JP2009542581A5 - - Google Patents
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- Publication number
- JP2009542581A5 JP2009542581A5 JP2009512609A JP2009512609A JP2009542581A5 JP 2009542581 A5 JP2009542581 A5 JP 2009542581A5 JP 2009512609 A JP2009512609 A JP 2009512609A JP 2009512609 A JP2009512609 A JP 2009512609A JP 2009542581 A5 JP2009542581 A5 JP 2009542581A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- allopurinol
- pharmaceutically acceptable
- acceptable salt
- composition according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000008194 pharmaceutical composition Substances 0.000 claims 8
- 239000003814 drug Substances 0.000 claims 6
- OFCNXPDARWKPPY-UHFFFAOYSA-N Allopurinol Chemical compound OC1=NC=NC2=C1C=NN2 OFCNXPDARWKPPY-UHFFFAOYSA-N 0.000 claims 5
- 229960003459 allopurinol Drugs 0.000 claims 5
- 150000003839 salts Chemical class 0.000 claims 5
- 239000011780 sodium chloride Substances 0.000 claims 5
- 239000000203 mixture Substances 0.000 claims 4
- 208000002375 Hand-Foot Syndrome Diseases 0.000 claims 3
- 238000002512 chemotherapy Methods 0.000 claims 3
- 230000000699 topical Effects 0.000 claims 3
- 210000003491 Skin Anatomy 0.000 claims 2
- 239000006071 cream Substances 0.000 claims 2
- LXNHXLLTXMVWPM-UHFFFAOYSA-N pyridoxine Chemical compound CC1=NC=C(CO)C(CO)=C1O LXNHXLLTXMVWPM-UHFFFAOYSA-N 0.000 claims 2
- WAVYAFBQOXCGSZ-UHFFFAOYSA-N 2-fluoropyrimidine Chemical compound FC1=NC=CC=N1 WAVYAFBQOXCGSZ-UHFFFAOYSA-N 0.000 claims 1
- GHASVSINZRGABV-UHFFFAOYSA-N 5-flurouricil Chemical compound FC1=CNC(=O)NC1=O GHASVSINZRGABV-UHFFFAOYSA-N 0.000 claims 1
- 229960004117 Capecitabine Drugs 0.000 claims 1
- GAGWJHPBXLXJQN-UORFTKCHSA-N Capecitabine Chemical compound C1=C(F)C(NC(=O)OCCCCC)=NC(=O)N1[C@H]1[C@H](O)[C@H](O)[C@@H](C)O1 GAGWJHPBXLXJQN-UORFTKCHSA-N 0.000 claims 1
- 229960002949 Fluorouracil Drugs 0.000 claims 1
- HHVIBTZHLRERCL-UHFFFAOYSA-N Methylsulfonylmethane Chemical compound CS(C)(=O)=O HHVIBTZHLRERCL-UHFFFAOYSA-N 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 claims 1
- 239000008309 hydrophilic cream Substances 0.000 claims 1
- 229940016409 methylsulfonylmethane Drugs 0.000 claims 1
- 229920001955 polyphenylene ether Polymers 0.000 claims 1
- 229960002862 pyridoxine Drugs 0.000 claims 1
- 235000008160 pyridoxine Nutrition 0.000 claims 1
- 239000011677 pyridoxine Substances 0.000 claims 1
Claims (13)
- アロプリノールまたはその薬学的に許容される塩を有効成分として含む、フルオロピリミジン化学療法によって誘発される手足症候群（ＰＰＥ）の治療または予防用医薬。
- 皮膚への局所投与用である、請求項１に記載の医薬。
- 手および足への局所投与用である、請求項１に記載の医薬
- クリームの形態である、請求項２または３に記載の医薬。
- 手足症候群が５−フルオロウラシル化学療法によって誘発される、請求項１〜４のいずれかに記載の医薬。
- 手足症候群がカペシタビン化学療法によって誘発される、請求項１〜４のいずれかに記載の医薬。
- 皮膚への局所投与用医薬組成物であって、全組成物の１〜１０重量％のアロプリノールまたはその薬学的に許容される塩を含み、ただし、メチルスルホニルメタンおよびセトマクロゴールとの組み合わせを含まない、医薬組成物。
- さらにピリドキシンを含む、請求項７に記載の医薬組成物。
- クリームの形態の形態である、請求項７または８に記載の医薬組成物。
- 親水性クリームの形態である、請求項７または８に記載の医薬組成物。
