0.000 claims 4
• 229910052760 oxygen Inorganic materials 0.000 claims 4
• 150000002148 esters Chemical class 0.000 claims 3
• 125000004043 oxo group Chemical group O=* 0.000 claims 3
• 125000004430 oxygen atom Chemical group O* 0.000 claims 3
• 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 3
• 150000003839 salts Chemical class 0.000 claims 3
• 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims 2
• 125000000623 heterocyclic group Chemical group 0.000 claims 2
• 125000001841 imino group Chemical group [H]N=* 0.000 claims 2
• 125000000896 monocarboxylic acid group Chemical group 0.000 claims 2
• 239000008194 pharmaceutical composition Substances 0.000 claims 2
• 229920006395 saturated elastomer Polymers 0.000 claims 2
• 241000711549 Hepacivirus C Species 0.000 claims 1
• 125000000815 N-oxide group Chemical group 0.000 claims 1
• 125000000304 alkynyl group Chemical group 0.000 claims 1
• 239000003443 antiviral agent Substances 0.000 claims 1
• 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 1
• -1 cyano, oxo, thioxo Chemical group 0.000 claims 1
• 239000003814 drug Substances 0.000 claims 1
• 239000003937 drug carrier Substances 0.000 claims 1
• 208000006454 hepatitis Diseases 0.000 claims 1
• 231100000283 hepatitis Toxicity 0.000 claims 1
• 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 1
• 238000004519 manufacturing process Methods 0.000 claims 1
• 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 1
• 230000003647 oxidation Effects 0.000 claims 1
• 238000007254 oxidation reaction Methods 0.000 claims 1
• LVTJOONKWUXEFR-FZRMHRINSA-N protoneodioscin Natural products O(C[C@@H](CC[C@]1(O)[C@H](C)[C@@H]2[C@]3(C)[C@H]([C@H]4[C@@H]([C@]5(C)C(=CC4)C[C@@H](O[C@@H]4[C@H](O[C@H]6[C@@H](O)[C@@H](O)[C@@H](O)[C@H](C)O6)[C@@H](O)[C@H](O[C@H]6[C@@H](O)[C@@H](O)[C@@H](O)[C@H](C)O6)[C@H](CO)O4)CC5)CC3)C[C@@H]2O1)C)[C@H]1[C@H](O)[C@H](O)[C@H](O)[C@@H](CO)O1 LVTJOONKWUXEFR-FZRMHRINSA-N 0.000 claims 1
• 238000006467 substitution reaction Methods 0.000 claims 1
• 230000009385 viral infection Effects 0.000 claims 1