JP2010046518A - ニキビ処置装置および方法 - Google Patents
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Abstract
【解決手段】強い紫青色ダイオード光源と、光放射中に皮膚と接触して皮膚に放熱板を提供する出力ウィンドウを備えるニキビ処置方法およびニキビ処置皮膚病学的装置を開示する。他の形態は、強い紫青色光源と、皮膚に接触する放熱板を備えるハンドヘルド型コードレス装置を備える装置の構成と方法を開示する。さらに、狭い領域を照射し、接触して利用する放熱板を備える構成と方法を開示する。さらに、狭い領域を照射し、接触して利用する放熱板を備えるハンドヘルド型コードレス装置の構成と方法を開示する。
【選択図】図1
Description
本出願は、2003年2月28日出願の米国仮出願第60/451,091号、2003年3月20日出願の米国仮出願第60/456,379号、2003年3月27日出願の米国仮出願第60/458,861号、2003年5月20日出願の米国仮出願第60/472,056号、2003年2月25日出願の米国仮出願第60/450,243号、2003年2月26日出願の米国仮出願第60/450,598号、2003年3月4日出願の米国仮出願第60/452,304号、2003年3月4日出願の米国仮出願第60/451,981号、2003年3月6日出願の米国仮出願第60/452,591号、2003年3月21日出願の米国仮出願第60/456,586号に基づく§35USC119(e)の優先権の利益を主張する。
科学技術
細菌がニキビ損傷部位に存在し、ざそうプロピオンバクテリウムから生成されるコプロポルフィリンやプロトポルフィリンなどの各種ポルフィリンを生成することは科学的に立証されている(コルネリウス、ルートウィヒ1967年、リー他1978年、ファンタ他1981年、メロ、ジョンソン1982年、クジェルドスタッド他1984年)。ポルフィリンは周知の環状分子であり、生物学的プロセスでは一般的に知られているものである。ポルフィリンはソレー帯で略400nmの強い吸収力をもち、その特長は、特定のポルフィリン種(ラング1996年)によって微妙に変化し、照射後に細胞に損傷を与える感光医薬品である(ジロッティ1983年)。
光線療法関連装置や方法は多くの特許文献に開示されている。
本発明に関連する周知の装置が医学界や消費者に市販されている。
本発明は、既存のニキビ光線治療の最新技術における上述の問題点のうちの少なくとも1つを改善するものである。一実施形態では、強い紫青色ダイオード光源と、光出力時に皮膚接触型放熱板として働く出力ウィンドウを備える装置および方法を開示している。別の一実施形態では、強い紫青色光源と、皮膚接触型放熱板を備えるハンドヘルド型コードレス装置を開示している。第三の実施形態では、狭い領域を照射し、接触型放熱板を備える装置および方法を開示している。第四の実施形態では、狭い領域を照射し、接触型放熱板を備えるハンドヘルド型コードレス装置を開示している。
以下に、上下で引用されている文献に加えて背景と本発明の概要で説明されたものを含む文献に対応する引用リストを示す。これらは、好適な実施形態の構成要素や特徴に対する代替えの実施形態を開示する際において、以下の好適な実施形態の詳細説明に対する援用文献となるものであって、以下で詳述されていないことがある。これらの文献を単独で、または、1つ以上を組み合わせたものを考慮することで、以下で詳述する好適な実施形態の構成要素もしくは特徴の変形例を提供することができる。その他の特許、特許出願、非特許文献も記述されており、それらは、以下の文献に関する記載と同様の効果を有する好適な実施形態の援用文献である。
米国出願公開第2001/0023363号、第2002/0128695号、第2002/0161418号、第2002/0173833号、第2003/0216795号、
2003年2月28日出願の米国仮出願第60/451,091号、2003年3月20日出願の米国仮出願第60/456,379号、2003年3月27日出願の米国仮出願第60/458,861号、2003年5月20日出願の米国仮出願第60/472,056号、2003年2月25日出願の米国仮出願第60/450,243号、2003年2月26日出願の米国仮出願第60/450,598号、2003年3月4日出願の米国仮出願第60/452,304号、2003年3月4日出願の米国仮出願第60/451,981号、2003年3月6日出願の米国仮出願第60/452,591号、2003年3月21日出願の米国仮出願第60/456,586号、これらは全て出願譲受人に譲渡される(「クロスリファレンス仮出願」と総称する)、