- 組成物の１〜８重量％のアロプリノールまたはその薬学的に許容される塩を含む、請求項７〜１０のいずれかに記載の医薬組成物。
- 組成物の１〜５重量％のアロプリノールまたはその薬学的に許容される塩を含む、請求項７〜１０のいずれかに記載の医薬組成物。
- 組成物の２〜４重量％のアロプリノールまたはその薬学的に許容される塩を含む、請求項７〜１０のいずれかに記載の医薬組成物。
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP06011432A EP1862166A1 (en) | 2006-06-01 | 2006-06-01 | Use of allopurinol for the treatment of palmar plantar erythrodysesthesia |
| EP06011432.9 | 2006-06-01 | ||
| EP07107744 | 2007-05-08 | ||
| EP07107744.0 | 2007-05-08 | ||
| PCT/EP2007/055367 WO2007138103A1 (en) | 2006-06-01 | 2007-05-31 | Use of allopurinol for the treatment of palmar plantar erythrodysesthesia |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012118062A Division JP5389980B2 (ja) | 2006-06-01 | 2012-05-23 | 手足症候群の治療のためのアロプリノールの使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009542581A JP2009542581A (ja) | 2009-12-03 |
| JP2009542581A5 true JP2009542581A5 (ja) | 2012-05-17 |
| JP5028480B2 JP5028480B2 (ja) | 2012-09-19 |
Family
ID=38512579
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009512609A Expired - Fee Related JP5028480B2 (ja) | 2006-06-01 | 2007-05-31 | 手足症候群の治療のためのアロプリノールの使用 |
| JP2012118062A Expired - Fee Related JP5389980B2 (ja) | 2006-06-01 | 2012-05-23 | 手足症候群の治療のためのアロプリノールの使用 |
| JP2013211700A Pending JP2014028851A (ja) | 2006-06-01 | 2013-10-09 | 手足症候群の治療のためのアロプリノールの使用 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012118062A Expired - Fee Related JP5389980B2 (ja) | 2006-06-01 | 2012-05-23 | 手足症候群の治療のためのアロプリノールの使用 |
| JP2013211700A Pending JP2014028851A (ja) | 2006-06-01 | 2013-10-09 | 手足症候群の治療のためのアロプリノールの使用 |
Country Status (21)
| Country | Link |
|---|---|
| US (3) | US7973046B2 (ja) |
| EP (1) | EP2035006B1 (ja) |
| JP (3) | JP5028480B2 (ja) |
| KR (1) | KR101471022B1 (ja) |
| AT (1) | ATE457729T1 (ja) |
| AU (1) | AU2007267069B2 (ja) |
| CA (1) | CA2654270C (ja) |
| CY (1) | CY1110336T1 (ja) |
| DE (1) | DE602007004849D1 (ja) |
| DK (1) | DK2035006T3 (ja) |
| ES (1) | ES2341379T3 (ja) |
| HR (1) | HRP20100210T1 (ja) |
| IL (1) | IL195472A (ja) |
| MX (1) | MX2008015266A (ja) |
| NZ (1) | NZ573248A (ja) |
| PL (1) | PL2035006T3 (ja) |
| PT (1) | PT2035006E (ja) |
| RS (1) | RS51252B (ja) |
| RU (1) | RU2438673C2 (ja) |
| SI (1) | SI2035006T1 (ja) |
| WO (1) | WO2007138103A1 (ja) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2246057A1 (en) * | 2009-04-29 | 2010-11-03 | Nobera Pharma, S.L. | Use of allopurinol for the treatment of hand foot skin reaction |
| CN102648279B (zh) | 2009-10-16 | 2015-11-25 | 杜克大学 | 用于治疗药物诱发的手足综合征的组合物与方法 |
| EP2368549A1 (en) | 2010-03-25 | 2011-09-28 | BioAlliance Pharma | Treating hand-foot syndrome and related pathologies using clonidine or its derivatives |
| JP4761000B1 (ja) * | 2010-11-08 | 2011-08-31 | 小野薬品工業株式会社 | 手足症候群の予防および／または治療剤 |
| JP4983989B2 (ja) * | 2010-03-31 | 2012-07-25 | 小野薬品工業株式会社 | 手足症候群の予防および治療剤 |
