JP2009545309A - 組換え型生物学的製剤を製造する方法 - Google Patents

組換え型生物学的製剤を製造する方法 Download PDF

Info

Publication number
JP2009545309A
JP2009545309A JP2009522414A JP2009522414A JP2009545309A JP 2009545309 A JP2009545309 A JP 2009545309A JP 2009522414 A JP2009522414 A JP 2009522414A JP 2009522414 A JP2009522414 A JP 2009522414A JP 2009545309 A JP2009545309 A JP 2009545309A
Authority
JP
Japan
Prior art keywords
cell
mirna
mammalian
cho
culture
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2009522414A
Other languages
English (en)
Japanese (ja)
Other versions
JP2009545309A5 (enExample
Inventor
パトリック ギャメル,
ナイアル バーロン,
マーティン クラインズ,
Original Assignee
ダブリン シティ ユニバーシティ
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=38720408&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=JP2009545309(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by ダブリン シティ ユニバーシティ filed Critical ダブリン シティ ユニバーシティ
Publication of JP2009545309A publication Critical patent/JP2009545309A/ja
Publication of JP2009545309A5 publication Critical patent/JP2009545309A5/ja
Pending legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/111General methods applicable to biologically active non-coding nucleic acids
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00Structure or type of the nucleic acid
    • C12N2310/10Type of nucleic acid
    • C12N2310/11Antisense
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00Structure or type of the nucleic acid
    • C12N2310/10Type of nucleic acid
    • C12N2310/11Antisense
    • C12N2310/111Antisense spanning the whole gene, or a large part of it
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00Structure or type of the nucleic acid
    • C12N2310/10Type of nucleic acid
    • C12N2310/14Type of nucleic acid interfering nucleic acids [NA]
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2320/00Applications; Uses
    • C12N2320/50Methods for regulating/modulating their activity

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2009522414A 2006-08-04 2007-08-03 組換え型生物学的製剤を製造する方法 Pending JP2009545309A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IE20060587 2006-08-04
PCT/IE2007/000078 WO2008015662A1 (en) 2006-08-04 2007-08-03 A method of producing recombinant biological products

Publications (2)

Publication Number Publication Date
JP2009545309A true JP2009545309A (ja) 2009-12-24
JP2009545309A5 JP2009545309A5 (enExample) 2010-09-16

Family

ID=38720408

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2009522414A Pending JP2009545309A (ja) 2006-08-04 2007-08-03 組換え型生物学的製剤を製造する方法

Country Status (7)

Country Link
US (1) US8476244B2 (enExample)
EP (1) EP2046970B2 (enExample)
JP (1) JP2009545309A (enExample)
CN (1) CN101541972A (enExample)
AU (1) AU2007280004A1 (enExample)
CA (1) CA2658301A1 (enExample)
WO (1) WO2008015662A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2016532445A (ja) * 2013-08-06 2016-10-20 ロンザ バイオロジクス ピーエルシー 組換えタンパク質の生産のための哺乳動物生産細胞の生成のための手段及び方法

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2520649A3 (en) * 2007-11-23 2013-02-20 Panagene, Inc. MicroRNA antisense PNAs, compositions comprising the same, and methods for using and evaluating the same
MX374424B (es) 2012-05-21 2025-03-06 Genentech Inc Metodos para mejorar la seguridad del transporte de la barrera hematoencefalica.
EP3536789A1 (en) * 2012-06-06 2019-09-11 Boehringer Ingelheim International GmbH Cell engineering using rnas
ES2743506T3 (es) 2013-03-14 2020-02-19 Medimmune Llc Producción de polipéptidos recombinantes
WO2014204405A1 (en) * 2013-06-18 2014-12-24 Agency For Science, Technology And Research Method for modulating recombinant protein production
PL3063278T3 (pl) * 2013-11-01 2018-08-31 Sementis Limited Wytwarzanie wektora wirusowego
DE102017128356B4 (de) 2017-11-30 2024-10-10 TRUMPF Laser SE Scanspiegel und Scanspiegel-Einheit für ein Laser-Scansystem

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2005046156A (ja) * 1998-06-30 2005-02-24 Daewoong Pharmaceutical Co Ltd 生体内血小板増殖効能が向上した新規なヒトトロンボポイエチン誘導体
WO2005047505A2 (en) * 2003-08-07 2005-05-26 Whitehead Institute For Biomedical Research Methods and products for expression of micro rnas

