JP2010265276A5 - - Google Patents

Download PDF

Info

Publication number
JP2010265276A5
JP2010265276A5 JP2010142096A JP2010142096A JP2010265276A5 JP 2010265276 A5 JP2010265276 A5 JP 2010265276A5 JP 2010142096 A JP2010142096 A JP 2010142096A JP 2010142096 A JP2010142096 A JP 2010142096A JP 2010265276 A5 JP2010265276 A5 JP 2010265276A5
Authority
JP
Japan
Prior art keywords
aryl
sulfonyl halide
bis
compound
substituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2010142096A
Other languages
English (en)
Japanese (ja)
Other versions
JP2010265276A (ja
Filing date
Publication date
Application filed filed Critical
Publication of JP2010265276A publication Critical patent/JP2010265276A/ja
Publication of JP2010265276A5 publication Critical patent/JP2010265276A5/ja
Pending legal-status Critical Current

Links

JP2010142096A 2002-06-12 2010-06-22 ヒトａｄａｍ−１０インヒビター Pending JP2010265276A (ja)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US38832602P 2002-06-12 2002-06-12

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
JP2004513217A Division JP4718172B2 (ja) 2002-06-12 2003-06-11 ヒトａｄａｍ−１０インヒビター

Publications (2)

Publication Number Publication Date
JP2010265276A JP2010265276A (ja) 2010-11-25
JP2010265276A5 true JP2010265276A5 (enExample) 2011-08-18

Family

ID=29736461

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2004513217A Expired - Fee Related JP4718172B2 (ja) 2002-06-12 2003-06-11 ヒトａｄａｍ−１０インヒビター
JP2010142096A Pending JP2010265276A (ja) 2002-06-12 2010-06-22 ヒトａｄａｍ−１０インヒビター

Family Applications Before (1)

Application Number Title Priority Date Filing Date
JP2004513217A Expired - Fee Related JP4718172B2 (ja) 2002-06-12 2003-06-11 ヒトａｄａｍ−１０インヒビター

Country Status (7)

