JP2009544758A5 - - Google Patents
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- JP2009544758A5 JP2009544758A5 JP2009522956A JP2009522956A JP2009544758A5 JP 2009544758 A5 JP2009544758 A5 JP 2009544758A5 JP 2009522956 A JP2009522956 A JP 2009522956A JP 2009522956 A JP2009522956 A JP 2009522956A JP 2009544758 A5 JP2009544758 A5 JP 2009544758A5
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- JP
- Japan
- Prior art keywords
- compound
- formula
- disease
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- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 150000001875 compounds Chemical class 0.000 claims 10
- -1 N-((1R, 2S, 5R) -5- (isopropyl (methyl) amino) -2-((S) -2-oxo-3- (6- (trifluoromethyl) quinazolin-4-ylamino) pyrrolidine- 1-yl) cyclohexyl) acetamide compound Chemical class 0.000 claims 6
- 150000003839 salts Chemical class 0.000 claims 6
- 239000013078 crystal Substances 0.000 claims 5
- 201000010099 disease Diseases 0.000 claims 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 4
- 201000001320 Atherosclerosis Diseases 0.000 claims 3
- 208000011231 Crohn disease Diseases 0.000 claims 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 3
- 206010012601 diabetes mellitus Diseases 0.000 claims 3
- 239000003814 drug Substances 0.000 claims 3
- 206010020718 hyperplasia Diseases 0.000 claims 3
- 201000006417 multiple sclerosis Diseases 0.000 claims 3
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 claims 3
- 238000000634 powder X-ray diffraction Methods 0.000 claims 3
- 229940124597 therapeutic agent Drugs 0.000 claims 3
- 238000002054 transplantation Methods 0.000 claims 3
- DLFVBJFMPXGRIB-UHFFFAOYSA-N Acetamide Chemical compound CC(N)=O DLFVBJFMPXGRIB-UHFFFAOYSA-N 0.000 claims 2
- 206010018364 Glomerulonephritis Diseases 0.000 claims 2
- 208000008589 Obesity Diseases 0.000 claims 2
- 201000004681 Psoriasis Diseases 0.000 claims 2
- 125000000217 alkyl group Chemical group 0.000 claims 2
- 150000001412 amines Chemical class 0.000 claims 2
- 239000001257 hydrogen Substances 0.000 claims 2
- 229910052739 hydrogen Inorganic materials 0.000 claims 2
- 150000002466 imines Chemical class 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 235000020824 obesity Nutrition 0.000 claims 2
- 210000000056 organ Anatomy 0.000 claims 2
- 229910052697 platinum Inorganic materials 0.000 claims 2
- 208000037803 restenosis Diseases 0.000 claims 2
- 201000000596 systemic lupus erythematosus Diseases 0.000 claims 2
- 206010065040 AIDS dementia complex Diseases 0.000 claims 1
- 206010001889 Alveolitis Diseases 0.000 claims 1
- 206010002329 Aneurysm Diseases 0.000 claims 1
- 206010003210 Arteriosclerosis Diseases 0.000 claims 1
- 208000023275 Autoimmune disease Diseases 0.000 claims 1
- 206010007559 Cardiac failure congestive Diseases 0.000 claims 1
- 208000024172 Cardiovascular disease Diseases 0.000 claims 1
- 208000031886 HIV Infections Diseases 0.000 claims 1
- 208000037357 HIV infectious disease Diseases 0.000 claims 1
- 206010019196 Head injury Diseases 0.000 claims 1
- 206010019280 Heart failures Diseases 0.000 claims 1
- 206010020772 Hypertension Diseases 0.000 claims 1
