JP2009537507A - アテローム性動脈硬化症に対して保護的な自己抗体を誘導するＩＬ−１α免疫法 - Google Patents

アテローム性動脈硬化症に対して保護的な自己抗体を誘導するＩＬ−１α免疫法 Download PDF

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JP2009537507A
JP2009537507A JP2009510567A JP2009510567A JP2009537507A JP 2009537507 A JP2009537507 A JP 2009537507A JP 2009510567 A JP2009510567 A JP 2009510567A JP 2009510567 A JP2009510567 A JP 2009510567A JP 2009537507 A JP2009537507 A JP 2009537507A
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ジョン シマード
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エクスバイオテク インコーポレーティッド
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K39/00—Medicinal preparations containing antigens or antibodies
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    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/20—Interleukins [IL]
    • A61K38/2006—IL-1
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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    • C07—ORGANIC CHEMISTRY
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    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
    • C07K16/245—IL-1
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
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    • A—HUMAN NECESSITIES
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    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
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    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6031—Proteins
    • A61K2039/6075—Viral proteins

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  • Gastroenterology & Hepatology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Compositions Of Oxide Ceramics (AREA)
JP2009510567A 2006-05-15 2007-05-15 アテローム性動脈硬化症に対して保護的な自己抗体を誘導するＩＬ−１α免疫法 Pending JP2009537507A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US80002906P 2006-05-15 2006-05-15
PCT/IB2007/001264 WO2007132338A2 (en) 2006-05-15 2007-05-15 IL-1α IMMUNIZATION INDUCES AUTOANTIBODIES PROTECTIVE AGAINST ATHEROSCLEROSIS

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JP2009537507A true JP2009537507A (ja) 2009-10-29
JP2009537507A5 JP2009537507A5 (https=) 2010-07-01

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JP2009510567A Pending JP2009537507A (ja) 2006-05-15 2007-05-15 アテローム性動脈硬化症に対して保護的な自己抗体を誘導するＩＬ−１α免疫法

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US (1) US20090191149A1 (https=)
EP (1) EP2021033B1 (https=)
JP (1) JP2009537507A (https=)
CN (1) CN101448528A (https=)
AT (1) ATE551365T1 (https=)
AU (1) AU2007251239B2 (https=)
CA (1) CA2652274A1 (https=)
ES (1) ES2384278T3 (https=)
WO (1) WO2007132338A2 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2015019617A (ja) * 2013-07-19 2015-02-02 国立大学法人三重大学 閉塞性動脈硬化症モデル動物、るい痩研究用モデル動物、及び全身性アミロイドーシスモデル動物としての非ヒト哺乳動物

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2617637C (en) * 2005-08-02 2017-07-18 Xbiotech Inc. Diagnosis, treatment, and prevention of vascular disorders using il-1.alpha. autoantibodies
US20110008282A1 (en) * 2006-05-15 2011-01-13 Xbiotech, Inc. IL-1alpha immunization induces autoantibodies protective against atherosclerosis
US20100040574A1 (en) * 2006-05-22 2010-02-18 Xbiotech Inc. TREATMENT OF CANCER WITH ANTI-IL-1alpha ANTIBODIES
EP2285409B1 (en) 2008-05-30 2016-04-20 XBiotech, Inc Il-1 alpha antibodies
CA2737056C (en) * 2008-09-12 2018-10-30 Xbiotech Inc. Targeting pathogenic monocytes
EP2569640A1 (en) 2010-05-12 2013-03-20 The University of Birmingham Biomarker
EP2582391B1 (en) 2010-06-18 2018-10-03 XBiotech, Inc Arthritis treatment
KR101910760B1 (ko) 2010-08-23 2018-10-22 엑스바이오테크, 인크. 종양성 질병들에 대한 치료
US9724409B2 (en) 2011-04-01 2017-08-08 Xbiotech, Inc. Treatment of inflammatory skin disease
CN108404127B (zh) 2011-09-23 2025-12-12 埃克斯生物科技公司 恶病质治疗
US9545441B2 (en) 2012-09-18 2017-01-17 Xbiotech, Inc. Treatment of diabetes
CN105175503A (zh) * 2015-09-08 2015-12-23 苏州普罗达生物科技有限公司 因子viii抑制多肽及其应用
CN105175504A (zh) * 2015-09-08 2015-12-23 苏州普罗达生物科技有限公司 血管性血友病因子抑制多肽及其应用
EP3582813A4 (en) 2017-02-16 2020-12-30 XBiotech, Inc TREATMENT OF SUPPURATIVE HIDRADENITIS
US10975146B2 (en) 2018-06-29 2021-04-13 Cedars-Sinai Medical Center Interleukin-1 inhibition for combination treatment of pancreatic cancer
CA3095740A1 (en) 2020-10-07 2022-04-07 Xbiotech Inc. True human antibody specific for interleukin alpha (il-1a)
CA3095679A1 (en) 2020-10-07 2022-04-07 Xbiotech Inc. True human antibody specific for interleuken 1 alpha (il-1a)
CA3095675A1 (en) 2020-10-07 2022-04-07 Xbiotech Inc. True human antibody specific for interleukin 1 alpha (il-1a)
CA3095676A1 (en) 2020-10-07 2022-04-07 Xbiotech Inc. True human antibody specific for interleukin 1 alpha (il-1a)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004100987A2 (en) * 2003-05-06 2004-11-25 Regeneron Pharmaceuticals, Inc. Methods of using il-1 antagonists to treat neointimal hyperplasia
JP2009503529A (ja) * 2005-08-02 2009-01-29 エクスバイオテク インコーポレーティッド ＩＬ−１α自己抗体を用いた血管障害の診断、処置、および予防
JP2009510025A (ja) * 2005-09-28 2009-03-12 サイトス バイオテクノロジー アーゲー インターロイキン−１コンジュゲート及びその使用