2004年2月に出願されたトビン・シー・アイランド(Tobin C. Island)、ロバート・イー・グローブ(Robert E. Grove)、マーク・ブイ・レックワース(Mark V. Weckwerth)の米国出願第10/ 、「目に安全な、独立型毛再生抑制装置および方法」、2004年2月に出願されたRobert E. Grove、Mark V. Weckwerth、Tobin C. Islandの出願第10/ 、「目に安全な、皮膚処置装置および方法」、2004年2月 日に出願されたマーク・ブイ・レックワース(Mark V. Weckwerth)、トビン・シー・アイランド(Tobin C. Island)、ロバート・イー・グローブ(Robert E. Grove)の出願10/ 、「レーザーダイオードを利用した独立型皮膚処置装置および方法」。これらは全て出願譲受人に譲渡される(「クロスリファレンスの出願」と総称する)
PCT出願公開第WO00/02491号、
科学文献:本願の好適な実施形態の詳細な説明の末尾にある科学文献リストを参照のこと。
皮膚病学的装置の各種態様を開示する出願の同一の発明者による上述のクロスリファレンス仮出願およびクロスリファレンスの出願が注目されているが、これには、毛除去装置および方法、および目に安全な装置および方法が含まれている。これらの出願で開示されている態様や特徴が本願のニキビ処置装置および方法での利用に適するように構成可能であることを、当業者は理解していることは明らかである。
装置と皮膚の有限要素モデルを作成することによって、皮膚の露光前、露光中、露光後に起こる熱伝達をシミュレーションした。様々なケースをモデル化した。本願では、4つのケースが含まれている。それらはケース1、ケース2、ケース3、ケース4と呼ばれ、それぞれ、図2、図3、図4、図5に結果のグラフを示す。図2から図5は皮膚およびウィンドウの温度対位置の関係を示すグラフである。位置x=0から左側の領域は皮膚を示す。位置x=0から右側の領域は、空気(ケース1)もしくは皮膚に接触するウィンドウ(ケース2、ケース3、ケース4)のいずれかを示す。
1.クジェルドスタッド・B他、「ポルフィリンによる細菌の感光性化」Adv Bxp Med Biol. 1985年;193:155-9. PMID: 4096295 [PubMed-MEDLINE用索引]
2.荒金他、「照射時、プロピオン酸菌属ニキビ中に含まれるコプロポルフィリンから一重項酸素(1デルタg)の生成」Biochem Biophys Res Commun.、1996年6月25日;223(3):
578-82. PMID: 8687438 [PubMed-MEDLINE用索引]
3.アシュケナージ・H他、「高強度青色光照射後の内因性ポルフィリンによるプロピオン酸菌属ニキビの撲滅」FEMS Immunol Med Microbiol. 2003年1月21日;35(1):17-24 PMID:12589953[PubMed-MEDLINE用索引]
4.コルネリウス・CE3世他、「吹出物の赤色蛍光:コリネバクテリアニキビによるポルフィリンの生成」J Invest Dermatol.、1967年10月;49(4):368-70. PMID: 4228644 [PubMed-MEDLINE用索引]
5.ファンタ・D他、「ニキビおよび脂漏症中に含まれるプロピオン酸菌属ニキビのポルフィリン合成」Arch Dermatol Res.、1978年4月7日;261(2):175-9. German.、PMID: 148872[PubMed-MEDLINE用索引]
6.フォルマネク・I他、「プロピオン酸菌属ニキビによるポルフィリン合成(著者の翻訳)」Arch Dermatol Res.、1977年8月22日;259(2).169-76. German. PMID:334087[PubMed - MEDLINE用索引]
7.川田A他、「高強度、拡張型、狭帯域の青色光源によるニキビ光線治療:一般試験および試験管内調査」J Dermantol Sci.、2002年11月;30(2): 129-35. PMID: 12413768 [PubMed-MEDLINE用索引]
