JP2009541332A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2009541332A5 JP2009541332A5 JP2009516593A JP2009516593A JP2009541332A5 JP 2009541332 A5 JP2009541332 A5 JP 2009541332A5 JP 2009516593 A JP2009516593 A JP 2009516593A JP 2009516593 A JP2009516593 A JP 2009516593A JP 2009541332 A5 JP2009541332 A5 JP 2009541332A5
- Authority
- JP
- Japan
- Prior art keywords
- oxime
- alkyl
- aryl
- amino
- hydrogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 229910052739 hydrogen Inorganic materials 0.000 claims description 168
- 239000001257 hydrogen Substances 0.000 claims description 168
- -1 alkyl oximes Chemical class 0.000 claims description 127
- 125000003545 alkoxy group Chemical group 0.000 claims description 117
- 229910052736 halogen Inorganic materials 0.000 claims description 109
- 150000002367 halogens Chemical class 0.000 claims description 109
- 125000000217 alkyl group Chemical group 0.000 claims description 104
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims description 99
- 125000003118 aryl group Chemical group 0.000 claims description 97
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 85
- 150000002431 hydrogen Chemical class 0.000 claims description 84
- 125000002252 acyl group Chemical group 0.000 claims description 80
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 78
- 150000002923 oximes Chemical class 0.000 claims description 76
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 76
- 125000004093 cyano group Chemical group *C#N 0.000 claims description 75
- 125000001072 heteroaryl group Chemical group 0.000 claims description 75
- 125000003282 alkyl amino group Chemical group 0.000 claims description 63
- 150000001875 compounds Chemical class 0.000 claims description 63
- 125000003342 alkenyl group Chemical group 0.000 claims description 61
- 125000004442 acylamino group Chemical group 0.000 claims description 60
- 125000004453 alkoxycarbonyl group Chemical group 0.000 claims description 60
- 125000004448 alkyl carbonyl group Chemical group 0.000 claims description 60
- 125000004390 alkyl sulfonyl group Chemical group 0.000 claims description 60
- 125000000304 alkynyl group Chemical group 0.000 claims description 60
- 125000004397 aminosulfonyl group Chemical group NS(=O)(=O)* 0.000 claims description 60
- 125000001769 aryl amino group Chemical group 0.000 claims description 60
- 125000005129 aryl carbonyl group Chemical group 0.000 claims description 60
- 125000005161 aryl oxy carbonyl group Chemical group 0.000 claims description 60
- 125000004391 aryl sulfonyl group Chemical group 0.000 claims description 60
- 125000004104 aryloxy group Chemical group 0.000 claims description 60
- 125000006297 carbonyl amino group Chemical group [H]N([*:2])C([*:1])=O 0.000 claims description 60
- 125000005241 heteroarylamino group Chemical group 0.000 claims description 60
- 125000005223 heteroarylcarbonyl group Chemical group 0.000 claims description 60
- 125000005553 heteroaryloxy group Chemical group 0.000 claims description 60
- 125000005226 heteroaryloxycarbonyl group Chemical group 0.000 claims description 60
- 125000000623 heterocyclic group Chemical group 0.000 claims description 60
- 108091023040 Transcription factor Proteins 0.000 claims description 52
- 102000040945 Transcription factor Human genes 0.000 claims description 52
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 51
