JP2010265276A5 - - Google Patents
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- Publication number
- JP2010265276A5 JP2010265276A5 JP2010142096A JP2010142096A JP2010265276A5 JP 2010265276 A5 JP2010265276 A5 JP 2010265276A5 JP 2010142096 A JP2010142096 A JP 2010142096A JP 2010142096 A JP2010142096 A JP 2010142096A JP 2010265276 A5 JP2010265276 A5 JP 2010265276A5
- Authority
- JP
- Japan
- Prior art keywords
- aryl
- sulfonyl halide
- bis
- compound
- substituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000000034 method Methods 0.000 claims 10
- -1 nitroaryl compound Chemical class 0.000 claims 9
- 150000003461 sulfonyl halides Chemical class 0.000 claims 5
- 125000002490 anilino group Chemical class [H]N(*)C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 claims 4
- 229910044991 metal oxide Inorganic materials 0.000 claims 4
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 claims 3
- TVFDJXOCXUVLDH-UHFFFAOYSA-N caesium atom Chemical class [Cs] TVFDJXOCXUVLDH-UHFFFAOYSA-N 0.000 claims 2
- ZYGHJZDHTFUPRJ-UHFFFAOYSA-N coumarin Chemical compound C1=CC=C2OC(=O)C=CC2=C1 ZYGHJZDHTFUPRJ-UHFFFAOYSA-N 0.000 claims 2
- TXCDCPKCNAJMEE-UHFFFAOYSA-N dibenzofuran Chemical compound C1=CC=C2C3=CC=CC=C3OC2=C1 TXCDCPKCNAJMEE-UHFFFAOYSA-N 0.000 claims 2
- ZUOUZKKEUPVFJK-UHFFFAOYSA-N diphenyl Chemical compound C1=CC=CC=C1C1=CC=CC=C1 ZUOUZKKEUPVFJK-UHFFFAOYSA-N 0.000 claims 2
- 229910052736 halogen Inorganic materials 0.000 claims 2
- 239000003960 organic solvent Substances 0.000 claims 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 2
- 125000000714 pyrimidinyl group Chemical group 0.000 claims 2
- 125000003107 substituted aryl group Chemical group 0.000 claims 2
- PTTUMBGORBMNBN-UHFFFAOYSA-N 1,2,3-trifluoro-5-nitrobenzene Chemical compound [O-][N+](=O)C1=CC(F)=C(F)C(F)=C1 PTTUMBGORBMNBN-UHFFFAOYSA-N 0.000 claims 1
- 125000004514 1,2,4-thiadiazolyl group Chemical group 0.000 claims 1
- NBWITVOFJWJOEF-UHFFFAOYSA-N 4-(4-chlorophenoxy)-3,5-difluorobenzenesulfonyl chloride Chemical group FC1=CC(S(Cl)(=O)=O)=CC(F)=C1OC1=CC=C(Cl)C=C1 NBWITVOFJWJOEF-UHFFFAOYSA-N 0.000 claims 1
- WXNZTHHGJRFXKQ-UHFFFAOYSA-N 4-chlorophenol Chemical compound OC1=CC=C(Cl)C=C1 WXNZTHHGJRFXKQ-UHFFFAOYSA-N 0.000 claims 1
- 150000008378 aryl ethers Chemical class 0.000 claims 1
- 125000003785 benzimidazolyl group Chemical group N1=C(NC2=C1C=CC=C2)* 0.000 claims 1
- 125000004196 benzothienyl group Chemical group S1C(=CC2=C1C=CC=C2)* 0.000 claims 1
- 235000010290 biphenyl Nutrition 0.000 claims 1
- 239000004305 biphenyl Substances 0.000 claims 1
- 125000000609 carbazolyl group Chemical group C1(=CC=CC=2C3=CC=CC=C3NC12)* 0.000 claims 1
- 239000012954 diazonium Substances 0.000 claims 1
- IJGRMHOSHXDMSA-UHFFFAOYSA-O diazynium Chemical compound [NH+]#N IJGRMHOSHXDMSA-UHFFFAOYSA-O 0.000 claims 1
- 125000001153 fluoro group Chemical group F* 0.000 claims 1
