JP2009543858A5 - - Google Patents
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- Publication number
- JP2009543858A5 JP2009543858A5 JP2009520129A JP2009520129A JP2009543858A5 JP 2009543858 A5 JP2009543858 A5 JP 2009543858A5 JP 2009520129 A JP2009520129 A JP 2009520129A JP 2009520129 A JP2009520129 A JP 2009520129A JP 2009543858 A5 JP2009543858 A5 JP 2009543858A5
- Authority
- JP
- Japan
- Prior art keywords
- gaba
- product
- chemical component
- chemical
- bond
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000126 substance Substances 0.000 claims 27
- 239000003477 4 aminobutyric acid receptor stimulating agent Substances 0.000 claims 11
- 229940001470 psychoactive drug Drugs 0.000 claims 9
- 239000004089 psychotropic agent Substances 0.000 claims 9
- 208000002193 Pain Diseases 0.000 claims 6
- BTCSSZJGUNDROE-UHFFFAOYSA-N gamma-aminobutyric acid Chemical group NCCCC(O)=O BTCSSZJGUNDROE-UHFFFAOYSA-N 0.000 claims 6
- 239000005022 packaging material Substances 0.000 claims 6
- 239000008194 pharmaceutical composition Substances 0.000 claims 4
- 239000004480 active ingredient Substances 0.000 claims 3
- 239000003937 drug carrier Substances 0.000 claims 3
- 150000007524 organic acids Chemical group 0.000 claims 3
- 208000000094 Chronic Pain Diseases 0.000 claims 2
- NIJJYAXOARWZEE-UHFFFAOYSA-N Valproic acid Chemical compound CCCC(C(O)=O)CCC NIJJYAXOARWZEE-UHFFFAOYSA-N 0.000 claims 2
- 239000002253 acid Substances 0.000 claims 2
- 230000001430 anti-depressive effect Effects 0.000 claims 2
- 239000001961 anticonvulsive agent Substances 0.000 claims 2
- 239000000935 antidepressant agent Substances 0.000 claims 2
- 229940005513 antidepressants Drugs 0.000 claims 2
- 229960003965 antiepileptics Drugs 0.000 claims 2
- 208000015114 central nervous system disease Diseases 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 208000035475 disorder Diseases 0.000 claims 2
- 229960003692 gamma aminobutyric acid Drugs 0.000 claims 2
- 230000001225 therapeutic effect Effects 0.000 claims 2
- RTHCYVBBDHJXIQ-MRXNPFEDSA-N (R)-fluoxetine Chemical compound O([C@H](CCNC)C=1C=CC=CC=1)C1=CC=C(C(F)(F)F)C=C1 RTHCYVBBDHJXIQ-MRXNPFEDSA-N 0.000 claims 1
- 208000007848 Alcoholism Diseases 0.000 claims 1
- 208000001294 Nociceptive Pain Diseases 0.000 claims 1
- PHVGLTMQBUFIQQ-UHFFFAOYSA-N Nortryptiline Chemical compound C1CC2=CC=CC=C2C(=CCCNC)C2=CC=CC=C21 PHVGLTMQBUFIQQ-UHFFFAOYSA-N 0.000 claims 1
- 208000005298 acute pain Diseases 0.000 claims 1
- 230000002411 adverse Effects 0.000 claims 1
- 201000007930 alcohol dependence Diseases 0.000 claims 1
- 125000000217 alkyl group Chemical group 0.000 claims 1
- 229940124277 aminobutyric acid Drugs 0.000 claims 1
- 125000004432 carbon atom Chemical group C* 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 230000002708 enhancing effect Effects 0.000 claims 1
- 229960002464 fluoxetine Drugs 0.000 claims 1
- 208000004296 neuralgia Diseases 0.000 claims 1
- 208000021722 neuropathic pain Diseases 0.000 claims 1
- 229960001158 nortriptyline Drugs 0.000 claims 1
- 238000012856 packing Methods 0.000 claims 1
- 230000000391 smoking effect Effects 0.000 claims 1
- AEQFSUDEHCCHBT-UHFFFAOYSA-M sodium valproate Chemical compound [Na+].CCCC(C([O-])=O)CCC AEQFSUDEHCCHBT-UHFFFAOYSA-M 0.000 claims 1