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 45
- 229910052799 carbon Inorganic materials 0.000 claims description 45
- 150000003839 salts Chemical class 0.000 claims description 35
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 claims description 32
- 229910052731 fluorine Inorganic materials 0.000 claims description 32
- 239000011737 fluorine Substances 0.000 claims description 32
- 229910052757 nitrogen Inorganic materials 0.000 claims description 31
- 150000002148 esters Chemical class 0.000 claims description 28
- 239000000651 prodrug Substances 0.000 claims description 27
- 229940002612 prodrug Drugs 0.000 claims description 27
- 125000004663 dialkyl amino group Chemical group 0.000 claims description 20
- 230000000813 microbial effect Effects 0.000 claims description 18
- 238000013518 transcription Methods 0.000 claims description 17
- 230000035897 transcription Effects 0.000 claims description 17
- 239000008194 pharmaceutical composition Substances 0.000 claims description 15
- 230000003115 biocidal effect Effects 0.000 claims description 14
- 125000004076 pyridyl group Chemical group 0.000 claims description 14
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims description 12
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims description 11
- 125000004473 dialkylaminocarbonyl group Chemical group 0.000 claims description 8
- 125000001153 fluoro group Chemical group F* 0.000 claims description 8
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 claims description 7
- VNWKTOKETHGBQD-UHFFFAOYSA-N methane Chemical compound C VNWKTOKETHGBQD-UHFFFAOYSA-N 0.000 claims description 7
- 239000003937 drug carrier Substances 0.000 claims description 4
- 241000894006 Bacteria Species 0.000 claims description 2
- 208000019206 urinary tract infection Diseases 0.000 claims description 2
- 125000006527 (C1-C5) alkyl group Chemical group 0.000 claims 18
- 230000001988 toxicity Effects 0.000 claims 1
- 231100000419 toxicity Toxicity 0.000 claims 1
- 238000000034 method Methods 0.000 description 268
- 125000001255 4-fluorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1F 0.000 description 8
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 8
- 230000001105 regulatory effect Effects 0.000 description 8
- 125000004435 hydrogen atom Chemical group [H]* 0.000 description 6
- 229920001184 polypeptide Polymers 0.000 description 5
- 102000004196 processed proteins & peptides Human genes 0.000 description 5
- 108090000765 processed proteins & peptides Proteins 0.000 description 5
- FGRBYDKOBBBPOI-UHFFFAOYSA-N 10,10-dioxo-2-[4-(N-phenylanilino)phenyl]thioxanthen-9-one Chemical compound O=C1c2ccccc2S(=O)(=O)c2ccc(cc12)-c1ccc(cc1)N(c1ccccc1)c1ccccc1 FGRBYDKOBBBPOI-UHFFFAOYSA-N 0.000 description 3
- QGZKDVFQNNGYKY-OUBTZVSYSA-N Ammonia-15N Chemical compound [15NH3] QGZKDVFQNNGYKY-OUBTZVSYSA-N 0.000 description 3
- YNAVUWVOSKDBBP-UHFFFAOYSA-N Morpholine Chemical group C1COCCN1 YNAVUWVOSKDBBP-UHFFFAOYSA-N 0.000 description 3
- 241000607481 Yersinia intermedia Species 0.000 description 3
- VNWKTOKETHGBQD-AKLPVKDBSA-N carbane Chemical compound [15CH4] VNWKTOKETHGBQD-AKLPVKDBSA-N 0.000 description 3
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 3
- RAXXELZNTBOGNW-UHFFFAOYSA-N imidazole Natural products C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 description 3
- 125000002883 imidazolyl group Chemical group 0.000 description 3
