JP2009539367A5 - - Google Patents
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- Publication number
- JP2009539367A5 JP2009539367A5 JP2009513764A JP2009513764A JP2009539367A5 JP 2009539367 A5 JP2009539367 A5 JP 2009539367A5 JP 2009513764 A JP2009513764 A JP 2009513764A JP 2009513764 A JP2009513764 A JP 2009513764A JP 2009539367 A5 JP2009539367 A5 JP 2009539367A5
- Authority
- JP
- Japan
- Prior art keywords
- polypeptide
- fkbp
- seq
- fragment
- amino acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0611405.2A GB0611405D0 (en) | 2006-06-09 | 2006-06-09 | FKBP-L: A novel inhibitor of angiogenesis |
| GB0611405.2 | 2006-06-09 | ||
| PCT/GB2007/002107 WO2007141533A2 (en) | 2006-06-09 | 2007-06-08 | Fkbp-l and uses thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009539367A JP2009539367A (ja) | 2009-11-19 |
| JP2009539367A5 true JP2009539367A5 (https=) | 2010-07-29 |
| JP5474535B2 JP5474535B2 (ja) | 2014-04-16 |
Family
ID=36745574
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009513764A Expired - Fee Related JP5474535B2 (ja) | 2006-06-09 | 2007-06-08 | Fkbp−lおよびその使用 |
Country Status (18)
| Country | Link |
|---|---|
| US (3) | US9381228B2 (https=) |
| EP (1) | EP2040728B1 (https=) |
| JP (1) | JP5474535B2 (https=) |
| CN (1) | CN101489575B (https=) |
| AU (1) | AU2007255196B2 (https=) |
| CA (1) | CA2657947C (https=) |
| CY (1) | CY1116970T1 (https=) |
| DK (1) | DK2040728T3 (https=) |
| ES (1) | ES2548332T3 (https=) |
| GB (1) | GB0611405D0 (https=) |
| HU (1) | HUE028099T2 (https=) |
| IL (1) | IL195580A (https=) |
| NZ (2) | NZ573425A (https=) |
| PL (1) | PL2040728T3 (https=) |
| PT (1) | PT2040728E (https=) |
| SI (1) | SI2040728T1 (https=) |
| WO (1) | WO2007141533A2 (https=) |
| ZA (1) | ZA200810323B (https=) |
Families Citing this family (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7192713B1 (en) | 1999-05-18 | 2007-03-20 | President And Fellows Of Harvard College | Stabilized compounds having secondary structure motifs |
| ES2586387T3 (es) | 2003-11-05 | 2016-10-14 | Dana-Farber Cancer Institute, Inc. | Péptidos alfa helicoidales adecuados para activar o inhibir la muerte celular |
| US7507842B2 (en) | 2005-08-12 | 2009-03-24 | Radiorx, Inc. | Cyclic nitro compounds, pharmaceutical compositions thereof and uses thereof |
| DK2118123T3 (en) | 2007-01-31 | 2016-01-25 | Dana Farber Cancer Inst Inc | Stabilized p53 peptides and uses thereof |
| US8592377B2 (en) | 2007-03-28 | 2013-11-26 | President And Fellows Of Harvard College | Stitched polypeptides |
| GB0724393D0 (en) * | 2007-12-14 | 2008-01-23 | Univ Ulster | Use of FKBPL gene to identify a cause of infertility |
| EP2356139A4 (en) | 2008-07-23 | 2013-01-09 | Harvard College | LIGURE COMBINED POLYPEPTIDES |
| CN102203126A (zh) | 2008-09-22 | 2011-09-28 | 爱勒让治疗公司 | 用于制备纯化的多肽组合物的方法 |
| US9175047B2 (en) | 2009-01-14 | 2015-11-03 | Aileron Therapeutics, Inc. | Peptidomimetic macrocycles |
| GB0908589D0 (en) | 2009-05-19 | 2009-06-24 | Univ Belfast | Assay method |
| AU2010273220B2 (en) | 2009-07-13 | 2015-10-15 | President And Fellows Of Harvard College | Bifunctional stapled polypeptides and uses thereof |
| CN102712675A (zh) | 2009-09-22 | 2012-10-03 | 爱勒让治疗公司 | 拟肽大环化合物 |
| ES2711526T3 (es) | 2010-08-13 | 2019-05-06 | Aileron Therapeutics Inc | Macrociclos peptidomiméticos |
| WO2012040459A2 (en) | 2010-09-22 | 2012-03-29 | President And Fellows Of Harvard College | Beta-catenin targeting peptides and uses thereof |
| US9487562B2 (en) | 2011-06-17 | 2016-11-08 | President And Fellows Of Harvard College | Stabilized polypeptides as regulators of RAB GTPase function |