- 229940102566 valproate Drugs 0.000 claims 1
- 229960000604 valproic acid Drugs 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US83119506P | 2006-07-17 | 2006-07-17 | |
| US83119206P | 2006-07-17 | 2006-07-17 | |
| US60/831,192 | 2006-07-17 | ||
| US60/831,195 | 2006-07-17 | ||
| PCT/IL2007/000903 WO2008010223A2 (en) | 2006-07-17 | 2007-07-17 | Conjugates comprising a psychotropic drug or a gaba agonist and an organic acid and their use in treating pain and other cns disorders |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009543858A JP2009543858A (ja) | 2009-12-10 |
| JP2009543858A5 true JP2009543858A5 (https=) | 2010-09-02 |
| JP5192485B2 JP5192485B2 (ja) | 2013-05-08 |
Family
ID=38621178
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009520129A Expired - Fee Related JP5192485B2 (ja) | 2006-07-17 | 2007-07-17 | 向精神性薬物またはｇａｂａアゴニストと有機酸とを含むコンジュゲート、ならびに疼痛および他のｃｎｓ障害を治療するためのそれらの使用 |
Country Status (11)
| Country | Link |
|---|---|
| US (3) | US8377990B2 (https=) |
| EP (1) | EP2051735B1 (https=) |
| JP (1) | JP5192485B2 (https=) |
| KR (1) | KR20090048462A (https=) |
| CN (1) | CN101511388B (https=) |
| AU (1) | AU2007274583B2 (https=) |
| CA (1) | CA2659521A1 (https=) |
| ES (1) | ES2393933T3 (https=) |
| IL (1) | IL196538A0 (https=) |
| MX (1) | MX2009000641A (https=) |
| WO (2) | WO2008010223A2 (https=) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7544681B2 (en) | 2001-09-27 | 2009-06-09 | Ramot At Tel Aviv University Ltd. | Conjugated psychotropic drugs and uses thereof |
| JP5284779B2 (ja) * | 2005-06-07 | 2013-09-11 | ラモット・アット・テル・アビブ・ユニバーシテイ・リミテッド | コンジュゲート化された向精神薬の新規な塩およびその調製方法 |
| EP2051735B1 (en) | 2006-07-17 | 2012-08-29 | Ramot, at Tel Aviv University Ltd. | Conjugates comprising a psychotropic drug or a gaba agonist and an organic acid and their use treating pain and other cns disorders |
| US20090074677A1 (en) * | 2007-01-08 | 2009-03-19 | Duke University | Neuroactive steroid compositions and methods of use therefor |
| WO2009101616A1 (en) * | 2008-02-11 | 2009-08-20 | Ramot At Tel Aviv University Ltd. | Novel conjugates for treating neurodegenerative diseases and disorders |
| WO2010027266A1 (en) * | 2008-09-05 | 2010-03-11 | Van De Langenberg, Hendrikus Theodorus Ardina Hubertus | Means and methods for counteracting neurological disorders |
| CN105330603A (zh) * | 2008-10-08 | 2016-02-17 | 凯飞药业公司 | Gaba偶联物及其使用方法 |
| US20100272652A1 (en) * | 2009-03-26 | 2010-10-28 | Seventh Sense Biosystems, Inc. | Determination of tracers within subjects |
| US8141697B2 (en) * | 2009-04-03 | 2012-03-27 | Ackley Machine Corporation | Method and apparatus for transporting caplets |
| JP5675821B2 (ja) * | 2009-09-23 | 2015-02-25 | ザ リージェンツ オブ ザ ユニバーシティ オブ コロラド，ア ボディー コーポレート | Ｔｏｌｌ様受容体モジュレーター及びその使用 |
| WO2011070579A1 (en) * | 2009-12-09 | 2011-06-16 | Biolinerx Ltd. | Methods of improving cognitive functions |
| WO2012038963A1 (en) | 2010-09-22 | 2012-03-29 | Ramot At Tel-Aviv University Ltd. | An acid addition salt of a nortriptyline-gaba conjugate and a process of preparing same |
| JP5893135B2 (ja) * | 2011-06-28 | 2016-03-23 | ビボゾーン インコーポレイテッド | 多重ターゲッティングの相乗効果を誘発する有効物質の組合せ及びその用途 |
| WO2014022807A2 (en) * | 2012-08-03 | 2014-02-06 | Alumend, Llc | Compositions and methods of using the compositions for plaque softening |