- ABLZXFCXXLZCGV-UHFFFAOYSA-N phosphonic acid group Chemical group P(O)(O)=O ABLZXFCXXLZCGV-UHFFFAOYSA-N 0.000 description 3
- 0 *C(N(*)[Al]c1nc(c(*)c(*)c(*)c2*)c2[n]1*)=O Chemical compound *C(N(*)[Al]c1nc(c(*)c(*)c(*)c2*)c2[n]1*)=O 0.000 description 2
- 208000002874 Acne Vulgaris Diseases 0.000 description 2
- 201000003883 Cystic fibrosis Diseases 0.000 description 2
- 241000606788 Haemophilus haemolyticus Species 0.000 description 2
- 241000186367 Mycobacterium avium Species 0.000 description 2
- 206010031252 Osteomyelitis Diseases 0.000 description 2
- 206010033078 Otitis media Diseases 0.000 description 2
- ZCQWOFVYLHDMMC-UHFFFAOYSA-N Oxazole Chemical compound C1=COC=N1 ZCQWOFVYLHDMMC-UHFFFAOYSA-N 0.000 description 2
- 241000606210 Parabacteroides distasonis Species 0.000 description 2
- 241000588777 Providencia rettgeri Species 0.000 description 2
- 241000589776 Pseudomonas putida Species 0.000 description 2
- 241000607762 Shigella flexneri Species 0.000 description 2
- 241000194017 Streptococcus Species 0.000 description 2
- 206010000496 acne Diseases 0.000 description 2
- 208000002925 dental caries Diseases 0.000 description 2
- 125000002147 dimethylamino group Chemical group [H]C([H])([H])N(*)C([H])([H])[H] 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 206010014665 endocarditis Diseases 0.000 description 2
- 208000022760 infectious otitis media Diseases 0.000 description 2
- 239000003112 inhibitor Substances 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 2
- XAEFZNCEHLXOMS-UHFFFAOYSA-M potassium benzoate Chemical group [K+].[O-]C(=O)C1=CC=CC=C1 XAEFZNCEHLXOMS-UHFFFAOYSA-M 0.000 description 2
- 201000007094 prostatitis Diseases 0.000 description 2
- 125000003226 pyrazolyl group Chemical group 0.000 description 2
- 210000005084 renal tissue Anatomy 0.000 description 2
- 159000000000 sodium salts Chemical class 0.000 description 2
- 125000000547 substituted alkyl group Chemical group 0.000 description 2
- 125000003107 substituted aryl group Chemical group 0.000 description 2
- 108091006106 transcriptional activators Proteins 0.000 description 2
- 241000588624 Acinetobacter calcoaceticus Species 0.000 description 1
- 241001148231 Acinetobacter haemolyticus Species 0.000 description 1
- 241000607528 Aeromonas hydrophila Species 0.000 description 1
- 241000606125 Bacteroides Species 0.000 description 1
- 241001135322 Bacteroides eggerthii Species 0.000 description 1
- 241000606124 Bacteroides fragilis Species 0.000 description 1
- 241000606123 Bacteroides thetaiotaomicron Species 0.000 description 1
- 241000606219 Bacteroides uniformis Species 0.000 description 1
- 241000606215 Bacteroides vulgatus Species 0.000 description 1
- 241000588779 Bordetella bronchiseptica Species 0.000 description 1
- 241000588780 Bordetella parapertussis Species 0.000 description 1
- 241000588832 Bordetella pertussis Species 0.000 description 1
- 241000908522 Borreliella Species 0.000 description 1
- 241000589513 Burkholderia cepacia Species 0.000 description 1
- GAWIXWVDTYZWAW-UHFFFAOYSA-N C[CH]O Chemical group C[CH]O GAWIXWVDTYZWAW-UHFFFAOYSA-N 0.000 description 1
- 241000589877 Campylobacter coli Species 0.000 description 1
- 241000589875 Campylobacter jejuni Species 0.000 description 1
- 241000588919 Citrobacter freundii Species 0.000 description 1
- 241000193163 Clostridioides difficile Species 0.000 description 1
