JP2009540826A5 - - Google Patents
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- JP2009540826A5 JP2009540826A5 JP2009516524A JP2009516524A JP2009540826A5 JP 2009540826 A5 JP2009540826 A5 JP 2009540826A5 JP 2009516524 A JP2009516524 A JP 2009516524A JP 2009516524 A JP2009516524 A JP 2009516524A JP 2009540826 A5 JP2009540826 A5 JP 2009540826A5
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- JP
- Japan
- Prior art keywords
- culture medium
- substantially pure
- supplemented
- medium
- osm
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000001963 growth medium Substances 0.000 claims 43
- 238000000034 method Methods 0.000 claims 36
- 239000007640 basal medium Substances 0.000 claims 24
- 210000001612 chondrocyte Anatomy 0.000 claims 18
- 102000004140 Oncostatin M Human genes 0.000 claims 15
- 108090000630 Oncostatin M Proteins 0.000 claims 15
- 102000010780 Platelet-Derived Growth Factor Human genes 0.000 claims 14
- 108010038512 Platelet-Derived Growth Factor Proteins 0.000 claims 14
- 102000004889 Interleukin-6 Human genes 0.000 claims 13
- 108090001005 Interleukin-6 Proteins 0.000 claims 13
- 229940100601 interleukin-6 Drugs 0.000 claims 13
- 102000004058 Leukemia inhibitory factor Human genes 0.000 claims 10
- 108090000581 Leukemia inhibitory factor Proteins 0.000 claims 10
- 210000004027 cell Anatomy 0.000 claims 9
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims 6
- YZXBAPSDXZZRGB-DOFZRALJSA-N arachidonic acid Chemical compound CCCCC\C=C/C\C=C/C\C=C/C\C=C/CCCC(O)=O YZXBAPSDXZZRGB-DOFZRALJSA-N 0.000 claims 4
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 claims 4
- IPCSVZSSVZVIGE-UHFFFAOYSA-N hexadecanoic acid Chemical compound CCCCCCCCCCCCCCCC(O)=O IPCSVZSSVZVIGE-UHFFFAOYSA-N 0.000 claims 4
- SECPZKHBENQXJG-FPLPWBNLSA-N palmitoleic acid Chemical compound CCCCCC\C=C/CCCCCCCC(O)=O SECPZKHBENQXJG-FPLPWBNLSA-N 0.000 claims 4
- GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 claims 4
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical group OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 claims 3
- 102000003816 Interleukin-13 Human genes 0.000 claims 3
- 108090000176 Interleukin-13 Proteins 0.000 claims 3
- 102000049556 Jagged-1 Human genes 0.000 claims 3
- 108700003486 Jagged-1 Proteins 0.000 claims 3
- 108700037966 Protein jagged-1 Proteins 0.000 claims 3
- 210000000845 cartilage Anatomy 0.000 claims 3
- 230000007547 defect Effects 0.000 claims 3
- 150000002632 lipids Chemical class 0.000 claims 3
- 239000000203 mixture Substances 0.000 claims 3
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- OYHQOLUKZRVURQ-NTGFUMLPSA-N (9Z,12Z)-9,10,12,13-tetratritiooctadeca-9,12-dienoic acid Chemical compound C(CCCCCCC\C(=C(/C\C(=C(/CCCCC)\[3H])\[3H])\[3H])\[3H])(=O)O OYHQOLUKZRVURQ-NTGFUMLPSA-N 0.000 claims 2
- WRIDQFICGBMAFQ-UHFFFAOYSA-N (E)-8-Octadecenoic acid Natural products CCCCCCCCCC=CCCCCCCC(O)=O WRIDQFICGBMAFQ-UHFFFAOYSA-N 0.000 claims 2
- LQJBNNIYVWPHFW-UHFFFAOYSA-N 20:1omega9c fatty acid Natural products CCCCCCCCCCC=CCCCCCCCC(O)=O LQJBNNIYVWPHFW-UHFFFAOYSA-N 0.000 claims 2
- QSBYPNXLFMSGKH-UHFFFAOYSA-N 9-Heptadecensaeure Natural products CCCCCCCC=CCCCCCCCC(O)=O QSBYPNXLFMSGKH-UHFFFAOYSA-N 0.000 claims 2
- 239000005642 Oleic acid Substances 0.000 claims 2
- ZQPPMHVWECSIRJ-UHFFFAOYSA-N Oleic acid Natural products CCCCCCCCC=CCCCCCCCC(O)=O ZQPPMHVWECSIRJ-UHFFFAOYSA-N 0.000 claims 2
- 235000021314 Palmitic acid Nutrition 0.000 claims 2
- 235000021319 Palmitoleic acid Nutrition 0.000 claims 2
