JP2009537176A5 - - Google Patents
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- JP2009537176A5 JP2009537176A5 JP2009512060A JP2009512060A JP2009537176A5 JP 2009537176 A5 JP2009537176 A5 JP 2009537176A5 JP 2009512060 A JP2009512060 A JP 2009512060A JP 2009512060 A JP2009512060 A JP 2009512060A JP 2009537176 A5 JP2009537176 A5 JP 2009537176A5
- Authority
- JP
- Japan
- Prior art keywords
- antigen
- cells
- subpopulation
- antibody
- cell
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 239000000427 antigen Substances 0.000 claims 41
- 102000036639 antigens Human genes 0.000 claims 41
- 108091007433 antigens Proteins 0.000 claims 41
- 238000000034 method Methods 0.000 claims 39
- 210000003719 b-lymphocyte Anatomy 0.000 claims 24
- 210000004027 cell Anatomy 0.000 claims 11
- 210000000628 antibody-producing cell Anatomy 0.000 claims 10
- 230000006698 induction Effects 0.000 claims 6
- 230000001629 suppression Effects 0.000 claims 6
- 239000011159 matrix material Substances 0.000 claims 5
- 239000007787 solid Substances 0.000 claims 5
- 240000004808 Saccharomyces cerevisiae Species 0.000 claims 3
- 239000011324 bead Substances 0.000 claims 3
- 241000282414 Homo sapiens Species 0.000 claims 2
- 241000283973 Oryctolagus cuniculus Species 0.000 claims 2
- 210000001744 T-lymphocyte Anatomy 0.000 claims 2
- 230000008484 agonism Effects 0.000 claims 2
- 230000008485 antagonism Effects 0.000 claims 2
- 230000008236 biological pathway Effects 0.000 claims 2
- 210000002798 bone marrow cell Anatomy 0.000 claims 2
- 230000006037 cell lysis Effects 0.000 claims 2
- 210000001165 lymph node Anatomy 0.000 claims 2
- 239000002609 medium Substances 0.000 claims 2
- 102000039446 nucleic acids Human genes 0.000 claims 2
- 108020004707 nucleic acids Proteins 0.000 claims 2
- 150000007523 nucleic acids Chemical class 0.000 claims 2
- 210000003819 peripheral blood mononuclear cell Anatomy 0.000 claims 2
- 230000035755 proliferation Effects 0.000 claims 2
- 210000000952 spleen Anatomy 0.000 claims 2
- 241000894006 Bacteria Species 0.000 claims 1
- 241000700199 Cavia porcellus Species 0.000 claims 1
- 102000006395 Globulins Human genes 0.000 claims 1
- 108010044091 Globulins Proteins 0.000 claims 1
- 241000238631 Hexapoda Species 0.000 claims 1
- 241000124008 Mammalia Species 0.000 claims 1
- 241000699666 Mus <mouse, genus> Species 0.000 claims 1
- 241000235648 Pichia Species 0.000 claims 1
- 241000700159 Rattus Species 0.000 claims 1
- 241000283984 Rodentia Species 0.000 claims 1
- 238000001261 affinity purification Methods 0.000 claims 1
- 239000003636 conditioned culture medium Substances 0.000 claims 1
- 230000001143 conditioned effect Effects 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 239000012634 fragment Substances 0.000 claims 1
- 210000004962 mammalian cell Anatomy 0.000 claims 1
- 229920001184 polypeptide Polymers 0.000 claims 1
- 102000004196 processed proteins & peptides Human genes 0.000 claims 1
