JP2009541332A - 転写因子調節化合物およびその使用法 - Google Patents
転写因子調節化合物およびその使用法 Download PDFInfo
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- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US81598406P | 2006-06-23 | 2006-06-23 | |
| PCT/US2007/014758 WO2008130368A2 (en) | 2006-06-23 | 2007-06-25 | Transcription factor modulating compounds and methods of use thereof |
Publications (2)
| Publication Number | Publication Date |
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| JP2009541332A true JP2009541332A (ja) | 2009-11-26 |
| JP2009541332A5 JP2009541332A5 (OSRAM) | 2010-08-12 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009516593A Pending JP2009541332A (ja) | 2006-06-23 | 2007-06-25 | 転写因子調節化合物およびその使用法 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20090170812A1 (OSRAM) |
| EP (1) | EP2038274A2 (OSRAM) |
| JP (1) | JP2009541332A (OSRAM) |
| CN (1) | CN101626765B (OSRAM) |
| AU (1) | AU2007351886A1 (OSRAM) |
| CA (1) | CA2656157A1 (OSRAM) |
| IL (1) | IL195992A0 (OSRAM) |
| WO (1) | WO2008130368A2 (OSRAM) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
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| WO2009005551A2 (en) * | 2007-03-27 | 2009-01-08 | Paratek Pharmaceuticals, Inc. | Transcription factor modulating compounds and methods of use thereof |
| US8647642B2 (en) | 2008-09-18 | 2014-02-11 | Aviex Technologies, Llc | Live bacterial vaccines resistant to carbon dioxide (CO2), acidic PH and/or osmolarity for viral infection prophylaxis or treatment |
| US20110177147A1 (en) * | 2010-01-21 | 2011-07-21 | General Electric Company | Stable biocidal delivery systems |
| CN102617561B (zh) * | 2012-02-21 | 2014-05-07 | 常州方圆制药有限公司 | 2-苄硫基苯并杂环衍生物、其制备方法及其医药用途 |
| US10676723B2 (en) | 2015-05-11 | 2020-06-09 | David Gordon Bermudes | Chimeric protein toxins for expression by therapeutic bacteria |
| US11180535B1 (en) | 2016-12-07 | 2021-11-23 | David Gordon Bermudes | Saccharide binding, tumor penetration, and cytotoxic antitumor chimeric peptides from therapeutic bacteria |
| US11129906B1 (en) | 2016-12-07 | 2021-09-28 | David Gordon Bermudes | Chimeric protein toxins for expression by therapeutic bacteria |
| CN108047216B (zh) * | 2017-12-06 | 2020-11-10 | 石家庄学院 | 一种3,4-二苯基吡唑化合物及其制备和应用 |
| CN109265412B (zh) * | 2018-11-19 | 2020-06-02 | 大连大学 | 一种用于检测氟离子的探针化合物及其检测方法 |
| CN111269293B (zh) * | 2018-12-04 | 2021-10-29 | 中国科学院微生物研究所 | 一种感应缬氨酸信号的转录因子及其应用 |
Citations (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2002036580A2 (en) * | 2000-10-31 | 2002-05-10 | Lynn Bonham | Benzoxazole lpaat- beta inhibitors and uses thereof |
| US20030004203A1 (en) * | 1998-05-22 | 2003-01-02 | Sircar Jagadish C. | Benzimidazole derivatives as modulators of IgE |
| WO2003057667A2 (en) * | 2001-12-31 | 2003-07-17 | The Ohio State University Research Foundation | Strapped and modified bis (benzimidazole) diamides for asymmetric catalysts and other applications |
