JP2010500331A5 - - Google Patents
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- Publication number
- JP2010500331A5 JP2010500331A5 JP2009523312A JP2009523312A JP2010500331A5 JP 2010500331 A5 JP2010500331 A5 JP 2010500331A5 JP 2009523312 A JP2009523312 A JP 2009523312A JP 2009523312 A JP2009523312 A JP 2009523312A JP 2010500331 A5 JP2010500331 A5 JP 2010500331A5
- Authority
- JP
- Japan
- Prior art keywords
- octapeptins
- residues
- polymyxins
- acid
- natural
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 108010040201 Polymyxins Proteins 0.000 description 3
- 229940041153 polymyxins Drugs 0.000 description 3
- 241000588724 Escherichia coli Species 0.000 description 1
- 125000000266 alpha-aminoacyl group Chemical group 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 125000004432 carbon atom Chemical group C* 0.000 description 1
- 125000001924 fatty-acyl group Chemical group 0.000 description 1
- HEDADCOWECPKFY-UHFFFAOYSA-N octapeptin Chemical compound CCC(C)CCCCC(O)CC(=O)NC(CCN)C(=O)NC1CCNC(=O)C(CC(C)C)NC(=O)C(CCN)NC(=O)C(CCN)NC(=O)C(CC(C)C)NC(=O)C(CC(C)C)NC(=O)C(CCN)NC1=O HEDADCOWECPKFY-UHFFFAOYSA-N 0.000 description 1
- 108010093294 octapeptin antibiotics Proteins 0.000 description 1
- 230000003389 potentiating effect Effects 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US83742606P | 2006-08-11 | 2006-08-11 | |
| US60/837,426 | 2006-08-11 | ||
| DKPA200601055 | 2006-08-11 | ||
| DKPA200601055 | 2006-08-11 | ||
| PCT/FI2007/050441 WO2008017734A1 (en) | 2006-08-11 | 2007-08-10 | Polymyxin derivatives and uses thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010500331A JP2010500331A (ja) | 2010-01-07 |
| JP2010500331A5 true JP2010500331A5 (cg-RX-API-DMAC7.html) | 2010-08-12 |
| JP5226685B2 JP5226685B2 (ja) | 2013-07-03 |
Family
ID=39032653
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009523312A Expired - Fee Related JP5226685B2 (ja) | 2006-08-11 | 2007-08-10 | ポリミキシン誘導体およびその使用 |
Country Status (21)
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20060004185A1 (en) | 2004-07-01 | 2006-01-05 | Leese Richard A | Peptide antibiotics and peptide intermediates for their prepartion |
| FI20085469A0 (fi) * | 2008-02-08 | 2008-05-16 | Northern Antibiotics Oy | Polymyksiinijohdannaiset, joissa on lyhyt rasvahappohäntä, ja niiden käyttöjä |
| US8343912B2 (en) | 2008-12-23 | 2013-01-01 | Biosource Pharm, Inc. | Antibiotic compositions for the treatment of gram negative infections |
| US8415307B1 (en) | 2010-06-23 | 2013-04-09 | Biosource Pharm, Inc. | Antibiotic compositions for the treatment of gram negative infections |
| WO2012051663A1 (en) * | 2010-10-21 | 2012-04-26 | Monash University | Antimicrobial compounds |
| BR112014012016A2 (pt) * | 2011-11-18 | 2017-05-16 | Cantab Anti-Infectives Ltd | compostos |
| PL2999711T3 (pl) * | 2013-05-22 | 2022-09-26 | Spero Therapeutics, Inc. | Pochodne polimyksyny i ich zastosowanie w terapii skojarzonej razem z różnymi antybiotykami |