- 201000009794 Idiopathic Pulmonary Fibrosis Diseases 0.000 claims 1
- 208000022559 Inflammatory bowel disease Diseases 0.000 claims 1
- 206010048858 Ischaemic cardiomyopathy Diseases 0.000 claims 1
- 208000001145 Metabolic Syndrome Diseases 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 206010037660 Pyrexia Diseases 0.000 claims 1
- 206010039710 Scleroderma Diseases 0.000 claims 1
- 208000006011 Stroke Diseases 0.000 claims 1
- 206010047115 Vasculitis Diseases 0.000 claims 1
- 201000000690 abdominal obesity-metabolic syndrome Diseases 0.000 claims 1
- 125000006242 amine protecting group Chemical group 0.000 claims 1
- 239000000010 aprotic solvent Substances 0.000 claims 1
- 208000011775 arteriosclerosis disease Diseases 0.000 claims 1
- 208000006673 asthma Diseases 0.000 claims 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 239000003054 catalyst Substances 0.000 claims 1
- 230000001684 chronic effect Effects 0.000 claims 1
- 206010009887 colitis Diseases 0.000 claims 1
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims 1
- 239000012024 dehydrating agents Substances 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 201000001155 extrinsic allergic alveolitis Diseases 0.000 claims 1
- 208000033519 human immunodeficiency virus infectious disease Diseases 0.000 claims 1
- 208000022098 hypersensitivity pneumonitis Diseases 0.000 claims 1
- 208000036971 interstitial lung disease 2 Diseases 0.000 claims 1
- 208000017169 kidney disease Diseases 0.000 claims 1
- 230000003589 nefrotoxic effect Effects 0.000 claims 1
- 201000008383 nephritis Diseases 0.000 claims 1
- 231100000381 nephrotoxic Toxicity 0.000 claims 1
- 208000004296 neuralgia Diseases 0.000 claims 1
- 208000021722 neuropathic pain Diseases 0.000 claims 1
- 201000008482 osteoarthritis Diseases 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 238000006268 reductive amination reaction Methods 0.000 claims 1
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 1
- 210000002966 serum Anatomy 0.000 claims 1
- 0 CCOC([C@](CC(CC1)N(C)C(C)C)C1N(CC[C@@]1*)C1=O)=O Chemical compound CCOC([C@](CC(CC1)N(C)C(C)C)C1N(CC[C@@]1*)C1=O)=O 0.000 description 1
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US83423506P | 2006-07-28 | 2006-07-28 | |
| US89602607P | 2007-03-21 | 2007-03-21 | |
| US11/782,704 US7671062B2 (en) | 2006-07-28 | 2007-07-25 | Modulators of chemokine receptor activity, crystalline forms and process |
| PCT/US2007/074438 WO2008014381A2 (en) | 2006-07-28 | 2007-07-26 | Modulators of chemokine receptor activity, crystalline forms and process |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2009544758A JP2009544758A (ja) | 2009-12-17 |
| JP2009544758A5 true JP2009544758A5 (OSRAM) | 2010-08-12 |
Family
ID=38823540
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009522956A Withdrawn JP2009544758A (ja) | 2006-07-28 | 2007-07-26 | ケモカイン受容体活性のモジュレーター、結晶形および方法 |
Country Status (29)
| Country | Link |
|---|---|
| US (1) | US7671062B2 (OSRAM) |
| EP (2) | EP2184283A1 (OSRAM) |
| JP (1) | JP2009544758A (OSRAM) |
| KR (1) | KR20090035036A (OSRAM) |
| CN (1) | CN101511822A (OSRAM) |
| AR (1) | AR062114A1 (OSRAM) |
| AT (1) | ATE471928T1 (OSRAM) |
