JP2010163438A5 - - Google Patents
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- JP2010163438A5 JP2010163438A5 JP2010030683A JP2010030683A JP2010163438A5 JP 2010163438 A5 JP2010163438 A5 JP 2010163438A5 JP 2010030683 A JP2010030683 A JP 2010030683A JP 2010030683 A JP2010030683 A JP 2010030683A JP 2010163438 A5 JP2010163438 A5 JP 2010163438A5
- Authority
- JP
- Japan
- Prior art keywords
- antibody
- fragment
- seq
- composition
- epitope
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000012634 fragment Substances 0.000 claims 37
- 210000004881 tumor cell Anatomy 0.000 claims 10
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 8
- 101100369076 Mus musculus Tdgf1 gene Proteins 0.000 claims 7
- 238000000034 method Methods 0.000 claims 7
- 210000004027 cell Anatomy 0.000 claims 6
- 239000002246 antineoplastic agent Substances 0.000 claims 4
- 229940127089 cytotoxic agent Drugs 0.000 claims 4
- 102000012545 EGF-like domains Human genes 0.000 claims 2
- 108050002150 EGF-like domains Proteins 0.000 claims 2
- 125000000539 amino acid group Chemical group 0.000 claims 2
- 235000018417 cysteine Nutrition 0.000 claims 2
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 claims 2
- 238000003018 immunoassay Methods 0.000 claims 2
- 206010006187 Breast cancer Diseases 0.000 claims 1
- 208000026310 Breast neoplasm Diseases 0.000 claims 1
- 206010009944 Colon cancer Diseases 0.000 claims 1
- 206010061968 Gastric neoplasm Diseases 0.000 claims 1
- 102000001706 Immunoglobulin Fab Fragments Human genes 0.000 claims 1
- 108010054477 Immunoglobulin Fab Fragments Proteins 0.000 claims 1
- 102000008394 Immunoglobulin Fragments Human genes 0.000 claims 1
- 108010021625 Immunoglobulin Fragments Proteins 0.000 claims 1
- 102000017727 Immunoglobulin Variable Region Human genes 0.000 claims 1
- 108010067060 Immunoglobulin Variable Region Proteins 0.000 claims 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 1
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 1
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 1
- 208000024313 Testicular Neoplasms Diseases 0.000 claims 1
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 claims 1
- 230000004663 cell proliferation Effects 0.000 claims 1
- 208000029742 colonic neoplasm Diseases 0.000 claims 1
- 210000004408 hybridoma Anatomy 0.000 claims 1
- 239000003446 ligand Substances 0.000 claims 1
- 201000005202 lung cancer Diseases 0.000 claims 1
- 208000020816 lung neoplasm Diseases 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 208000025189 neoplasm of testis Diseases 0.000 claims 1
- 201000002528 pancreatic cancer Diseases 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 229920001184 polypeptide Polymers 0.000 claims 1
- 102000004196 processed proteins & peptides Human genes 0.000 claims 1
- 108090000765 processed proteins & peptides Proteins 0.000 claims 1
- 102000005962 receptors Human genes 0.000 claims 1
- 108020003175 receptors Proteins 0.000 claims 1
- 230000001105 regulatory effect Effects 0.000 claims 1
- 230000011664 signaling Effects 0.000 claims 1
- 201000003120 testicular cancer Diseases 0.000 claims 1
- 230000004565 tumor cell growth Effects 0.000 claims 1
- 230000004614 tumor growth Effects 0.000 claims 1
- 208000025421 tumor of uterus Diseases 0.000 claims 1
- 206010046766 uterine cancer Diseases 0.000 claims 1
- 208000024719 uterine cervix neoplasm Diseases 0.000 claims 1
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US28678201P | 2001-04-26 | 2001-04-26 | |
| US29302001P | 2001-05-17 | 2001-05-17 | |
| US30109101P | 2001-06-26 | 2001-06-26 | |
| US36700202P | 2002-03-22 | 2002-03-22 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009025420A Division JP4575983B2 (ja) | 2001-04-26 | 2009-02-05 | Ｃｒｉｐｔｏをブロックする抗体およびその使用 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2010163438A JP2010163438A (ja) | 2010-07-29 |