- 241000186227 Corynebacterium diphtheriae Species 0.000 description 1
- 241000918600 Corynebacterium ulcerans Species 0.000 description 1
- 241001600125 Delftia acidovorans Species 0.000 description 1
- 241000588697 Enterobacter cloacae Species 0.000 description 1
- 241000194032 Enterococcus faecalis Species 0.000 description 1
- 241000194031 Enterococcus faecium Species 0.000 description 1
- 241000588724 Escherichia coli Species 0.000 description 1
- 241000589602 Francisella tularensis Species 0.000 description 1
- 241000233866 Fungi Species 0.000 description 1
- 241000207201 Gardnerella vaginalis Species 0.000 description 1
- 241000606768 Haemophilus influenzae Species 0.000 description 1
- 241000606766 Haemophilus parainfluenzae Species 0.000 description 1
- 241000590002 Helicobacter pylori Species 0.000 description 1
- 206010061598 Immunodeficiency Diseases 0.000 description 1
- 241000588915 Klebsiella aerogenes Species 0.000 description 1
- 241000588749 Klebsiella oxytoca Species 0.000 description 1
- 241000588747 Klebsiella pneumoniae Species 0.000 description 1
- 241000589248 Legionella Species 0.000 description 1
- 208000007764 Legionnaires' Disease Diseases 0.000 description 1
- 241000186779 Listeria monocytogenes Species 0.000 description 1
- 241000124008 Mammalia Species 0.000 description 1
- 241001293418 Mannheimia haemolytica Species 0.000 description 1
- 241000588655 Moraxella catarrhalis Species 0.000 description 1
- 241000186364 Mycobacterium intracellulare Species 0.000 description 1
- 241000186362 Mycobacterium leprae Species 0.000 description 1
- 241000187479 Mycobacterium tuberculosis Species 0.000 description 1
- 241000588652 Neisseria gonorrhoeae Species 0.000 description 1
- 241000588650 Neisseria meningitidis Species 0.000 description 1
- 241001135232 Odoribacter splanchnicus Species 0.000 description 1
- 241000606856 Pasteurella multocida Species 0.000 description 1
- 241000588770 Proteus mirabilis Species 0.000 description 1
- 241000588767 Proteus vulgaris Species 0.000 description 1
- 241000588768 Providencia Species 0.000 description 1
- 241000576783 Providencia alcalifaciens Species 0.000 description 1
- 241000589517 Pseudomonas aeruginosa Species 0.000 description 1
- 241000168225 Pseudomonas alcaligenes Species 0.000 description 1
- 241000589540 Pseudomonas fluorescens Species 0.000 description 1
- 241001354013 Salmonella enterica subsp. enterica serovar Enteritidis Species 0.000 description 1
- 241000531795 Salmonella enterica subsp. enterica serovar Paratyphi A Species 0.000 description 1
- 241000293871 Salmonella enterica subsp. enterica serovar Typhi Species 0.000 description 1
- 241000293869 Salmonella enterica subsp. enterica serovar Typhimurium Species 0.000 description 1
- 241000047412 Serratella Species 0.000 description 1
- 241000607764 Shigella dysenteriae Species 0.000 description 1
- 241000607760 Shigella sonnei Species 0.000 description 1
- 241000191940 Staphylococcus Species 0.000 description 1
- 241000191967 Staphylococcus aureus Species 0.000 description 1
- 241000191963 Staphylococcus epidermidis Species 0.000 description 1
- 241000191984 Staphylococcus haemolyticus Species 0.000 description 1
- 241000191982 Staphylococcus hyicus Species 0.000 description 1
- 241000191980 Staphylococcus intermedius Species 0.000 description 1
- 241001464905 Staphylococcus saccharolyticus Species 0.000 description 1
