JP2009543566A - ヒト成長および分化因子gdf−5 - Google Patents

ヒト成長および分化因子gdf−5 Download PDF

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JP2009543566A
JP2009543566A JP2009519863A JP2009519863A JP2009543566A JP 2009543566 A JP2009543566 A JP 2009543566A JP 2009519863 A JP2009519863 A JP 2009519863A JP 2009519863 A JP2009519863 A JP 2009519863A JP 2009543566 A JP2009543566 A JP 2009543566A
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protein
gdf
precursor
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pharmaceutical composition
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JP2009543566A5 (enExample
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イェンス・ポール
フランク・プレゲール
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ビオファーム・ゲゼルシャフト・ツァ・ビオテヒノロジッシェン・エントヴィックルング・フォン・ファルマカ・エムベーハー
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18Growth factors; Growth regulators
    • A61K38/1875Bone morphogenic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46Hydrolases (3)
    • A61K38/48Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/482Serine endopeptidases (3.4.21)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/14Drugs for dermatological disorders for baldness or alopecia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/08Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02Muscle relaxants, e.g. for tetanus or cramps
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16Anti-Parkinson drugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475Growth factors; Growth regulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • Rheumatology (AREA)
  • Psychology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Dermatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
JP2009519863A 2006-07-18 2007-07-17 ヒト成長および分化因子gdf−5 Pending JP2009543566A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP06014928A EP1880731A1 (en) 2006-07-18 2006-07-18 Human growth and differentiation factor GDF-5
PCT/EP2007/006331 WO2008009419A1 (en) 2006-07-18 2007-07-17 Human growth and differentiation factor gdf-5

Publications (2)

Publication Number Publication Date
JP2009543566A true JP2009543566A (ja) 2009-12-10
JP2009543566A5 JP2009543566A5 (enExample) 2010-09-02

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JP2009519863A Pending JP2009543566A (ja) 2006-07-18 2007-07-17 ヒト成長および分化因子gdf−5

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US (2) US8361745B2 (enExample)
EP (2) EP1880731A1 (enExample)
JP (1) JP2009543566A (enExample)
CA (1) CA2657349A1 (enExample)
WO (1) WO2008009419A1 (enExample)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2014522918A (ja) * 2011-06-22 2014-09-08 ビオファーム ゲゼルシャフト ツァ ビオテクノロギシェン エントヴィックルンク フォン ファーマカ エムベーハー 生体吸収性創傷被覆材
JP2016183118A (ja) * 2015-03-25 2016-10-20 東ソー株式会社 増殖因子前駆体のリフォールディング方法

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2007234612B2 (en) 2006-12-14 2013-06-27 Johnson & Johnson Regenerative Therapeutics, Llc Protein stabilization formulations
EP2121142B1 (en) * 2007-01-25 2013-04-03 Biopharm Gesellschaft Zur Biotechnologischen Entwicklung Von Pharmaka mbH Use of gdf-5 for the improvement or maintenance of dermal appearance
US7678764B2 (en) 2007-06-29 2010-03-16 Johnson & Johnson Regenerative Therapeutics, Llc Protein formulations for use at elevated temperatures
JP5323832B2 (ja) 2007-08-07 2013-10-23 アドバンスト・テクノロジーズ・アンド・リジェネレイティブ・メディスン・エルエルシー 酸性水溶液中にgdf−5を含むタンパク質製剤
BRPI0911048A2 (pt) 2008-04-14 2015-12-29 Atrm Llc formulações líquidas tamponadas de gdf-5
WO2009152085A1 (en) * 2008-06-09 2009-12-17 Wyeth Novel bmp-12-related proteins and methods of their manufacture
US9051389B2 (en) 2013-01-25 2015-06-09 Warsaw Orthopedic, Inc. Expression conditions and methods of human recombinant growth and differentiation factor-5 (rhGDF-5)
US9359417B2 (en) 2013-01-25 2016-06-07 Warsaw Orthopedic, Inc. Cell cultures and methods of human recombinant growth and differentiaton factor-5 (rhGDF-5)
US9169308B2 (en) 2013-01-25 2015-10-27 Warsaw Orthopedic, Inc. Methods and compositions of human recombinant growth and differentiation factor-5 (rhGDF-5) isolated from inclusion bodies
US8945872B2 (en) 2013-01-25 2015-02-03 Warsaw Orthopedic, Inc. Methods of purifying human recombinant growth and differentiation factor-5 (rhGDF-5) protein
US8956829B2 (en) 2013-01-25 2015-02-17 Warsaw Orthopedic, Inc. Human recombinant growth and differentiaton factor-5 (rhGDF-5)
US11324806B2 (en) 2018-10-19 2022-05-10 Warsaw Orthopedic, Inc. Sustained delivery of a growth differentiation factor
EP3723212B1 (en) 2019-04-11 2024-05-29 Aptiv Technologies Limited Network connector module for a network connector

Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH08505548A (ja) * 1993-01-12 1996-06-18 ジェネンテク,インコーポレイテッド 骨成長を誘発させるためのTGF−β製剤
WO1996033215A1 (en) * 1995-04-19 1996-10-24 Hoechst Pharmaceuticals & Chemicals K.K. Novel protein and process for producing the same
JPH11509097A (ja) * 1995-07-12 1999-08-17 バイオファーム ゲセルシャフト ツァール バイオテクノロジーシェン エントヴィックラングフォン ファルマカ エムベーハー 神経系疾患の治療および予防のためのmp52またはmp121の使用
JP2001505097A (ja) * 1996-11-19 2001-04-17 バイオファーム ゲセルシャフト ツァール バイオテクノロジーシェン エントヴィックラング フォン ファルマカ エムベーハー 改良された軟骨誘導活性および/または硬骨誘導活性を有する複合体
JP2003506086A (ja) * 1999-08-06 2003-02-18 ハイゲン アーゲー TGF−βファミリーの単量体タンパク質
WO2004024890A2 (en) * 2002-09-16 2004-03-25 The Johns Hopkins University Metalloprotease activation of myostatin, and methods of modulating myostatin activity
JP2004525930A (ja) * 2001-03-23 2004-08-26 バイオファーム・ゲゼルシャフト・ツア・バイオテクノロジシェン・エントヴィックルング・フォン・ファーマカ・ミット・ベシュレンクテル・ハフツング 皮膚関連疾患の治療及び診断のためのTGF−βスーパーファミリーのサイトカインの使用
WO2004084965A2 (en) * 2003-03-28 2004-10-07 Biopharm Gesellschaft Zur Biotechnologischen Entwicklung Von Pharmaka Mbh Improved osteoinductive materials
WO2005093071A1 (ja) * 2004-03-29 2005-10-06 Matsushita Electric Industrial Co., Ltd. 人工放線菌h+-ピロホスファターゼ遺伝子及びその大腸菌での発現システム

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5935815A (en) * 1989-10-25 1999-08-10 Katholieke Universiteit Leuven Process for micro biological production of proteins
EP1439190A1 (en) * 1993-01-12 2004-07-21 The Johns Hopkins University School Of Medicine Growth differentiation factor-5
US6344541B1 (en) * 1998-09-25 2002-02-05 Amgen Inc. DKR polypeptides
CA2484556A1 (en) * 2001-12-21 2003-07-24 Human Genome Sciences, Inc. Albumin fusion proteins

