JP2009519008A5 - - Google Patents
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- Publication number
- JP2009519008A5 JP2009519008A5 JP2008540526A JP2008540526A JP2009519008A5 JP 2009519008 A5 JP2009519008 A5 JP 2009519008A5 JP 2008540526 A JP2008540526 A JP 2008540526A JP 2008540526 A JP2008540526 A JP 2008540526A JP 2009519008 A5 JP2009519008 A5 JP 2009519008A5
- Authority
- JP
- Japan
- Prior art keywords
- tissue
- alanine
- protein
- isoleucine
- valine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 235000004279 alanine Nutrition 0.000 claims 17
- 108090000623 proteins and genes Proteins 0.000 claims 17
- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 claims 16
- 235000018102 proteins Nutrition 0.000 claims 16
- 102000004169 proteins and genes Human genes 0.000 claims 16
- 210000001519 tissue Anatomy 0.000 claims 16
- AGPKZVBTJJNPAG-WHFBIAKZSA-N L-isoleucine Chemical compound CC[C@H](C)[C@H](N)C(O)=O AGPKZVBTJJNPAG-WHFBIAKZSA-N 0.000 claims 12
- AGPKZVBTJJNPAG-UHFFFAOYSA-N isoleucine Natural products CCC(C)C(N)C(O)=O AGPKZVBTJJNPAG-UHFFFAOYSA-N 0.000 claims 12
- 229960000310 isoleucine Drugs 0.000 claims 12
- KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical compound CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 claims 11
- KZSNJWFQEVHDMF-UHFFFAOYSA-N Valine Natural products CC(C)C(N)C(O)=O KZSNJWFQEVHDMF-UHFFFAOYSA-N 0.000 claims 11
- 239000004474 valine Substances 0.000 claims 11
- 108010090254 Growth Differentiation Factor 5 Proteins 0.000 claims 9
- 102000012966 Growth Differentiation Factor 5 Human genes 0.000 claims 9
- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 claims 9
- CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 claims 8
- 235000003704 aspartic acid Nutrition 0.000 claims 8
- OQFSQFPPLPISGP-UHFFFAOYSA-N beta-carboxyaspartic acid Natural products OC(=O)C(N)C(C(O)=O)C(O)=O OQFSQFPPLPISGP-UHFFFAOYSA-N 0.000 claims 8
- WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 claims 7
- FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 claims 7
- AYFVYJQAPQTCCC-UHFFFAOYSA-N Threonine Natural products CC(O)C(N)C(O)=O AYFVYJQAPQTCCC-UHFFFAOYSA-N 0.000 claims 7
- 239000004473 Threonine Substances 0.000 claims 7
- 229940024606 amino acid Drugs 0.000 claims 7
- 235000001014 amino acid Nutrition 0.000 claims 7
- 150000001413 amino acids Chemical class 0.000 claims 7
- 210000004027 cell Anatomy 0.000 claims 7
- 235000013922 glutamic acid Nutrition 0.000 claims 7
- 239000004220 glutamic acid Substances 0.000 claims 7
- 229930182817 methionine Natural products 0.000 claims 7
- 102000039446 nucleic acids Human genes 0.000 claims 7
- 108020004707 nucleic acids Proteins 0.000 claims 7
- 150000007523 nucleic acids Chemical class 0.000 claims 7
- DCXYFEDJOCDNAF-UHFFFAOYSA-N Asparagine Natural products OC(=O)C(N)CC(N)=O DCXYFEDJOCDNAF-UHFFFAOYSA-N 0.000 claims 6
- DCXYFEDJOCDNAF-REOHCLBHSA-N L-asparagine Chemical compound OC(=O)[C@@H](N)CC(N)=O DCXYFEDJOCDNAF-REOHCLBHSA-N 0.000 claims 6
- 235000009582 asparagine Nutrition 0.000 claims 6
- 229960001230 asparagine Drugs 0.000 claims 6
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 6
- 201000010099 disease Diseases 0.000 claims 5
- 239000013604 expression vector Substances 0.000 claims 5
- 210000003491 skin Anatomy 0.000 claims 5
- 239000004475 Arginine Substances 0.000 claims 4
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims 4
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 claims 4
- 239000004472 Lysine Substances 0.000 claims 4
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims 4
- 210000000988 bone and bone Anatomy 0.000 claims 4
- 238000004519 manufacturing process Methods 0.000 claims 4
- 208000015122 neurodegenerative disease Diseases 0.000 claims 4
- 239000008194 pharmaceutical composition Substances 0.000 claims 4