8.クジェルドスタッド・B他「プロピオン酸菌属ニキビの青色および近紫外線不活性化の作用スペクトル;ポルフィリンによる感光性化の可能性の強調」Photochem Photobiol. 1986年1月;43(1):67-70. PMID:3952162 [PubMed-MEDLINE用索引]
9.クジェルドスタッド・B他「プロピオン酸菌属ニキビ中に精製されるポルフィリンへ与えるpHの影響」Arch Dermatol Res. 1984年;276(6):396-400. PMID: 6517611 [PubMed - MEDLINE用索引]
10.リー・WL他「プロピオン酸菌属ニキビおよびプロピオン酸菌属顆粒膜中に精製されるポルフィリンの比較研究」S Bacteriol. 1978年2月;133(2):811-5. PMID: 637914 [PubMed-MEDLINE用索引]
11.マギンリー・KJ他「顔用濾胞性ポルフィリン蛍光:年齢とプロピオン酸菌属ニキビ密度の相関関係」Br J Dermatol. 1980年4月;102(4): 437-41. PMID: 7387886 [PubMed-MEDLINE用索引]
12.メフェール・H他「可視光を利用したニキビ治療。青色光高エネルギーランプを利用して照射時間を削減(翻訳)」Dermatol Monatsschr. 1990年;176(10):597-603. German. PMID: 2150382 [PubMed-MEDLINE用索引]
13.メフェール・H他「『TuR』UV10胴部照射ユニットを用いた尋常性ニキビの光線治療(翻訳)」Dermatol Monatsschr.、1986年;172(1):9-13. German. PMID:2938991 [PubMed - MEDLINE用索引]
14.メフェール・H他「UVA照射器具TBG400を用いた尋常性ニキビの光線治療(翻訳)」Dermatol Monatsschr.、1986年;172(2):105-6. German. PMID: 2937663 [PubMed - MEDLINE用索引]
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16.クジェルドスタッド・B他「プロピオン酸菌属ニキビ中の近紫外線誘導ラジカル、77Kでの電子スピン共鳴分光分析による研究」J Photochem Photobiol B. 1991年5月; 9(2):181-7. PMID: 1650821 [PubMed-MEDLINE用索引]
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18.メロ・TB他「プロピオン酸菌属ニキビ中のポルフィリンの光線破壊」Z Naturforsch [C]. 1985年1月―2月;40(1-2):125-8. PMID:3993179 [PubMed-MEDLINE用索引]
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20.ミルス・OH他「紫外線による尋常性ニキビの光線治療および光線化学療法」Arch Dermatol. 1978年2月;114(2):221-3. PMID: 147054 [PubMed-MEDLINE用索引]
21.パパジョルジュ・P他「尋常性ニキビの処置に青色(415nm)光および赤色(660nm)光を用いた光線治療」Br J Dermatol. 2000年5月; 142(5):973-8. PMID: 10809858 [PubMed-MEDLINE用索引]
22.ロミティ・R他「プロピオン酸菌属ニキビ中のポルフィリンの高性能液体クロマトグラフィー分析」Arch Dermatol Res. 2000年6月;292(6):320-2. PMID: 10929774 [PubMed-MEDLINE用索引]
23.シガードソン・V他「可視光を利用した尋常性ニキビの光線治療」Dermatology. 1997年;194(3):256-60. PMID: 9187844 [PubMed-MEDLINE用索引]
24.ウェブスター・GF「尋常性ニキビ中の炎症」J Am Acad Dermatol 1995年8月;33(2 Pt 1):247-53. Review. PMID: 7622652 [PubMed-MEDLINE用索引]