Country Link
US (5) US7629341B2 (enExample)
EP (3) EP1511488B1 (enExample)
JP (2) JP4718172B2 (enExample)
AU (2) AU2003237532B2 (enExample)
CA (1) CA2485346C (enExample)
ES (1) ES2425013T3 (enExample)
WO (1) WO2003106381A2 (enExample)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7517884B2 (en) * 1998-03-30 2009-04-14 Kalypsys Inc. Sulfonyl-substituted bicyclic compounds as modulators of PPAR
US7629341B2 (en) * 2002-06-12 2009-12-08 Symphony Evolution, Inc. Human ADAM-10 inhibitors
EP1613269B1 (en) 2003-04-04 2015-02-25 Incyte Corporation Compositions, methods and kits relating to her-2 cleavage
EP1623995A1 (en) 2004-08-06 2006-02-08 Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts Inhibitors of L1 and ADAM10 for the treatment of carcinomas
HUE039584T2 (hu) 2004-10-29 2019-01-28 Kalypsys Inc PPAR-modulátor szulfonil-szubsztituált biciklusos vegyületek
US20070190079A1 (en) * 2004-10-29 2007-08-16 Kalypsys, Inc. Methods for the selective modulation of ppar
AU2006235260A1 (en) * 2005-04-07 2006-10-19 Novartis Vaccines And Diagnostics Inc. ADAM10 in cancer diagnosis, detection and treatment
HUE040020T2 (hu) * 2005-10-25 2019-02-28 Kalypsys Inc PPAR modulátorok sói és eljárások metabolikus betegségek kezelésére
US8247451B2 (en) 2006-01-13 2012-08-21 Vanderbilt University ADAM10 and its uses related to infection
CN100506804C (zh) * 2006-01-26 2009-07-01 于学敏 羟苯磺酸烷基吡嗪药物及其制备方法和应用
US20070249519A1 (en) * 2006-04-20 2007-10-25 Kalypsys, Inc. Methods for the upregulation of glut4 via modulation of ppar delta in adipose tissue and for the treatment of disease
AR060937A1 (es) * 2006-05-16 2008-07-23 Kalypsys Inc Compuestos biciclicos sustituidos con sulfonilo como moduladores de ppar
US20080176861A1 (en) * 2007-01-23 2008-07-24 Kalypsys, Inc. Sulfonyl-substituted bicyclic compounds as ppar modulators for the treatment of non-alcoholic steatohepatitis
US8426415B2 (en) 2007-10-16 2013-04-23 Symphony Evolution, Inc. Human ADAM-10 inhibitors
JP5632379B2 (ja) 2008-10-09 2014-11-26 アメリカ合衆国 ヒトピルビン酸キナーゼ活性化剤
WO2011041545A1 (en) 2009-10-01 2011-04-07 Symphony Evolution, Inc. Methods of treating aneurysmal dilatation, blood vessel wall weakness and specifically abdominal aortic and thoracic aneurysm using matrix metalloprotease-2 inhibitors
CA2797694A1 (en) 2010-04-29 2011-11-03 The United States Of America, As Represented By The Secretary, Departmen T Of Health And Human Services Activators of human pyruvate kinase
JP5888667B2 (ja) * 2010-04-30 2016-03-22 国立大学法人名古屋大学 Ａｄａｍ作用阻害物質のスクリーニング方法、仮足の保持方法、仮足保持剤、仮足の制御物質のスクリーニング方法、及びａｄａｍ作用阻害剤
US9150865B2 (en) 2010-11-09 2015-10-06 The University Of Chicago Role of ADAM10 and its relevance to disease and therapeutics
WO2014028334A1 (en) * 2012-08-11 2014-02-20 Symphony Evolution, Inc. Selective mmp inhibitors
EP3097420A4 (en) * 2014-01-24 2018-01-17 Ntercept, LLC Methods and compositions for immune dis-inhibition
KR102510540B1 (ko) 2014-10-03 2023-03-16 나노틱스 엘엘씨 가용성 생물분자의 생물학적 활성을 억제하기 위한 조성물 및 방법
KR20180034619A (ko) 2015-07-29 2018-04-04 나노틱스 엘엘씨 가용성 생체분자를 소거하기 위한 모듈 조성물 및 이와 관련된 방법
US11065345B2 (en) 2017-01-04 2021-07-20 Nanotics, Llc Methods for assembling scavenging particles
CN108947850B (zh) * 2018-07-23 2021-05-18 蚌埠中实化学技术有限公司 一种3,4,5-三氟苯胺的制备方法
MX2021013766A (es) * 2019-05-14 2022-02-21 Werewolf Therapeutics Inc Restos de separacion y metodos de uso de los mismos.
AU2020384375A1 (en) 2019-11-14 2022-05-26 Werewolf Therapeutics, Inc. Activatable cytokine polypeptides and methods of use thereof
CN113563235B (zh) * 2021-07-28 2023-04-11 上海毕得医药科技股份有限公司 一种3-(卤代苯氧基)苯磺酰氯衍生物的合成方法
JP2025507975A (ja) * 2022-03-08 2025-03-21 ノバ サウスイースタン ユニバーシティー ディスインテグリンおよびメタロプロテアーゼ１０（ａｄａｍ１０）の酵素・基質選択的エキソサイト阻害剤を用いた関節リウマチ（ｒａ）の処置方法