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 claims 3
- ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 claims 3
- 210000004204 blood vessel Anatomy 0.000 claims 3
- 210000000845 cartilage Anatomy 0.000 claims 3
- 210000002808 connective tissue Anatomy 0.000 claims 3
- ZDXPYRJPNDTMRX-UHFFFAOYSA-N glutamine Natural products OC(=O)C(N)CCC(N)=O ZDXPYRJPNDTMRX-UHFFFAOYSA-N 0.000 claims 3
- 239000000203 mixture Substances 0.000 claims 3
- 230000004770 neurodegeneration Effects 0.000 claims 3
- 230000035755 proliferation Effects 0.000 claims 3
- 230000001737 promoting effect Effects 0.000 claims 3
- 230000001225 therapeutic effect Effects 0.000 claims 3
- 206010007710 Cartilage injury Diseases 0.000 claims 2
- 239000004471 Glycine Substances 0.000 claims 2
- 208000023105 Huntington disease Diseases 0.000 claims 2
- COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 claims 2
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 claims 2
- 208000018737 Parkinson disease Diseases 0.000 claims 2
- ONIBWKKTOPOVIA-UHFFFAOYSA-N Proline Natural products OC(=O)C1CCCN1 ONIBWKKTOPOVIA-UHFFFAOYSA-N 0.000 claims 2
- 102000007056 Recombinant Fusion Proteins Human genes 0.000 claims 2
- 108010008281 Recombinant Fusion Proteins Proteins 0.000 claims 2
- 208000025865 Ulcer Diseases 0.000 claims 2
- 206010002026 amyotrophic lateral sclerosis Diseases 0.000 claims 2
- 230000033115 angiogenesis Effects 0.000 claims 2
- 210000002798 bone marrow cell Anatomy 0.000 claims 2
- 230000006378 damage Effects 0.000 claims 2
- 210000003038 endothelium Anatomy 0.000 claims 2
- 230000012010 growth Effects 0.000 claims 2
- 210000002216 heart Anatomy 0.000 claims 2
- 208000014674 injury Diseases 0.000 claims 2
- 210000003734 kidney Anatomy 0.000 claims 2
- 210000004185 liver Anatomy 0.000 claims 2
- 230000005499 meniscus Effects 0.000 claims 2
- 210000004400 mucous membrane Anatomy 0.000 claims 2
- 210000005036 nerve Anatomy 0.000 claims 2
- 210000000056 organ Anatomy 0.000 claims 2
- 210000000496 pancreas Anatomy 0.000 claims 2
- 210000002379 periodontal ligament Anatomy 0.000 claims 2
- COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 claims 2
- 230000002265 prevention Effects 0.000 claims 2
- 210000000697 sensory organ Anatomy 0.000 claims 2
- 210000000130 stem cell Anatomy 0.000 claims 2
- 210000002435 tendon Anatomy 0.000 claims 2
- 210000001685 thyroid gland Anatomy 0.000 claims 2
- 230000017423 tissue regeneration Effects 0.000 claims 2
- 238000002054 transplantation Methods 0.000 claims 2
- 230000008733 trauma Effects 0.000 claims 2
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 claims 2
- 231100000397 ulcer Toxicity 0.000 claims 2
- 210000004291 uterus Anatomy 0.000 claims 2
- 230000029663 wound healing Effects 0.000 claims 2
- 208000024827 Alzheimer disease Diseases 0.000 claims 1
- 208000020084 Bone disease Diseases 0.000 claims 1
- 206010061452 Complication of pregnancy Diseases 0.000 claims 1
- 101001023988 Homo sapiens Growth/differentiation factor 5 Proteins 0.000 claims 1
- 208000018650 Intervertebral disc disease Diseases 0.000 claims 1
- 241001272720 Medialuna californiensis Species 0.000 claims 1
- 208000001132 Osteoporosis Diseases 0.000 claims 1
- 241000251539 Vertebrata <Metazoa> Species 0.000 claims 1
- 239000002671 adjuvant Substances 0.000 claims 1
- 125000003295 alanine group Chemical group N[C@@H](C)C(=O)* 0.000 claims 1
- 230000015572 biosynthetic process Effects 0.000 claims 1
- 230000008468 bone growth Effects 0.000 claims 1
- 230000022159 cartilage development Effects 0.000 claims 1
- 208000015100 cartilage disease Diseases 0.000 claims 1
- 235000018417 cysteine Nutrition 0.000 claims 1
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 claims 1
- 230000007850 degeneration Effects 0.000 claims 1
