JP2009538873A - 新規複素環化合物 - Google Patents
新規複素環化合物 Download PDFInfo
- Publication number
- JP2009538873A JP2009538873A JP2009512577A JP2009512577A JP2009538873A JP 2009538873 A JP2009538873 A JP 2009538873A JP 2009512577 A JP2009512577 A JP 2009512577A JP 2009512577 A JP2009512577 A JP 2009512577A JP 2009538873 A JP2009538873 A JP 2009538873A
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- Prior art keywords
- compound
- phenyl
- oxy
- methyl
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 150000002391 heterocyclic compounds Chemical class 0.000 title description 2
- 238000000034 method Methods 0.000 claims abstract description 39
- 239000008194 pharmaceutical composition Substances 0.000 claims abstract description 23
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- 150000001875 compounds Chemical class 0.000 claims description 259
- 150000003839 salts Chemical class 0.000 claims description 32
- 125000005843 halogen group Chemical group 0.000 claims description 31
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 27
- 125000000217 alkyl group Chemical group 0.000 claims description 23
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 21
- 238000011282 treatment Methods 0.000 claims description 19
- 239000003054 catalyst Substances 0.000 claims description 15
- 125000001153 fluoro group Chemical group F* 0.000 claims description 15
- 125000001309 chloro group Chemical group Cl* 0.000 claims description 14
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- 229910052739 hydrogen Inorganic materials 0.000 claims description 9
- 229910052799 carbon Inorganic materials 0.000 claims description 8
- QGQFNQWZHHSZIC-UHFFFAOYSA-N 5-chloro-2-(hydroxymethyl)-6-methyl-3-[4-[4-(trifluoromethoxy)phenoxy]phenyl]-1h-pyridin-4-one Chemical compound O=C1C(Cl)=C(C)NC(CO)=C1C(C=C1)=CC=C1OC1=CC=C(OC(F)(F)F)C=C1 QGQFNQWZHHSZIC-UHFFFAOYSA-N 0.000 claims description 7
- 241001465754 Metazoa Species 0.000 claims description 6
- 229910052794 bromium Inorganic materials 0.000 claims description 6
- 239000003937 drug carrier Substances 0.000 claims description 6
- LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 claims description 6
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- FPLYZPSLKQLYKK-UHFFFAOYSA-N 3-chloro-2-(hydroxyiminomethyl)-6-methyl-5-[4-[4-(trifluoromethoxy)phenoxy]phenyl]-1H-pyridin-4-one Chemical compound N1C(C=NO)=C(Cl)C(=O)C(C=2C=CC(OC=3C=CC(OC(F)(F)F)=CC=3)=CC=2)=C1C FPLYZPSLKQLYKK-UHFFFAOYSA-N 0.000 claims description 3
- VBDWNBIKGCBULL-UHFFFAOYSA-N 3-chloro-2-(hydroxymethyl)-6-methyl-5-[4-[3-(trifluoromethyl)phenoxy]phenyl]-1h-pyridin-4-one Chemical compound N1C(CO)=C(Cl)C(=O)C(C=2C=CC(OC=3C=C(C=CC=3)C(F)(F)F)=CC=2)=C1C VBDWNBIKGCBULL-UHFFFAOYSA-N 0.000 claims description 3
- PBBRXPIBBBJNSH-UHFFFAOYSA-N 3-chloro-2-(hydroxymethyl)-6-methyl-5-[4-[4-(trifluoromethoxy)phenoxy]phenyl]-1h-pyridin-4-one Chemical compound N1C(CO)=C(Cl)C(=O)C(C=2C=CC(OC=3C=CC(OC(F)(F)F)=CC=3)=CC=2)=C1C PBBRXPIBBBJNSH-UHFFFAOYSA-N 0.000 claims description 3
- YVUMFLJJKXPWIK-UHFFFAOYSA-N 5-chloro-2-(3-hydroxypropyl)-6-methyl-3-[4-[4-(trifluoromethoxy)phenoxy]phenyl]-1h-pyridin-4-one Chemical compound O=C1C(Cl)=C(C)NC(CCCO)=C1C(C=C1)=CC=C1OC1=CC=C(OC(F)(F)F)C=C1 YVUMFLJJKXPWIK-UHFFFAOYSA-N 0.000 claims description 3