- 108090000765 processed proteins & peptides Proteins 0.000 claims 1
- 238000012163 sequencing technique Methods 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US80141206P | 2006-05-19 | 2006-05-19 | |
| US60/801,412 | 2006-05-19 | ||
| PCT/US2007/011980 WO2008045140A1 (en) | 2006-05-19 | 2007-05-21 | Culture method for obtaining a clonal population of antigen-specific b cells |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009537176A JP2009537176A (ja) | 2009-10-29 |
| JP2009537176A5 true JP2009537176A5 (https=) | 2010-07-08 |
| JP5607357B2 JP5607357B2 (ja) | 2014-10-15 |
Family
ID=39283142
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009512060A Expired - Fee Related JP5607357B2 (ja) | 2006-05-19 | 2007-05-21 | 抗原特異的ｂ細胞のクローン集団を獲得するための培養方法 |
Country Status (12)
| Country | Link |
|---|---|
| US (3) | US20070269868A1 (https=) |
| EP (1) | EP2021463B1 (https=) |
| JP (1) | JP5607357B2 (https=) |
| CN (1) | CN101600793B (https=) |
| AU (1) | AU2007307324B2 (https=) |
| CA (1) | CA2652392C (https=) |
| DK (1) | DK2021463T3 (https=) |
| IL (1) | IL195285A (https=) |
| MX (1) | MX2008014692A (https=) |
| NO (1) | NO20084835L (https=) |
| NZ (1) | NZ572807A (https=) |
| WO (1) | WO2008045140A1 (https=) |
Families Citing this family (68)
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| DK2164514T3 (en) | 2007-05-21 | 2017-02-27 | Alderbio Holdings Llc | Antibodies to IL-6 and its use |
| US8404235B2 (en) | 2007-05-21 | 2013-03-26 | Alderbio Holdings Llc | Antagonists of IL-6 to raise albumin and/or lower CRP |
| US9701747B2 (en) | 2007-05-21 | 2017-07-11 | Alderbio Holdings Llc | Method of improving patient survivability and quality of life by anti-IL-6 antibody administration |
| US8062864B2 (en) | 2007-05-21 | 2011-11-22 | Alderbio Holdings Llc | Nucleic acids encoding antibodies to IL-6, and recombinant production of anti-IL-6 antibodies |
| US8178101B2 (en) | 2007-05-21 | 2012-05-15 | Alderbio Holdings Inc. | Use of anti-IL-6 antibodies having specific binding properties to treat cachexia |
| US7906117B2 (en) | 2007-05-21 | 2011-03-15 | Alderbio Holdings Llc | Antagonists of IL-6 to prevent or treat cachexia, weakness, fatigue, and/or fever |
| US8252286B2 (en) | 2007-05-21 | 2012-08-28 | Alderbio Holdings Llc | Antagonists of IL-6 to prevent or treat thrombosis |
| US9212223B2 (en) | 2008-11-25 | 2015-12-15 | Alderbio Holdings Llc | Antagonists of IL-6 to prevent or treat thrombosis |
| US9452227B2 (en) | 2008-11-25 | 2016-09-27 | Alderbio Holdings Llc | Methods of treating or diagnosing conditions associated with elevated IL-6 using anti-IL-6 antibodies or fragments |
| US8420089B2 (en) | 2008-11-25 | 2013-04-16 | Alderbio Holdings Llc | Antagonists of IL-6 to raise albumin and/or lower CRP |
| US8323649B2 (en) | 2008-11-25 | 2012-12-04 | Alderbio Holdings Llc | Antibodies to IL-6 and use thereof |