| DK3116897T3 (da) * | 2014-03-11 | 2022-03-28 | Spero Therapeutics Inc | Polymyxinderivater og deres anvendelse i kombinationsterapi sammen med forskellige antibiotika |
| KR101664106B1 (ko) | 2014-09-11 | 2016-10-10 | 한국화학연구원 | 폴리믹신 b 화합물을 포함하는 심혈관 질환의 예방 및 치료용 약학적 조성물 |
| CN107108699A (zh) * | 2014-11-26 | 2017-08-29 | 新药物许可控股有限公司 | 化合物 |
| CA2970546A1 (en) | 2014-12-16 | 2016-06-23 | Micurx Pharmaceuticals, Inc. | Antimicrobial polymyxins for treatment of bacterial infections |
| WO2016097754A1 (en) * | 2014-12-18 | 2016-06-23 | Helperby Therapeutics Limited | Novel combination and use |
| FI126143B (en) * | 2015-01-15 | 2016-07-15 | Northern Antibiotics Oy | Polymyxine derivative and its uses |
| US9763996B2 (en) | 2015-01-16 | 2017-09-19 | Northern Antibiotics, Ltd. | Polymyxin derivative and uses thereof |
| CN104672307B (zh) * | 2015-03-23 | 2017-09-29 | 吉林大学 | 一种提高阳离子短肽抗菌性和稳定性的方法 |
| EP3072956A1 (en) * | 2015-03-25 | 2016-09-28 | Université de Fribourg | Selective culture medium for polymyxin-resistant, gram-negative bacteria |
| FR3036406B1 (fr) | 2015-05-20 | 2019-07-19 | Biomerieux | Identification des bacteries resistantes aux carbapenemes par impermeabilite membranaire |
| WO2017083859A1 (en) * | 2015-11-12 | 2017-05-18 | The Trustees Of Columbia University In The City Of New York | Rational drug design targeting resistant gram-negative bacterial infections to polymyxin-class antibiotics |
| WO2017189868A1 (en) * | 2016-04-27 | 2017-11-02 | Spero Opco | Serine replacement polymyxin analogues useful as antibiotic potentiators |
| WO2017189866A1 (en) * | 2016-04-27 | 2017-11-02 | Spero Opco | Polymyxin analogs useful as antibiotic potentiators |
| GB201703898D0 (en) | 2017-03-10 | 2017-04-26 | Helperby Therapeautics Ltd | Method |
| GB201704620D0 (en) | 2017-03-23 | 2017-05-10 | Helperby Therapeautics Ltd | Combinations |
| CN111527100A (zh) * | 2017-11-02 | 2020-08-11 | 昆士兰大学 | 肽类抗生素 |
| EP3560489A1 (en) * | 2018-04-27 | 2019-10-30 | European Molecular Biology Laboratory | Pharmaceutical compositions for prevention and/or treatment of infections and antibacterial-induced dysfunctions |
| BR112020026663A2 (pt) | 2018-06-25 | 2021-03-23 | Spero Therapeutics, Inc. | Compostos |
| WO2020018173A1 (en) * | 2018-07-19 | 2020-01-23 | Northeastern University | Compounds with antimicrobial properties |
| CN110179967A (zh) * | 2019-05-28 | 2019-08-30 | 中国医药集团总公司四川抗菌素工业研究所 | 多粘菌素母核和一种抗生素的组合物及其应用 |
| IT201900025414A1 (it) * | 2019-12-23 | 2021-06-23 | Univ Bologna Alma Mater Studiorum | Composto per il trattamento della sindrome emolitico uremica |
| WO2021150792A1 (en) | 2020-01-21 | 2021-07-29 | Micurx Pharmaceuticals, Inc. | Novel compounds and composition for targeted therapy of kidney-associated cancers |
| CN118028504B (zh) * | 2022-08-30 | 2024-08-02 | 四川大学华西医院 | 一类phoQ基因突变体、应用及其验证方法 |
| WO2024123712A1 (en) * | 2022-12-04 | 2024-06-13 | Genentech, Inc. | Analysis of candidate cytotoxic compositions |
