JP2009543566A5 - - Google Patents
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- JP2009543566A5 JP2009543566A5 JP2009519863A JP2009519863A JP2009543566A5 JP 2009543566 A5 JP2009543566 A5 JP 2009543566A5 JP 2009519863 A JP2009519863 A JP 2009519863A JP 2009519863 A JP2009519863 A JP 2009519863A JP 2009543566 A5 JP2009543566 A5 JP 2009543566A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- composition according
- precursor protein
- spc
- tissue
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 235000018102 proteins Nutrition 0.000 claims 20
- 102000004169 proteins and genes Human genes 0.000 claims 20
- 108090000623 proteins and genes Proteins 0.000 claims 20
- 239000008194 pharmaceutical composition Substances 0.000 claims 16
- 239000002243 precursor Substances 0.000 claims 14
- 102000035195 Peptidases Human genes 0.000 claims 11
- 108091005804 Peptidases Proteins 0.000 claims 11
- 239000004365 Protease Substances 0.000 claims 11
- 235000001014 amino acid Nutrition 0.000 claims 7
- 150000001413 amino acids Chemical class 0.000 claims 7
- 210000001519 tissue Anatomy 0.000 claims 7
- 108020004414 DNA Proteins 0.000 claims 5
- 238000000034 method Methods 0.000 claims 5
- 102000053602 DNA Human genes 0.000 claims 4
- 102000004961 Furin Human genes 0.000 claims 4
- 108090001126 Furin Proteins 0.000 claims 4
- 239000000203 mixture Substances 0.000 claims 4
- 108010090254 Growth Differentiation Factor 5 Proteins 0.000 claims 3
- 102000012966 Growth Differentiation Factor 5 Human genes 0.000 claims 3
- 210000004027 cell Anatomy 0.000 claims 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 3
- 238000009472 formulation Methods 0.000 claims 3
- 238000007911 parenteral administration Methods 0.000 claims 3
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 3
- 108020004705 Codon Proteins 0.000 claims 2
- LEVWYRKDKASIDU-QWWZWVQMSA-N D-cystine Chemical compound OC(=O)[C@H](N)CSSC[C@@H](N)C(O)=O LEVWYRKDKASIDU-QWWZWVQMSA-N 0.000 claims 2
- 102000006437 Proprotein Convertases Human genes 0.000 claims 2
- 108010044159 Proprotein Convertases Proteins 0.000 claims 2
- 108010076504 Protein Sorting Signals Proteins 0.000 claims 2
- 206010002026 amyotrophic lateral sclerosis Diseases 0.000 claims 2
- 210000000988 bone and bone Anatomy 0.000 claims 2
- 210000000845 cartilage Anatomy 0.000 claims 2
- 229960003067 cystine Drugs 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 230000002068 genetic effect Effects 0.000 claims 2
- 210000003000 inclusion body Anatomy 0.000 claims 2
- 230000006698 induction Effects 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 208000015122 neurodegenerative disease Diseases 0.000 claims 2
- 238000002360 preparation method Methods 0.000 claims 2
- 230000035755 proliferation Effects 0.000 claims 2
- 239000000243 solution Substances 0.000 claims 2
- 238000002054 transplantation Methods 0.000 claims 2
- 208000024827 Alzheimer disease Diseases 0.000 claims 1
- 239000004475 Arginine Substances 0.000 claims 1
- 241000894006 Bacteria Species 0.000 claims 1
- 101000708016 Caenorhabditis elegans Sentrin-specific protease Proteins 0.000 claims 1
- 206010007710 Cartilage injury Diseases 0.000 claims 1
- 108010013369 Enteropeptidase Proteins 0.000 claims 1
- 102100029727 Enteropeptidase Human genes 0.000 claims 1