| US20140308260A1 (en) * | 2011-10-07 | 2014-10-16 | Radiorx, Inc. | Methods and compositions comprising a nitrite-reductase promoter for treatment of medical disorders and preservation of blood products |
| TW201806968A (zh) | 2011-10-18 | 2018-03-01 | 艾利倫治療公司 | 擬肽巨環化合物 |
| BR112014020103A2 (pt) | 2012-02-15 | 2018-10-09 | Aileron Therapeutics, Inc. | macrociclos peptidomiméticos |
| EP2819688A4 (en) | 2012-02-15 | 2015-10-28 | Aileron Therapeutics Inc | TRIAZOL AND THIOETHER-COUPLED PEPTIDOMIMETIC MACROCYCLES |
| WO2014052647A2 (en) | 2012-09-26 | 2014-04-03 | President And Fellows Of Harvard College | Proline-locked stapled peptides and uses thereof |
| WO2014071241A1 (en) | 2012-11-01 | 2014-05-08 | Aileron Therapeutics, Inc. | Disubstituted amino acids and methods of preparation and use thereof |
| EP3391898A3 (en) | 2013-03-13 | 2019-02-13 | President and Fellows of Harvard College | Stapled and stitched polypeptides and uses thereof |
| JP2016523241A (ja) | 2013-06-14 | 2016-08-08 | プレジデント アンド フェローズ オブ ハーバード カレッジ | 安定化されたポリペプチドインスリン受容体調節剤 |
| CA2949535C (en) | 2014-05-21 | 2023-09-12 | President And Fellows Of Harvard College | Ras inhibitory peptides and uses thereof |
| EP3197478A4 (en) | 2014-09-24 | 2018-05-30 | Aileron Therapeutics, Inc. | Peptidomimetic macrocycles and uses thereof |
| AU2015320545C1 (en) | 2014-09-24 | 2020-05-14 | Aileron Therapeutics, Inc. | Peptidomimetic macrocycles and formulations thereof |
| WO2016154058A1 (en) | 2015-03-20 | 2016-09-29 | Aileron Therapeutics, Inc. | Peptidomimetic macrocycles and uses thereof |
| US10059741B2 (en) | 2015-07-01 | 2018-08-28 | Aileron Therapeutics, Inc. | Peptidomimetic macrocycles |
| WO2017044633A1 (en) | 2015-09-10 | 2017-03-16 | Aileron Therapeutics, Inc. | Peptidomimetic macrocycles as modulators of mcl-1 |
| US10342778B1 (en) | 2015-10-20 | 2019-07-09 | Epicentrx, Inc. | Treatment of brain metastases using organonitro compound combination therapy |
| US9987270B1 (en) | 2015-10-29 | 2018-06-05 | Epicentrix, Inc. | Treatment of gliomas using organonitro compound combination therapy |
| CN109069420A (zh) | 2016-01-11 | 2018-12-21 | 埃皮辛特瑞柯斯公司 | 2-溴-1-(3,3-二硝基氮杂环丁烷-1-基)乙酮静脉施用的组合物和方法 |
| US20190381127A1 (en) | 2016-02-02 | 2019-12-19 | Splash Pharmaceuticals, Inc. | Combination therapy with a6, chemotherapeutic agents, radiation therapy, or a combination thereof for the treatment of cancer |
| JP2019523234A (ja) * | 2016-06-22 | 2019-08-22 | アルマック・ディスカバリー・リミテッドAlmac Discovery Limited | 眼疾患の処置 |
| CN110352190A (zh) | 2016-10-14 | 2019-10-18 | 埃皮辛特瑞柯斯公司 | 用于医疗用途的磺氧基烷基有机硝基和相关化合物和药物组合物 |
| EP3528831B1 (en) * | 2016-10-19 | 2022-09-21 | Royal College of Surgeons in Ireland | Use of fkbp-l polypeptides and nucleic acids for the treatment of obesity |
| CN108362870A (zh) * | 2017-01-27 | 2018-08-03 | 武汉三鹰生物技术有限公司 | 一种用于人fkbpl蛋白的酶联免疫检测及制备方法 |
| US11744859B2 (en) | 2017-07-07 | 2023-09-05 | Epicentrx, Inc. | Compositions and methods for parenteral administration of therapeutic agents |
| US11510901B2 (en) | 2018-01-08 | 2022-11-29 | Epicentrx, Inc. | Methods and compositions utilizing RRx-001 combination therapy for radioprotection |
| CN111603567B (zh) * | 2019-02-22 | 2024-12-27 | 赣江新区博瑞创新医药有限公司 | Cd44靶向多臂偶联物 |
| CN113702632A (zh) * | 2021-09-02 | 2021-11-26 | 深圳市光与生物科技有限公司 | 一种快速检测子痫前期的免疫层析检测卡及其制备方法与应用 |
| CN114702564A (zh) * | 2021-12-15 | 2022-07-05 | 江苏省人民医院(南京医科大学第一附属医院) | 一种外泌体肽及其制备方法和应用 |
Family Cites Families (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3194732A (en) * | 1960-10-03 | 1965-07-13 | Neuhauser Irene | Assisting healing of skin-denuded areas on the body with dried non-fibrous egg-shellmembrane products and compositions therefor |