- OROGEAPBNAKLSB-UHFFFAOYSA-N 5-chloro-2-(methoxyiminomethyl)-6-methyl-3-[4-[4-(trifluoromethoxy)phenoxy]phenyl]-1h-pyridin-4-one Chemical compound N1C(C)=C(Cl)C(=O)C(C=2C=CC(OC=3C=CC(OC(F)(F)F)=CC=3)=CC=2)=C1C=NOC OROGEAPBNAKLSB-UHFFFAOYSA-N 0.000 claims description 3
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- OTKMQZNYPLNRQB-UHFFFAOYSA-N 5-chloro-2-(hydroxyiminomethyl)-6-methyl-3-[4-[4-(trifluoromethoxy)phenoxy]phenyl]-1H-pyridin-4-one Chemical compound O=C1C(Cl)=C(C)NC(C=NO)=C1C(C=C1)=CC=C1OC1=CC=C(OC(F)(F)F)C=C1 OTKMQZNYPLNRQB-UHFFFAOYSA-N 0.000 claims description 2
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- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 description 22
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- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 18
- -1 alkaline earth metal salts Chemical class 0.000 description 18
- 238000003556 assay Methods 0.000 description 18
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- HPALAKNZSZLMCH-UHFFFAOYSA-M sodium;chloride;hydrate Chemical compound O.[Na+].[Cl-] HPALAKNZSZLMCH-UHFFFAOYSA-M 0.000 description 18
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- BWHMMNNQKKPAPP-UHFFFAOYSA-L potassium carbonate Chemical compound [K+].[K+].[O-]C([O-])=O BWHMMNNQKKPAPP-UHFFFAOYSA-L 0.000 description 16
- 241000223960 Plasmodium falciparum Species 0.000 description 15
- 239000010410 layer Substances 0.000 description 15
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- FDGQSTZJBFJUBT-UHFFFAOYSA-N hypoxanthine Chemical compound O=C1NC=NC2=C1NC=N2 FDGQSTZJBFJUBT-UHFFFAOYSA-N 0.000 description 14
- MZRVEZGGRBJDDB-UHFFFAOYSA-N n-Butyllithium Substances [Li]CCCC MZRVEZGGRBJDDB-UHFFFAOYSA-N 0.000 description 14
- 239000012044 organic layer Substances 0.000 description 14
- 229910052763 palladium Inorganic materials 0.000 description 13
- GCNTZFIIOFTKIY-UHFFFAOYSA-N 4-hydroxypyridine Chemical compound OC1=CC=NC=C1 GCNTZFIIOFTKIY-UHFFFAOYSA-N 0.000 description 12
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- SECXISVLQFMRJM-UHFFFAOYSA-N N-Methylpyrrolidone Chemical compound CN1CCCC1=O SECXISVLQFMRJM-UHFFFAOYSA-N 0.000 description 10
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- 229910052757 nitrogen Inorganic materials 0.000 description 9
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 9
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- 0 CCC(NC(CO)=C1c(cc2)ccc2OC2=CC=CC(C)(*)C=C2)=CC1=O Chemical compound CCC(NC(CO)=C1c(cc2)ccc2OC2=CC=CC(C)(*)C=C2)=CC1=O 0.000 description 8
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- 150000002148 esters Chemical class 0.000 description 8
- DLEDOFVPSDKWEF-UHFFFAOYSA-N lithium butane Chemical compound [Li+].CCC[CH2-] DLEDOFVPSDKWEF-UHFFFAOYSA-N 0.000 description 8
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- 239000012453 solvate Substances 0.000 description 8
- YRIZYWQGELRKNT-UHFFFAOYSA-N 1,3,5-trichloro-1,3,5-triazinane-2,4,6-trione Chemical compound ClN1C(=O)N(Cl)C(=O)N(Cl)C1=O YRIZYWQGELRKNT-UHFFFAOYSA-N 0.000 description 7
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- PSZYNBSKGUBXEH-UHFFFAOYSA-M naphthalene-1-sulfonate Chemical compound C1=CC=C2C(S(=O)(=O)[O-])=CC=CC2=C1 PSZYNBSKGUBXEH-UHFFFAOYSA-M 0.000 description 1