- 235000021355 Stearic acid Nutrition 0.000 claims 2
- 229940087168 alpha tocopherol Drugs 0.000 claims 2
- DTOSIQBPPRVQHS-PDBXOOCHSA-N alpha-linolenic acid Chemical compound CC\C=C/C\C=C/C\C=C/CCCCCCCC(O)=O DTOSIQBPPRVQHS-PDBXOOCHSA-N 0.000 claims 2
- 235000020661 alpha-linolenic acid Nutrition 0.000 claims 2
- 229940114079 arachidonic acid Drugs 0.000 claims 2
- 235000021342 arachidonic acid Nutrition 0.000 claims 2
- 239000002738 chelating agent Substances 0.000 claims 2
- 235000012000 cholesterol Nutrition 0.000 claims 2
- 229940107161 cholesterol Drugs 0.000 claims 2
- SECPZKHBENQXJG-UHFFFAOYSA-N cis-palmitoleic acid Natural products CCCCCCC=CCCCCCCCC(O)=O SECPZKHBENQXJG-UHFFFAOYSA-N 0.000 claims 2
- QXJSBBXBKPUZAA-UHFFFAOYSA-N isooleic acid Natural products CCCCCCCC=CCCCCCCCCC(O)=O QXJSBBXBKPUZAA-UHFFFAOYSA-N 0.000 claims 2
- 229960004488 linolenic acid Drugs 0.000 claims 2
- KQQKGWQCNNTQJW-UHFFFAOYSA-N linolenic acid Natural products CC=CCCC=CCC=CCCCCCCCC(O)=O KQQKGWQCNNTQJW-UHFFFAOYSA-N 0.000 claims 2
- WQEPLUUGTLDZJY-UHFFFAOYSA-N n-Pentadecanoic acid Natural products CCCCCCCCCCCCCCC(O)=O WQEPLUUGTLDZJY-UHFFFAOYSA-N 0.000 claims 2
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 claims 2
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 claims 2
- ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 claims 2
- 235000021313 oleic acid Nutrition 0.000 claims 2
- 210000002966 serum Anatomy 0.000 claims 2
- 239000008117 stearic acid Substances 0.000 claims 2
- TUNFSRHWOTWDNC-HKGQFRNVSA-N tetradecanoic acid Chemical compound CCCCCCCCCCCCC[14C](O)=O TUNFSRHWOTWDNC-HKGQFRNVSA-N 0.000 claims 2
- 229960000984 tocofersolan Drugs 0.000 claims 2
- 239000002076 α-tocopherol Substances 0.000 claims 2
- 235000004835 α-tocopherol Nutrition 0.000 claims 2
- 102000004142 Trypsin Human genes 0.000 claims 1
- 108090000631 Trypsin Proteins 0.000 claims 1
- 238000004113 cell culture Methods 0.000 claims 1
- 238000012136 culture method Methods 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 210000003494 hepatocyte Anatomy 0.000 claims 1
- 239000012588 trypsin Substances 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US80530706P | 2006-06-20 | 2006-06-20 | |
| PCT/US2007/014075 WO2007149328A1 (en) | 2006-06-20 | 2007-06-15 | Serum-free media and their uses for chondrocyte expansion |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2009540826A JP2009540826A (ja) | 2009-11-26 |
| JP2009540826A5 true JP2009540826A5 (https=) | 2010-08-05 |
Family
ID=38626563
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009516524A Pending JP2009540826A (ja) | 2006-06-20 | 2007-06-15 | 軟骨細胞増幅のための無血清培地およびその使用 |
Country Status (9)
| Country | Link |
|---|---|
| US (3) | US20070292949A1 (https=) |
| EP (1) | EP2032689A1 (https=) |
| JP (1) | JP2009540826A (https=) |
| CN (1) | CN101490245B (https=) |
| AU (1) | AU2007261530B2 (https=) |
| BR (1) | BRPI0713572A2 (https=) |
| IL (1) | IL196025A (https=) |
| MX (1) | MX2008016429A (https=) |
| WO (1) | WO2007149328A1 (https=) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8889127B2 (en) | 2004-07-01 | 2014-11-18 | Icahn School Of Medicine At Mount Sinai | Targeted protein replacement for the treatment of lysosomal storage disorders |
| SI2132562T1 (sl) | 2007-04-06 | 2012-05-31 | Genzyme Corp | Metode za ovrednotenje celic in celičnih kultur |
| CN102411484B (zh) * | 2010-09-20 | 2015-01-28 | 联想(北京)有限公司 | 一种显示系统中的图像显示方法和装置 |
| KR101138091B1 (ko) * | 2011-08-31 | 2012-04-24 | 세원셀론텍(주) | 중간엽 줄기세포 기본 배양 배지 조성방법, 중간엽 줄기세포 기본 배양 배지 및 이를 이용하여 배양분화된 세포치료제 |