- 125000002541 furyl group Chemical group 0.000 claims 1
- 150000004820 halides Chemical group 0.000 claims 1
- 125000005843 halogen group Chemical group 0.000 claims 1
- 150000002367 halogens Chemical class 0.000 claims 1
- 125000001072 heteroaryl group Chemical group 0.000 claims 1
- 125000002883 imidazolyl group Chemical group 0.000 claims 1
- 125000001041 indolyl group Chemical group 0.000 claims 1
- 239000013067 intermediate product Substances 0.000 claims 1
- 125000005956 isoquinolyl group Chemical group 0.000 claims 1
- 125000001786 isothiazolyl group Chemical group 0.000 claims 1
- 125000000842 isoxazolyl group Chemical group 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 125000001624 naphthyl group Chemical group 0.000 claims 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 1
- 125000004999 nitroaryl group Chemical group 0.000 claims 1
- XAEFZNCEHLXOMS-UHFFFAOYSA-M potassium benzoate Chemical compound [K+].[O-]C(=O)C1=CC=CC=C1 XAEFZNCEHLXOMS-UHFFFAOYSA-M 0.000 claims 1
- 125000000561 purinyl group Chemical group N1=C(N=C2N=CNC2=C1)* 0.000 claims 1
- 125000003373 pyrazinyl group Chemical group 0.000 claims 1
- 125000003226 pyrazolyl group Chemical group 0.000 claims 1
- 125000001725 pyrenyl group Chemical group 0.000 claims 1
- 125000004076 pyridyl group Chemical group 0.000 claims 1
- 125000005493 quinolyl group Chemical group 0.000 claims 1
- 125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 claims 1
- CXWXQJXEFPUFDZ-UHFFFAOYSA-N tetralin Chemical compound C1=CC=C2CCCCC2=C1 CXWXQJXEFPUFDZ-UHFFFAOYSA-N 0.000 claims 1
- 125000003831 tetrazolyl group Chemical group 0.000 claims 1
- 125000001544 thienyl group Chemical group 0.000 claims 1
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US38832602P | 2002-06-12 | 2002-06-12 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004513217A Division JP4718172B2 (ja) | 2002-06-12 | 2003-06-11 | ヒトａｄａｍ−１０インヒビター |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2010265276A JP2010265276A (ja) | 2010-11-25 |
| JP2010265276A5 true JP2010265276A5 (enExample) | 2011-08-18 |
Family
ID=29736461
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004513217A Expired - Fee Related JP4718172B2 (ja) | 2002-06-12 | 2003-06-11 | ヒトａｄａｍ−１０インヒビター |
| JP2010142096A Pending JP2010265276A (ja) | 2002-06-12 | 2010-06-22 | ヒトａｄａｍ−１０インヒビター |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004513217A Expired - Fee Related JP4718172B2 (ja) | 2002-06-12 | 2003-06-11 | ヒトａｄａｍ−１０インヒビター |
Country Status (7)
| Country | Link |
|---|---|
| US (5) | US7629341B2 (enExample) |
| EP (3) | EP2428509A1 (enExample) |
| JP (2) | JP4718172B2 (enExample) |
| AU (2) | AU2003237532B2 (enExample) |
| CA (1) | CA2485346C (enExample) |
| ES (1) | ES2425013T3 (enExample) |
| WO (1) | WO2003106381A2 (enExample) |
Families Citing this family (29)
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|---|---|---|---|---|
