JP2009538915A - 妊娠の合併症を診断および治療する方法 - Google Patents
妊娠の合併症を診断および治療する方法 Download PDFInfo
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- JP2009538915A JP2009538915A JP2009513263A JP2009513263A JP2009538915A JP 2009538915 A JP2009538915 A JP 2009538915A JP 2009513263 A JP2009513263 A JP 2009513263A JP 2009513263 A JP2009513263 A JP 2009513263A JP 2009538915 A JP2009538915 A JP 2009538915A
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- Prior art keywords
- soluble endoglin
- pregnancy
- eclampsia
- endoglin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
- A61K38/4886—Metalloendopeptidases (3.4.24), e.g. collagenase
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/455—Nicotinic acids, e.g. niacin; Derivatives thereof, e.g. esters, amides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
- A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/1841—Transforming growth factor [TGF]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/1858—Platelet-derived growth factor [PDGF]
- A61K38/1866—Vascular endothelial growth factor [VEGF]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/1875—Bone morphogenic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
- A61K38/482—Serine endopeptidases (3.4.21)
- A61K38/486—Elastase (3.4.21.36 or 3.4.21.37)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/36—Gynecology or obstetrics
- G01N2800/368—Pregnancy complicated by disease or abnormalities of pregnancy, e.g. preeclampsia, preterm labour
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Microbiology (AREA)
- Food Science & Technology (AREA)
- Analytical Chemistry (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Heart & Thoracic Surgery (AREA)
- Biotechnology (AREA)
- Cell Biology (AREA)
- Endocrinology (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Reproductive Health (AREA)
- Physics & Mathematics (AREA)
- Diabetes (AREA)
- Biochemistry (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US11/443,920 US7740849B2 (en) | 2004-09-24 | 2006-05-31 | Use of compounds that bind soluble endoglin and SFLT-1 for the treatment of pregnancy related hypertensive disorders |
US85276106P | 2006-10-19 | 2006-10-19 | |
PCT/US2007/012787 WO2008030283A1 (en) | 2006-05-31 | 2007-05-31 | Methods of diagnosing and treating complications of pregnancy |
Publications (1)
Publication Number | Publication Date |
---|---|
JP2009538915A true JP2009538915A (ja) | 2009-11-12 |
Family
ID=39157545
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2009513263A Pending JP2009538915A (ja) | 2006-05-31 | 2007-05-31 | 妊娠の合併症を診断および治療する方法 |
Country Status (9)
Country | Link |
---|---|
EP (1) | EP2029743A4 (es) |
JP (1) | JP2009538915A (es) |
KR (1) | KR20090040874A (es) |
CN (1) | CN101517078A (es) |
AU (1) | AU2007293475A1 (es) |
BR (1) | BRPI0713122A2 (es) |
CA (1) | CA2654283A1 (es) |
MX (1) | MX2008015197A (es) |
WO (1) | WO2008030283A1 (es) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2011525241A (ja) * | 2008-06-18 | 2011-09-15 | アボット・ラボラトリーズ | PlGF−1コンパニオン診断方法および製品 |
JP2014524417A (ja) * | 2011-08-01 | 2014-09-22 | タフツ メディカル センター インコーポレイテッド | 心不全および関連状態の処置 |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MX2007003522A (es) | 2004-09-24 | 2007-06-11 | Beth Israel Hospital | Complicaciones del embarazo. |
US7740849B2 (en) | 2004-09-24 | 2010-06-22 | Beth Israel Deaconess Medical Center | Use of compounds that bind soluble endoglin and SFLT-1 for the treatment of pregnancy related hypertensive disorders |
BRPI0519096A2 (pt) | 2004-12-15 | 2008-12-23 | Beth Israel Hospital | Ácidos nuclÉicos e polipeptÍdeos éteis para o diagnàstico e tratamento de complicaÇÕes na gravidez |
WO2009097584A1 (en) * | 2008-01-30 | 2009-08-06 | Proteogenix, Inc. | Maternal serum biomarkers for detection of pre-eclampsia |
AU2010240781B2 (en) * | 2009-04-23 | 2015-05-28 | Wallac Oy | Methods for determining maternal health risks |
BR112012024175A2 (pt) * | 2010-03-24 | 2016-07-05 | Preelumina Diagnostics Ab | hbf e a1m como marcadores de estágio precoce para preeclampsia |