| LT2753346T (lt) | 2011-09-07 | 2020-08-10 | Mount Sinai School Of Medicine | Ceramidazė ir ląstelių diferenciacija |
| ES2897825T3 (es) | 2012-06-01 | 2022-03-02 | Icahn School Med Mount Sinai | Niveles de ceramida en el tratamiento y prevención de infecciones |
| US9664671B2 (en) | 2012-07-24 | 2017-05-30 | Nissan Chemical Industries, Ltd. | Culture medium composition and method of culturing cell or tissue using thereof |
| US10017805B2 (en) | 2012-08-23 | 2018-07-10 | Nissan Chemical Industries, Ltd. | Enhancing ingredients for protein production from various cells |
| CN104781389B (zh) * | 2012-08-23 | 2018-05-29 | 日产化学工业株式会社 | 蛋白质生产促进剂 |
| US8835175B2 (en) * | 2012-11-13 | 2014-09-16 | Grifols, S.A. | Culture medium for human mesenchymal stem cells |
| EP2733200A1 (en) | 2012-11-15 | 2014-05-21 | Biorigen International SA | Cell culture supplements |
| PT2968479T (pt) | 2013-03-14 | 2019-08-07 | Icahn School Med Mount Sinai | Composições terapêuticas de ceramidase ácida e métodos de fabrico e utilização |
| WO2015016357A1 (ja) * | 2013-08-01 | 2015-02-05 | 株式会社ツーセル | 軟骨損傷治療剤及びその製造方法 |
| CN104630138B (zh) * | 2013-11-06 | 2017-11-14 | 陕西瑞盛生物科技有限公司 | 一种无血清软骨细胞培养液 |
| JP2016067312A (ja) * | 2014-09-30 | 2016-05-09 | 株式会社ジーシー | 軟骨分化培養液、及び軟骨組織 |
| WO2016076102A1 (ja) * | 2014-11-14 | 2016-05-19 | 株式会社リジェネシスサイエンス | 軟骨細胞の無血清培養方法，及び無血清培地 |
| CN107849529A (zh) * | 2014-12-31 | 2018-03-27 | 迈克尔·莫勒 | 用于人脂肪基质细胞临床生长的细胞培养基的人血清 |
| CN108295243A (zh) * | 2018-02-27 | 2018-07-20 | 上海中医药大学附属龙华医院 | 可溶性Jagged1肽在制备促进关节软骨修复的药物中的应用 |
| CN109022356A (zh) * | 2018-08-30 | 2018-12-18 | 丰泽康生物医药（深圳）有限公司 | 一种提高间充质干细胞向软骨细胞分化的无血清培养基 |
| PH12021552425A1 (en) * | 2019-03-29 | 2022-07-11 | Kolon Tissuegene Inc | Mixed-cell gene therapy |
| CN111019887A (zh) * | 2019-11-11 | 2020-04-17 | 浙江卫未生物医药科技有限公司 | 阻止软骨细胞去分化的培育方法 |
| CN113215085B (zh) * | 2021-05-07 | 2024-05-10 | 澳门大学 | 一种脂类物质添加剂及其应用 |
| CN113106066B (zh) * | 2021-05-13 | 2022-08-23 | 杭州艾名医学科技有限公司 | 一种肉瘤细胞培养基以及采用该培养基体外生产Matrigel原液的方法 |
| US11692167B2 (en) | 2021-08-02 | 2023-07-04 | Montana State University | Chemically defined serum replacements for cell culture |
| WO2025117331A1 (en) | 2023-12-01 | 2025-06-05 | Eli Lilly And Company | Methods of making stem cell-derived islet-like cells, as well as populations and compositions including the same |
| CN118909927B (zh) * | 2024-09-12 | 2025-09-12 | 上海多宁生物科技股份有限公司 | 一种高表达的cho细胞培养方法 |
Family Cites Families (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT87133B (pt) * | 1987-04-02 | 1992-07-31 | Amrad Corp Ltd | Metodo de purificacao do factor inibidor da leucemia (lif) e de composicoes farmaceuticas contendo polipeptidos com actividade do lif |
| US5202116A (en) * | 1989-04-10 | 1993-04-13 | Oncogen | Methods for controlling human endothelial cell proliferation and effector functions using oncostatin m |
| US5814307A (en) * | 1989-04-10 | 1998-09-29 | Bristol-Myers Squibb Company | Method for regulating cell growth, leukocyte differentiation and tumor cell growth using Oncostatin M to stimulate synthesis of IL-6 |
| US5843892A (en) * | 1989-12-18 | 1998-12-01 | California Institute Of Technology | Stimulation of nerve growth and/or vitality |
| US5188828A (en) * | 1990-11-08 | 1993-02-23 | Brigham And Women's Hospital | Interleukin-6 to stimulate erythropoietin production |
| AU2882992A (en) * | 1991-11-06 | 1993-06-07 | Arthur A. Axelrad | Cell culture medium |