| AU (1) | AU2007279256A1 (OSRAM) |
| BR (1) | BRPI0715066A2 (OSRAM) |
| CA (1) | CA2659259A1 (OSRAM) |
| CL (3) | CL2007002195A1 (OSRAM) |
| CO (1) | CO6190527A2 (OSRAM) |
| CY (1) | CY1110785T1 (OSRAM) |
| DE (1) | DE602007007335D1 (OSRAM) |
| DK (1) | DK2049477T3 (OSRAM) |
| EA (1) | EA014960B1 (OSRAM) |
| ES (1) | ES2346591T3 (OSRAM) |
| HR (1) | HRP20100371T1 (OSRAM) |
| IL (1) | IL196518A0 (OSRAM) |
| MX (1) | MX2009000803A (OSRAM) |
| NO (1) | NO20090256L (OSRAM) |
| NZ (1) | NZ574656A (OSRAM) |
| PE (1) | PE20080838A1 (OSRAM) |
| PL (1) | PL2049477T3 (OSRAM) |
| PT (1) | PT2049477E (OSRAM) |
| SG (1) | SG158925A1 (OSRAM) |
| SI (1) | SI2049477T1 (OSRAM) |
| TW (1) | TW200823203A (OSRAM) |
| WO (1) | WO2008014381A2 (OSRAM) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7687508B2 (en) * | 2006-07-28 | 2010-03-30 | Bristol-Myers Squibb Company | Cyclic derivatives as modulators of chemokine receptor activity |
| US8383812B2 (en) * | 2009-10-13 | 2013-02-26 | Bristol-Myers Squibb Company | N-((1R,2S,5R)-5-(tert-butylamino)-2-((S)-3-(7-tert-butylpyrazolo[1,5-A][1,3,5]triazin-4-ylamino)-2-oxopyrrolidin-1-yl)cyclohexyl)acetamide, a dual modulator of chemokine receptor activity, crystalline forms and processes |
| EP2567959B1 (en) | 2011-09-12 | 2014-04-16 | Sanofi | 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
| PT3297438T (pt) | 2015-05-21 | 2022-01-25 | Chemocentryx Inc | Moduladores de ccr2 |
| AU2018304290B2 (en) * | 2017-07-20 | 2022-11-17 | Bristol-Myers Squibb Company | Process for the preparation of N-((1R,2S,5R)-5-(tert,-butylamino)-2- ((S)-3-(7-tert-butylpyrazolo[l,5-a][1,3,5]triazin-4-ylamino)-2- oxopyrrolidin- 1 -yl)c yclohexyl) acetamide |
| IL273188B2 (en) | 2017-09-25 | 2023-03-01 | Chemocentryx Inc | Treatment with a combination of chemokine receptor 2 (ccr2) inhibitors and a pd-1/pd-l1 inhibitor |
| US20190269664A1 (en) | 2018-01-08 | 2019-09-05 | Chemocentryx, Inc. | Methods of treating solid tumors with ccr2 antagonists |
| MA50423A (fr) | 2018-01-08 | 2020-08-26 | Chemocentryx Inc | Procédés de traitement de tumeurs solides au moyen d'antagonistes du ccr2 |
| CN115494184B (zh) * | 2022-05-09 | 2023-07-28 | 浙江海正药业股份有限公司 | 一种同时检测药物中异丙苯磺酸甲酯、异丙苯磺酸乙酯的方法 |
Family Cites Families (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6383082A (ja) | 1986-09-26 | 1988-04-13 | Takeda Chem Ind Ltd | テトラヒドロフランカルボン酸誘導体の製造法 |
| EP0550924A1 (en) | 1991-12-16 | 1993-07-14 | Merck & Co. Inc. | 2-Pyrrolidinone derivatives as HIV protease inhibitors |
| GB9515411D0 (en) | 1995-07-27 | 1995-09-27 | Pharmacia Spa | N-(4-substituted-benzyl)-2-aminolactam derivatives |
| US5827875A (en) | 1996-05-10 | 1998-10-27 | Bristol-Myers Squibb Company | Inhibitors of microsomal triglyceride transfer protein and method |
| UA51716C2 (uk) | 1996-07-08 | 2002-12-16 | Авентіс Фармасьютікалз Продактс Інк. | Сполуки, що мають гіпотензивну, кардіопротекторну, анти-ішемічну та антиліполітичну властивості, фармацевтична композиція та способи лікування |
| US6054579A (en) | 1997-06-26 | 2000-04-25 | Leukosite, Inc. | Synthesis of substituted lactams |
| GB9716656D0 (en) | 1997-08-07 | 1997-10-15 | Zeneca Ltd | Chemical compounds |