Family Cites Families (51)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1016245A (en) 1962-11-06 1966-01-05 Ici Ltd Manufacture of polysulphones
US4213775A (en) * 1977-07-28 1980-07-22 Ube Industries, Ltd. Diphenyl ether derivatives and herbicidal compositions containing the same
DE3107700A1 (de) * 1981-02-28 1982-09-16 Basf Ag, 6700 Ludwigshafen Verfahren zur herstellung von aromatischen sulfohalogeniden
WO1991013146A1 (en) * 1990-03-01 1991-09-05 The Upjohn Company Ruminal bacterium for preventing acute lactic acidosis
DE4015834A1 (de) * 1990-05-17 1991-11-21 Bayer Ag Phenoxyphenylsulfonylverbindungen
US5215549A (en) * 1991-05-08 1993-06-01 Mobil Oil Corporation Thioester derived hindered phenols and aryl-amines as antioxidant and antiwear additives
DE4327026A1 (de) 1993-08-12 1995-02-16 Bayer Ag Arylsulfonyloxyphosphonsäurederivate
DK0821671T3 (da) * 1995-04-20 2001-04-23 Pfizer Arylsulfonylhydroxamsyrederivater som MMP- og TNF-inhibitorer
JP3837761B2 (ja) * 1995-08-04 2006-10-25 住友精化株式会社 ハロベンゼンスルホニルクロリド類の製造方法
DE19537334A1 (de) * 1995-10-09 1997-04-10 Hoechst Ag Antiadhäsive Piperidin- und Pyrrolidin-Carbonsäuren
ES2233275T3 (es) * 1995-12-08 2005-06-16 Agouron Pharmaceuticals, Inc. Intermediarios que sirven para la preparacion de inhibidores de metaloproteinasas.
US5753653A (en) * 1995-12-08 1998-05-19 Agouron Pharmaceuticals, Inc. Metalloproteinase inhibitors, pharmaceutical compositions containing them and their pharmaceutical uses
US6500948B1 (en) * 1995-12-08 2002-12-31 Agouron Pharmaceuticals, Inc. Metalloproteinase inhibitors-compositions, uses preparation and intermediates thereof
CZ62799A3 (cs) 1996-08-28 1999-07-14 The Procter & Gamble Company Heterocyklické metaloproteázové inhibitory
CA2263883C (en) 1996-08-29 2003-07-08 The Regents Of The University Of California Kuz, a novel family of metalloproteases
WO1998027069A1 (en) 1996-12-17 1998-06-25 Fujisawa Pharmaceutical Co., Ltd. Piperazine compounds as inhibitors of mmp or tnf
PT958287E (pt) * 1997-01-23 2002-12-31 Hoffmann La Roche Inibidores de sulfamida-metaloprotease
BR9807678A (pt) 1997-02-11 2000-02-15 Pfizer Derivados de ácidos arilsulfonil-hidroxâmicos
WO1998043963A1 (en) * 1997-04-01 1998-10-08 Agouron Pharmaceuticals, Inc. Metalloproteinase inhibitors, pharmaceutical compositions containing them and their pharmaceutical uses
US5922546A (en) 1997-08-25 1999-07-13 Smithkline Beecham Corporation Human disintegrin metalloprotease KUZ gene
JP4327915B2 (ja) * 1998-03-30 2009-09-09 株式会社デ・ウエスタン・セラピテクス研究所 スルフォンアミド誘導体
GT199900044A (es) * 1998-04-10 2000-09-14 Procedimientos para preparar haluros de fenoxifenilsulfonilo.
JP2002514647A (ja) 1998-05-14 2002-05-21 デュポン ファーマシューティカルズ カンパニー メタロプロテイナーゼ阻害薬としての新規な置換アリールヒドロキサム酸
AU4925099A (en) * 1998-08-12 2000-03-06 Pfizer Products Inc. Tace inhibitors
US6509337B1 (en) * 1998-09-17 2003-01-21 Pfizer Inc. Arylsulfonyl Hydroxamic Acid derivatives as MMP and TNF inhibitors
AR035313A1 (es) 1999-01-27 2004-05-12 Wyeth Corp Inhibidores de tace acetilenicos de acido hidroxamico de sulfonamida a base de alfa-aminoacidos, composiciones farmaceuticas y el uso de los mismos para la manufactura de medicamentos.
US6225311B1 (en) * 1999-01-27 2001-05-01 American Cyanamid Company Acetylenic α-amino acid-based sulfonamide hydroxamic acid tace inhibitors
JP2000247975A (ja) 1999-02-25 2000-09-12 Nissan Chem Ind Ltd ヘテロ環縮合ピリミジノン誘導体及びそれらを含む除草剤
US6387901B1 (en) * 1999-07-06 2002-05-14 Pfizer Inc Alkyne containing metalloproteinase inhibitors
EP1081137A1 (en) * 1999-08-12 2001-03-07 Pfizer Products Inc. Selective inhibitors of aggrecanase in osteoarthritis treatment
WO2001055112A1 (en) * 2000-01-27 2001-08-02 American Cyanamid Company Method for preparing alpha-sulfonyl hydroxamic acid derivatives
US6664291B2 (en) * 2000-03-31 2003-12-16 Pfizer, Inc. Malonamic acids and derivatives thereof as thyroid receptor ligands
JP4635162B2 (ja) * 2000-04-27 2011-02-16 独立行政法人理化学研究所 芳香族ジアミンの製造方法及び芳香族ジアミン化合物
AU2002255613A1 (en) 2001-02-27 2002-09-12 Axys Pharmaceuticals, Inc. Piperazine derivatives as metalloprotease inhibitors
CA2357110A1 (en) 2001-04-11 2002-10-11 American Cyanamid Company Method for the treatment of polycystic kidney disease
EP1389204A4 (en) * 2001-04-26 2005-03-23 Kolon Inc NEW SULPHONAMIDE DERIVATIVES, THEIR INTERMEDIATES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITION CONTAINING THESE COMPOUNDS
US6399823B1 (en) * 2001-04-30 2002-06-04 General Electric Company Method for producing phosgene
MXPA04004010A (es) * 2001-11-01 2004-07-23 Wyeth Corp Acidos hidroxamicos de aril sulfonamida alenicos como inhibidores de tace y metaloproteinasa de matriz.
CN1173960C (zh) 2001-12-06 2004-11-03 中国人民解放军军事医学科学院毒物药物研究所 取代六元氮杂环类化合物及其作为神经调节剂的用途
WO2003051825A1 (en) * 2001-12-14 2003-06-26 Exelixis, Inc. Human adam-10 inhibitors
CA2471814C (en) 2001-12-27 2011-03-15 Sumitomo Pharmaceuticals Co., Ltd. Hydroxamic acid derivative and mmp inhibitor containing the same as active ingredient
WO2003057214A1 (en) 2001-12-28 2003-07-17 Somatocor Pharmaceuticals, Inc. Imidazolidin-2,4-dione derivatives as non-peptide somatostatin receptor ligands
US7488754B2 (en) * 2002-04-05 2009-02-10 Wyeth Method for the treatment of polycystic kidney disease
US7629341B2 (en) 2002-06-12 2009-12-08 Symphony Evolution, Inc. Human ADAM-10 inhibitors
EP1537098A1 (en) * 2002-08-13 2005-06-08 Warner-Lambert Company LLC Monocyclic derivatives as matrix metalloproteinase inhibitors
EP1400244A1 (en) * 2002-09-17 2004-03-24 Warner-Lambert Company LLC New spirocondensed quinazolinones and their use as phosphodiesterase inhibitors
EP1592389B1 (en) * 2003-02-14 2009-04-22 Laboratoires Serono SA Piperazine-2-carboxamide derivatives
BRPI0407587A (pt) * 2003-02-18 2006-02-14 Pfizer inibidores do vìrus da hepatite c, composições e tratamentos que os utilizam
WO2006076442A2 (en) 2005-01-14 2006-07-20 Janssen Pharmaceutica N.V. Triazolopyrimidine derivatives
JP2009509923A (ja) 2005-08-26 2009-03-12 メシルジーン、インコーポレイテッド ヒストンデアセチラーゼのベンゾジアゼピン及びベンゾピペラジン類似体阻害薬
JP5155171B2 (ja) 2005-10-06 2013-02-27 アストラゼネカ・アクチエボラーグ 新規化合物

