JP2007511216A5 - - Google Patents
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- Publication number
- JP2007511216A5 JP2007511216A5 JP2006538967A JP2006538967A JP2007511216A5 JP 2007511216 A5 JP2007511216 A5 JP 2007511216A5 JP 2006538967 A JP2006538967 A JP 2006538967A JP 2006538967 A JP2006538967 A JP 2006538967A JP 2007511216 A5 JP2007511216 A5 JP 2007511216A5
- Authority
- JP
- Japan
- Prior art keywords
- herpes simplex
- simplex virus
- nucleic acid
- virus according
- sequence
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 241000700584 Simplexvirus Species 0.000 claims 43
- 108020004707 nucleic acids Proteins 0.000 claims 22
- 102000039446 nucleic acids Human genes 0.000 claims 22
- 150000007523 nucleic acids Chemical class 0.000 claims 22
- 108020004459 Small interfering RNA Proteins 0.000 claims 11
- 239000002773 nucleotide Substances 0.000 claims 11
- 125000003729 nucleotide group Chemical group 0.000 claims 11
- 230000001105 regulatory effect Effects 0.000 claims 8
- 230000000295 complement effect Effects 0.000 claims 7
- 108020004999 messenger RNA Proteins 0.000 claims 6
- 108091033319 polynucleotide Proteins 0.000 claims 6
- 102000040430 polynucleotide Human genes 0.000 claims 6
- 239000002157 polynucleotide Substances 0.000 claims 6
- 239000003550 marker Substances 0.000 claims 5
- 239000012634 fragment Substances 0.000 claims 4
- 206010041823 squamous cell carcinoma Diseases 0.000 claims 4
- 238000011144 upstream manufacturing Methods 0.000 claims 4
- 108700020796 Oncogene Proteins 0.000 claims 3
- 230000030279 gene silencing Effects 0.000 claims 3
- 238000013518 transcription Methods 0.000 claims 3
- 230000035897 transcription Effects 0.000 claims 3
- 241000700588 Human alphaherpesvirus 1 Species 0.000 claims 2
- 101100508081 Human herpesvirus 1 (strain 17) ICP34.5 gene Proteins 0.000 claims 2
- 101150076998 ICP34.5 gene Proteins 0.000 claims 2
- 206010028980 Neoplasm Diseases 0.000 claims 2
- 101150027249 RL1 gene Proteins 0.000 claims 2
- 230000000692 anti-sense effect Effects 0.000 claims 2
- 230000001276 controlling effect Effects 0.000 claims 2
- 108091026890 Coding region Proteins 0.000 claims 1
- 102100026982 DCN1-like protein 1 Human genes 0.000 claims 1
- 241000700589 Herpes simplex virus (type 1 / strain 17) Species 0.000 claims 1
- 101000911746 Homo sapiens DCN1-like protein 1 Proteins 0.000 claims 1
- 241000701074 Human alphaherpesvirus 2 Species 0.000 claims 1
- 239000002671 adjuvant Substances 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 231100000501 nonneurotoxic Toxicity 0.000 claims 1
- 230000000174 oncolytic effect Effects 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 229920001184 polypeptide Polymers 0.000 claims 1
- 102000004196 processed proteins & peptides Human genes 0.000 claims 1
- 108090000765 processed proteins & peptides Proteins 0.000 claims 1
- 241001529453 unidentified herpesvirus Species 0.000 claims 1
- 229960005486 vaccine Drugs 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0326798.6A GB0326798D0 (en) | 2003-11-17 | 2003-11-17 | Methods for generating mutant virus |
| US54130804P | 2004-02-03 | 2004-02-03 | |
| PCT/GB2004/004908 WO2005049846A2 (en) | 2003-11-17 | 2004-11-17 | Mutant herpes simplex virus and use thereof in the treatment of squamous cell cancer |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2007511216A JP2007511216A (ja) | 2007-05-10 |
| JP2007511216A5 true JP2007511216A5 (https=) | 2008-01-10 |
Family
ID=34621663
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006538967A Pending JP2007511216A (ja) | 2003-11-17 | 2004-11-17 | 変異ウイルス |