| JP2005525378A (ja) * | 2002-03-05 | 2005-08-25 | トランス テック ファーマ,インコーポレイテッド | リガンドのrageとの相互作用を阻害する単環式および二環式アゾール誘導体 |
| JP2005526028A (ja) * | 2002-02-06 | 2005-09-02 | バーテックス ファーマシューティカルズ インコーポレイテッド | Gsk−3の阻害剤として有用なヘテロアリール化合物 |
| JP2006503020A (ja) * | 2002-09-06 | 2006-01-26 | アルケミア リミティッド | キナーゼと相互作用する化合物 |
| JP2006513162A (ja) * | 2002-11-01 | 2006-04-20 | パラテック ファーマシューティカルズ インコーポレイテッド | 転写因子調節化合物およびその使用方法 |
| JP2009516649A (ja) * | 2005-10-31 | 2009-04-23 | メルク エンド カムパニー インコーポレーテッド | Cetp阻害薬 |
| JP2010507581A (ja) * | 2006-10-20 | 2010-03-11 | ナームローゼ・フエンノートチヤツプ・オルガノン | PKC−θ阻害薬としてのプリン類 |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3300505A (en) * | 1964-12-07 | 1967-01-24 | Ciba Geigy Corp | Ether-2-r-substituted benzimidazoles and derivatives and acid addition salts thereof |
| US3429890A (en) * | 1964-12-31 | 1969-02-25 | Merck & Co Inc | Certain 2-thiazolylbenzimidazole-1-oxy derivatives |
| US3325356A (en) * | 1965-08-20 | 1967-06-13 | Merck & Co Inc | Compositions and method for treating helminthiasis |
| US3449498A (en) * | 1965-11-18 | 1969-06-10 | Ciba Geigy Corp | Analgesic compositions of a 4-aminoal-kylamino-quinazoline and 1-amino-alkoxybenzimidazole |
| GB1141936A (en) * | 1966-03-26 | 1969-02-05 | Shionogi & Co | Improvements in or relating to benzimidazole derivatives |
| US3549754A (en) * | 1969-04-21 | 1970-12-22 | Merck & Co Inc | Combination of 2-substituted benzimidazoles and substituted phenothiazines in the treatment of helminthiasis |
| US3686110A (en) * | 1970-02-27 | 1972-08-22 | Meuch & Co Inc | 1-oxybenzimidazoles |
| US3873558A (en) * | 1970-03-05 | 1975-03-25 | Merck & Co Inc | Process for preparing 1,5-substituted or 1,6-substituted benzimidazoles |
| US3646049A (en) * | 1970-03-05 | 1972-02-29 | Merck & Co Inc | Acylaminobenzimidazole derivatives |
| US5552426A (en) * | 1994-04-29 | 1996-09-03 | Eli Lilly And Company | Methods for treating a physiological disorder associated with β-amyloid peptide |
| JP2000516611A (ja) * | 1996-08-14 | 2000-12-12 | ワーナー―ランバート・コンパニー | Mcp―1アンタゴニストとしての2―フェニルベンズイミダゾール誘導体 |
| AU6328498A (en) * | 1997-02-21 | 1998-09-09 | Hybridon, Inc. | Oligonucleotides specific for the (marorab) operon |
| US5942532A (en) * | 1997-09-05 | 1999-08-24 | Ortho Pharmaceutical Corporation | 2-substituted phenyl-benzimidazole antibacterial agents |
| WO1999061579A2 (en) * | 1998-05-22 | 1999-12-02 | Tufts University | MarA FAMILY HELIX-TURN-HELIX DOMAINS AND THEIR METHODS OF USE |
| US6204264B1 (en) * | 1998-09-21 | 2001-03-20 | Shiseido Co., Ltd. | Benzimidazole derivative, hair growth promoter and external composition for skin using the same |
| ES2246240T3 (es) * | 1999-06-23 | 2006-02-16 | Sanofi-Aventis Deutschland Gmbh | Bencimidazoles sustituidos. |
| US7405235B2 (en) * | 2001-05-04 | 2008-07-29 | Paratek Pharmaceuticals, Inc. | Transcription factor modulating compounds and methods of use thereof |
| US20060160799A1 (en) * | 2004-04-23 | 2006-07-20 | Alekshun Michael N | Transcription factor modulating compounds and methods of use thereof |
