JP2009537551A - ホルモン受容体を調節するためのピリミジン低分子量リガンド - Google Patents

ホルモン受容体を調節するためのピリミジン低分子量リガンド Download PDF

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Publication number
JP2009537551A
JP2009537551A JP2009511097A JP2009511097A JP2009537551A JP 2009537551 A JP2009537551 A JP 2009537551A JP 2009511097 A JP2009511097 A JP 2009511097A JP 2009511097 A JP2009511097 A JP 2009511097A JP 2009537551 A JP2009537551 A JP 2009537551A
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aralkyl
lower alkyl
compound
cycloalkyl
compounds
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JP2009511097A
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Japanese (ja)
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JP2009537551A5 (https=
Inventor
マービン シー． ガーシェンゴーン
スザンヌ ネウマン
クレイグ トーマス
ホルガー ジャエスチケ
スザンナ モーア
ガード クラウセ
ブルース ラーカ
ラルフ パスチケ
ガンナー クレイナウ
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Government of the United States of America
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Government of the United States of America
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Publication of JP2009537551A publication Critical patent/JP2009537551A/ja
Publication of JP2009537551A5 publication Critical patent/JP2009537551A5/ja
Withdrawn legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
    • A61P5/08—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH for decreasing, blocking or antagonising the activity of the anterior pituitary hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
JP2009511097A 2006-05-17 2007-05-17 ホルモン受容体を調節するためのピリミジン低分子量リガンド Withdrawn JP2009537551A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US80137006P 2006-05-17 2006-05-17
PCT/US2007/011951 WO2007136776A2 (en) 2006-05-17 2007-05-17 Pyrimidine low molecular weight ligands for modulating hormone receptors

Publications (2)

Publication Number Publication Date
JP2009537551A true JP2009537551A (ja) 2009-10-29
JP2009537551A5 JP2009537551A5 (https=) 2010-07-01

Family

ID=38566208

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2009511097A Withdrawn JP2009537551A (ja) 2006-05-17 2007-05-17 ホルモン受容体を調節するためのピリミジン低分子量リガンド

Country Status (6)

Country Link
US (1) US20090203716A1 (https=)
EP (1) EP2018384A2 (https=)
JP (1) JP2009537551A (https=)
AU (1) AU2007254165A1 (https=)
CA (1) CA2652061A1 (https=)
WO (1) WO2007136776A2 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2016501883A (ja) * 2012-12-07 2016-01-21 シガ テクノロジーズ，インコーポレーテッド デングウイルス感染症の治療及び予防のためのチエノピリジン誘導体

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010047674A1 (en) 2008-10-20 2010-04-29 The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Low molecular weight thyroid stimulating hormone receptor (tshr) agonists
CN104856991A (zh) 2009-02-27 2015-08-26 西佳技术公司 用于治疗和预防登革热病毒感染的噻吩并吡啶衍生物
JP5965387B2 (ja) 2010-04-08 2016-08-03 アメリカ合衆国 Ｔｓｈ受容体用のインバースアゴニストおよびニュートラルアンタゴニスト

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1990008528A1 (en) * 1989-01-11 1990-08-09 The United States Of America, Represented By The Secretary, United States Department Of Commerce Biologically active synthetic thyrotropin and cloned gene for producing same
US6235755B1 (en) * 1998-08-07 2001-05-22 Applied Research Systems Ars Holding N.A. FSH mimetics for the treatment of infertility
TW564247B (en) * 1999-04-08 2003-12-01 Akzo Nobel Nv Bicyclic heteraromatic compound
US6426357B1 (en) * 1999-07-27 2002-07-30 Affymax, Inc. Antagonists of follicle stimulating hormone activity
CA2422054C (en) * 2000-09-22 2011-01-11 Akzo Nobel Nv Bicyclic heteroaromatic compounds
AU2007207536A1 (en) * 2006-01-17 2007-07-26 Signal Pharmaceuticals, Llc Inhibitors of TNFalpha, PDE4 and B-RAF, compositions thereof and methods of use therewith

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2016501883A (ja) * 2012-12-07 2016-01-21 シガ テクノロジーズ，インコーポレーテッド デングウイルス感染症の治療及び予防のためのチエノピリジン誘導体

Also Published As

Publication number Publication date
US20090203716A1 (en) 2009-08-13
WO2007136776A2 (en) 2007-11-29
WO2007136776A3 (en) 2008-01-24
EP2018384A2 (en) 2009-01-28
CA2652061A1 (en) 2007-11-29
AU2007254165A1 (en) 2007-11-29

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