| US3773919A (en) * | 1969-10-23 | 1973-11-20 | Du Pont | Polylactide-drug mixtures |
| US4179337A (en) * | 1973-07-20 | 1979-12-18 | Davis Frank F | Non-immunogenic polypeptides |
| US4263428A (en) | 1978-03-24 | 1981-04-21 | The Regents Of The University Of California | Bis-anthracycline nucleic acid function inhibitors and improved method for administering the same |
| AU7757581A (en) | 1980-11-19 | 1982-05-27 | United Energy Technologies Inc. | Enhanced surface tubing |
| IE52535B1 (en) | 1981-02-16 | 1987-12-09 | Ici Plc | Continuous release pharmaceutical compositions |
| US4485045A (en) * | 1981-07-06 | 1984-11-27 | Research Corporation | Synthetic phosphatidyl cholines useful in forming liposomes |
| DE3374837D1 (en) | 1982-02-17 | 1988-01-21 | Ciba Geigy Ag | Lipids in the aqueous phase |
| DE3218121A1 (de) | 1982-05-14 | 1983-11-17 | Leskovar, Peter, Dr.-Ing., 8000 München | Arzneimittel zur tumorbehandlung |
| US4630115A (en) | 1983-05-09 | 1986-12-16 | The General Electric Company, P.L.C. | Cathode ray tube display device |
| US4544545A (en) * | 1983-06-20 | 1985-10-01 | Trustees University Of Massachusetts | Liposomes containing modified cholesterol for organ targeting |
| DE3474511D1 (en) | 1983-11-01 | 1988-11-17 | Terumo Corp | Pharmaceutical composition containing urokinase |
| JP3065628B2 (ja) * | 1988-12-19 | 2000-07-17 | 三井化学株式会社 | ヒト免疫グロブリン遺伝子関連dna断片及び該dna断片を用いる診断方法 |
| US5766883A (en) * | 1989-04-29 | 1998-06-16 | Delta Biotechnology Limited | Polypeptides |
| FR2650598B1 (fr) | 1989-08-03 | 1994-06-03 | Rhone Poulenc Sante | Derives de l'albumine a fonction therapeutique |
| US5073627A (en) * | 1989-08-22 | 1991-12-17 | Immunex Corporation | Fusion proteins comprising GM-CSF and IL-3 |
| AU648140B2 (en) * | 1991-02-01 | 1994-04-14 | Virtual Drug Development, Inc. | Reverse antimicrobial peptides and antimicrobial compositions |
| IL99120A0 (en) * | 1991-08-07 | 1992-07-15 | Yeda Res & Dev | Multimers of the soluble forms of tnf receptors,their preparation and pharmaceutical compositions containing them |
| FR2686899B1 (fr) * | 1992-01-31 | 1995-09-01 | Rhone Poulenc Rorer Sa | Nouveaux polypeptides biologiquement actifs, leur preparation et compositions pharmaceutiques les contenant. |
| PT672141E (pt) | 1992-10-23 | 2003-09-30 | Immunex Corp | Metodos de preparacao de proteinas oligomericas soluveis |
| US5359030A (en) * | 1993-05-10 | 1994-10-25 | Protein Delivery, Inc. | Conjugation-stabilized polypeptide compositions, therapeutic delivery and diagnostic formulations comprising same, and method of making and using the same |
| US5681811A (en) * | 1993-05-10 | 1997-10-28 | Protein Delivery, Inc. | Conjugation-stabilized therapeutic agent compositions, delivery and diagnostic formulations comprising same, and method of making and using the same |
| CA2166278A1 (en) * | 1993-06-29 | 1995-01-12 | Denis J. Gospodarowicz | A truncated keratinocyte growth factor (kgf) having increased biological activity |
| PT871730E (pt) * | 1995-10-11 | 2004-11-30 | Chiron Corp | Combinacao de pdgf, kgf, igf e igfbp para cicatrizacao de ferimentos |
| CA2288351A1 (en) | 1997-05-01 | 1998-11-05 | Amgen Inc. | Chimeric opg polypeptides |
| US6583168B1 (en) | 1997-11-25 | 2003-06-24 | Applera Corporation | Sulfonated diarylrhodamine dyes |
| US6180095B1 (en) * | 1997-12-17 | 2001-01-30 | Enzon, Inc. | Polymeric prodrugs of amino- and hydroxyl-containing bioactive agents |
| CA2331382A1 (en) * | 1998-06-18 | 1999-12-23 | Curagen Corporation | Interaction of p27(kip1) with fkbp-12 |
