JP2009537538A - ピマバンセリン医薬製剤 - Google Patents

ピマバンセリン医薬製剤 Download PDF

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Publication number
JP2009537538A
JP2009537538A JP2009511049A JP2009511049A JP2009537538A JP 2009537538 A JP2009537538 A JP 2009537538A JP 2009511049 A JP2009511049 A JP 2009511049A JP 2009511049 A JP2009511049 A JP 2009511049A JP 2009537538 A JP2009537538 A JP 2009537538A
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composition
weight
pimavanserin
pharmaceutical composition
formulation
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JP2009511049A
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Japanese (ja)
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JP2009537538A5 (https=
Inventor
トルフ ボ‐ラグナル
スクフリエンゲル ナトハリエ
ボアス トフイゲセン ミクケル
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アカドイア プハルマセウチカルス インコーポレーテッド
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Publication of JP2009537538A publication Critical patent/JP2009537538A/ja
Publication of JP2009537538A5 publication Critical patent/JP2009537538A5/ja
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2095—Tabletting processes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4468—Non condensed piperidines, e.g. piperocaine having a nitrogen directly attached in position 4, e.g. clebopride, fentanyl
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2009511049A 2006-05-15 2007-05-15 ピマバンセリン医薬製剤 Pending JP2009537538A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US80086406P 2006-05-15 2006-05-15
US85466506P 2006-10-26 2006-10-26
PCT/US2007/011720 WO2007133802A2 (en) 2006-05-15 2007-05-15 Pharmaceutical formulations of pimavanserin

Publications (2)

Publication Number Publication Date
JP2009537538A true JP2009537538A (ja) 2009-10-29
JP2009537538A5 JP2009537538A5 (https=) 2010-07-01

Family

ID=38669082

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2009511049A Pending JP2009537538A (ja) 2006-05-15 2007-05-15 ピマバンセリン医薬製剤

Country Status (5)

Country Link
US (1) US20070264330A1 (https=)
EP (1) EP2037918A2 (https=)
JP (1) JP2009537538A (https=)
CA (1) CA2652300A1 (https=)
WO (1) WO2007133802A2 (https=)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2015512919A (ja) * 2012-04-11 2015-04-30 兆科薬業（合肥）有限公司Ｚｈａｏｋｅ Ｐｈａｒｍａｃｅｕｔｉｃａｌ（Ｈｅｆｅｉ） Ｃｏｍｐａｎｙ Ｌｉｍｉｔｅｄ 塩酸レルカニジピンおよびロサルタンカリウム配合剤およびその調製法
JP2015537013A (ja) * 2012-11-19 2015-12-24 アサンタ・アー／エス 速崩性錠剤