Country Status (4)
| Country | Link |
|---|---|
| US (2) | US20070003520A1 (https=) |
| EP (1) | EP1694852B1 (https=) |
| JP (1) | JP2007511216A (https=) |
| WO (1) | WO2005049846A2 (https=) |
Families Citing this family (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9415320D0 (en) | 1994-07-29 | 1994-09-21 | Medical Res Council | Cancer treatment |
| US20070003520A1 (en) | 2003-11-17 | 2007-01-04 | Brown Susanne M | Mutant viruses |
| US7897146B2 (en) | 2003-11-17 | 2011-03-01 | Crusade Laboratories Limited | Treatment using herpes simplex virus |
| GB2446721B (en) * | 2007-02-16 | 2009-03-25 | Crusade Lab Ltd | Herpes simplex viruses and methods of viral replication |
| CA2690627C (en) | 2007-06-15 | 2014-12-02 | Genelux Corporation | Microorganisms for imaging and/or treatment of tumors |
| EP2593796A4 (en) | 2010-07-16 | 2016-07-27 | Auckland Uniservices Ltd | BACTERIAL NITROREDUCTASE ENZYMES AND METHOD THEREFOR |
| US20130309246A1 (en) * | 2011-02-02 | 2013-11-21 | The Trustees Of Princeton University | Jagged1 as a marker and therapeutic target for breast cancer bone metastasis |
| US9447156B2 (en) | 2011-05-17 | 2016-09-20 | St. Jude Children's Research Hospital | Methods and compositions for inhibiting neddylation of proteins |
| WO2013052915A2 (en) | 2011-10-05 | 2013-04-11 | Genelux Corporation | Method for detecting replication or colonization of a biological therapeutic |
| US20140087362A1 (en) | 2012-03-16 | 2014-03-27 | Aladar A. Szalay | Methods for assessing effectiveness and monitoring oncolytic virus treatment |
| WO2013158265A1 (en) | 2012-04-20 | 2013-10-24 | Genelux Corporation | Imaging methods for oncolytic virus therapy |
| EP2662117A1 (en) | 2012-05-11 | 2013-11-13 | Virttu Biologics Limited | Herpes Simplex Virus for the treatment of liver cancer |
| US20140140959A1 (en) | 2012-10-05 | 2014-05-22 | Aladar A. Szalay | Energy Absorbing-Based Diagnostic and Therapeutic Methods Employing Nucleic Acid Molecules Encoding Chromophore-Producing Enzymes |
| US10238700B2 (en) | 2014-01-02 | 2019-03-26 | Genelux Corporation | Oncolytic virus adjunct therapy with agents that increase virus infectivity |
| BR112017007765B1 (pt) | 2014-10-14 | 2023-10-03 | Halozyme, Inc | Composições de adenosina deaminase-2 (ada2), variantes do mesmo e métodos de usar o mesmo |
| GB201520345D0 (en) * | 2015-11-18 | 2015-12-30 | Virttu Biolog Ltd | Herpes simplex viruses |
| WO2017181152A2 (en) | 2016-04-15 | 2017-10-19 | Alpine Immune Sciences, Inc. | Cd80 variant immunomodulatory proteins and uses thereof |
| MX2018012472A (es) | 2016-04-15 | 2019-08-12 | Alpine Immune Sciences Inc | Proteinas inmunomoduladoras variantes de ligando icos y sus usos. |
| WO2018022946A1 (en) | 2016-07-28 | 2018-02-01 | Alpine Immune Sciences, Inc. | Cd155 variant immunomodulatory proteins and uses thereof |
| WO2018022945A1 (en) | 2016-07-28 | 2018-02-01 | Alpine Immune Sciences, Inc. | Cd112 variant immunomodulatory proteins and uses thereof |
| US11471488B2 (en) | 2016-07-28 | 2022-10-18 | Alpine Immune Sciences, Inc. | CD155 variant immunomodulatory proteins and uses thereof |
| WO2018075978A1 (en) | 2016-10-20 | 2018-04-26 | Alpine Immune Sciences, Inc. | Secretable variant immunomodulatory proteins and engineered cell therapy |
| CN110869052A (zh) | 2016-12-23 | 2020-03-06 | 维图生物制剂公司 | 癌症的治疗 |
| CN110546265A (zh) | 2017-02-09 | 2019-12-06 | 因达普塔治疗公司 | 工程化自然杀伤(nk)细胞及其组合物和方法 |
| SG11201907769XA (en) | 2017-03-16 | 2019-09-27 | Alpine Immune Sciences Inc | Cd80 variant immunomodulatory proteins and uses thereof |