| JP2010163438A5 true JP2010163438A5 (OSRAM) | 2011-04-07 |
Family
ID=27501437
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002585468A Expired - Fee Related JP4307845B2 (ja) | 2001-04-26 | 2002-04-17 | Ｃｒｉｐｔｏをブロックする抗体およびその使用 |
| JP2005202361A Pending JP2005314436A (ja) | 2001-04-26 | 2005-07-11 | Ｃｒｉｐｔｏをブロックする抗体およびその使用 |
| JP2009025420A Expired - Fee Related JP4575983B2 (ja) | 2001-04-26 | 2009-02-05 | Ｃｒｉｐｔｏをブロックする抗体およびその使用 |
| JP2010030683A Withdrawn JP2010163438A (ja) | 2001-04-26 | 2010-02-15 | Ｃｒｉｐｔｏをブロックする抗体およびその使用 |
Family Applications Before (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002585468A Expired - Fee Related JP4307845B2 (ja) | 2001-04-26 | 2002-04-17 | Ｃｒｉｐｔｏをブロックする抗体およびその使用 |
| JP2005202361A Pending JP2005314436A (ja) | 2001-04-26 | 2005-07-11 | Ｃｒｉｐｔｏをブロックする抗体およびその使用 |
| JP2009025420A Expired - Fee Related JP4575983B2 (ja) | 2001-04-26 | 2009-02-05 | Ｃｒｉｐｔｏをブロックする抗体およびその使用 |
Country Status (33)
| Country | Link |
|---|---|
| US (6) | US7531174B2 (OSRAM) |
| EP (3) | EP2316486A3 (OSRAM) |
| JP (4) | JP4307845B2 (OSRAM) |
| KR (1) | KR100592357B1 (OSRAM) |
| CN (1) | CN100352501C (OSRAM) |
| AR (3) | AR037223A1 (OSRAM) |
| AT (2) | ATE533508T1 (OSRAM) |
| BG (1) | BG108363A (OSRAM) |
| BR (1) | BR0209254A (OSRAM) |
| CA (2) | CA2715570A1 (OSRAM) |
| CL (1) | CL2009002199A1 (OSRAM) |
| CY (1) | CY1108960T1 (OSRAM) |
| CZ (1) | CZ20033208A3 (OSRAM) |
| DE (1) | DE60230868D1 (OSRAM) |
| DK (1) | DK1390389T3 (OSRAM) |
| EA (1) | EA007469B1 (OSRAM) |
| EE (1) | EE200300528A (OSRAM) |
| ES (1) | ES2321065T3 (OSRAM) |
| GE (1) | GEP20074091B (OSRAM) |
| HU (1) | HUP0501113A3 (OSRAM) |
| IS (1) | IS2662B (OSRAM) |
| MX (1) | MXPA03009797A (OSRAM) |
| MY (2) | MY157382A (OSRAM) |
| NO (1) | NO20034805L (OSRAM) |
| NZ (1) | NZ566268A (OSRAM) |
| PL (1) | PL207087B1 (OSRAM) |
| PT (1) | PT1390389E (OSRAM) |
| RS (2) | RS20110024A (OSRAM) |
| SG (1) | SG157951A1 (OSRAM) |
| SI (1) | SI1390389T1 (OSRAM) |
| SK (1) | SK14432003A3 (OSRAM) |
| TR (1) | TR200301846T2 (OSRAM) |
| WO (1) | WO2002088170A2 (OSRAM) |
Families Citing this family (104)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US20090123470A1 (en) * | 2001-03-26 | 2009-05-14 | The Macfarlane Burnet Istitute For Medical Research And Public Health Ltd. | Antibodies Against Cancer |
| AUPR395801A0 (en) | 2001-03-26 | 2001-04-26 | Austin Research Institute, The | Antibodies against cancer |
| US7582299B2 (en) | 2001-04-26 | 2009-09-01 | Biogen Idec Ma Inc. | Cripto-specific antibodies |
| JP4307845B2 (ja) | 2001-04-26 | 2009-08-05 | バイオジェン・アイデック・エムエイ・インコーポレイテッド | Ｃｒｉｐｔｏをブロックする抗体およびその使用 |
| EP1494693B1 (en) * | 2002-03-22 | 2010-12-08 | Biogen Idec MA Inc. | Cripto-specific antibodies |
| US20050276812A1 (en) | 2004-06-01 | 2005-12-15 | Genentech, Inc. | Antibody-drug conjugates and methods |
| US20050163782A1 (en) | 2003-06-27 | 2005-07-28 | Biogen Idec Ma Inc. | Modified binding molecules comprising connecting peptides |
| WO2005028433A2 (en) * | 2003-09-15 | 2005-03-31 | Research Development Foundation | CRIPTO ANTAGONISM OF ACTIVIN AND TGF-β SIGNALING |
| SG149815A1 (en) | 2003-11-06 | 2009-02-27 | Seattle Genetics Inc | Monomethylvaline compounds capable of conjugation to ligands |
| WO2005047327A2 (en) | 2003-11-12 | 2005-05-26 | Biogen Idec Ma Inc. | NEONATAL Fc RECEPTOR (FcRn)-BINDING POLYPEPTIDE VARIANTS, DIMERIC Fc BINDING PROTEINS AND METHODS RELATED THERETO |
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| CA2743057C (en) * | 2008-11-07 | 2019-11-26 | Research Development Foundation | Compositions and methods for the inhibition of cripto/grp78 complex formation and signaling |
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