| WO2000021992A1 (en) * | 1998-10-09 | 2000-04-20 | Shanghai Second Medical University | A human fk506 binding protein (fkbp) |
| EP1088857A4 (en) | 1999-04-13 | 2005-01-19 | Hayashibara Biochem Lab | CYANINE COLOR |
| EP1210046A4 (en) * | 1999-06-22 | 2007-05-02 | Res Dev Foundation | IMPROVED DRESSING THAT CAN ACCELERATE THE HEALING OF INJURIES |
| EP1196567A2 (en) * | 1999-07-06 | 2002-04-17 | Incyte Genomics, Inc. | Human immune response molecules |
| US6413507B1 (en) * | 1999-12-23 | 2002-07-02 | Shearwater Corporation | Hydrolytically degradable carbamate derivatives of poly (ethylene glycol) |
| US20030125246A9 (en) * | 2000-01-31 | 2003-07-03 | Rosen Craig A. | Nucleic acids, proteins, and antibodies |
| CA2429722A1 (en) * | 2000-11-28 | 2002-06-06 | Wyeth | Expression analysis of fkbp nucleic acids and polypeptides useful in the diagnosis and treatment of prostate cancer |
| AU2002255478A1 (en) * | 2001-01-10 | 2002-09-12 | Pe Corporation (Ny) | Kits, such as nucleic acid arrays, comprising a majority of human exons or transcripts, for detecting expression and other uses thereof |
| US7235358B2 (en) * | 2001-06-08 | 2007-06-26 | Expression Diagnostics, Inc. | Methods and compositions for diagnosing and monitoring transplant rejection |
| MXPA03011455A (es) | 2001-06-22 | 2004-04-05 | Hoffmann La Roche | Complejo soluble que comprende glucoproteina de superficie retroviral. |
| US6856185B2 (en) * | 2001-10-23 | 2005-02-15 | Arris International, Inc. | Simple RMS to DC converter |
| US20040053388A1 (en) * | 2002-01-03 | 2004-03-18 | Eckert Jorg H. | Detection of protein conformation using a split ubiquitin reporter system |
| US20040047835A1 (en) * | 2002-09-06 | 2004-03-11 | Cell Therapeutics, Inc. | Combinatorial drug therapy using polymer drug conjugates |
| AU2006259583A1 (en) * | 2005-06-13 | 2006-12-28 | The Regents Of The University Of Michigan | Compositions and methods for treating and diagnosing cancer |
-
2006
- 2006-06-09 GB GBGB0611405.2A patent/GB0611405D0/en not_active Ceased
-
2007
- 2007-06-08 CA CA2657947A patent/CA2657947C/en not_active Expired - Fee Related
- 2007-06-08 SI SI200731701T patent/SI2040728T1/sl unknown
- 2007-06-08 AU AU2007255196A patent/AU2007255196B2/en not_active Ceased
- 2007-06-08 WO PCT/GB2007/002107 patent/WO2007141533A2/en not_active Ceased
- 2007-06-08 JP JP2009513764A patent/JP5474535B2/ja not_active Expired - Fee Related
- 2007-06-08 PT PT77331189T patent/PT2040728E/pt unknown
- 2007-06-08 EP EP07733118.9A patent/EP2040728B1/en not_active Not-in-force
- 2007-06-08 CN CN2007800276683A patent/CN101489575B/zh not_active Expired - Fee Related
- 2007-06-08 NZ NZ573425A patent/NZ573425A/en not_active IP Right Cessation
- 2007-06-08 US US12/303,343 patent/US9381228B2/en not_active Expired - Fee Related
- 2007-06-08 NZ NZ600690A patent/NZ600690A/en not_active IP Right Cessation
- 2007-06-08 DK DK07733118.9T patent/DK2040728T3/en active
- 2007-06-08 ES ES07733118.9T patent/ES2548332T3/es active Active
- 2007-06-08 HU HUE07733118A patent/HUE028099T2/en unknown
- 2007-06-08 PL PL07733118T patent/PL2040728T3/pl unknown
-
2008
- 2008-11-27 IL IL195580A patent/IL195580A/en not_active IP Right Cessation
- 2008-12-04 ZA ZA2008/10323A patent/ZA200810323B/en unknown
-
2015
- 2015-11-26 CY CY20151101070T patent/CY1116970T1/el unknown
-
2016
- 2016-05-31 US US15/169,460 patent/US10577406B2/en not_active Expired - Fee Related
- 2016-05-31 US US15/169,452 patent/US20160340401A1/en not_active Abandoned
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