25.ファンタ・D他「外部要因に基づくプロピオニバクテリアによるポルフィリン合成」Arch Dermatol Res (1981年) 271:127-133
26.レイデン・J「尋常性ニキビの治療法」ニュー・イングランド・ジャーナル・オブ・メディスン、1997年4月17日、レビュー記事
27.シャリータ・A他「最新の高強度、拡張型、狭帯域青色光源を用いたニキビフォトクリーニング(APC)」臨床アプリケーションノート、第9巻第1号、ESCメディカルシステムズ(ヨクナム、イスラエル)PB 558-0230 Rev. A
28.シュニットキント・F他「狭帯域青色光の抗炎症性特性」ポスター・プレゼンテーション(会議不明)
29.ラング・S ウェブサイト「ポルフィリンのページ」1996年4月16日作成、2002年11月11日更新http://www.washburn.edu/cas/chemistry/sleung/porphyrin/porphyrin_page.html
Claims (103)
- ニキビ処置用の皮膚病学的装置であって、
主に400〜450nmの波長帯域の光を生成する光源と、
出力ウィンドウであって、前記光が当該出力ウィンドウを通って出力され、前記光が当該出力ウィンドウを通って出力されるときに処置を受ける対象の表皮に接触するように構成される、当該出力ウィンドウと
を備え、
前記出力ウィンドウの出力面での前記光の強度は少なくとも100mW/cm2であり、
前記表皮と前記出力ウィンドウ間の接触によって、前記光による表皮で起こる温度上昇を実質的に低下させるような熱伝導が、前記出力ウィンドウで起こる装置。 - 前記光源は、ダイオード光源を備える、請求項1の皮膚病学的装置。
- 前記光源は、1つ以上の発光ダイオードを備える、請求項2の皮膚病学的装置。
- 前記1つ以上の発光ダイオードはレンズなしであって、2つ以上の場合は2次元アレイとして配列される、請求項3の皮膚病学的装置。
- 前記光源は、ダイオードレーザーを備える、請求項2の皮膚病学的装置。
- 前記光は光路に沿って伝搬し、前記光の積分放射輝度を目に安全な値まで下げるための光拡散器が、前記光路に沿って配置される、請求項5の皮膚病学的装置。
- 前記光拡散器は、透過型である、請求項6の皮膚病学的装置。
- 前記光拡散器は、反射型である、請求項6の皮膚病学的装置。
- 前記出力面における前記光の強度は、500mW/cm2より大きい、請求項2の皮膚病学的装置。
- 前記出力面における前記光のスポット・サイズは、5cm2より小さい、請求項2の皮膚病学的装置。
- 前記出力ウィンドウは、表皮温度の公称値よりも低い温度に維持される、請求項2の皮膚病学的装置。
- 前記出力ウィンドウは、サファイヤ、石英ガラス、溶融石英、高分子材料、ガラスから選択された材料を備える、請求項11の皮膚病学的装置。
- 前記出力ウィンドウは、サファイヤを備える、請求項12の皮膚病学的装置。
- 前記出力ウィンドウは、ほぼ表皮温度の公称値に維持される、請求項2の皮膚病学的装置。
- 前記出力ウィンドウは、サファイヤ、石英ガラス、溶融石英、高分子材料、ガラスから選択された材料を備える、請求項14の皮膚病学的装置。
- 前記出力ウィンドウは、サファイヤを備える、請求項15の皮膚病学的装置。
- 前記光源による光の生成を制御するために接続された接触センサーをさらに備え、
前記接触センサーと接触面とが実質的に接触したときのみ、前記出力ウィンドウから光を放射するように制御される、請求項2の皮膚病学的装置。 - 実質的な接触がされたときに、前記光源が自動的に誘発され、前記出力ウィンドウから前記光が放射される、請求項17の皮膚病学的装置。
- 前記出力ウィンドウに結合された熱バッテリーをさらに備え、
前記熱バッテリーは、金属、相変化物質、圧縮物質のうちの1つ以上を備える、請求項2の皮膚病学的装置。 - 熱電冷却モジュールをさらに備える、請求項2の皮膚病学的装置。
- コードレスの内蔵型ニキビ処置用の皮膚病学的装置であって、
ハンドヘルド操作用に構成されたハウジングと、
前記ハウジング内に組み込まれた1つ以上のバッテリーと、
前記ハウジング内に組み込まれ、前記バッテリーから電源を供給され、実質的に400〜450nmの波長帯域の光を生成する光源と、
前記光が放射される出力ウィンドウであって、前記光が前記出力ウィンドウから放射されるときに治療を受ける対象の表皮に接触するように構成される当該出力ウィンドウと、