- 108010074860 Factor Xa Proteins 0.000 claims 1
- 101001023988 Homo sapiens Growth/differentiation factor 5 Proteins 0.000 claims 1
- 208000023105 Huntington disease Diseases 0.000 claims 1
- ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 claims 1
- HNDVDQJCIGZPNO-YFKPBYRVSA-N L-histidine Chemical compound OC(=O)[C@@H](N)CC1=CN=CN1 HNDVDQJCIGZPNO-YFKPBYRVSA-N 0.000 claims 1
- KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 claims 1
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 claims 1
- 239000004472 Lysine Substances 0.000 claims 1
- 241000124008 Mammalia Species 0.000 claims 1
- 208000001132 Osteoporosis Diseases 0.000 claims 1
- 208000018737 Parkinson disease Diseases 0.000 claims 1
- 108090000190 Thrombin Proteins 0.000 claims 1
- 208000025865 Ulcer Diseases 0.000 claims 1
- 125000003295 alanine group Chemical group N[C@@H](C)C(=O)* 0.000 claims 1
- 230000033115 angiogenesis Effects 0.000 claims 1
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims 1
- 210000004204 blood vessel Anatomy 0.000 claims 1
- 210000002798 bone marrow cell Anatomy 0.000 claims 1
- 230000022159 cartilage development Effects 0.000 claims 1
- 239000003638 chemical reducing agent Substances 0.000 claims 1
- 210000002808 connective tissue Anatomy 0.000 claims 1
- 235000018417 cysteine Nutrition 0.000 claims 1
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 claims 1
- 125000000151 cysteine group Chemical group N[C@@H](CS)C(=O)* 0.000 claims 1
- 230000003412 degenerative effect Effects 0.000 claims 1
- 230000003111 delayed effect Effects 0.000 claims 1
- 238000003745 diagnosis Methods 0.000 claims 1
- 230000004069 differentiation Effects 0.000 claims 1
- 238000007865 diluting Methods 0.000 claims 1
- 208000035475 disorder Diseases 0.000 claims 1
- 230000002500 effect on skin Effects 0.000 claims 1
- 210000003038 endothelium Anatomy 0.000 claims 1
- 210000000981 epithelium Anatomy 0.000 claims 1
- 230000012010 growth Effects 0.000 claims 1
- 230000003779 hair growth Effects 0.000 claims 1
- 210000002216 heart Anatomy 0.000 claims 1
- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 claims 1
- 239000007943 implant Substances 0.000 claims 1
- 230000001939 inductive effect Effects 0.000 claims 1
- 238000001802 infusion Methods 0.000 claims 1
- 238000002347 injection Methods 0.000 claims 1
- 239000007924 injection Substances 0.000 claims 1
- 208000014674 injury Diseases 0.000 claims 1
- 210000003734 kidney Anatomy 0.000 claims 1
- 210000003041 ligament Anatomy 0.000 claims 1
- 210000004185 liver Anatomy 0.000 claims 1
- 239000000463 material Substances 0.000 claims 1
- 239000011159 matrix material Substances 0.000 claims 1
- 230000005499 meniscus Effects 0.000 claims 1
- 239000000178 monomer Substances 0.000 claims 1
- 210000004400 mucous membrane Anatomy 0.000 claims 1
- 201000006417 multiple sclerosis Diseases 0.000 claims 1
- 230000035772 mutation Effects 0.000 claims 1
- 210000005036 nerve Anatomy 0.000 claims 1
- 210000000944 nerve tissue Anatomy 0.000 claims 1
- 230000002981 neuropathic effect Effects 0.000 claims 1
- 210000000056 organ Anatomy 0.000 claims 1
- 230000011164 ossification Effects 0.000 claims 1
- 210000000496 pancreas Anatomy 0.000 claims 1
- 230000003239 periodontal effect Effects 0.000 claims 1
- 239000013612 plasmid Substances 0.000 claims 1