| EP3596116B1 (en) | 2017-03-16 | 2023-09-06 | Alpine Immune Sciences, Inc. | Pd-l1 variant immunomodulatory proteins and uses thereof |
| KR20190141146A (ko) | 2017-03-16 | 2019-12-23 | 알파인 이뮨 사이언시즈, 인코포레이티드 | Pd-l2 변이체 면역조절 단백질 및 그의 용도 |
| BR112020007542A2 (pt) | 2017-10-18 | 2020-12-01 | Alpine Immune Sciences, Inc. | proteínas imunomoduladoras ligantes de icos variantes e composições e métodos relacionados |
| AU2019205273B2 (en) | 2018-01-03 | 2024-04-04 | Alpine Immune Sciences, Inc. | Multi-domain immunomodulatory proteins and methods of use thereof |
| IL278294B2 (en) | 2018-05-01 | 2025-01-01 | Albert Einstein College Medicine | HSV-2-DELTA-gD vaccines and methods for their production and use |
| EA202000353A1 (ru) | 2018-06-04 | 2022-01-14 | Калиди Биотерапьютикс, Инк. | Основанные на клетках носители для потенциализации вирусной терапии |
| US11505782B2 (en) | 2018-06-04 | 2022-11-22 | Calidi Biotherapeutics, Inc. | Cell-based vehicles for potentiation of viral therapy |
| WO2019241758A1 (en) | 2018-06-15 | 2019-12-19 | Alpine Immune Sciences, Inc. | Pd-1 variant immunomodulatory proteins and uses thereof |
| US11242528B2 (en) | 2018-08-28 | 2022-02-08 | Actym Therapeutics, Inc. | Engineered immunostimulatory bacterial strains and uses thereof |
| CA3116192C (en) | 2018-11-06 | 2025-09-23 | Calidi Biotherapeutics (Nevada), Inc. | IMPROVED SYSTEMS FOR CELL-MEDIATED ONCOLYTIC VIRAL THERAPY |
| EP3884041A2 (en) | 2018-11-21 | 2021-09-29 | Indapta Therapeutics, Inc. | Methods for expansion of natural killer (nk) cell subset and related compositions and methods |
| CA3120868A1 (en) | 2018-11-30 | 2020-06-04 | Alpine Immune Sciences, Inc. | Cd86 variant immunomodulatory proteins and uses thereof |
| US12024709B2 (en) | 2019-02-27 | 2024-07-02 | Actym Therapeutics, Inc. | Immunostimulatory bacteria engineered to colonize tumors, tumor-resident immune cells, and the tumor microenvironment |
| JP2022524951A (ja) | 2019-02-27 | 2022-05-11 | アクティム・セラピューティクス・インコーポレイテッド | 腫瘍、腫瘍常在免疫細胞および腫瘍微小環境にコロニー形成するよう操作した免疫刺激性細菌 |
| AU2021258194A1 (en) | 2020-04-22 | 2022-11-24 | Indapta Therapeutics, Inc. | Natural killer (NK) cell compositions and methods for generating same |
| WO2022147480A1 (en) | 2020-12-30 | 2022-07-07 | Ansun Biopharma, Inc. | Oncolytic virus encoding sialidase and multispecific immune cell engager |
| WO2025129492A1 (zh) * | 2023-12-20 | 2025-06-26 | 中国科学院深圳先进技术研究院 | 一种减毒单纯疱疹病毒在制备神经环路逆向示踪工具病毒中的应用 |
Family Cites Families (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5965138A (en) | 1985-09-06 | 1999-10-12 | Syntro Corporation | Recombinant chimeric virus and uses thereof |
| JP2538367B2 (ja) | 1988-06-24 | 1996-09-25 | ブリティッシュ・テクノロジー・グループ・リミテッド | Ｆｏｗｌｐｏｘウィルスの非必須領域 |
| DK0538496T3 (da) | 1991-08-26 | 2004-02-23 | Baxter Healthcare Sa | Rekombinant fjerkrækoppevirus med intakt FPV tk-gen |
| WO1995004139A1 (en) | 1993-07-27 | 1995-02-09 | The Wistar Institute Of Anatomy And Biology | Modified dna virus vectors and uses therefor |
| US6025127A (en) * | 1994-01-14 | 2000-02-15 | The Johns Hopkins University School Of Medicine | Nucleic acid mutation detection in histologic tissue |
| GB9415320D0 (en) | 1994-07-29 | 1994-09-21 | Medical Res Council | Cancer treatment |
| EP0753581A1 (en) | 1995-07-10 | 1997-01-15 | Immuno Ag | Improved recombinant eukaryotic cytoplasmic viruses, method for their production and their use as vaccines |
| ZA966287B (en) | 1995-07-27 | 1998-03-09 | American Cyanamid Co | Avirulent herpetic viruses useful as tumoricidal agents and vaccines. |