| US7517884B2 (en) * | 1998-03-30 | 2009-04-14 | Kalypsys Inc. | Sulfonyl-substituted bicyclic compounds as modulators of PPAR |
| EP2428509A1 (en) | 2002-06-12 | 2012-03-14 | Symphony Evolution, Inc. | Human adam-10 inhibitors |
| EP1613269B1 (en) | 2003-04-04 | 2015-02-25 | Incyte Corporation | Compositions, methods and kits relating to her-2 cleavage |
| EP1623995A1 (en) * | 2004-08-06 | 2006-02-08 | Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts | Inhibitors of L1 and ADAM10 for the treatment of carcinomas |
| JP5138377B2 (ja) * | 2004-10-29 | 2013-02-06 | カリプシス・インコーポレーテッド | Ｐｐａｒのモジュレータとしての置換スルホニル二環式化合物 |
| US20070190079A1 (en) * | 2004-10-29 | 2007-08-16 | Kalypsys, Inc. | Methods for the selective modulation of ppar |
| EP1896580A2 (en) * | 2005-04-07 | 2008-03-12 | Novartis Vaccines and Diagnostics, Inc. | Adam10 in cancer diagnosis, detection and treatment |
| DK1940815T3 (en) * | 2005-10-25 | 2018-11-05 | Kalypsys Inc | SALTS OF MODULATORS OF PPAR AND PROCEDURES FOR TREATMENT OF SUBSTITUTE DISEASES |
| EP1984500A2 (en) | 2006-01-13 | 2008-10-29 | Vanderbilt University | Adam10 and its uses related to infection |
| CN100506804C (zh) * | 2006-01-26 | 2009-07-01 | 于学敏 | 羟苯磺酸烷基吡嗪药物及其制备方法和应用 |
| US20070249519A1 (en) * | 2006-04-20 | 2007-10-25 | Kalypsys, Inc. | Methods for the upregulation of glut4 via modulation of ppar delta in adipose tissue and for the treatment of disease |
| AR060937A1 (es) * | 2006-05-16 | 2008-07-23 | Kalypsys Inc | Compuestos biciclicos sustituidos con sulfonilo como moduladores de ppar |
| WO2008091863A1 (en) | 2007-01-23 | 2008-07-31 | Kalypsys, Inc. | Sulfonyl-substituted bicyclic compounds as ppar modulators for the treatment of non-alcoholic steatohepatitis |
| US8426415B2 (en) | 2007-10-16 | 2013-04-23 | Symphony Evolution, Inc. | Human ADAM-10 inhibitors |
| ES2620634T3 (es) | 2008-10-09 | 2017-06-29 | The U.S.A. As Represented By The Secretary, Department Of Health And Human Services | Activadores de piruvato quinasa humana |
| CA2774389A1 (en) | 2009-10-01 | 2011-04-07 | Symphony Evolution, Inc. | Methods of treating aneurysmal dilatation, blood vessel wall weakness and specifically abdominal aortic and thoracic aneurysm using matrix metalloprotease-2 inhibitors |
| JP2013525438A (ja) | 2010-04-29 | 2013-06-20 | アメリカ合衆国 | ヒトピルビン酸キナーゼ活性剤 |
| JP5888667B2 (ja) * | 2010-04-30 | 2016-03-22 | 国立大学法人名古屋大学 | Ａｄａｍ作用阻害物質のスクリーニング方法、仮足の保持方法、仮足保持剤、仮足の制御物質のスクリーニング方法、及びａｄａｍ作用阻害剤 |
| US9150865B2 (en) | 2010-11-09 | 2015-10-06 | The University Of Chicago | Role of ADAM10 and its relevance to disease and therapeutics |
| WO2014028334A1 (en) * | 2012-08-11 | 2014-02-20 | Symphony Evolution, Inc. | Selective mmp inhibitors |
| US20170038382A1 (en) * | 2014-01-24 | 2017-02-09 | Ntercept, Llc | Methods and compositions for immune dis-inhibition |
| KR102510540B1 (ko) | 2014-10-03 | 2023-03-16 | 나노틱스 엘엘씨 | 가용성 생물분자의 생물학적 활성을 억제하기 위한 조성물 및 방법 |