- 238000004321 preservation Methods 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 230000001737 promoting effect Effects 0.000 claims 1
- 230000002797 proteolythic effect Effects 0.000 claims 1
- 230000006337 proteolytic cleavage Effects 0.000 claims 1
- 230000002685 pulmonary effect Effects 0.000 claims 1
- 230000001953 sensory effect Effects 0.000 claims 1
- 210000003491 skin Anatomy 0.000 claims 1
- 238000005063 solubilization Methods 0.000 claims 1
- 230000007928 solubilization Effects 0.000 claims 1
- 210000000130 stem cell Anatomy 0.000 claims 1
- 210000002435 tendon Anatomy 0.000 claims 1
- 230000001225 therapeutic effect Effects 0.000 claims 1
- 229960004072 thrombin Drugs 0.000 claims 1
- 210000001685 thyroid gland Anatomy 0.000 claims 1
- 230000017423 tissue regeneration Effects 0.000 claims 1
- 230000000699 topical effect Effects 0.000 claims 1
- 230000001131 transforming effect Effects 0.000 claims 1
- 230000008733 trauma Effects 0.000 claims 1
- 231100000397 ulcer Toxicity 0.000 claims 1
- 210000004291 uterus Anatomy 0.000 claims 1
- 230000029663 wound healing Effects 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP06014928A EP1880731A1 (en) | 2006-07-18 | 2006-07-18 | Human growth and differentiation factor GDF-5 |
| PCT/EP2007/006331 WO2008009419A1 (en) | 2006-07-18 | 2007-07-17 | Human growth and differentiation factor gdf-5 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2009543566A JP2009543566A (ja) | 2009-12-10 |
| JP2009543566A5 true JP2009543566A5 (enExample) | 2010-09-02 |
Family
ID=37663742
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009519863A Pending JP2009543566A (ja) | 2006-07-18 | 2007-07-17 | ヒト成長および分化因子ｇｄｆ−５ |
Country Status (5)
| Country | Link |
|---|---|
| US (2) | US8361745B2 (enExample) |
| EP (2) | EP1880731A1 (enExample) |
| JP (1) | JP2009543566A (enExample) |
| CA (1) | CA2657349A1 (enExample) |
| WO (1) | WO2008009419A1 (enExample) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2007234612B2 (en) | 2006-12-14 | 2013-06-27 | Johnson & Johnson Regenerative Therapeutics, Llc | Protein stabilization formulations |
| EP2121142B1 (en) * | 2007-01-25 | 2013-04-03 | Biopharm Gesellschaft Zur Biotechnologischen Entwicklung Von Pharmaka mbH | Use of gdf-5 for the improvement or maintenance of dermal appearance |
| US7678764B2 (en) | 2007-06-29 | 2010-03-16 | Johnson & Johnson Regenerative Therapeutics, Llc | Protein formulations for use at elevated temperatures |
| JP5323832B2 (ja) | 2007-08-07 | 2013-10-23 | アドバンスト・テクノロジーズ・アンド・リジェネレイティブ・メディスン・エルエルシー | 酸性水溶液中にｇｄｆ−５を含むタンパク質製剤 |
| BRPI0911048A2 (pt) | 2008-04-14 | 2015-12-29 | Atrm Llc | formulações líquidas tamponadas de gdf-5 |
| WO2009152085A1 (en) * | 2008-06-09 | 2009-12-17 | Wyeth | Novel bmp-12-related proteins and methods of their manufacture |
| EP2537538A1 (en) * | 2011-06-22 | 2012-12-26 | Biopharm Gesellschaft Zur Biotechnologischen Entwicklung Von Pharmaka mbH | Bioresorbable Wound Dressing |
| US9051389B2 (en) | 2013-01-25 | 2015-06-09 | Warsaw Orthopedic, Inc. | Expression conditions and methods of human recombinant growth and differentiation factor-5 (rhGDF-5) |
| US9359417B2 (en) | 2013-01-25 | 2016-06-07 | Warsaw Orthopedic, Inc. | Cell cultures and methods of human recombinant growth and differentiaton factor-5 (rhGDF-5) |