前記ハウジング内に組み込まれた熱除去エレメントと
を備え、
前記出力ウィンドウの出力面における前記光の強度は、少なくとも100mW/cm2であり、
前記コードレス装置の総重量は1キログラム未満であり、容積は1500cm3よりも小さく、
前記光による前記表皮での温度上昇は、前記表皮および前記出力ウィンドウ間の接触により実質的に低下する、コードレスの内蔵型ニキビ処置用皮膚病学的装置。 - 前記熱除去エレメントは、1つ以上の熱バッテリー、或いは1つ以上のフィン付き放熱板、又はその両方を備える、請求項21のコードレスの内蔵型ニキビ処置用皮膚病学的装置。
- 前記光源は、ダイオード光源を備える、請求項22のコードレスの内蔵型ニキビ処置用皮膚病学的装置。
- 前記光源は、1つ以上の発光ダイオードを備える、請求項23のコードレスの内蔵型ニキビ処置用皮膚病学的装置。
- 前記1つ以上の発光ダイオードは、レンズなしであって、2つ以上の場合は2次元アレイに配列される、請求項24のコードレスの内蔵型ニキビ処置用皮膚病学的装置。
- 前記光源は、ダイオードレーザーを備える、請求項23のコードレスの内蔵型ニキビ処置用皮膚病学的装置。
- 前記光は光路に沿って伝搬し、
前記光の積分放射輝度を目に安全な値まで下げるべく前記光路に沿ってさらに配置された光拡散器をさらに備える、請求項26のコードレスの内蔵型ニキビ処置用皮膚病学的装置。 - 前記光拡散器は、透過型である、請求項27のコードレスの内蔵型ニキビ処置用皮膚病学的装置。
- 前記光拡散器は、反射型である、請求項27のコードレスの内蔵型ニキビ処置用皮膚病学的装置。
- 前記出力面での前記光の強度は、500mW/cm2より大きい、請求項23のコードレスの内蔵型ニキビ処置用皮膚病学的装置。
- 前記出力面での前記光のスポット・サイズは、5cm2より小さい、請求項23のコードレスの内蔵型ニキビ処置用皮膚病学的装置。
- 前記出力ウィンドウは、表皮温度の公称値より低い温度に維持される、請求項23のコードレスの内蔵型ニキビ処置用皮膚病学的装置。
- 前記出力ウィンドウは、サファイヤ、石英ガラス、溶融石英、高分子材料、ガラスから選択された材料を備える、請求項32のコードレスの内蔵型ニキビ処置用皮膚病学的装置。
- 前記出力ウィンドウは、サファイヤを備える、請求項33のコードレスの内蔵型ニキビ処置用皮膚病学的装置。
- 前記出力ウィンドウは、ほぼ表皮温度の公称値に維持される、請求項23のコードレスの内蔵型ニキビ処置用皮膚病学的装置。
- 前記出力ウィンドウは、サファイヤ、石英ガラス、溶融石英、高分子材料、ガラスから選択された材料を備える、請求項35のコードレスの内蔵型ニキビ処置用皮膚病学的装置。
- 前記出力ウィンドウは、サファイヤを備える、請求項37のコードレスの内蔵型ニキビ処置用皮膚病学的装置。
- 前記光源による光の生成を制御するために結合された接触センサーをさらに備え、
前記接触センサーと接触面とが実質的に接触したときのみ前記出力ウィンドウから光が放射されるように制御される、請求項23のコードレスの内蔵型ニキビ処置用皮膚病学的装置。 - 実質的な接触がされたときに前記光源は自動的に誘発され、前記出力ウィンドウから前記光が放射される、請求項38のコードレスの内蔵型ニキビ処置用皮膚病学的装置。
- 前記出力ウィンドウに結合された熱バッテリーをさらに備え、
前記熱バッテリーは、金属、相変化物質、圧縮物質の1つ以上を備える、請求項23のコードレスの内蔵型ニキビ処置用皮膚病学的装置。 - 熱電冷却モジュールをさらに備える、請求項23のコードレスの内蔵型ニキビ処置用皮膚病学的装置。
- 前記光源に通電するダイレクト・ドライブ電気回路をさらに備える、請求項23のコードレスの内蔵型ニキビ処置用皮膚病学的装置。
- ニキビ処置用皮膚病学的装置であって、
400〜450nmの波長帯域の光を生成するダイオード光源と、
前記光が出力される出力ウィンドウであって、前記光が前記出力ウィンドウから出力されるときに処置を受ける対象の表皮に接触するように構成される、当該出力ウィンドウと
を備え、
前記出力ウィンドウの出力面での前記光の強度は、少なくとも100mW/cm2であり、
前記出力面での前記光のスポット・サイズは、25cm2未満であり、
前記表皮および前記出力ウィンドウ間の接触により、前記光による前記表皮の温度上昇は、実質的に低下する皮膚病学的装置。 - 前記ダイオード光源は、1つ以上の発光ダイオードを備える、請求項43の皮膚病学的装置。