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2530157B1 (en) * 2003-07-31 2016-09-28 Regulus Therapeutics Inc. Oligomeric compounds and compositions for use in modulation of miRNAs
EP1791954A1 (en) * 2004-09-07 2007-06-06 Yissum Research Development Company Of The Hebrew University Of Jerusalem Agents, compositions and methods for treating pathologies in which regulating an ache-associated biological pathway is beneficial
CA2857878A1 (en) 2004-11-12 2006-12-28 Asuragen, Inc. Methods and compositions involving mirna and mirna inhibitor molecules
WO2006133022A2 (en) 2005-06-03 2006-12-14 The Johns Hopkins University Compositions and methods for decreasing microrna expression for the treatment of neoplasia
EP2377559A1 (en) 2005-06-03 2011-10-19 Southern Adelaide Health Service - Flinders Medical Centre Targeting cells with altered microRNA expression

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2005046156A (ja) * 1998-06-30 2005-02-24 Daewoong Pharmaceutical Co Ltd 生体内血小板増殖効能が向上した新規なヒトトロンボポイエチン誘導体
WO2005047505A2 (en) * 2003-08-07 2005-05-26 Whitehead Institute For Biomedical Research Methods and products for expression of micro rnas

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
JPN6012043315; Nucleic Acids Res., 2005年, 第33巻, 1290-1297ページ *
JPN6012043316; J Biotechnol., 2007年6月, 第130巻, 213-218ページ *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2016532445A (ja) * 2013-08-06 2016-10-20 ロンザ バイオロジクス ピーエルシー 組換えタンパク質の生産のための哺乳動物生産細胞の生成のための手段及び方法

Also Published As

Publication number Publication date
EP2046970A1 (en) 2009-04-15
US20100190258A1 (en) 2010-07-29
WO2008015662A8 (en) 2009-07-23
WO2008015662A1 (en) 2008-02-07
US8476244B2 (en) 2013-07-02
EP2046970B2 (en) 2020-04-29
CA2658301A1 (en) 2008-02-07
AU2007280004A1 (en) 2008-02-07
EP2046970B1 (en) 2014-01-08
CN101541972A (zh) 2009-09-23

Similar Documents

Publication Publication Date Title
JP5735927B2 (ja) タンパク質生産の増強のためのmRNAの一次構造の再操作
Gammell et al. Initial identification of low temperature and culture stage induction of miRNA expression in suspension CHO-K1 cells
EP2937417B1 (en) MiRNAs enhancing cell productivity
US8476244B2 (en) Method of producing recombinant biological products
WO2008029790A1 (fr) Nouvel acide nucléique
JPWO2008084319A1 (ja) 新規核酸
CN107130024B (zh) 一种基于依赖解旋酶DNA恒温扩增技术检测microRNA的方法
Xiao et al. Role of microRNA-129-5p in osteoblast differentiation from bone marrow mesenchymal stem cells
CN107058360A (zh) 一种基于快速克隆技术的环状rna表达载体构建方法及其应用
US20100136547A1 (en) Pure miRNA Sample Preparation Method
CN109652529B (zh) 骨质疏松特异性miRNA、组合物及其诊疗用途
JP2016532445A (ja) 組換えタンパク質の生産のための哺乳動物生産細胞の生成のための手段及び方法
CN109402118B (zh) 与蛋鸭卵泡发育相关的miRNA apla-mir-145-4及其检测引物、抑制物和应用
US9896727B2 (en) Regulator targetting fatty acid synthase and method of using the same for improving meat quality
CN103740842A (zh) 高灵敏度小rna定量检测方法及试剂盒
WO2010103522A1 (en) Method for detection of nucleic acid sequences
CN102586237A (zh) 一种多聚核酸分子及其应用
CN106148343B (zh) 驴的miRNA序列、制备方法及其应用
JP2015180203A (ja) タンパク質生産の増強のためのmRNAの一次構造の再操作
JP5572814B2 (ja) 未分化細胞の心筋分化活性検出用マーカー、核酸分子、プライマーペア、キット、心筋分化抑制剤、未分化細胞の心筋分化活性検出方法、心筋分化活性を有する細胞の単離方法、未分化細胞の心筋分化活性のモニタリング方法、および未分化細胞の心筋分化の抑制方法
CN106148342B (zh) 一种miRNA序列、制备方法及其应用
WO2026074556A1 (en) Methods for rejuvenating human cells with micro rnas
KR20260056818A (ko) 소 골격근 발육 관련 circRNA 및 이의 응용
Mitchell et al. Detection and Assessment of MicroRNA Expression in Human Disease
CN119120463A (zh) 一种具有RNA切割活性的苏糖核酶Tz2及其应用

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20100730

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20100730

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20120821

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20130205