Patent Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH08505548A (ja) * 1993-01-12 1996-06-18 ジェネンテク,インコーポレイテッド 骨成長を誘発させるためのTGF−β製剤
WO1996033215A1 (en) * 1995-04-19 1996-10-24 Hoechst Pharmaceuticals & Chemicals K.K. Novel protein and process for producing the same
JPH11509097A (ja) * 1995-07-12 1999-08-17 バイオファーム ゲセルシャフト ツァール バイオテクノロジーシェン エントヴィックラングフォン ファルマカ エムベーハー 神経系疾患の治療および予防のためのmp52またはmp121の使用
JP2001505097A (ja) * 1996-11-19 2001-04-17 バイオファーム ゲセルシャフト ツァール バイオテクノロジーシェン エントヴィックラング フォン ファルマカ エムベーハー 改良された軟骨誘導活性および/または硬骨誘導活性を有する複合体
JP2003506086A (ja) * 1999-08-06 2003-02-18 ハイゲン アーゲー TGF−βファミリーの単量体タンパク質
JP2004525930A (ja) * 2001-03-23 2004-08-26 バイオファーム・ゲゼルシャフト・ツア・バイオテクノロジシェン・エントヴィックルング・フォン・ファーマカ・ミット・ベシュレンクテル・ハフツング 皮膚関連疾患の治療及び診断のためのTGF−βスーパーファミリーのサイトカインの使用
WO2004024890A2 (en) * 2002-09-16 2004-03-25 The Johns Hopkins University Metalloprotease activation of myostatin, and methods of modulating myostatin activity
WO2004084965A2 (en) * 2003-03-28 2004-10-07 Biopharm Gesellschaft Zur Biotechnologischen Entwicklung Von Pharmaka Mbh Improved osteoinductive materials
WO2005093071A1 (ja) * 2004-03-29 2005-10-06 Matsushita Electric Industrial Co., Ltd. 人工放線菌h+-ピロホスファターゼ遺伝子及びその大腸菌での発現システム

Non-Patent Citations (10)

* Cited by examiner, † Cited by third party
Title
JPN5009009981; SCHMIDT F R: APPLIED MICROBIOLOGY AND BIOTECHNOLOGY V65 N4, 200409, P363-372 *
JPN6012043989; JIN, H.-J. et al.: Protein Expr. Purif. Vol.35, 2004, pp.1-10 *
JPN6012043990; ASHRAF, S. et al.: Protein Expr. Purif. Vol.33, 2004, pp.238-245 *
JPN6012043991; RATTENHOLL, A. et al.: J. Mol. Biol. Vol.305, 2001, pp.523-533 *
JPN6012043994; EDER, J. and FERSHT, A.R.: Mol. Microbiol. Vol.16, No.4, 1995, pp.609-614 *
JPN6012043996; NOVY, R. et al.: inNovations No.12, 2001, pp.1-3 *
JPN6013055256; KRIEGLSTEIN, K. et al.: J. Neurosci. Res. Vol.42, 1995, pp.724-732 *
JPN6013055257; SULLIVAN, A.M. et al.: Neurosci. Lett. Vol.233, 1997, pp.73-76 *
JPN6013055258; SULLIVAN, A.M. et al.: Eur. J. Neurosci. Vol.10, 1998, pp.3681-3688 *
JPN6014037541; CONSTAM, D.B. et al.: J. Cell Biol. Vol.134, 1996, pp.181-191 *

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2014522918A (ja) * 2011-06-22 2014-09-08 ビオファーム ゲゼルシャフト ツァ ビオテクノロギシェン エントヴィックルンク フォン ファーマカ エムベーハー 生体吸収性創傷被覆材
KR20140146035A (ko) * 2011-06-22 2014-12-24 바이오팜 게젤샤프트 쭈어 바이오테히놀로지셴 엔트비클룽 폰 파르마카 엠베하 생체흡수성 상처 드레싱
US9782511B2 (en) 2011-06-22 2017-10-10 Biopharm Gesellschaft Zur Biotechnologischen Entwicklung Von Pharmaka Mbh Bioresorbable wound dressing
KR101964482B1 (ko) * 2011-06-22 2019-04-01 바이오팜 게젤샤프트 쭈어 바이오테히놀로지셴 엔트비클룽 폰 파르마카 엠베하 생체흡수성 상처 드레싱
JP2016183118A (ja) * 2015-03-25 2016-10-20 東ソー株式会社 増殖因子前駆体のリフォールディング方法

Also Published As

Publication number Publication date
US8871710B2 (en) 2014-10-28
WO2008009419A1 (en) 2008-01-24
CA2657349A1 (en) 2008-01-24
US20130309221A1 (en) 2013-11-21
EP2043674A1 (en) 2009-04-08
EP2043674B1 (en) 2014-05-07
US20100129342A1 (en) 2010-05-27
EP1880731A1 (en) 2008-01-23
US8361745B2 (en) 2013-01-29

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