- PSZYNBSKGUBXEH-UHFFFAOYSA-N naphthalene-1-sulfonic acid Chemical compound C1=CC=C2C(S(=O)(=O)O)=CC=CC2=C1 PSZYNBSKGUBXEH-UHFFFAOYSA-N 0.000 description 1
- KVBGVZZKJNLNJU-UHFFFAOYSA-M naphthalene-2-sulfonate Chemical compound C1=CC=CC2=CC(S(=O)(=O)[O-])=CC=C21 KVBGVZZKJNLNJU-UHFFFAOYSA-M 0.000 description 1
- KVBGVZZKJNLNJU-UHFFFAOYSA-N naphthalene-2-sulfonic acid Chemical compound C1=CC=CC2=CC(S(=O)(=O)O)=CC=C21 KVBGVZZKJNLNJU-UHFFFAOYSA-N 0.000 description 1
- 210000003928 nasal cavity Anatomy 0.000 description 1
- 150000002823 nitrates Chemical class 0.000 description 1
- 229910017604 nitric acid Inorganic materials 0.000 description 1
- 150000002829 nitrogen Chemical class 0.000 description 1
- 150000007523 nucleic acids Chemical class 0.000 description 1
- 102000039446 nucleic acids Human genes 0.000 description 1
- 108020004707 nucleic acids Proteins 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
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- 229910052760 oxygen Inorganic materials 0.000 description 1
- PIBWKRNGBLPSSY-UHFFFAOYSA-L palladium(II) chloride Chemical compound Cl[Pd]Cl PIBWKRNGBLPSSY-UHFFFAOYSA-L 0.000 description 1
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- VLTRZXGMWDSKGL-UHFFFAOYSA-M perchlorate Inorganic materials [O-]Cl(=O)(=O)=O VLTRZXGMWDSKGL-UHFFFAOYSA-M 0.000 description 1
- 230000000737 periodic effect Effects 0.000 description 1
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- SSOLNOMRVKKSON-UHFFFAOYSA-N proguanil Chemical compound CC(C)\N=C(/N)N=C(N)NC1=CC=C(Cl)C=C1 SSOLNOMRVKKSON-UHFFFAOYSA-N 0.000 description 1
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 150000005299 pyridinones Chemical group 0.000 description 1
- 238000004445 quantitative analysis Methods 0.000 description 1
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- 238000012552 review Methods 0.000 description 1
- 238000005070 sampling Methods 0.000 description 1
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- 125000002914 sec-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
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- 201000002612 sleeping sickness Diseases 0.000 description 1
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- 239000001509 sodium citrate Substances 0.000 description 1
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
- 159000000000 sodium salts Chemical class 0.000 description 1
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- 208000024891 symptom Diseases 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- CBXCPBUEXACCNR-UHFFFAOYSA-N tetraethylammonium Chemical compound CC[N+](CC)(CC)CC CBXCPBUEXACCNR-UHFFFAOYSA-N 0.000 description 1
- WHRNULOCNSKMGB-UHFFFAOYSA-N tetrahydrofuran thf Chemical compound C1CCOC1.C1CCOC1 WHRNULOCNSKMGB-UHFFFAOYSA-N 0.000 description 1
- 125000001412 tetrahydropyranyl group Chemical group 0.000 description 1
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- 125000002221 trityl group Chemical group [H]C1=C([H])C([H])=C([H])C([H])=C1C([*])(C1=C(C(=C(C(=C1[H])[H])[H])[H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/63—One oxygen atom
- C07D213/68—One oxygen atom attached in position 4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A61P33/06—Antimalarials