| WO1997014808A2 (en) | 1995-10-19 | 1997-04-24 | St. Jude Children's Research Hospital | Herpesvirus vectors and their uses |
| ATE241994T1 (de) | 1996-01-25 | 2003-06-15 | Univ Glasgow | Hsv-mutant-1716 zur behandlung von mesotheliomen |
| US5998174A (en) | 1997-05-12 | 1999-12-07 | University Of Pittsburgh Of The Commonwealth System Of Higher Education | Multigene vectors |
| GB9801930D0 (en) | 1998-01-29 | 1998-03-25 | Univ London | Mutant herpes simplex viruses and uses thereof |
| US5922576A (en) * | 1998-02-27 | 1999-07-13 | The John Hopkins University | Simplified system for generating recombinant adenoviruses |
| EP1153136A2 (en) * | 1998-12-09 | 2001-11-14 | The General Hospital Corporation | Enhanced packaging of herpes virus amplicons and generation of recombinant virus vectors |
| AU3391200A (en) | 1999-03-04 | 2000-09-21 | Corixa Corporation | Compositions and methods for breast cancer therapy and diagnosis |
| US6428968B1 (en) * | 1999-03-15 | 2002-08-06 | The Trustees Of The University Of Pennsylvania | Combined therapy with a chemotherapeutic agent and an oncolytic virus for killing tumor cells in a subject |
| PT1212428E (pt) | 1999-08-31 | 2005-03-31 | Gen Hospital Corp | Redireccionamento da expressao do gene gama 34.5 de herpes atraves de um promotor especifico de celulas e/ou especifico de tumores |
| GB9930418D0 (en) | 1999-12-22 | 2000-02-16 | Neurovex Ltd | Replication incompetent herpes virus vectors |
| GB2375113B (en) * | 2000-01-21 | 2004-10-20 | Biovex Ltd | A modified, oncolytic, non-laboratory HSV strain and its use in treating cancer |
| US20030073099A1 (en) * | 2000-04-18 | 2003-04-17 | Tang Y. Tom | Novel nucleic acids and polypeptides |
| DE60135482D1 (de) * | 2000-11-09 | 2008-10-02 | Cenix Bioscience Gmbh | Eukaryontische zellteilungsgene und deren verwendung in der diagnostik sowie in der behandlung von proliferativen erkrankungen |
| US20020164666A1 (en) * | 2000-12-21 | 2002-11-07 | Myraid Genetics, Inc. | Protein-protein interactions |
| JP2004535813A (ja) * | 2001-07-17 | 2004-12-02 | ミルナー，アン，ジョセフィーヌ | 遺伝子発現のサイレンシング |
| US7348418B2 (en) * | 2002-02-08 | 2008-03-25 | Memorial Sloan-Kettering Cancer Center | Carcinoma-related genes and polypeptides and methods of use thereof |
| GB0203285D0 (en) * | 2002-02-12 | 2002-03-27 | Brown Susanne M | An herpes simplex virus complex |
| US7288529B2 (en) * | 2003-04-24 | 2007-10-30 | New York University | ALK protein tyrosine kinase, cells and methods embodying and using same |
| WO2007026146A1 (en) | 2005-08-30 | 2007-03-08 | Crusade Laboratories Limited | Treatment using herpes simplex virus |
| GB0326798D0 (en) | 2003-11-17 | 2003-12-24 | Crusade Lab Ltd | Methods for generating mutant virus |
| US20070003520A1 (en) | 2003-11-17 | 2007-01-04 | Brown Susanne M | Mutant viruses |
| US9085777B2 (en) | 2006-05-11 | 2015-07-21 | Virttu Biologics Limited | Mutant HSV, materials and methods for generation of mutant HSV |
| GB2446721B (en) | 2007-02-16 | 2009-03-25 | Crusade Lab Ltd | Herpes simplex viruses and methods of viral replication |
| GB0714578D0 (en) | 2007-07-26 | 2007-09-05 | Crusade Lab Ltd | Viruses |
-
2004
- 2004-11-17 US US10/579,622 patent/US20070003520A1/en not_active Abandoned
- 2004-11-17 WO PCT/GB2004/004908 patent/WO2005049846A2/en not_active Ceased
- 2004-11-17 EP EP04798619A patent/EP1694852B1/en not_active Expired - Lifetime
- 2004-11-17 JP JP2006538967A patent/JP2007511216A/ja active Pending
-
2009
- 2009-05-06 US US12/436,382 patent/US8530437B2/en not_active Expired - Fee Related
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