| WO2009005551A2 (en) * | 2007-03-27 | 2009-01-08 | Paratek Pharmaceuticals, Inc. | Transcription factor modulating compounds and methods of use thereof |
| WO2010124097A2 (en) * | 2009-04-22 | 2010-10-28 | Paratek Pharmaceuticals, Inc. | Transcription factor modulating compounds and methods of use thereof |
-
2007
- 2007-06-25 AU AU2007351886A patent/AU2007351886A1/en not_active Abandoned
- 2007-06-25 CN CN200780029895XA patent/CN101626765B/zh not_active Expired - Fee Related
- 2007-06-25 US US11/823,103 patent/US20090170812A1/en not_active Abandoned
- 2007-06-25 CA CA002656157A patent/CA2656157A1/en not_active Abandoned
- 2007-06-25 WO PCT/US2007/014758 patent/WO2008130368A2/en not_active Ceased
- 2007-06-25 JP JP2009516593A patent/JP2009541332A/ja active Pending
- 2007-06-25 EP EP07873415A patent/EP2038274A2/en not_active Withdrawn
-
2008
- 2008-12-16 IL IL195992A patent/IL195992A0/en unknown
Patent Citations (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030004203A1 (en) * | 1998-05-22 | 2003-01-02 | Sircar Jagadish C. | Benzimidazole derivatives as modulators of IgE |
| WO2002036580A2 (en) * | 2000-10-31 | 2002-05-10 | Lynn Bonham | Benzoxazole lpaat- beta inhibitors and uses thereof |
| WO2003057667A2 (en) * | 2001-12-31 | 2003-07-17 | The Ohio State University Research Foundation | Strapped and modified bis (benzimidazole) diamides for asymmetric catalysts and other applications |
| JP2005526028A (ja) * | 2002-02-06 | 2005-09-02 | バーテックス ファーマシューティカルズ インコーポレイテッド | Gsk−3の阻害剤として有用なヘテロアリール化合物 |
| JP2005525378A (ja) * | 2002-03-05 | 2005-08-25 | トランス テック ファーマ,インコーポレイテッド | リガンドのrageとの相互作用を阻害する単環式および二環式アゾール誘導体 |
| JP2006503020A (ja) * | 2002-09-06 | 2006-01-26 | アルケミア リミティッド | キナーゼと相互作用する化合物 |
| JP2006513162A (ja) * | 2002-11-01 | 2006-04-20 | パラテック ファーマシューティカルズ インコーポレイテッド | 転写因子調節化合物およびその使用方法 |
| JP2009516649A (ja) * | 2005-10-31 | 2009-04-23 | メルク エンド カムパニー インコーポレーテッド | Cetp阻害薬 |
| JP2010507581A (ja) * | 2006-10-20 | 2010-03-11 | ナームローゼ・フエンノートチヤツプ・オルガノン | PKC−θ阻害薬としてのプリン類 |
Non-Patent Citations (6)
| Title |
|---|
| JPN6012055382; Macromolecules 28(7), 1995, pp.2526-2532 * |
| JPN6012055384; J.Comb.Chem. 4(5), 2002, pp.475-483 * |
| JPN6012055386; Organic Letters 6(6), 2004, pp.989-992 * |
| JPN6012055388; Bioorganic & Medicinal Chemistry Letters 14(6), 2004, pp.1455-1459 * |
| JPN6012055390; IL FARMACO 58(12), 2003, pp.1345-1350 * |
| JPN6012055391; European Journal of Organic Chemistry vol.12, 2004, pp.2620-2626 * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN101626765A (zh) | 2010-01-13 |
| IL195992A0 (en) | 2009-09-01 |
| US20090170812A1 (en) | 2009-07-02 |
| AU2007351886A1 (en) | 2008-10-30 |
| WO2008130368A3 (en) | 2009-07-09 |
| CA2656157A1 (en) | 2008-10-30 |
| CN101626765B (zh) | 2012-12-26 |
| WO2008130368A2 (en) | 2008-10-30 |
| EP2038274A2 (en) | 2009-03-25 |
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