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Tropical Medicine & Parasitology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP06381025A EP1862459A1 (en) | 2006-05-31 | 2006-05-31 | Novel heterocyclic compounds |
| EP07380072A EP1967515A1 (en) | 2007-03-08 | 2007-03-08 | Heterocyclic compounds |
| PCT/EP2007/055188 WO2007138048A1 (en) | 2006-05-31 | 2007-05-29 | Novel heterocyclic compounds |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2009538873A true JP2009538873A (ja) | 2009-11-12 |
| JP2009538873A5 JP2009538873A5 (enExample) | 2010-07-15 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009512577A Pending JP2009538873A (ja) | 2006-05-31 | 2007-05-29 | 新規複素環化合物 |
Country Status (17)
| Country | Link |
|---|---|
| US (2) | US7674808B2 (enExample) |
| EP (1) | EP2024332A1 (enExample) |
| JP (1) | JP2009538873A (enExample) |
| KR (1) | KR20090012342A (enExample) |
| AR (1) | AR060974A1 (enExample) |
| AU (1) | AU2007267093A1 (enExample) |
| BR (1) | BRPI0711783A2 (enExample) |
| CA (1) | CA2653872A1 (enExample) |
| CR (1) | CR10492A (enExample) |
| EA (1) | EA200870545A1 (enExample) |
| IL (1) | IL195158A0 (enExample) |
| MA (1) | MA30487B1 (enExample) |
| MX (1) | MX2008015291A (enExample) |
| NO (1) | NO20085087L (enExample) |
| PE (1) | PE20080453A1 (enExample) |
| TW (1) | TW200817331A (enExample) |
| WO (1) | WO2007138048A1 (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2021527216A (ja) * | 2018-06-12 | 2021-10-11 | バイオリレバント．コム エルティーディー． | 薬剤溶解性のイン・ビトロ試験用緩衝液の調製プロセス、緩衝液作製用パッケージ、及び病態試験用キット |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050158294A1 (en) | 2003-12-19 | 2005-07-21 | The Procter & Gamble Company | Canine probiotic Bifidobacteria pseudolongum |
| US8877178B2 (en) | 2003-12-19 | 2014-11-04 | The Iams Company | Methods of use of probiotic bifidobacteria for companion animals |
| WO2006130187A1 (en) | 2005-05-31 | 2006-12-07 | The Iams Company | Feline probiotic lactobacilli |
| JP4938006B2 (ja) | 2005-05-31 | 2012-05-23 | ザ・アイムス・カンパニー | ネコ科動物プロバイオティク・ビフィドバクテリア |
| RU2436581C2 (ru) | 2007-02-01 | 2011-12-20 | Дзе Иамс Компани | Способ уменьшения воспаления и снижения стресса у млекопитающего |
| EP2220043A1 (en) * | 2007-11-30 | 2010-08-25 | Glaxo Group Limited | Crystalline form of an antimalarial compound |
| US9771199B2 (en) * | 2008-07-07 | 2017-09-26 | Mars, Incorporated | Probiotic supplement, process for making, and packaging |
| US9232813B2 (en) * | 2008-07-07 | 2016-01-12 | The Iams Company | Probiotic supplement, process for making, and packaging |
| WO2010081904A1 (en) | 2009-01-19 | 2010-07-22 | Glaxo Group Limited | 4 ( 1h) -pyridinone derivatives and their use as antimalaria agents |
| EP2246329A1 (en) | 2009-01-19 | 2010-11-03 | Glaxo Group Limited | 4(1H)-pyridinone derivatives and their use as antimalaria agents |
| TW201039834A (en) | 2009-02-20 | 2010-11-16 | Glaxo Group Ltd | Novel heterocyclic compounds |
| WO2010142741A1 (en) * | 2009-06-12 | 2010-12-16 | Glaxo Group Limited | Phenylpyridylpyridones for use as antimalarial agents |
| US10104903B2 (en) | 2009-07-31 | 2018-10-23 | Mars, Incorporated | Animal food and its appearance |
| US10206677B2 (en) * | 2014-09-26 | 2019-02-19 | Ethicon Llc | Surgical staple and driver arrangements for staple cartridges |
| JOP20180072A1 (ar) | 2014-09-11 | 2019-01-30 | Lilly Co Eli | علاج الأعراض المرتبطة بالعلاج بالحرمان من الأندروجين |