- 前記1つ以上の発光ダイオードは、レンズなしであって、2つ以上の場合は2次元アレイに配列される、請求項44の皮膚病学的装置。
- 前記光源は、ダイオードレーザーを備える、請求項43の皮膚病学的装置。
- 前記光は光路に沿って伝搬し、
前記光の積分放射輝度を目に安全な値まで下げるべく前記光路に沿って配置された光拡散器をさらに備える、請求項46の皮膚病学的装置。 - 前記光拡散器は、透過型である、請求項47の皮膚病学的装置。
- 前記光拡散器は、反射型である、請求項47の皮膚病学的装置。
- 前記出力面における前記光の強度は、500mW/cm2より大きい、請求項43の皮膚病学的装置。
- 前記出力面における前記光のスポット・サイズは、5cm2より小さい、請求項43の皮膚病学的装置。
- 前記出力ウィンドウは、公称表皮温度より低い温度に保持される、請求項43の皮膚病学的装置。
- 前記出力ウィンドウは、サファイヤ、石英ガラス、溶融石英、高分子材料、ガラスから選択された材料を備える、請求項52の皮膚病学的装置。
- 前記出力ウィンドウは、サファイヤを備える、請求項53の皮膚病学的装置。
- 前記出力ウィンドウは、ほぼ公称表皮温度に維持される、請求項43の皮膚病学的装置。
- 前記出力ウィンドウは、サファイヤ、石英ガラス、溶融石英、高分子材料、またはガラスから選択された材料を備える、請求項55の皮膚病学的装置。
- 前記出力ウィンドウは、サファイヤを備える、請求項56の皮膚病学的装置。
- 前記光源による光の生成を制御するために接続された接触センサーをさらに備え、
前記接触センサーと接触面とが実質的に接触したときのみ前記出力ウィンドウから光が放射されるように制御される、請求項43の皮膚病学的装置。 - 実質的な接触がされたときに前記光源は自動的に誘発され、前記出力ウィンドウから前記光が放射される、請求項58の皮膚病学的装置。
- 前記出力ウィンドウに結合される熱バッテリーをさらに備え、
前記熱バッテリーは、金属、相変化物質、あるいは圧縮物質のうちの1つ以上を備える、請求項43の皮膚病学的装置。 - 熱電冷却モジュールをさらに備える、請求項43の皮膚病学的装置。
- コードレスの内蔵型ニキビ処置用の皮膚病学的装置であって、
ハンドヘルド操作用に構成されたハウジングと、
前記ハウジング内に組み込まれ、400〜450nmの波長帯域の光を生成するダイオード光源と、
前記ハウジング内に組み込まれ、前記ダイオード光源に電源を供給するために結合される1つ以上のバッテリーと、
前記ハウジング内に組み込まれ、前記ハウジング内に組み込まれた1つ以上のバッテリー、若しくは前記ハウジング内に組み込まれた1つ以上のフィン付き放熱板、又はその双方を備える熱除去エレメントと、
前記光が放射される出力ウィンドウであって、前記光が前記出力ウィンドウから放射されるときに治療を受ける対象の表皮に接触するように構成される当該出力ウィンドウと
を備え、
前記出力ウィンドウの出力面における前記光の強度は、少なくとも100mW/cm2であり、
前記出力面での前記光のスポット・サイズは10cm2未満であり、
前記表皮および前記出力ウィンドウ間の接触により、前記光による前記表皮の温度上昇が実質的に低下する、コードレスの内蔵型ニキビ処置用皮膚病学的装置。 - 前記ダイオード光源は1つ以上の発光ダイオードを備える、請求項62のコードレスの内蔵型ニキビ処置用皮膚病学的装置。
- 前記1つ以上の発光ダイオードは、レンズなしであって、2つ以上の場合は2次元アレイに配列される、請求項63のコードレスの内蔵型ニキビ処置用皮膚病学的装置。
- 前記光源は、ダイオードレーザーを備える、請求項62のコードレスの内蔵型ニキビ処置用皮膚病学的装置。
- 前記光は光路に沿って伝搬し、
前記光の積分放射輝度を目に安全な値まで下げるべく前記光路に沿って配置された光拡散器をさらに備える、請求項65のコードレスの内蔵型ニキビ処置用皮膚病学的装置。 - 前記光拡散器は、透過型である、請求項66のコードレスの内蔵型ニキビ処置用皮膚病学的装置。
- 前記光拡散器は、反射型である、請求項66のコードレスの内蔵型ニキビ処置用皮膚病学的装置。
- 前記出力面における前記光の強度は、500mW/cm2より大きい、請求項62のコードレスの内蔵型ニキビ処置用皮膚病学的装置。
- 前記出力面での前記光のスポット・サイズは、5cm2より小さい、請求項62のコードレスの内蔵型ニキビ処置用皮膚病学的装置。