- 241001147691 Staphylococcus saprophyticus Species 0.000 description 1
- 241000122973 Stenotrophomonas maltophilia Species 0.000 description 1
- 241000193998 Streptococcus pneumoniae Species 0.000 description 1
- 241000193996 Streptococcus pyogenes Species 0.000 description 1
- 241000607626 Vibrio cholerae Species 0.000 description 1
- 241000607272 Vibrio parahaemolyticus Species 0.000 description 1
- 241000607447 Yersinia enterocolitica Species 0.000 description 1
- 241000607479 Yersinia pestis Species 0.000 description 1
- 241000607477 Yersinia pseudotuberculosis Species 0.000 description 1
- 241000606834 [Haemophilus] ducreyi Species 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 230000000249 desinfective effect Effects 0.000 description 1
- 229940092559 enterobacter aerogenes Drugs 0.000 description 1
- 229940032049 enterococcus faecalis Drugs 0.000 description 1
- RTZKZFJDLAIYFH-UHFFFAOYSA-N ether Substances CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 1
- 229940118764 francisella tularensis Drugs 0.000 description 1
- 125000002541 furyl group Chemical group 0.000 description 1
- 229940047650 haemophilus influenzae Drugs 0.000 description 1
- 229940037467 helicobacter pylori Drugs 0.000 description 1
- 239000007943 implant Substances 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
- 230000000399 orthopedic effect Effects 0.000 description 1
- 229940051027 pasteurella multocida Drugs 0.000 description 1
- 229940007042 proteus vulgaris Drugs 0.000 description 1
- 229940007046 shigella dysenteriae Drugs 0.000 description 1
- 229940115939 shigella sonnei Drugs 0.000 description 1
- 229940037649 staphylococcus haemolyticus Drugs 0.000 description 1
- 229940031000 streptococcus pneumoniae Drugs 0.000 description 1
- 150000003852 triazoles Chemical class 0.000 description 1
- 229940118696 vibrio cholerae Drugs 0.000 description 1
- 229940098232 yersinia enterocolitica Drugs 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US81598406P | 2006-06-23 | 2006-06-23 | |
| PCT/US2007/014758 WO2008130368A2 (en) | 2006-06-23 | 2007-06-25 | Transcription factor modulating compounds and methods of use thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2009541332A JP2009541332A (ja) | 2009-11-26 |
| JP2009541332A5 true JP2009541332A5 (OSRAM) | 2010-08-12 |
Family
ID=39796835
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009516593A Pending JP2009541332A (ja) | 2006-06-23 | 2007-06-25 | 転写因子調節化合物およびその使用法 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20090170812A1 (OSRAM) |
| EP (1) | EP2038274A2 (OSRAM) |
| JP (1) | JP2009541332A (OSRAM) |
| CN (1) | CN101626765B (OSRAM) |
| AU (1) | AU2007351886A1 (OSRAM) |
| CA (1) | CA2656157A1 (OSRAM) |
| IL (1) | IL195992A0 (OSRAM) |
| WO (1) | WO2008130368A2 (OSRAM) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2009005551A2 (en) * | 2007-03-27 | 2009-01-08 | Paratek Pharmaceuticals, Inc. | Transcription factor modulating compounds and methods of use thereof |
| US8647642B2 (en) | 2008-09-18 | 2014-02-11 | Aviex Technologies, Llc | Live bacterial vaccines resistant to carbon dioxide (CO2), acidic PH and/or osmolarity for viral infection prophylaxis or treatment |
| US20110177147A1 (en) * | 2010-01-21 | 2011-07-21 | General Electric Company | Stable biocidal delivery systems |
| CN102617561B (zh) * | 2012-02-21 | 2014-05-07 | 常州方圆制药有限公司 | 2-苄硫基苯并杂环衍生物、其制备方法及其医药用途 |