- 239000004053 dental implant Substances 0.000 claims 1
- 210000004268 dentin Anatomy 0.000 claims 1
- 238000003745 diagnosis Methods 0.000 claims 1
- 230000004069 differentiation Effects 0.000 claims 1
- 239000000539 dimer Substances 0.000 claims 1
- 208000035475 disorder Diseases 0.000 claims 1
- 210000000981 epithelium Anatomy 0.000 claims 1
- 230000035558 fertility Effects 0.000 claims 1
- 230000004927 fusion Effects 0.000 claims 1
- 210000001035 gastrointestinal tract Anatomy 0.000 claims 1
- 210000004209 hair Anatomy 0.000 claims 1
- 230000003779 hair growth Effects 0.000 claims 1
- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 claims 1
- 208000021600 intervertebral disc degenerative disease Diseases 0.000 claims 1
- 210000003041 ligament Anatomy 0.000 claims 1
- 239000011159 matrix material Substances 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 201000006417 multiple sclerosis Diseases 0.000 claims 1
- 210000000944 nerve tissue Anatomy 0.000 claims 1
- 230000001537 neural effect Effects 0.000 claims 1
- 230000002981 neuropathic effect Effects 0.000 claims 1
- 230000011164 ossification Effects 0.000 claims 1
- 208000012113 pregnancy disease Diseases 0.000 claims 1
- 230000002062 proliferating effect Effects 0.000 claims 1
- 230000000069 prophylactic effect Effects 0.000 claims 1
- 230000006798 recombination Effects 0.000 claims 1
- 238000005215 recombination Methods 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
- 239000013598 vector Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP05025261 | 2005-11-18 | ||
| EP05025261.8 | 2005-11-18 | ||
| PCT/EP2006/011074 WO2007057212A1 (en) | 2005-11-18 | 2006-11-17 | High activity growth factor mutants |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009519008A JP2009519008A (ja) | 2009-05-14 |
| JP2009519008A5 true JP2009519008A5 (enExample) | 2010-01-07 |
| JP5654730B2 JP5654730B2 (ja) | 2015-01-14 |
Family
ID=37628151
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008540526A Expired - Fee Related JP5654730B2 (ja) | 2005-11-18 | 2006-11-17 | 高活性の増殖因子変異体 |
Country Status (13)
| Country | Link |
|---|---|
| US (3) | US8188226B2 (enExample) |
| EP (1) | EP1948689B1 (enExample) |
| JP (1) | JP5654730B2 (enExample) |
| AT (1) | ATE553123T1 (enExample) |
| AU (1) | AU2006314713B2 (enExample) |
| CA (1) | CA2627370C (enExample) |
| CY (1) | CY1112877T1 (enExample) |
| DK (1) | DK1948689T3 (enExample) |
| ES (1) | ES2382464T3 (enExample) |
| PL (1) | PL1948689T3 (enExample) |
| PT (1) | PT1948689E (enExample) |
| SI (1) | SI1948689T1 (enExample) |
| WO (1) | WO2007057212A1 (enExample) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4938628B2 (ja) * | 2007-10-29 | 2012-05-23 | Ｈｏｙａ株式会社 | リン酸カルシウム系化合物、リン酸カルシウム系化合物／コラーゲン複合体及びリン酸カルシウム系細胞培養担体に付着又は吸着したエンドトキシンの抽出方法及び定量方法 |
| WO2009152085A1 (en) * | 2008-06-09 | 2009-12-17 | Wyeth | Novel bmp-12-related proteins and methods of their manufacture |
| EP2602264A1 (en) * | 2011-12-05 | 2013-06-12 | Biopharm Gesellschaft Zur Biotechnologischen Entwicklung Von Pharmaka mbH | GDF-5 mutant for inducing cartilage formation |
| US8956829B2 (en) | 2013-01-25 | 2015-02-17 | Warsaw Orthopedic, Inc. | Human recombinant growth and differentiaton factor-5 (rhGDF-5) |
| US9169308B2 (en) | 2013-01-25 | 2015-10-27 | Warsaw Orthopedic, Inc. | Methods and compositions of human recombinant growth and differentiation factor-5 (rhGDF-5) isolated from inclusion bodies |
| US9359417B2 (en) | 2013-01-25 | 2016-06-07 | Warsaw Orthopedic, Inc. | Cell cultures and methods of human recombinant growth and differentiaton factor-5 (rhGDF-5) |
| US9051389B2 (en) | 2013-01-25 | 2015-06-09 | Warsaw Orthopedic, Inc. | Expression conditions and methods of human recombinant growth and differentiation factor-5 (rhGDF-5) |