| JP7539221B2 (ja) | 2015-07-29 | 2024-08-23 | ナノティックス，エルエルシー | 可溶性生体分子を捕捉するためのモジュラー組成物及びそれと関連する方法 |
| IL299915A (en) | 2017-01-04 | 2023-03-01 | Nanotics Llc | Methods for assembling cleaning particles |
| CN108947850B (zh) * | 2018-07-23 | 2021-05-18 | 蚌埠中实化学技术有限公司 | 一种3,4,5-三氟苯胺的制备方法 |
| KR20220023988A (ko) * | 2019-05-14 | 2022-03-03 | 웨어울프 세라퓨틱스, 인크. | 분리 모이어티 및 이의 사용 방법 |
| CA3155981A1 (en) | 2019-11-14 | 2021-05-20 | William Winston | Activatable cytokine polypeptides and methods of use thereof |
| CN113563235B (zh) * | 2021-07-28 | 2023-04-11 | 上海毕得医药科技股份有限公司 | 一种3-(卤代苯氧基)苯磺酰氯衍生物的合成方法 |
| US20250177333A1 (en) * | 2022-03-08 | 2025-06-05 | Nova Southeastern University | Method for treating rheumatoid arthritis (ra) using an enzyme-and substrate selective exosite inhibitor of a disintegrin and metalloprotease 10 (adam10) |
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| DE3107700A1 (de) * | 1981-02-28 | 1982-09-16 | Basf Ag, 6700 Ludwigshafen | Verfahren zur herstellung von aromatischen sulfohalogeniden |
| AU645834B2 (en) * | 1990-03-01 | 1994-01-27 | Pharmacia & Upjohn Company | Ruminal bacterium for preventing acute lactic acidosis |
| DE4015834A1 (de) * | 1990-05-17 | 1991-11-21 | Bayer Ag | Phenoxyphenylsulfonylverbindungen |
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| DE4327026A1 (de) | 1993-08-12 | 1995-02-16 | Bayer Ag | Arylsulfonyloxyphosphonsäurederivate |
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| EP0963432A4 (en) | 1996-08-29 | 2002-11-20 | Univ California | KUZ, NEW FAMILY OF METALLOPROTEASES |
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-
2003
- 2003-06-11 EP EP11188701A patent/EP2428509A1/en not_active Withdrawn
- 2003-06-11 US US10/518,110 patent/US7629341B2/en not_active Expired - Fee Related
- 2003-06-11 AU AU2003237532A patent/AU2003237532B2/en not_active Ceased
- 2003-06-11 WO PCT/US2003/018262 patent/WO2003106381A2/en not_active Ceased
- 2003-06-11 ES ES03736979T patent/ES2425013T3/es not_active Expired - Lifetime
- 2003-06-11 EP EP03736979.0A patent/EP1511488B1/en not_active Expired - Lifetime
- 2003-06-11 EP EP11188699A patent/EP2436676A1/en not_active Withdrawn
- 2003-06-11 CA CA2485346A patent/CA2485346C/en not_active Expired - Fee Related
- 2003-06-11 JP JP2004513217A patent/JP4718172B2/ja not_active Expired - Fee Related
-
2009
- 2009-10-23 US US12/605,118 patent/US7989661B2/en not_active Expired - Fee Related
- 2009-10-28 AU AU2009230801A patent/AU2009230801A1/en not_active Abandoned
-
2010
- 2010-06-22 JP JP2010142096A patent/JP2010265276A/ja active Pending
-
2011
- 2011-06-23 US US13/167,128 patent/US20120071653A1/en not_active Abandoned
-
2012
- 2012-07-03 US US13/541,503 patent/US20130144056A1/en not_active Abandoned
-
2014
- 2014-03-21 US US14/221,937 patent/US20140206865A1/en not_active Abandoned
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