| US8992920B2 (en) | 2008-11-25 | 2015-03-31 | Alderbio Holdings Llc | Anti-IL-6 antibodies for the treatment of arthritis |
| KR20110112307A (ko) * | 2008-11-25 | 2011-10-12 | 앨더 바이오파마슈티컬즈, 인코포레이티드 | 알부민을 상승시키고 및／또는 ｃｒｐ를 낮추는 ｉｌ６의 길항제 |
| US8337847B2 (en) | 2008-11-25 | 2012-12-25 | Alderbio Holdings Llc | Methods of treating anemia using anti-IL-6 antibodies |
| US9079942B2 (en) * | 2009-02-09 | 2015-07-14 | Epitomics, Inc. | CDR-anchored amplification method |
| US20100317539A1 (en) * | 2009-06-12 | 2010-12-16 | Guo-Liang Yu | Library of Engineered-Antibody Producing Cells |
| KR101790802B1 (ko) | 2009-09-03 | 2017-10-27 | 머크 샤프 앤드 돔 코포레이션 | 항-ｇｉｔｒ 항체 |
| US8293483B2 (en) | 2009-09-11 | 2012-10-23 | Epitomics, Inc. | Method for identifying lineage-related antibodies |
| CN102740888B (zh) | 2009-11-24 | 2016-10-12 | 奥尔德生物制药公司 | Il-6抗体及其用途 |
| US9775921B2 (en) | 2009-11-24 | 2017-10-03 | Alderbio Holdings Llc | Subcutaneously administrable composition containing anti-IL-6 antibody |
| TWI667257B (zh) | 2010-03-30 | 2019-08-01 | 中外製藥股份有限公司 | 促進抗原消失之具有經修飾的ＦｃＲｎ親和力之抗體 |
| SI2400298T1 (sl) | 2010-05-28 | 2013-11-29 | F. Hoffmann-La Roche Ag | Postopek kultivacije posamezne B-celice in izdelava specifičnih protiteles |
| CA2818813C (en) | 2010-11-23 | 2020-10-06 | Alder Biopharmaceuticals, Inc. | Anti-il-6 antibodies for the treatment of oral mucositis |
| EP2646468B1 (en) | 2010-12-01 | 2018-07-25 | AlderBio Holdings LLC | Anti-ngf compositions and use thereof |
| JP5963746B2 (ja) | 2011-03-30 | 2016-08-03 | 国立大学法人富山大学 | 形質細胞または形質芽細胞の選択方法、目的抗原特異的な抗体の製造方法、新規モノクローナル抗体 |
| TWI705825B (zh) | 2011-05-20 | 2020-10-01 | 美商艾爾德生物控股有限責任公司 | 抗降血鈣素基因相關胜肽（ａｎｔｉ－ｃｇｒｐ）或抗降血鈣素基因相關胜肽受器（ａｎｔｉ－ｃｇｒｐ－ｒ）抗體或抗體片段治療或預防慢性及急性型腹瀉之用途 |
| PE20141787A1 (es) | 2011-05-20 | 2014-12-07 | Alderbio Holdings Llc | Composiciones anti-cgrp y uso de las mismas |
| CN107827982B (zh) | 2011-05-20 | 2021-07-06 | H.伦德贝克公司 | 抗cgrp抗体和抗体片段用于在有需要的受试者中预防或抑制畏光或厌光的用途 |
| EP2724157B1 (en) * | 2011-06-27 | 2017-03-08 | Valneva | Method for screening cells |
| CN109254143A (zh) * | 2011-09-28 | 2019-01-22 | 艾瑞普特公司 | 使用Arm-PCR和高通量测序鉴定抗原特异的适应性免疫应答 |
| ES2617488T3 (es) | 2011-11-23 | 2017-06-19 | F. Hoffmann-La Roche Ag | Células de mamífero que expresan CD40L y su uso |
| EP2794652B1 (en) | 2011-12-21 | 2017-11-15 | F. Hoffmann-La Roche AG | Rapid method for cloning and expression of cognate antibody variable region gene segments |
| EP2727943A1 (en) | 2012-11-05 | 2014-05-07 | MAB Discovery GmbH | Trispecific antibodies against human EGFR, HER2 and HER3 |
| EP2727941A1 (en) | 2012-11-05 | 2014-05-07 | MAB Discovery GmbH | Method for the production of multispecific antibodies |
| EP2727942A1 (en) | 2012-11-05 | 2014-05-07 | MAB Discovery GmbH | Bispecific antibodies against human EGFR, HER2, and HER3 |
| EP2914629A1 (en) | 2012-11-05 | 2015-09-09 | MAB Discovery GmbH | Method for the production of multispecific antibodies |