| EP2554184B1 (en) * | 2010-03-31 | 2016-10-26 | ONO Pharmaceutical Co., Ltd. | Preventive and/or remedy for hand and foot syndrome |
| US9259343B2 (en) | 2012-07-06 | 2016-02-16 | Newman Technologies LLC | Device for mitigating plantar fasciitis |
| EP2712613B1 (en) * | 2012-09-28 | 2017-02-08 | Pharmadab d.o.o. | Vitamin K1 and uses thereof |
| JP2019512536A (ja) * | 2016-03-28 | 2019-05-16 | ヴィダック ファーマ リミテッド | 局所投与のための安定な医薬組成物およびその使用 |
| TW201927292A (zh) | 2017-12-13 | 2019-07-16 | 大陸商上海小午醫藥科技有限公司 | 一種用於預防或治療與ｅｇｆｒ被抑制相關疾病的方法 |
| CN113975264A (zh) | 2018-04-16 | 2022-01-28 | 上海岸阔医药科技有限公司 | 预防或治疗肿瘤疗法副作用的方法 |
| RU2722396C2 (ru) * | 2018-07-11 | 2020-05-29 | Федеральное государственное бюджетное учреждение дополнительного профессионального образования "Центральная государственная медицинская академия" Управления делами Президента Российской Федерации (ФГБУ ДПО "ЦГМА") | Способ лечения пальмарно-плантарной эритродизестезии |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3011A (en) * | 1843-03-21 | Improvement in water-wheels | ||
| EP0278040B1 (de) | 1987-02-13 | 1991-08-14 | Pharm-Allergan Gmbh | Verwendung von Pteridinen und/oder Purinen oder eines Xanthinoxidase-Hemmers zur Herstellung eines Arzneimittels zur Behandlung von genetisch bedingten degenerativen Netzhauterkrankungen |
| JPH03106817A (ja) | 1989-09-20 | 1991-05-07 | Nippon Kayaku Co Ltd | アロプリノール製剤 |
| JPH066700A (ja) | 1992-06-22 | 1994-01-14 | Fujitsu General Ltd | ハイビジョン受像機 |
| GB9218711D0 (en) | 1992-09-04 | 1992-10-21 | Salim Aws S M | Skin cancer treatment |
| AU4974893A (en) | 1992-09-04 | 1994-03-29 | Aws Shakir Mustafa Salim | Skin treatment compositions containing dimethylsulphone and allopurinol or oxypurinol |
| JP3106817B2 (ja) | 1993-11-02 | 2000-11-06 | 富士電機株式会社 | 漏電遮断器 |
| US6284234B1 (en) * | 1998-08-04 | 2001-09-04 | Johnson & Johnson Consumer Companies, Inc. | Topical delivery systems for active agents |
| US6060083A (en) | 1999-04-01 | 2000-05-09 | Topical Technologies, Inc. | Topical DMSO treatment for palmar-plantar erythrodysethesia |
| AU2001267533A1 (en) * | 2000-06-20 | 2002-01-02 | Henkel Kommanditgesellschaft Auf Aktien | Structure-improving hair care agents |
| ATE316786T1 (de) | 2000-11-22 | 2006-02-15 | Rxkinetix Inc | Behandlung von mukositis |
| US7544348B2 (en) | 2001-02-15 | 2009-06-09 | Access Pharmaceuticals, Inc. | Liquid formulations for the prevention and treatment of mucosal diseases and disorders |
| DK1455888T3 (da) * | 2001-08-29 | 2009-08-24 | Pharmakodex Ltd | Topisk indgivelsesindretning |
| EP1461033B1 (en) * | 2001-11-29 | 2013-02-27 | Sound Pharmaceuticals Incorporated | Methods and compositions for ameliorating the undesirable effects of chemotherapy |
| DE10200578A1 (de) * | 2002-01-09 | 2003-07-10 | Roehm Gmbh | Haft- und Bindemittel für dermale oder transdermale Therapiesysteme |