- 前記出力ウィンドウは、表皮温度の公称値より低い温度に維持される、請求項62のコードレスの内蔵型ニキビ処置用皮膚病学的装置。
- 前記出力ウィンドウは、サファイヤ、石英ガラス、溶融石英、高分子材料、ガラスから選択された材料を備える、請求項71のコードレスの内蔵型ニキビ処置用皮膚病学的装置。
- 前記出力ウィンドウは、サファイヤを備える、請求項72のコードレスの内蔵型ニキビ処置用皮膚病学的装置。
- 前記出力ウィンドウは、ほぼ表皮温度の公称値に維持される、請求項62のコードレスの内蔵型ニキビ処置用皮膚病学的装置。
- 前記出力ウィンドウは、サファイヤ、石英ガラス、溶融石英、高分子材料、ガラスから選択された材料を備える、請求項74のコードレスの独立型ニキビ処置用
皮膚病学的装置。 - 前記出力ウィンドウは、サファイヤを備える、請求項75のコードレスの内蔵型ニキビ処置用皮膚病学的装置。
- 前記光源による光の生成を制御するために接続された接触センサーをさらに備え、
前記接触センサーと接触面とが実質的に接触したときにのみ前記出力ウィンドウから光が放射されるように制御される、請求項62のコードレスの内蔵型ニキビ処置用皮膚病学的装置。 - 実質的な接触がされたときに前記光源は自動的に誘発され、前記出力ウィンドウから前記光が放射される、請求項77のコードレスの内蔵型ニキビ処置用皮膚病学的装置。
- 前記熱バッテリーは、金属、相変化物質、圧縮物質のうちの1つ以上を備える、請求項62のコードレスの内蔵型ニキビ処置用皮膚病学的装置。
- 熱電冷却モジュールをさらに備える、請求項62のコードレスの内蔵型ニキビ処置用皮膚病学的装置。
- 前記光源に通電するダイレクト・ドライブ電気回路をさらに備える、請求項62のコードレスの内蔵型ニキビ処置用皮膚病学的装置。
- 前記表皮の温度上昇は、25℃以下である、請求項1の皮膚病学的装置。
- 前記表皮の温度上昇は、25℃以下である、請求項21のコードレスの内蔵型皮膚病学的装置。
- 前記表皮の温度上昇は、25℃以下である、請求項43の皮膚病学的装置。
- 前記表皮の温度上昇は、25℃以下である、請求項62のコードレスの内蔵型皮膚病学的装置。
- ニキビ処置方法であって、
処置対象の皮膚に出力ウィンドウを接触させて配置し、
前記出力ウィンドウを通して前記出力ウィンドウから400〜450nmの波長帯域の光を出力し、前記出力ウィンドウの出力面での前記光の強度は少なくとも100mW/cm2であり、
前記光によって表皮で起こる温度上昇が、前記表皮と前記出力ウィンドウとの間の接触によって実質的に低下するように、前記出力ウィンドウを通して熱を伝導することを含む方法。 - 前記出力ウィンドウの温度を、表皮温度の公称値より低い温度に維持することを含む、請求項86の方法。
- 前記出力ウィンドウの温度を、ほぼ表皮温度の公称値に維持することを含む、請求項86の方法。
- 前記熱を伝導するステップは、前記表皮の温度上昇が25℃以下になるように十分熱を伝導させることを含む、請求項86の方法。
- 前記出力ウィンドウと前記表皮との接触が接触センサーによって感知されない限り、前記出力ウィンドウから光の放射を禁止することをさらに含む、請求項86の方法。
- 前記光の積分放射輝度を目に安全なレベルまで下げるべく前記光を拡散することをさらに含む、請求項86の方法。
- ニキビ処置装置を構成する方法であって、
(a)ハンドヘルド操作用に構成されたハウジング内に
(i)400〜450nmの波長帯域の光を生成するダイオード光源と、
(ii)1つ以上のバッテリーと、
(iii)熱除去エレメントと、
(iv)出力ウィンドウであって、当該出力ウィンドウを通して前記光を出力する、当該出
力ウィンドウと
を供給することと、
(b)前記出力ウィンドウの出力面での前記光の強度が少なくとも100mW/cm2になるように、前記1つ以上のバッテリーからのみ前記ダイオード光源に通電することと、
(c)表皮と接触するように前記出力ウィンドウを構成することと、
(d)前記表皮と前記出力ウィンドウとの間の接触によって、前記光により表皮で起こる温度上昇が実質的に低下するように前記出力ウィンドウを通して熱を伝導することと
を含む方法。 - 前記熱を伝導することは、前記表皮の温度上昇が25℃以下になるように十分熱を伝導させることを含む、請求項92の方法。
- 前記出力ウィンドウの温度を、表皮温度の公称値より低い温度に維持することを含む、請求項92の方法。