| EA200000768A1 (ru) | 1998-01-27 | 2001-06-25 | Эвентис Фармасьютикалз Продактс Инк. | ЗАМЕЩЕННЫЕ ОКСОАЗАГЕТЕРОЦИКЛИЧЕСКИЕ ИНГИБИТОРЫ ФАКТОРА Ха |
| US6492553B1 (en) | 1998-01-29 | 2002-12-10 | Aventis Pharamaceuticals Inc. | Methods for preparing N-[(aliphatic or aromatic)carbonyl)]-2-aminoaetamide compounds and for cyclizing such compounds |
| IL137571A0 (en) | 1998-01-29 | 2001-07-24 | Aventis Pharm Prod Inc | Method for preparing an n-[(aliphatic or aromatic)carboxyl]-2-aminoacetamide compound and a cyclyzed compound |
| GB9803228D0 (en) | 1998-02-17 | 1998-04-08 | Zeneca Ltd | Chemical compounds |
| US6541208B1 (en) | 1998-03-17 | 2003-04-01 | University Of Maryland Biotechnology Institute | Diagnostic method for distinguishing HIV-associated dementia from other forms of dementia |
| AU7354900A (en) | 1999-09-09 | 2001-04-10 | Merck & Co., Inc. | Inhibitors of prenyl-protein transferase |
| US6620823B2 (en) | 2000-07-11 | 2003-09-16 | Bristol-Myers Squibb Pharme Company | Lactam metalloprotease inhibitors |
| JP2005506949A (ja) | 2000-12-20 | 2005-03-10 | ブリストル−マイヤーズ・スクイブ・ファーマ・カンパニー | ケモカイン受容体の調節剤としてのジアミン |
| JP2004523534A (ja) | 2000-12-20 | 2004-08-05 | ブリストル−マイヤーズ スクイブ カンパニー | ケモカイン受容体活性調節剤としての環状誘導体 |
| WO2002078679A2 (en) | 2001-03-29 | 2002-10-10 | Topo Target Aps | Succinimide and maleimide derivatives and their use as topoisomerase ii catalytic inhibitors |
| GB0114867D0 (en) | 2001-06-18 | 2001-08-08 | Merck Sharp & Dohme | Therapeutic agents |
| DE10135043A1 (de) | 2001-07-11 | 2003-01-30 | Bayer Cropscience Gmbh | Substituierte 3-Heteroaryl(amino- oder oxy)-pyrrolidin-2-one, Verfahren zu deren Herstellung und Verwendung als Herbizide oder als Pflanzenwachstumsregulatoren |
| EP1483241A4 (en) | 2002-03-08 | 2006-12-13 | Bristol Myers Squibb Co | CYCLIC DERIVATIVES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY |
| TW200307667A (en) | 2002-05-06 | 2003-12-16 | Bristol Myers Squibb Co | Sulfonylaminovalerolactams and derivatives thereof as factor Xa inhibitors |
| WO2004022536A1 (en) | 2002-09-04 | 2004-03-18 | Glenmark Pharmaceuticals Limited | New heterocyclic amide compounds useful for the treatment of inflammatory and allergic disorders: process for their preparation and pharmaceutical compositions containing them |
| TW200508224A (en) | 2003-02-12 | 2005-03-01 | Bristol Myers Squibb Co | Cyclic derivatives as modulators of chemokine receptor activity |
| US7338975B2 (en) | 2003-02-12 | 2008-03-04 | Bristol-Myers Squibb Co. | Lactams as modulators of chemokine receptor activity |
| US7230133B2 (en) | 2003-05-01 | 2007-06-12 | Bristol-Myers Squibb Company | Malonamides and malonamide derivatives as modulators of chemokine receptor activity |
| US7291615B2 (en) | 2003-05-01 | 2007-11-06 | Bristol-Myers Squibb Company | Cyclic derivatives as modulators of chemokine receptor activity |
| US20060205761A1 (en) | 2003-06-06 | 2006-09-14 | Catherine Abbadie | Ccr-2 antagonists for treatment of neuropathic pain |
| US7863317B2 (en) | 2003-08-21 | 2011-01-04 | Bristol-Myers Squibb Company | Lactams of alkylated acyclic diamine derivatives as modulators of chemokine receptor activity |