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE9802402D0 (sv) * 1998-07-03 1998-07-03 Karolinska Innovations Ab Method of diagnosing cardiovascular disease and early atherosclerosis
US6555579B2 (en) * 1998-08-13 2003-04-29 The Wistar Institute Methods for reducing atherosclerotic plaques
US20030040617A9 (en) * 1999-03-12 2003-02-27 Rosen Craig A. Nucleic acids, proteins and antibodies
US20030232054A1 (en) * 2000-01-25 2003-12-18 Tang Y. Tom Novel nucleic acids and polypeptides
US20030026806A1 (en) * 2000-10-27 2003-02-06 Amgen Inc. Antibodies and other selective IL-1 binding agents that allow binding to IL-1 receptor but not activation thereof
HN2004000285A (es) * 2003-08-04 2006-04-27 Pfizer Prod Inc ANTICUERPOS DIRIGIDOS A c-MET
EP2285409B1 (en) * 2008-05-30 2016-04-20 XBiotech, Inc Il-1 alpha antibodies
CA2737056C (en) * 2008-09-12 2018-10-30 Xbiotech Inc. Targeting pathogenic monocytes

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004100987A2 (en) * 2003-05-06 2004-11-25 Regeneron Pharmaceuticals, Inc. Methods of using il-1 antagonists to treat neointimal hyperplasia
JP2009503529A (ja) * 2005-08-02 2009-01-29 エクスバイオテク インコーポレーティッド ＩＬ−１α自己抗体を用いた血管障害の診断、処置、および予防
JP2009510025A (ja) * 2005-09-28 2009-03-12 サイトス バイオテクノロジー アーゲー インターロイキン−１コンジュゲート及びその使用

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
JPN5008011508; Ｄａｒｄｉｋ　Ａ，　ｅｔ　ａｌ．: 'Ｓｈｅａｒ　ｓｔｒｅｓｓ-ｓｔｉｍｕｌａｔｅｄ　ｅｎｄｏｔｈｅｌｉａｌ　ｃｅｌｌｓ　ｉｎｄｕｃｅ　ｓｍｏｏｔｈ　ｍｕｓｃｌｅ　ｃｅｌｌ　ｃｈｅｍｏｔａｘｉｓ　ｖｉａ　ｐｌａｔｅｌｅｔ-ｄｅｒｉｖｅｄ' Ｊｏｕｒｎａｌ　ｏｆ　Ｖａｓｃｕｌａｒ　Ｓｕｒｇｅｒｙ Ｖｏｌ．　４１，　Ｎｏ．　２, 200502, ｐ．　３２１-３３１ *
JPN5008011515; Ｇａｒｒｏｎｅ　Ｐ，　ｅｔ　ａｌ．: 'Ｇｅｎｅｒａｔｉｏｎ　ａｎｄ　ｃｈａｒａｃｔｅｒｉｚａｔｉｏｎ　ｏｆ　ａ　ｈｕｍａｎ　ｍｏｎｏｃｌｏｎａｌ　ａｕｔｏａｎｔｉｂｏｄｙ　ｔｈａｔ　ａｃｔｓ　ａｓ　ａ　ｈｉｇｈ　ａｆｆｉｎｉｔｙ　ｉｎｔｅ' Ｍｏｌｅｃｕｌａｒ　Ｉｍｍｕｎｏｌｏｇｙ Ｖｏｌ．　３３，　Ｎｏ．　７-８, 199605, ｐ．　６４９-６５８ *
JPN6012002566; Ｊｏｕｒｎａｌ　ｏｆ　Ｉｍｍｕｎｏｌｏｇｉｃａｌ　Ｍｅｔｈｏｄｓ Ｖｏｌ．２３６，Ｎｏ．１-２, 2000, ｐ１-８ *
JPN6012028876; Ｃａｒｄｉｏｖａｓｃｕｌａｒ　Ｒｅｓｅａｒｃｈ Ｖｏｌ．６６, 2005, ｐ．５８３-５９３ *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2015019617A (ja) * 2013-07-19 2015-02-02 国立大学法人三重大学 閉塞性動脈硬化症モデル動物、るい痩研究用モデル動物、及び全身性アミロイドーシスモデル動物としての非ヒト哺乳動物

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AU2007251239A1 (en) 2007-11-22
ES2384278T3 (es) 2012-07-03
WO2007132338A3 (en) 2008-06-12
EP2021033B1 (en) 2012-03-28
CA2652274A1 (en) 2007-11-22
US20090191149A1 (en) 2009-07-30
EP2021033A2 (en) 2009-02-11
EP2021033A4 (en) 2010-02-24
WO2007132338A2 (en) 2007-11-22
ATE551365T1 (de) 2012-04-15
CN101448528A (zh) 2009-06-03
AU2007251239B2 (en) 2013-08-22

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