| CN104903349B (zh) | 2012-11-08 | 2018-10-19 | 十一生物治疗股份有限公司 | Il-6拮抗剂及其应用 |
| MX2015005862A (es) * | 2012-11-13 | 2015-09-10 | Genentech Inc | Enriquecimiento de plasmablastos especificos de antigeno. |
| JP2016506974A (ja) * | 2013-02-15 | 2016-03-07 | エスバテック − ア ノバルティスカンパニー エルエルシー | Ｃｄｒグラフトのためのアクセプターフレームワーク |
| WO2014153166A2 (en) * | 2013-03-14 | 2014-09-25 | Alder Biopharmaceuticals, Inc. | Therapeutic use of antibodies to hgf |
| US20160033504A1 (en) * | 2013-03-15 | 2016-02-04 | Alder Biopharmaceuticals, Inc. | Protocol for identifying and isolating antigen-specific b cells and producing antibodies to desired antigens |
| TWI670279B (zh) | 2013-03-15 | 2019-09-01 | Alder Biopharmaceuticals, Inc. | 抗體純化及純度監測 |
| CA2905180C (en) | 2013-03-15 | 2023-03-07 | Alder Biopharmaceuticals, Inc. | Temperature shift for high yield expression of polypeptides in yeast and other transformed cells |
| US20160075766A1 (en) | 2013-05-21 | 2016-03-17 | Roche Diagnostics Operations, Inc. | Method for producing antibodies using ovine b-cells and uses thereof |
| CN104232577B (zh) * | 2013-06-20 | 2017-12-01 | 中国人民解放军军事医学科学院基础医学研究所 | 一种获得自身反应性b细胞的方法 |
| IL243355B2 (en) | 2013-07-03 | 2024-10-01 | Lundbeck Seattle Biopharmaceuticals Inc | Regulation of glucose metabolism using anti-cgrp antibodies |
| JP6594438B2 (ja) | 2014-11-07 | 2019-10-23 | セセン バイオ， インコーポレイテッド | 改善されたｉｌ−６抗体 |
| EP4691556A3 (en) | 2014-12-19 | 2026-04-29 | H. Lundbeck A/S | Humanized anti-acth antibodies and use thereof |
| WO2016149137A1 (en) * | 2015-03-18 | 2016-09-22 | Epitomics, Inc. | High throughput monoclonal antibody generation by b cell panning and proliferation |
| US11174317B2 (en) | 2015-06-04 | 2021-11-16 | National Center Of Neurology And Psychiatry | Therapeutic agent for mental illness comprising IL-6 inhibitor as active ingredient |
| JP7114460B2 (ja) | 2015-06-26 | 2022-08-08 | サノフィ・バイオテクノロジー | モノクローナル抗ＩＬ－１ＲＡｃＰ抗体 |
| CN108718522A (zh) | 2016-02-23 | 2018-10-30 | 赛森生物股份有限公司 | Il-6拮抗剂制剂及其用途 |
| CN108884442B (zh) | 2016-03-30 | 2023-06-02 | 豪夫迈·罗氏有限公司 | B细胞培养方法 |
| KR102444717B1 (ko) | 2016-04-15 | 2022-09-16 | 하. 룬드벡 아크티에셀스카브 | 인간화 항-pacap 항체 및 그의 용도 |
| EP3241845A1 (en) | 2016-05-06 | 2017-11-08 | MAB Discovery GmbH | Humanized anti-il-1r3 antibodies |
| CN106350485B (zh) * | 2016-08-24 | 2020-02-21 | 杭州百凌生物科技有限公司 | 一种快速高效分离单个抗原特异性b细胞的方法 |
| EP3562936B1 (en) | 2017-01-02 | 2024-05-22 | F. Hoffmann-La Roche AG | B-cell cultivation method |
| EP3401332A1 (en) | 2017-05-08 | 2018-11-14 | MAB Discovery GmbH | Anti-il-1r3 antibodies for use in inflammatory conditions |
| CN110621773B (zh) | 2017-05-19 | 2023-06-09 | 豪夫迈·罗氏有限公司 | 用于产生胸腺细胞上清液的方法 |
| US11125757B2 (en) * | 2017-05-26 | 2021-09-21 | Emory University | Methods of culturing and characterizing antibody secreting cells |
| WO2019105864A1 (en) | 2017-11-30 | 2019-06-06 | F. Hoffmann-La Roche Ag | B-cell cultivation method |