| US7163937B2 (en) | 2003-08-21 | 2007-01-16 | Bristol-Myers Squibb Company | Cyclic derivatives as modulators of chemokine receptor activity |
| US7317019B2 (en) | 2003-08-21 | 2008-01-08 | Bristol Myers Squibb Co. | N-alkylated diaminopropane derivatives as modulators of chemokine receptor activity |
| US20050043392A1 (en) | 2003-08-21 | 2005-02-24 | Carter Percy H. | Lactams of alkylated acyclic diamine derivatives as modulators of chemokine receptor activity |
| US7378409B2 (en) | 2003-08-21 | 2008-05-27 | Bristol-Myers Squibb Company | Substituted cycloalkylamine derivatives as modulators of chemokine receptor activity |
| CA2575612A1 (en) | 2004-07-30 | 2006-02-09 | Pfizer Products Inc. | Methods of treating ccr2 mediated diseases or disorders |
| KR20070063562A (ko) | 2004-09-28 | 2007-06-19 | 얀센 파마슈티카 엔.브이. | 치환 디피페리딘 ｃｃｒ２ 길항제 |
-
2007
- 2007-07-25 US US11/782,704 patent/US7671062B2/en active Active
- 2007-07-26 CL CL200702195A patent/CL2007002195A1/es unknown
- 2007-07-26 KR KR1020097004327A patent/KR20090035036A/ko not_active Withdrawn
- 2007-07-26 SG SG201000704-5A patent/SG158925A1/en unknown
- 2007-07-26 SI SI200730305T patent/SI2049477T1/sl unknown
- 2007-07-26 CN CNA2007800327628A patent/CN101511822A/zh active Pending
- 2007-07-26 DK DK07799831.8T patent/DK2049477T3/da active
- 2007-07-26 AU AU2007279256A patent/AU2007279256A1/en not_active Abandoned
- 2007-07-26 DE DE602007007335T patent/DE602007007335D1/de active Active
- 2007-07-26 PL PL07799831T patent/PL2049477T3/pl unknown
- 2007-07-26 CL CL200702196A patent/CL2007002196A1/es unknown
- 2007-07-26 EP EP10001344A patent/EP2184283A1/en not_active Withdrawn
- 2007-07-26 EP EP07799831A patent/EP2049477B1/en active Active
- 2007-07-26 WO PCT/US2007/074438 patent/WO2008014381A2/en not_active Ceased
- 2007-07-26 BR BRPI0715066-0A patent/BRPI0715066A2/pt not_active IP Right Cessation
- 2007-07-26 NZ NZ574656A patent/NZ574656A/en not_active IP Right Cessation
- 2007-07-26 AT AT07799831T patent/ATE471928T1/de active
- 2007-07-26 CA CA002659259A patent/CA2659259A1/en not_active Abandoned
- 2007-07-26 PE PE2007000968A patent/PE20080838A1/es not_active Application Discontinuation
- 2007-07-26 AR ARP070103321A patent/AR062114A1/es not_active Application Discontinuation
- 2007-07-26 MX MX2009000803A patent/MX2009000803A/es active IP Right Grant
- 2007-07-26 JP JP2009522956A patent/JP2009544758A/ja not_active Withdrawn
- 2007-07-26 HR HR20100371T patent/HRP20100371T1/hr unknown
- 2007-07-26 PT PT07799831T patent/PT2049477E/pt unknown
- 2007-07-26 EA EA200900244A patent/EA014960B1/ru not_active IP Right Cessation
- 2007-07-26 TW TW096127306A patent/TW200823203A/zh unknown
- 2007-07-26 CL CL200702194A patent/CL2007002194A1/es unknown
- 2007-07-26 ES ES07799831T patent/ES2346591T3/es active Active
-
2009
- 2009-01-15 IL IL196518A patent/IL196518A0/en unknown
- 2009-01-16 NO NO20090256A patent/NO20090256L/no not_active Application Discontinuation
- 2009-01-27 CO CO09007271A patent/CO6190527A2/es not_active Application Discontinuation
-
2010
- 2010-09-22 CY CY20101100852T patent/CY1110785T1/el unknown
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