| CN120399010B (zh) * | 2025-07-01 | 2025-09-12 | 杭州肽佳生物科技有限公司 | 抗生素多粘菌素的制备方法 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3450687A (en) | 1966-02-24 | 1969-06-17 | Pfizer & Co C | Lower alkanoyl esters of polymyxin antibiotics |
| JPS4915537B1 (cg-RX-API-DMAC7.html) | 1970-03-25 | 1974-04-16 | ||
| BE754411A (fr) | 1969-08-05 | 1971-02-04 | Rhone Poulenc Sa | Cyclopeptides derives des polymyxines et leur |
| GB2128617A (en) | 1982-10-06 | 1984-05-02 | Martti Vaara | Polypeptides for use in antibacterial therapy |
| US20040063754A1 (en) * | 2000-11-20 | 2004-04-01 | Hisashi Takahashi | Dehalogeno compounds |
| CA2444637A1 (en) | 2001-01-16 | 2002-07-18 | Ramot University Authority For Applied Research & Industrial Development Ltd. | Hybrid peptides for treatment of bacteremia and septicemia |
| EP1340506B1 (en) * | 2002-03-01 | 2006-12-27 | CHIESI FARMACEUTICI S.p.A. | Compositions comprising pulmonary surfactants and a polymyxin having improved surface properties |
| US20060004185A1 (en) * | 2004-07-01 | 2006-01-05 | Leese Richard A | Peptide antibiotics and peptide intermediates for their prepartion |
-
2007
- 2007-08-10 EP EP07803704.1A patent/EP2057185B1/en active Active
- 2007-08-10 NZ NZ575421A patent/NZ575421A/en not_active IP Right Cessation
- 2007-08-10 KR KR1020097004841A patent/KR101502453B1/ko not_active Expired - Fee Related
- 2007-08-10 PL PL07803704.1T patent/PL2057185T3/pl unknown
- 2007-08-10 WO PCT/FI2007/050441 patent/WO2008017734A1/en not_active Ceased
- 2007-08-10 PT PT07803704T patent/PT2057185E/pt unknown
- 2007-08-10 MX MX2009001398A patent/MX2009001398A/es active IP Right Grant
- 2007-08-10 CA CA 2694289 patent/CA2694289C/en active Active
- 2007-08-10 CN CN201310011979.8A patent/CN103059106B/zh not_active Expired - Fee Related
- 2007-08-10 SI SI200731783A patent/SI2057185T1/sl unknown
- 2007-08-10 JP JP2009523312A patent/JP5226685B2/ja not_active Expired - Fee Related
- 2007-08-10 EP EP16168287.7A patent/EP3078672A1/en not_active Withdrawn
- 2007-08-10 CN CN200780029855.5A patent/CN101501063B/zh not_active Expired - Fee Related
- 2007-08-10 HU HUE07803704A patent/HUE028271T2/en unknown
- 2007-08-10 AU AU2007283514A patent/AU2007283514B2/en not_active Ceased
- 2007-08-10 HR HRP20160552TT patent/HRP20160552T1/hr unknown
- 2007-08-10 DK DK07803704.1T patent/DK2057185T3/en active
- 2007-08-10 KR KR1020147036680A patent/KR20150008198A/ko not_active Ceased
- 2007-08-10 BR BRPI0715095A patent/BRPI0715095B8/pt not_active IP Right Cessation
- 2007-08-10 RU RU2009107857/04A patent/RU2455311C2/ru active
- 2007-08-10 ES ES07803704.1T patent/ES2575521T3/es active Active
-
2009
- 2009-01-22 IL IL196693A patent/IL196693B/en active IP Right Grant
- 2009-02-12 NO NO20090674A patent/NO341982B1/no unknown
-
2012
- 2012-06-07 IL IL220270A patent/IL220270A0/en unknown
-
2016
- 2016-06-09 CY CY20161100502T patent/CY1117848T1/el unknown
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