Similar Documents

Publication Publication Date Title
JP2010265276A5 (enExample)
Kang et al. Copper-catalyzed trifluoromethylthiolation of aryl and vinyl boronic acids with a shelf-stable electrophilic trifluoromethylthiolating reagent
RU2017102355A (ru) Способ получения конденсированного гетероциклического соединения
Singh et al. Aerobic oxysulfonylation of alkynes in aqueous media: highly selective access to β-keto sulfones
JP2009263394A5 (enExample)
JP2013079282A5 (enExample)
JP2016153424A5 (enExample)
JP2014512451A5 (enExample)
JP2013505929A5 (enExample)
JP2014508811A5 (enExample)
JP2013063963A5 (ja) 複素環化合物
JP2012521377A5 (enExample)
JP2013529602A5 (enExample)
RU2016135762A (ru) Способ получения (r)-1,1,3-триметил-4-аминоиндана
JP2016512547A5 (enExample)
RU2011154176A (ru) Способ получения 6-(арил)-4-аминопиколинатов
JP2010522214A5 (enExample)
JP2012508747A5 (enExample)
Talukdar et al. Ullmann-Type N-, S-, and O-Arylation Using a Well-Defined 7-Azaindole-N-oxide (7-AINO)-Based Copper (II) Catalyst: Scope and Application to Drug Synthesis
RU2019138773A (ru) Производство транс-[тетрахлорбис(1h-индазол)рутената(iii)] и его композиций
JP2015518469A5 (enExample)
RU2018104555A (ru) Новое соединение, специфически связывающееся с рецептором ampa
Feng et al. Copper-catalyzed conversion of aryl and heteroaryl bromides into the corresponding chlorides
CN102603735B (zh) 一种c-2芳基化吲哚嗪化合物的制备方法
JP2014524464A5 (enExample)