| US5908782A (en) * | 1995-06-05 | 1999-06-01 | Osiris Therapeutics, Inc. | Chemically defined medium for human mesenchymal stem cells |
| EP0891419A4 (en) * | 1996-03-12 | 2000-03-01 | Life Technologies Inc | NUTRIENT ADDITIVE FOR HEMATOPOETIC CELL CULTURES |
| WO1998004681A2 (en) * | 1996-07-25 | 1998-02-05 | Genzyme Corporation | Chondrocyte media formulations and culture procedures |
| US5945337A (en) * | 1996-10-18 | 1999-08-31 | Quality Biological, Inc. | Method for culturing CD34+ cells in a serum-free medium |
| US6156729A (en) * | 1997-10-15 | 2000-12-05 | California Institute Of Technology | Leukemia inhibitory factor for use in modulating inflammation and pain |
| JP2000319250A (ja) * | 1998-04-03 | 2000-11-21 | Sankyo Co Ltd | スルホンアミド誘導体 |
| CA2348687A1 (en) * | 1998-11-09 | 2000-05-18 | Consorzio Per La Gestione Del Centro Di Biotecnologie Avanzate | Serum free medium for chondrocyte-like cells |
| US20030202977A1 (en) * | 1998-11-16 | 2003-10-30 | New York University | Treatment of osteoarthritis |
| JP2001089390A (ja) * | 1999-09-16 | 2001-04-03 | Sumitomo Pharmaceut Co Ltd | 軟骨障害治療剤の新規なスクリーニング方法 |
| JP2001163885A (ja) * | 1999-09-29 | 2001-06-19 | Sankyo Co Ltd | スルホンアミド誘導体 |
| US6635802B1 (en) * | 2000-01-10 | 2003-10-21 | The Texas A&M University System | Nuclear transfer using cells cultured in serum starvation media containing apoptosis inhibitors |
| US7005252B1 (en) * | 2000-03-09 | 2006-02-28 | Wisconsin Alumni Research Foundation | Serum free cultivation of primate embryonic stem cells |
| EP1326980B1 (en) * | 2000-10-16 | 2008-03-19 | Genentech, Inc. | Methods of treatment using wisp polypeptides |
| PT1364023E (pt) * | 2000-12-08 | 2006-10-31 | Genentech Inc | Gene altamente expresso em tecidos de cartilagem |
| JP2002284686A (ja) * | 2001-03-28 | 2002-10-03 | Sankyo Co Ltd | スルホンアミド化合物を含有する医薬組成物 |
| EP1478734A4 (en) * | 2002-01-25 | 2006-04-05 | Genzyme Corp | NON-SERUM MEDIUM FOR CHONDROCYTES AND METHODS OF USE THEREOF |
| AU2003222043A1 (en) * | 2002-03-18 | 2003-10-08 | National Jewish Medical And Research Center | Method for production of neutrophils and uses therefor |
| JP2006522453A (ja) * | 2003-03-31 | 2006-09-28 | リットン・システムズ・インコーポレイテッド | マイクロチャネルプレートの接合方法 |
| DK1656130T3 (da) * | 2003-08-11 | 2008-11-24 | Hills Pet Nutrition Inc | Omega-3-fedtsyrer til behandling af osteoarthritis hos hunde |
| JP2007536936A (ja) * | 2004-05-14 | 2007-12-20 | ベクトン・ディキンソン・アンド・カンパニー | 幹細胞集団および使用方法 |
| US7615374B2 (en) * | 2007-09-25 | 2009-11-10 | Wisconsin Alumni Research Foundation | Generation of clonal mesenchymal progenitors and mesenchymal stem cell lines under serum-free conditions |
-
2007
- 2007-06-15 US US11/763,587 patent/US20070292949A1/en not_active Abandoned
- 2007-06-15 AU AU2007261530A patent/AU2007261530B2/en not_active Ceased
- 2007-06-15 BR BRPI0713572-6A patent/BRPI0713572A2/pt not_active IP Right Cessation
- 2007-06-15 JP JP2009516524A patent/JP2009540826A/ja active Pending
- 2007-06-15 CN CN2007800274495A patent/CN101490245B/zh active Active
- 2007-06-15 EP EP07809587A patent/EP2032689A1/en not_active Withdrawn
- 2007-06-15 WO PCT/US2007/014075 patent/WO2007149328A1/en not_active Ceased
- 2007-06-15 MX MX2008016429A patent/MX2008016429A/es active IP Right Grant
-
2008
- 2008-12-18 IL IL196025A patent/IL196025A/en not_active IP Right Cessation
-
2012
- 2012-02-21 US US13/401,037 patent/US20120213745A1/en not_active Abandoned
-
2013
- 2013-04-16 US US13/864,149 patent/US20130273010A1/en not_active Abandoned
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