| US9169308B2 (en) | 2013-01-25 | 2015-10-27 | Warsaw Orthopedic, Inc. | Methods and compositions of human recombinant growth and differentiation factor-5 (rhGDF-5) isolated from inclusion bodies |
| US8945872B2 (en) | 2013-01-25 | 2015-02-03 | Warsaw Orthopedic, Inc. | Methods of purifying human recombinant growth and differentiation factor-5 (rhGDF-5) protein |
| US8956829B2 (en) | 2013-01-25 | 2015-02-17 | Warsaw Orthopedic, Inc. | Human recombinant growth and differentiaton factor-5 (rhGDF-5) |
| JP2016183118A (ja) * | 2015-03-25 | 2016-10-20 | 東ソー株式会社 | 増殖因子前駆体のリフォールディング方法 |
| US11324806B2 (en) | 2018-10-19 | 2022-05-10 | Warsaw Orthopedic, Inc. | Sustained delivery of a growth differentiation factor |
| EP3723212B1 (en) | 2019-04-11 | 2024-05-29 | Aptiv Technologies Limited | Network connector module for a network connector |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5935815A (en) * | 1989-10-25 | 1999-08-10 | Katholieke Universiteit Leuven | Process for micro biological production of proteins |
| DE19525416A1 (de) * | 1995-07-12 | 1997-01-16 | Bioph Biotech Entw Pharm Gmbh | Verwendung von MP52 zur Behandlung und Prävention von Erkrankungen des Nervensystems |
| EP1439190A1 (en) * | 1993-01-12 | 2004-07-21 | The Johns Hopkins University School Of Medicine | Growth differentiation factor-5 |
| DE69403439T2 (de) * | 1993-01-12 | 1997-10-23 | Genentech Inc | Tgf-beta zusammensetzung zum herbeiführen von knochenwachstum |
| PT955313E (pt) * | 1995-04-19 | 2006-07-31 | Bioph Biotech Entw Pharm Gmbh | Nova proteina e processo para a sua producao |
| DE19647853A1 (de) | 1996-11-19 | 1998-05-20 | Bioph Biotech Entw Pharm Gmbh | Verbindungen mit verbesserter knorpel- und/oder knocheninduzierender Aktivität |
| EP1074620A1 (en) * | 1999-08-06 | 2001-02-07 | HyGene AG | Monomeric protein of the TGF-beta family |
| US6344541B1 (en) * | 1998-09-25 | 2002-02-05 | Amgen Inc. | DKR polypeptides |
| CA2441588A1 (en) * | 2001-03-23 | 2002-10-03 | Biopharm Gesellschaft Zue Biotechnologischen Entwicklung Von Pharmaka Mbh | Use of cytokines of the tgf-.beta. superfamily for the treatment and diagnosis of skin related disorders |
| CA2484556A1 (en) * | 2001-12-21 | 2003-07-24 | Human Genome Sciences, Inc. | Albumin fusion proteins |
| BR0314270A (pt) * | 2002-09-16 | 2005-08-02 | Univ Johns Hopkins | Ativação de miostatina com metaloprotease e processos de modulação da atividade da miostatina |
| EP1462126A1 (en) * | 2003-03-28 | 2004-09-29 | BIOPHARM GESELLSCHAFT ZUR BIOTECHNOLOGISCHEN ENTWICKLUNG VON PHARMAKA mbH | Improved Osteoinductive Materials |
| JP2007222003A (ja) | 2004-03-29 | 2007-09-06 | Matsushita Electric Ind Co Ltd | 放線菌Ｈ＋−ｐｙｒｏｐｈｏｓｐｈａｔａｓｅ合成遺伝子の作成と大腸菌での発現システム |
-
2006
- 2006-07-18 EP EP06014928A patent/EP1880731A1/en not_active Withdrawn
-
2007
- 2007-07-17 CA CA002657349A patent/CA2657349A1/en not_active Abandoned
- 2007-07-17 WO PCT/EP2007/006331 patent/WO2008009419A1/en not_active Ceased
- 2007-07-17 US US12/374,080 patent/US8361745B2/en not_active Expired - Fee Related
- 2007-07-17 EP EP07786127.6A patent/EP2043674B1/en not_active Not-in-force
- 2007-07-17 JP JP2009519863A patent/JP2009543566A/ja active Pending
-
2012
- 2012-12-20 US US13/721,513 patent/US8871710B2/en not_active Expired - Fee Related
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