| US8945872B2 (en) | 2013-01-25 | 2015-02-03 | Warsaw Orthopedic, Inc. | Methods of purifying human recombinant growth and differentiation factor-5 (rhGDF-5) protein |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6150328A (en) * | 1986-07-01 | 2000-11-21 | Genetics Institute, Inc. | BMP products |
| US5013649A (en) * | 1986-07-01 | 1991-05-07 | Genetics Institute, Inc. | DNA sequences encoding osteoinductive products |
| DE19525416A1 (de) | 1995-07-12 | 1997-01-16 | Bioph Biotech Entw Pharm Gmbh | Verwendung von MP52 zur Behandlung und Prävention von Erkrankungen des Nervensystems |
| EP1439190A1 (en) * | 1993-01-12 | 2004-07-21 | The Johns Hopkins University School Of Medicine | Growth differentiation factor-5 |
| IL110589A0 (en) | 1993-08-10 | 1994-11-11 | Bioph Biotech Entw Pharm Gmbh | Growth/differentiation factor of the TGF- beta family |
| DK0733109T3 (da) * | 1993-12-07 | 2006-07-03 | Genetics Inst Llc | BMP-12, BMP-13 og seneinducerende præparater dermed |
| WO1996014335A1 (en) | 1994-11-07 | 1996-05-17 | The Government Of The United States Of America, Asrepresented By The Secretary, Department Of Health And Human Services | Cartilage-derived morphogenetic proteins |
| PT955313E (pt) | 1995-04-19 | 2006-07-31 | Bioph Biotech Entw Pharm Gmbh | Nova proteina e processo para a sua producao |
| JPH0931098A (ja) | 1995-07-24 | 1997-02-04 | Hoechst Japan Ltd | 新規なタンパク質ｈｍｗヒトｍｐ５２ |
| US5758328A (en) * | 1996-02-22 | 1998-05-26 | Giovannoli; Joseph | Computerized quotation system and method |
| EP1074620A1 (en) * | 1999-08-06 | 2001-02-07 | HyGene AG | Monomeric protein of the TGF-beta family |
| JPH11335398A (ja) | 1998-05-22 | 1999-12-07 | Hoechst Marion Roussel Kk | 新規な骨誘導活性を有する単量体蛋白質およびそれらからなる軟骨・骨疾患の予防および治療薬 |
| AU1024899A (en) | 1997-09-19 | 1999-04-12 | Biopharm Gesellschaft Zur Biotechnologischen Entwicklung Von Pharmaka Mbh | Cytokines having neurotrophic activity |
| AU778998B2 (en) * | 1998-09-22 | 2004-12-23 | University Of Maryland At Baltimore | Cystine knot growth factor mutants |
| JP2000119192A (ja) * | 1998-10-09 | 2000-04-25 | Aventis Pharma Ltd | 骨誘導因子アンタゴニスト活性を有する成熟型蛋白質 |
| US5989863A (en) * | 1998-10-14 | 1999-11-23 | Incyte Pharmaceuticals, Inc. | Human ankyrin family protein |
| WO2002021998A2 (en) | 2000-09-12 | 2002-03-21 | Axya Medical, Inc. | Apparatus and method for securing suture to bone |
| CA2441588A1 (en) * | 2001-03-23 | 2002-10-03 | Biopharm Gesellschaft Zue Biotechnologischen Entwicklung Von Pharmaka Mbh | Use of cytokines of the tgf-.beta. superfamily for the treatment and diagnosis of skin related disorders |
| US7148051B2 (en) | 2004-08-16 | 2006-12-12 | E. I. Du Pont De Nemours And Company | Production of 3-hydroxycarboxylic acid using nitrilase |
-
2006
- 2006-11-17 SI SI200631358T patent/SI1948689T1/sl unknown
- 2006-11-17 AU AU2006314713A patent/AU2006314713B2/en not_active Ceased
- 2006-11-17 US US12/094,227 patent/US8188226B2/en not_active Expired - Fee Related
- 2006-11-17 PL PL06818642T patent/PL1948689T3/pl unknown
- 2006-11-17 ES ES06818642T patent/ES2382464T3/es active Active
- 2006-11-17 AT AT06818642T patent/ATE553123T1/de active
- 2006-11-17 EP EP06818642A patent/EP1948689B1/en not_active Not-in-force
- 2006-11-17 PT PT06818642T patent/PT1948689E/pt unknown
- 2006-11-17 DK DK06818642.8T patent/DK1948689T3/da active
- 2006-11-17 WO PCT/EP2006/011074 patent/WO2007057212A1/en not_active Ceased
- 2006-11-17 CA CA2627370A patent/CA2627370C/en not_active Expired - Fee Related
- 2006-11-17 JP JP2008540526A patent/JP5654730B2/ja not_active Expired - Fee Related
-
2012
- 2012-04-27 US US13/457,957 patent/US20120322729A1/en not_active Abandoned
- 2012-07-06 CY CY20121100604T patent/CY1112877T1/el unknown
-
2014
- 2014-02-18 US US14/182,604 patent/US9200048B2/en not_active Expired - Fee Related
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