- 前記出力ウィンドウの温度を、ほぼ表皮温度の公称値に維持することを含む、請求項92の方法。
- 前記接触センサーによって前記出力ウィンドウと前記表皮との間の接触が感知されない限り、前記出力ウィンドウからの光の放射が禁止されるように、前記ハウジング上に出力センサーを配置することをさらに含む、請求項92の方法。
- 前記出力ウィンドウの出力面で出力される光のスポット・サイズが、10cm2未満となるように構成することをさらに含む、請求項92の方法。
- 前記光の積分放射輝度を目に安全なレベルまで下げるように、前記光を拡散することをさらに含む、請求項92の方法。
- ニキビ処置装置を操作する方法であって、
前記装置は、ハンドヘルド操作用に構成されたハウジングと、400〜450nmの波長帯域の光を生成するダイオード光源と、1つ以上のバッテリーと、熱除去エレメントと、前記光を出力する出力ウィンドウとを備え、前記出力ウィンドウは表皮と接触するように構成され、
(a)前記1つ以上のバッテリーからのみ前記ダイオード光源に通電することと、
(b)前記出力ウィンドウの出力面で少なくとも100mW/cm2の強度の光が生成されるように前記ダイオード光源に通電することと、
(c)前記表皮と前記出力ウィンドウとの間の接触によって前記光により表皮で起こる温度上昇が実質的に低下するように、前記出力ウィンドウから熱を伝導することと
を含む方法。 - 前記出力ウィンドウと前記表皮との接触が接触センサーによって感知されない限り、前記出力ウィンドウから光の放射を禁止することをさらに含む、請求項99の方法。
- 前記光の積分放射輝度を目に安全なレベルまで下げるように前記光を拡散することをさらに含む、請求項99の方法。
- 前記熱を伝導することは、前記熱除去エレメントを、前記出力ウィンドウに熱的に結合することを含む、請求項99の方法。
- 前記出力ウィンドウの出力面で出力される光のスポット・サイズが10cm2未満となるように構成することをさらに含む、請求項99の方法。
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-
2004
- 2004-02-19 EP EP13159309.7A patent/EP2604216B1/en not_active Expired - Lifetime
- 2004-02-19 EP EP13159308.9A patent/EP2604215B1/en not_active Expired - Lifetime
-
2008
- 2008-11-14 US US12/271,819 patent/US20090204109A1/en not_active Abandoned
-
2009
- 2009-11-16 JP JP2009261364A patent/JP2010046518A/ja active Pending
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2013
- 2013-10-07 US US14/047,998 patent/US10342617B2/en active Active
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2014
- 2014-02-03 US US14/171,592 patent/US10342618B2/en active Active
Also Published As
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EP2604216B1 (en) | 2018-08-22 |
US10342617B2 (en) | 2019-07-09 |
EP2604215B1 (en) | 2017-10-11 |
US10342618B2 (en) | 2019-07-09 |
US20090204109A1 (en) | 2009-08-13 |
US20140155876A1 (en) | 2014-06-05 |
EP2604215A1 (en) | 2013-06-19 |
US20140171929A1 (en) | 2014-06-19 |
EP2604216A1 (en) | 2013-06-19 |
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