| WO2016169908A1 (en) * | 2015-04-21 | 2016-10-27 | Glaxosmithkline Intellectual Property Development Limited | Uracil derivatives for the treatment of malaria |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH05504961A (ja) * | 1990-03-12 | 1993-07-29 | ザ・ウエルカム・ファウンデーション・リミテッド | 複素環化合物 |
| JPH06507377A (ja) * | 1991-01-09 | 1994-08-25 | ブリティッシュ・テクノロジー・グループ・リミテッド | 薬剤組成物 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5403934A (en) * | 1990-03-12 | 1995-04-04 | Burroughs Wellcome Co. | Heterocyclic compounds |
-
2007
- 2007-05-29 MX MX2008015291A patent/MX2008015291A/es unknown
- 2007-05-29 EA EA200870545A patent/EA200870545A1/ru unknown
- 2007-05-29 PE PE2007000667A patent/PE20080453A1/es not_active Application Discontinuation
- 2007-05-29 WO PCT/EP2007/055188 patent/WO2007138048A1/en not_active Ceased
- 2007-05-29 JP JP2009512577A patent/JP2009538873A/ja active Pending
- 2007-05-29 KR KR1020087029153A patent/KR20090012342A/ko not_active Withdrawn
- 2007-05-29 AU AU2007267093A patent/AU2007267093A1/en not_active Abandoned
- 2007-05-29 EP EP07729610A patent/EP2024332A1/en not_active Withdrawn
- 2007-05-29 US US11/754,382 patent/US7674808B2/en not_active Expired - Fee Related
- 2007-05-29 CA CA002653872A patent/CA2653872A1/en not_active Abandoned
- 2007-05-29 AR ARP070102297A patent/AR060974A1/es not_active Application Discontinuation
- 2007-05-29 BR BRPI0711783-3A patent/BRPI0711783A2/pt not_active IP Right Cessation
- 2007-05-29 TW TW096119056A patent/TW200817331A/zh unknown
- 2007-05-31 US US11/755,849 patent/US7629365B2/en not_active Expired - Fee Related
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2008
- 2008-11-06 IL IL195158A patent/IL195158A0/en unknown
- 2008-12-01 MA MA31430A patent/MA30487B1/fr unknown
- 2008-12-05 NO NO20085087A patent/NO20085087L/no not_active Application Discontinuation
- 2008-12-10 CR CR10492A patent/CR10492A/es not_active Application Discontinuation
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH05504961A (ja) * | 1990-03-12 | 1993-07-29 | ザ・ウエルカム・ファウンデーション・リミテッド | 複素環化合物 |
| JPH06507377A (ja) * | 1991-01-09 | 1994-08-25 | ブリティッシュ・テクノロジー・グループ・リミテッド | 薬剤組成物 |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2021527216A (ja) * | 2018-06-12 | 2021-10-11 | バイオリレバント．コム エルティーディー． | 薬剤溶解性のイン・ビトロ試験用緩衝液の調製プロセス、緩衝液作製用パッケージ、及び病態試験用キット |
| JP7541927B2 (ja) | 2018-06-12 | 2024-08-29 | バイオリレバント．コム エルティーディー． | 薬剤溶解性のイン・ビトロ試験用緩衝液の調製プロセス、緩衝液作製用パッケージ、及び病態試験用キット |
Also Published As
| Publication number | Publication date |
|---|---|
| AR060974A1 (es) | 2008-07-23 |
| WO2007138048A1 (en) | 2007-12-06 |
| EP2024332A1 (en) | 2009-02-18 |
| TW200817331A (en) | 2008-04-16 |
| US20080021073A1 (en) | 2008-01-24 |
| BRPI0711783A2 (pt) | 2011-11-29 |
| NO20085087L (no) | 2009-02-20 |
| AU2007267093A1 (en) | 2007-12-06 |
| CA2653872A1 (en) | 2007-12-06 |
| US7629365B2 (en) | 2009-12-08 |
| US7674808B2 (en) | 2010-03-09 |
| US20070281977A1 (en) | 2007-12-06 |
| PE20080453A1 (es) | 2008-05-29 |
| EA200870545A1 (ru) | 2009-12-30 |
| CR10492A (es) | 2009-01-27 |
| MX2008015291A (es) | 2008-12-12 |
| IL195158A0 (en) | 2009-08-03 |
| KR20090012342A (ko) | 2009-02-03 |
| MA30487B1 (fr) | 2009-06-01 |
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