JP2013524251A (ja) * | 2010-04-13 | 2013-06-17 | プロノタ エヌ.ヴェ. | 妊娠高血圧疾患のバイオマーカー |
US20110251094A1 (en) | 2010-04-13 | 2011-10-13 | Pronota N.V. | Biomarkers for hypertensive disorders of pregnancy |
JP5959506B2 (ja) | 2010-05-14 | 2016-08-02 | ベス イスラエル デアコネス メディカル センター インコーポレイテッド | 妊娠合併症を治療するための体外デバイスおよび方法 |
CN102058435B (zh) * | 2011-01-17 | 2012-05-09 | 北京工业大学 | 基于理化和血流动力学信息的妊娠期高血压风险监测装置 |
WO2013000992A1 (en) | 2011-06-28 | 2013-01-03 | Vitateq Biotechnology Gmbh | Method for diagnosing preeclampsia |
EP2890816B1 (en) * | 2012-08-30 | 2019-06-05 | Ansh Labs LLC | Papp-a2 as a marker for monitoring, predicting and diagnosing preeclampsia |
KR101417379B1 (ko) * | 2012-10-30 | 2014-07-10 | 곽호석 | 질량분석기를 이용한 태아의 폐 성숙도 진단방법 |
CN103207274B (zh) * | 2013-04-28 | 2015-02-25 | 成都中医药大学 | 一种胎儿7号染色体异常疾病的筛查试剂盒 |
CN103235142B (zh) * | 2013-04-28 | 2015-04-15 | 成都中医药大学 | 一种孕妇初次妊娠筛查试剂盒 |
US20190105631A1 (en) * | 2016-03-31 | 2019-04-11 | ImMutriX Therapeutics, Inc. | Method for extracorporeal treatment of preeclampsia and related disorders |
CN113919453B (zh) * | 2021-09-13 | 2024-06-11 | 深圳大学龙华生物产业创新研究院 | 用于记录生物特征的区块链集成系统 |
CN113933129B (zh) * | 2021-09-14 | 2024-01-12 | 深圳大学 | 子痫前期诊断试剂盒以及荧光染料的应用 |
CN115791340B (zh) * | 2023-01-17 | 2023-05-02 | 北京水木济衡生物技术有限公司 | 一种子痫复合质控品及其制备方法和应用 |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2006034507A2 (en) * | 2004-09-24 | 2006-03-30 | Beth Israel - Deaconess Medical Center | Methods of diagnosing and treating complications of pregnancy |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20020031513A1 (en) * | 1997-11-24 | 2002-03-14 | Shamir Leibovitz | Method and pharmaceutical composition for inhibiting premature rapture of fetal membranes, ripening of uterine cervix and preterm labor in mammals |
NZ514305A (en) * | 1999-04-16 | 2004-01-30 | Univ Yale | eNOS mutations useful for gene therapy and therapeutic screening |
EP1407276B1 (en) * | 2001-04-24 | 2009-10-21 | Vlaams Interuniversitair Instituut voor Biotechnologie vzw. | Use of hypoxia inducible factor 2alpha for curing neonatal respiratory distress syndrome |
-
2007
- 2007-05-31 MX MX2008015197A patent/MX2008015197A/es active IP Right Grant
- 2007-05-31 KR KR1020087032270A patent/KR20090040874A/ko not_active Application Discontinuation
- 2007-05-31 EP EP07795515A patent/EP2029743A4/en not_active Withdrawn
- 2007-05-31 CA CA002654283A patent/CA2654283A1/en not_active Abandoned
- 2007-05-31 JP JP2009513263A patent/JP2009538915A/ja active Pending
- 2007-05-31 CN CNA2007800268583A patent/CN101517078A/zh active Pending
- 2007-05-31 WO PCT/US2007/012787 patent/WO2008030283A1/en active Application Filing
- 2007-05-31 AU AU2007293475A patent/AU2007293475A1/en not_active Abandoned
- 2007-05-31 BR BRPI0713122-4A patent/BRPI0713122A2/pt not_active IP Right Cessation
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2006034507A2 (en) * | 2004-09-24 | 2006-03-30 | Beth Israel - Deaconess Medical Center | Methods of diagnosing and treating complications of pregnancy |
Non-Patent Citations (3)
Title |
---|
JPN6012035695; Br. J. Pharmacol. (2002) vol.137, no.7, p.1021-1030 * |
JPN6012035696; Cardiovasc. Res. (2003) vol.59, no.3, p.844-853 * |
JPN6012035697; 宮島篤編, わかる実験医学シリーズ 基礎から最新トピックスまでのサイトカインがわかる, 2002年6月, 株式 * |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2011525241A (ja) * | 2008-06-18 | 2011-09-15 | アボット・ラボラトリーズ | PlGF−1コンパニオン診断方法および製品 |
JP2014524417A (ja) * | 2011-08-01 | 2014-09-22 | タフツ メディカル センター インコーポレイテッド | 心不全および関連状態の処置 |
Also Published As
Publication number | Publication date |
---|---|
CA2654283A1 (en) | 2008-03-13 |
WO2008030283A1 (en) | 2008-03-13 |
BRPI0713122A2 (pt) | 2012-04-17 |
AU2007293475A1 (en) | 2008-03-13 |
MX2008015197A (es) | 2009-06-23 |
EP2029743A1 (en) | 2009-03-04 |
KR20090040874A (ko) | 2009-04-27 |
EP2029743A4 (en) | 2010-12-08 |
CN101517078A (zh) | 2009-08-26 |
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