| US10676723B2 (en) | 2015-05-11 | 2020-06-09 | David Gordon Bermudes | Chimeric protein toxins for expression by therapeutic bacteria |
| US11180535B1 (en) | 2016-12-07 | 2021-11-23 | David Gordon Bermudes | Saccharide binding, tumor penetration, and cytotoxic antitumor chimeric peptides from therapeutic bacteria |
| US11129906B1 (en) | 2016-12-07 | 2021-09-28 | David Gordon Bermudes | Chimeric protein toxins for expression by therapeutic bacteria |
| CN108047216B (zh) * | 2017-12-06 | 2020-11-10 | 石家庄学院 | 一种3,4-二苯基吡唑化合物及其制备和应用 |
| CN109265412B (zh) * | 2018-11-19 | 2020-06-02 | 大连大学 | 一种用于检测氟离子的探针化合物及其检测方法 |
| CN111269293B (zh) * | 2018-12-04 | 2021-10-29 | 中国科学院微生物研究所 | 一种感应缬氨酸信号的转录因子及其应用 |
Family Cites Families (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3300505A (en) * | 1964-12-07 | 1967-01-24 | Ciba Geigy Corp | Ether-2-r-substituted benzimidazoles and derivatives and acid addition salts thereof |
| US3429890A (en) * | 1964-12-31 | 1969-02-25 | Merck & Co Inc | Certain 2-thiazolylbenzimidazole-1-oxy derivatives |
| US3325356A (en) * | 1965-08-20 | 1967-06-13 | Merck & Co Inc | Compositions and method for treating helminthiasis |
| US3449498A (en) * | 1965-11-18 | 1969-06-10 | Ciba Geigy Corp | Analgesic compositions of a 4-aminoal-kylamino-quinazoline and 1-amino-alkoxybenzimidazole |
| GB1141936A (en) * | 1966-03-26 | 1969-02-05 | Shionogi & Co | Improvements in or relating to benzimidazole derivatives |
| US3549754A (en) * | 1969-04-21 | 1970-12-22 | Merck & Co Inc | Combination of 2-substituted benzimidazoles and substituted phenothiazines in the treatment of helminthiasis |
| US3686110A (en) * | 1970-02-27 | 1972-08-22 | Meuch & Co Inc | 1-oxybenzimidazoles |
| US3873558A (en) * | 1970-03-05 | 1975-03-25 | Merck & Co Inc | Process for preparing 1,5-substituted or 1,6-substituted benzimidazoles |
| US3646049A (en) * | 1970-03-05 | 1972-02-29 | Merck & Co Inc | Acylaminobenzimidazole derivatives |
| US5552426A (en) * | 1994-04-29 | 1996-09-03 | Eli Lilly And Company | Methods for treating a physiological disorder associated with β-amyloid peptide |
| JP2000516611A (ja) * | 1996-08-14 | 2000-12-12 | ワーナー―ランバート・コンパニー | Ｍｃｐ―１アンタゴニストとしての２―フェニルベンズイミダゾール誘導体 |
| AU6328498A (en) * | 1997-02-21 | 1998-09-09 | Hybridon, Inc. | Oligonucleotides specific for the (marorab) operon |
| US5942532A (en) * | 1997-09-05 | 1999-08-24 | Ortho Pharmaceutical Corporation | 2-substituted phenyl-benzimidazole antibacterial agents |
| WO1999061579A2 (en) * | 1998-05-22 | 1999-12-02 | Tufts University | MarA FAMILY HELIX-TURN-HELIX DOMAINS AND THEIR METHODS OF USE |
| US6919366B2 (en) * | 1998-05-22 | 2005-07-19 | Avanir Pharmaceuticals | Benzimidazole derivatives as modulators of IgE |
| US6204264B1 (en) * | 1998-09-21 | 2001-03-20 | Shiseido Co., Ltd. | Benzimidazole derivative, hair growth promoter and external composition for skin using the same |
| ES2246240T3 (es) * | 1999-06-23 | 2006-02-16 | Sanofi-Aventis Deutschland Gmbh | Bencimidazoles sustituidos. |
| AU2002216649A1 (en) * | 2000-10-31 | 2002-05-15 | Lynn Bonham | Benzoxazole lpaat- beta inhibitors and uses thereof |
| US7405235B2 (en) * | 2001-05-04 | 2008-07-29 | Paratek Pharmaceuticals, Inc. | Transcription factor modulating compounds and methods of use thereof |