| CN113061089A (zh) | 2015-09-23 | 2021-07-02 | 凯瑞康宁生物工程（武汉）有限公司 | γ-羟基丁酸的前药及其组合物和用途 |
| CN110709386B (zh) | 2017-03-30 | 2022-06-07 | 凯瑞康宁生物工程（武汉）有限公司 | 双环杂芳基衍生物及其制备与用途 |
| JPWO2018199174A1 (ja) * | 2017-04-25 | 2020-02-27 | 生化学工業株式会社 | 第３級アミン化合物又はイミン化合物−ポリマーコンジュゲートとその製造方法 |
| GB2571696B (en) | 2017-10-09 | 2020-05-27 | Compass Pathways Ltd | Large scale method for the preparation of Psilocybin and formulations of Psilocybin so produced |
| US12459965B2 (en) | 2017-10-09 | 2025-11-04 | Compass Pathfinder Limited | Preparation of psilocybin, different polymorphic forms, intermediates, formulations and their use |
| CN112424158A (zh) * | 2018-05-14 | 2021-02-26 | 昌郁医药公司 | 萘普生和普瑞巴林的1-(酰氧基)-烷基氨基甲酸酯药物缀合物的结晶形式 |
| ES2947089T3 (es) | 2018-09-30 | 2023-08-01 | Xwpharma Ltd | Compuestos como antagonistas del receptor histamínico 3 neuronal y usos de los mismos |
| KR20220009954A (ko) | 2019-04-17 | 2022-01-25 | 컴퍼스 패쓰파인더 리미티드 | 신경인지 장애, 만성 통증을 치료하고 염증을 감소시키는 방법 |
| KR102881504B1 (ko) | 2019-12-20 | 2025-11-06 | 엑스더블유파마 리미티드 | 4-발레릴옥시부티르산의 합성 방법 |
| CN115803017A (zh) | 2020-06-18 | 2023-03-14 | 凯瑞康宁生物工程有限公司 | 水溶性活性药物成分的药物造粒物 |
| AU2021292406B2 (en) | 2020-06-18 | 2024-03-14 | XWPharma Ltd. | Controlled release granulations of water-soluble active pharmaceutical ingredients |
| CN116261451A (zh) | 2020-07-24 | 2023-06-13 | 凯瑞康宁生物工程有限公司 | γ-羟基丁酸衍生物的药物组合物和药物动力学 |
| KR20230058151A (ko) | 2020-10-05 | 2023-05-02 | 엑스더블유파마 리미티드 | 감마-하이드록시부티르산 유도체의 변형된 방출 조성물 |
| EP4588471A3 (en) | 2021-03-19 | 2025-09-24 | XWPharma Ltd. | Pharmacokinetics of combined release formulations of a gamma-hydroxybutyric acid derivative |
| CN114452256A (zh) * | 2021-12-31 | 2022-05-10 | 浙江大学 | 脊髓损伤靶向药物、聚合物-疏水化合物胶束及其制备方法 |
| CN115057865B (zh) * | 2022-05-10 | 2023-03-31 | 国药集团工业有限公司 | 一种磷酸可待因半水合物的制备方法 |
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| EP2250148B1 (en) | 2008-01-25 | 2016-08-17 | XenoPort, Inc. | Crystalline form of calcium-salts of (3s)-aminomethyl-5-methyl-hexanoic acids and methods of use |
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-
2007
- 2007-07-17 EP EP07789958A patent/EP2051735B1/en not_active Not-in-force
- 2007-07-17 KR KR1020097003169A patent/KR20090048462A/ko not_active Ceased
- 2007-07-17 CA CA002659521A patent/CA2659521A1/en not_active Abandoned
- 2007-07-17 JP JP2009520129A patent/JP5192485B2/ja not_active Expired - Fee Related
- 2007-07-17 US US12/309,361 patent/US8377990B2/en not_active Expired - Fee Related
- 2007-07-17 US US12/373,542 patent/US8222296B2/en not_active Expired - Fee Related
- 2007-07-17 WO PCT/IL2007/000903 patent/WO2008010223A2/en not_active Ceased
- 2007-07-17 WO PCT/IL2007/000902 patent/WO2008010222A2/en not_active Ceased
- 2007-07-17 CN CN2007800332946A patent/CN101511388B/zh not_active Expired - Fee Related
- 2007-07-17 ES ES07789958T patent/ES2393933T3/es active Active
- 2007-07-17 MX MX2009000641A patent/MX2009000641A/es active IP Right Grant
- 2007-07-17 AU AU2007274583A patent/AU2007274583B2/en not_active Ceased
-
2009
- 2009-01-15 IL IL196538A patent/IL196538A0/en unknown
-
2012
- 2012-09-06 US US13/604,718 patent/US20130059910A1/en not_active Abandoned
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