| US6979688B2 (en) | 2002-02-12 | 2005-12-27 | Ford John P | Treatment method against side-effects of chemotherapy |
| US20040214215A1 (en) * | 2003-03-07 | 2004-10-28 | Yu Ruey J. | Bioavailability and improved delivery of alkaline pharmaceutical drugs |
| JP2007501865A (ja) | 2003-06-11 | 2007-02-01 | ノバセア インコーポレイティッド | 放射線治療薬および放射線治療と併用した、活性ビタミンｄ化合物による癌の治療法 |
| CA2528378A1 (en) | 2003-06-11 | 2004-12-23 | Novacea, Inc. | Treatment of immune-mediated disorders with active vitamin d compounds alone or in combination with other therapeutic agents |
| US20050148908A1 (en) | 2003-12-24 | 2005-07-07 | Gregory Skover | Apparatus containing a receiving element for treatment of skin |
| WO2005084301A2 (en) * | 2004-03-01 | 2005-09-15 | Lumen Therapeutics, Llc | Compositions and methods for treating diseases |
| JP4405326B2 (ja) | 2004-06-28 | 2010-01-27 | 株式会社東芝 | ランドリー機器 |
| EP1791535B1 (en) * | 2004-09-17 | 2008-07-30 | BioMAS Ltd. | Novel tellurium compounds and their use as immunomodulators |
-
2007
- 2007-05-31 NZ NZ573248A patent/NZ573248A/en not_active IP Right Cessation
- 2007-05-31 DE DE602007004849T patent/DE602007004849D1/de active Active
- 2007-05-31 ES ES07729768T patent/ES2341379T3/es active Active
- 2007-05-31 PL PL07729768T patent/PL2035006T3/pl unknown
- 2007-05-31 PT PT07729768T patent/PT2035006E/pt unknown
- 2007-05-31 WO PCT/EP2007/055367 patent/WO2007138103A1/en active Application Filing
- 2007-05-31 SI SI200730172T patent/SI2035006T1/sl unknown
- 2007-05-31 MX MX2008015266A patent/MX2008015266A/es active IP Right Grant
- 2007-05-31 AT AT07729768T patent/ATE457729T1/de active
- 2007-05-31 EP EP07729768A patent/EP2035006B1/en active Active
- 2007-05-31 RS RSP-2010/0163A patent/RS51252B/sr unknown
- 2007-05-31 RU RU2008152341/15A patent/RU2438673C2/ru not_active IP Right Cessation
- 2007-05-31 CA CA2654270A patent/CA2654270C/en not_active Expired - Fee Related
- 2007-05-31 AU AU2007267069A patent/AU2007267069B2/en not_active Ceased
- 2007-05-31 DK DK07729768.7T patent/DK2035006T3/da active
- 2007-05-31 US US12/227,807 patent/US7973046B2/en not_active Expired - Fee Related
- 2007-05-31 JP JP2009512609A patent/JP5028480B2/ja not_active Expired - Fee Related
-
2008
- 2008-11-24 IL IL195472A patent/IL195472A/en not_active IP Right Cessation
- 2008-12-31 KR KR1020087032168A patent/KR101471022B1/ko not_active IP Right Cessation
-
2010
- 2010-03-23 CY CY20101100279T patent/CY1110336T1/el unknown
- 2010-04-14 HR HR20100210T patent/HRP20100210T1/hr unknown
-
2011
- 2011-05-24 US US13/114,768 patent/US8557829B2/en not_active Expired - Fee Related
-
2012
- 2012-05-23 JP JP2012118062A patent/JP5389980B2/ja not_active Expired - Fee Related
-
2013
- 2013-09-09 US US14/021,723 patent/US20140011820A1/en not_active Abandoned
- 2013-10-09 JP JP2013211700A patent/JP2014028851A/ja active Pending
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