| WO2003057667A2 (en) * | 2001-12-31 | 2003-07-17 | The Ohio State University Research Foundation | Strapped and modified bis (benzimidazole) diamides for asymmetric catalysts and other applications |
| WO2003066629A2 (en) * | 2002-02-06 | 2003-08-14 | Vertex Pharmaceuticals Incorporated | Heteroaryl compounds useful as inhibitors of gsk-3 |
| DK1482931T3 (da) * | 2002-03-05 | 2011-12-19 | Transtech Pharma Inc | Mono- og bicycliske azolderivater der inhiberer interaktionen af ligander med RAGE |
| AU2002951247A0 (en) * | 2002-09-06 | 2002-09-19 | Alchemia Limited | Compounds that interact with kinases |
| JP2006513162A (ja) * | 2002-11-01 | 2006-04-20 | パラテック ファーマシューティカルズ インコーポレイテッド | 転写因子調節化合物およびその使用方法 |
| US20060160799A1 (en) * | 2004-04-23 | 2006-07-20 | Alekshun Michael N | Transcription factor modulating compounds and methods of use thereof |
| US8334290B2 (en) * | 2005-10-31 | 2012-12-18 | Merck Sharp & Dohme Corp. | CETP inhibitors |
| WO2008051826A2 (en) * | 2006-10-20 | 2008-05-02 | N.V. Organon | Purines as pkc-theta inhibitors |
| WO2009005551A2 (en) * | 2007-03-27 | 2009-01-08 | Paratek Pharmaceuticals, Inc. | Transcription factor modulating compounds and methods of use thereof |
| WO2010124097A2 (en) * | 2009-04-22 | 2010-10-28 | Paratek Pharmaceuticals, Inc. | Transcription factor modulating compounds and methods of use thereof |
-
2007
- 2007-06-25 AU AU2007351886A patent/AU2007351886A1/en not_active Abandoned
- 2007-06-25 CN CN200780029895XA patent/CN101626765B/zh not_active Expired - Fee Related
- 2007-06-25 US US11/823,103 patent/US20090170812A1/en not_active Abandoned
- 2007-06-25 CA CA002656157A patent/CA2656157A1/en not_active Abandoned
- 2007-06-25 WO PCT/US2007/014758 patent/WO2008130368A2/en not_active Ceased
- 2007-06-25 JP JP2009516593A patent/JP2009541332A/ja active Pending
- 2007-06-25 EP EP07873415A patent/EP2038274A2/en not_active Withdrawn
-
2008
- 2008-12-16 IL IL195992A patent/IL195992A0/en unknown
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2009541332A5 (OSRAM) | ||
| CA2504448A1 (en) | Transcription factor modulating compounds and methods of use thereof | |
| JP2017517567A5 (OSRAM) | ||
| JP2020510044A5 (OSRAM) | ||
| JP2016501864A5 (OSRAM) | ||
| SI2344129T1 (en) | AEROSOL FLUOROKINOLONAL FORMULATIONS FOR IMPROVED PHARMACOKINETICS | |
| IL165715A (en) | 2-ureido-6-heteroaryl-3h-benzimidazole-4-carboxylic acid derivatives, pharmaceutical compositions containing the same and methods for the preparation thereof | |
| CA2433197A1 (en) | Gyrase inhibitors and uses thereof | |
| JP2005533061A5 (OSRAM) | ||
| WO2011101710A1 (en) | Efflux pump inhibitors | |
| US20150119363A1 (en) | Methods of treating bacterial infections | |
| RU2018122505A (ru) | Макроциклические антибиотики широкого спектра действия | |
| JP2016528257A5 (OSRAM) | ||
| HRP20161230T2 (hr) | Aerosolizirani fluorokinoloni i njihova uporaba | |
| RU2016107436A (ru) | Линейные пептидные антибиотики | |
| JP2020507564A5 (OSRAM) | ||
| JP2022137011A5 (OSRAM) | ||
| HRP20250815T1 (hr) | Derivati boronične kiseline i njihova terapijska upotreba | |
| RU2018122498A (ru) | Макроциклические антибиотики широкого спектра действия | |
| JP2019502659A5 (OSRAM) | ||
| US20130059774A1 (en) | Efflux pump inhibitors | |
| JP7577376B2 (ja) | ジドブジン及び抗微生物化合物を含む組み合わせ | |
| JP2019501123A5 (OSRAM) | ||
| JP2011522797A5 (OSRAM) | ||
| EP4662327A1 (en) | Methods for the determination of susceptibility of siderophore beta-lactams |