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US7790899B2 (en) * 2004-09-27 2010-09-07 Acadia Pharmaceuticals, Inc. Synthesis of N-(4-fluorobenzyl)-N-(1-methylpiperidin-4-yl)-N′-(4-(2-methylpropyloxy)phenylmethyl)carbamide and its tartrate salt and crystalline forms
CA2681506C (en) * 2007-03-19 2016-05-24 Perry Peters Combinations of 5-ht2a inverse agonists and antagonists with antipsychotics
WO2008144665A1 (en) * 2007-05-18 2008-11-27 Acadia Pharmaceuticals Inc. Use of pimavanserin in the treatment of parkinson and symptoms thereof
CA2816957A1 (en) * 2010-11-07 2012-05-10 Targegen, Inc. Compositions and methods for treating myelofibrosis
WO2014085362A1 (en) * 2012-11-27 2014-06-05 Acadia Pharmaceuticals Inc. Methods for the treatment of parkinson's disease psychosis using pimavanserin
ES2890492T3 (es) * 2015-07-20 2022-01-20 Acadia Pharm Inc Métodos para preparar N-(4-fluorobencil)-N-(1-metilpiperidin-4-il)-N'-(4-(2-metilpropiloxi)fenilmetil)carbamida y su sal de tartrato y forma polimórfica C
CN105929030B (zh) * 2015-12-18 2018-08-21 重庆两江药物研发中心有限公司 一种哌马色林中有机杂质的检测方法
WO2017165635A1 (en) 2016-03-25 2017-09-28 Acadia Pharmaceuticals Inc. Combination of pimavanserin and cytochrome p450 modulators
US10953000B2 (en) 2016-03-25 2021-03-23 Acadia Pharmaceuticals Inc. Combination of pimavanserin and cytochrome P450 modulators
EP3436010B1 (en) * 2016-03-29 2021-03-10 Acadia Pharmaceuticals Inc. 5-ht2a serotonin receptor inverse agonists or antagonists for use in reducing amyloid-beta peptides and accumulation of amyloid plaques
EP3558311A1 (en) 2016-12-20 2019-10-30 Acadia Pharmaceuticals Inc. Pimavanserin alone or in combination for use in the treatment of alzheimer's disease psychosis
EP3615028A1 (en) 2017-04-28 2020-03-04 Acadia Pharmaceuticals Inc. Pimavanserin for treating impulse control disorder
EP3675827A1 (en) 2017-08-30 2020-07-08 Acadia Pharmaceuticals Inc. Formulations of pimavanserin
CA3084953A1 (en) 2017-12-05 2019-06-13 Sunovion Pharmaceuticals Inc. Nonracemic mixtures and uses thereof
AU2018378348B2 (en) 2017-12-05 2024-09-19 Sunovion Pharmaceuticals Inc. Crystal forms and production methods thereof
CN109908097A (zh) * 2017-12-13 2019-06-21 北京万全德众医药生物技术有限公司 匹莫范色林口崩缓释片
IT201800003736A1 (it) 2018-03-19 2019-09-19 Lundbeck Pharmaceuticals Italy S P A Processo per la produzione di Pimavanserin
IT201800009690A1 (it) 2018-10-23 2020-04-23 Lundbeck Pharmaceuticals Italy Spa Processo per la produzione di pimavanserina
US20220016101A1 (en) 2018-10-30 2022-01-20 Acadia Pharmaceuticals Inc. Methods of treating depression, anxiety and sexual dysfunction using the compound pimavanserin
CN109613163B (zh) * 2019-01-08 2021-01-26 丽珠集团新北江制药股份有限公司 一种酒石酸匹莫范色林及其杂质的检测方法
CN109613164B (zh) * 2019-01-08 2021-02-09 丽珠集团新北江制药股份有限公司 一种酒石酸匹莫范色林的检测方法
AU2020286441A1 (en) 2019-06-04 2022-01-06 Sunovion Pharmaceuticals Inc. Modified release formulations and uses thereof
WO2021016369A1 (en) 2019-07-22 2021-01-28 Acadia Pharmaceuticals Inc. Pimavanserin for trating schizophrenia or for treating psychosis secondary to neurodegenerative disorders or depressive disorder
US20220323429A1 (en) 2019-08-15 2022-10-13 Acadia Pharmaceuticals Inc. Pimavanserin for treating neurodegenerative diseases
EP4069863A4 (en) * 2019-12-05 2024-02-28 Fresenius Kabi USA, LLC METHOD FOR ANALYZING DEGARELIX AND RELATED PRODUCTS
US11648242B2 (en) * 2019-12-12 2023-05-16 Aurobindo Pharma Ltd Pharmaceutical composition comprising pimavanserin, process of preparation and use thereof
WO2022094230A1 (en) 2020-11-02 2022-05-05 Acadia Pharmaceuticals Inc. Compounds for treating psychosis or depression
WO2023128900A1 (en) * 2021-12-30 2023-07-06 Pharmactive Ilac Sanayi Ve Ticaret A.S. Pharmaceutical compositions comprising pimavanserin as active ingredient and relevant excipients
CN117074579B (zh) * 2023-10-16 2023-12-22 江苏东科康德药业有限公司 一种氨磺必利口服溶液有关物质的分析方法

Citations (7)

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JPS63211227A (ja) * 1986-11-28 1988-09-02 グラクソ、グループ、リミテッド 医薬
WO2004064738A2 (en) * 2003-01-16 2004-08-05 Acadia Pharmaceuticals Inc. Selective serotonin 2a/2c receptor inverse agonists as therapeutics for neurodegenerative diseases
WO2005013987A1 (en) * 2003-07-31 2005-02-17 Sandoz Ag Fexofenadine composition and process for preparing
WO2005094793A1 (en) * 2004-03-29 2005-10-13 Krka, Tovarna Zdravil, D.D., Novo Mesto Process for preparing a solid pharmaceutical composition
WO2005112927A1 (en) * 2004-05-21 2005-12-01 Acadia Pharmaceuticals Inc. Selective serotonin receptor inverse agonists as therapeutics for disease
WO2006037043A1 (en) * 2004-09-27 2006-04-06 Acadia Pharmaceuticals Inc. Synthesis of n-(4-fluorobenzyl)-n-(1-methylpiperidin-4-yl)-n'-(4-(2-methylpropyloxy)phenylmethyl)carbamide and its tartrate salt and crystalline forms
WO2006045512A1 (en) * 2004-10-19 2006-05-04 Krka, Tovarna Zdravil Solid pharmaceutical composition comprising donepezil hydrochloride

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US6419956B1 (en) * 1999-12-30 2002-07-16 Ancile Pharmaceuticals Odor-masking coating for a pharmaceutical preparation
SG133606A1 (en) * 2003-12-22 2007-07-30 Acadia Pharm Inc Amino substituted diaryl [a,d] cycloheptene analogs as muscarinic agonists and methods of treatment of neuropsychiatric disorders
MXPA06012059A (es) * 2004-04-22 2007-01-25 Boehringer Ingelheim Int Nuevas composiciones farmaceuticas para el tratamiento de los trastornos sexuales ii.
US7820695B2 (en) * 2004-05-21 2010-10-26 Acadia Pharmaceuticals, Inc. Selective serotonin receptor inverse agonists as therapeutics for disease

Patent Citations (8)

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JPS63211227A (ja) * 1986-11-28 1988-09-02 グラクソ、グループ、リミテッド 医薬
WO2004064738A2 (en) * 2003-01-16 2004-08-05 Acadia Pharmaceuticals Inc. Selective serotonin 2a/2c receptor inverse agonists as therapeutics for neurodegenerative diseases
WO2005013987A1 (en) * 2003-07-31 2005-02-17 Sandoz Ag Fexofenadine composition and process for preparing
WO2005094793A1 (en) * 2004-03-29 2005-10-13 Krka, Tovarna Zdravil, D.D., Novo Mesto Process for preparing a solid pharmaceutical composition
WO2005112927A1 (en) * 2004-05-21 2005-12-01 Acadia Pharmaceuticals Inc. Selective serotonin receptor inverse agonists as therapeutics for disease
WO2006037043A1 (en) * 2004-09-27 2006-04-06 Acadia Pharmaceuticals Inc. Synthesis of n-(4-fluorobenzyl)-n-(1-methylpiperidin-4-yl)-n'-(4-(2-methylpropyloxy)phenylmethyl)carbamide and its tartrate salt and crystalline forms
WO2006036874A1 (en) * 2004-09-27 2006-04-06 Acadia Pharmaceuticals Inc. Salts of n-(4-fluorobenzyl)-n-(1-methylpiperidin-4-yl)-n'-(4-(2-methylpropyloxy)phenylmethyl)carbamide and their preparation
WO2006045512A1 (en) * 2004-10-19 2006-05-04 Krka, Tovarna Zdravil Solid pharmaceutical composition comprising donepezil hydrochloride

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2015512919A (ja) * 2012-04-11 2015-04-30 兆科薬業（合肥）有限公司Ｚｈａｏｋｅ Ｐｈａｒｍａｃｅｕｔｉｃａｌ（Ｈｅｆｅｉ） Ｃｏｍｐａｎｙ Ｌｉｍｉｔｅｄ 塩酸レルカニジピンおよびロサルタンカリウム配合剤およびその調製法
JP2015537013A (ja) * 2012-11-19 2015-12-24 アサンタ・アー／エス 速崩性錠剤

Also Published As

Publication number Publication date
CA2652300A1 (en) 2007-11-22
WO2007133802A2 (en) 2007-11-22
EP2037918A2 (en) 2009-03-25
WO2007133802A3 (en) 2008-01-24
US20070264330A1 (en) 2007-11-15

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