| JP2021525070A (ja) * | 2018-05-18 | 2021-09-24 | チャン ザッカーバーグ バイオハブ， インコーポレイテッド | ヒト由来のアレルゲン特異的抗体を単離する方法およびその使用 |
| WO2021014389A1 (en) | 2019-07-24 | 2021-01-28 | H. Lundbeck A/S | Anti-mglur5 antibodies and uses thereof |
| JP2023106635A (ja) | 2020-04-17 | 2023-08-02 | 中外製薬株式会社 | 二重特異性抗原結合分子ならびに、それに関連する組成物、組成物の製造のための使用、キット、および方法 |
| JPWO2022004620A1 (https=) * | 2020-06-29 | 2022-01-06 | ||
| EP4305190A4 (en) | 2021-03-11 | 2025-03-26 | Iggenix, Inc. | METHODS AND SYSTEMS FOR PREDICTING AN ALLERGIC REACTION |
| WO2022241415A1 (en) * | 2021-05-11 | 2022-11-17 | Yale University | Methods for monoclonal antibody generation |
| AR130550A1 (es) | 2022-09-21 | 2024-12-18 | Sanofi Biotechnology | Anticuerpo anti-il-1r3 humanizado y métodos de uso |
Family Cites Families (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6657103B1 (en) * | 1990-01-12 | 2003-12-02 | Abgenix, Inc. | Human antibodies derived from immunized xenomice |
| AU7796291A (en) * | 1990-05-04 | 1991-11-27 | Baxter Diagnostics Inc. | High affinity antibodies to small peptides |
| CA2090126C (en) | 1990-08-02 | 2002-10-22 | John W. Schrader | Methods for the production of proteins with a desired function |
| DK0488470T3 (da) * | 1990-11-26 | 1997-12-22 | Akzo Nobel Nv | Fremgangsmåde til fremstilling af antistoffer |
| US6277969B1 (en) * | 1991-03-18 | 2001-08-21 | New York University | Anti-TNF antibodies and peptides of human tumor necrosis factor |
| US5256542A (en) * | 1992-03-09 | 1993-10-26 | Tanox Biosystems, Inc. | Selecting low frequency antigen-specific single B lymphocytes with correction for background noise |
| US6972125B2 (en) * | 1999-02-12 | 2005-12-06 | Genetics Institute, Llc | Humanized immunoglobulin reactive with B7-2 and methods of treatment therewith |
| PT2308888T (pt) * | 2001-11-14 | 2017-05-03 | Janssen Biotech Inc | Anticorpos anti-il-6, composições, métodos e utilizações |
| US20040185040A1 (en) * | 2001-11-21 | 2004-09-23 | Celltech R & D Limited | Modulating immune responses |
| US8188231B2 (en) * | 2002-09-27 | 2012-05-29 | Xencor, Inc. | Optimized FC variants |
| ES2374068T3 (es) | 2002-12-03 | 2012-02-13 | Ucb Pharma, S.A. | Ensayo para identificar células productoras de anticuerpos. |
| GB0312481D0 (en) | 2003-05-30 | 2003-07-09 | Celltech R&D Ltd | Antibodies |
| AU2003259718A1 (en) * | 2003-08-07 | 2005-03-07 | Epitomics, Inc. | Methods for humanizing rabbit monoclonal antibodies |
| US7771969B2 (en) | 2003-08-20 | 2010-08-10 | Celltech R&D Limited | Methods for obtaining antibodies |
| ES2385829T3 (es) | 2003-08-20 | 2012-08-01 | Ucb Pharma, S.A. | Métodos para obtener anticuerpos |
| AU2004266159A1 (en) * | 2003-08-22 | 2005-03-03 | Biogen Idec Ma Inc. | Improved antibodies having altered effector function and methods for making the same |
| US9128090B2 (en) * | 2003-08-29 | 2015-09-08 | Janssen Biotech, Inc. | Rapid way to obtain high expression clones of mammalian cells using a methylcellulose and immunoprecipitation screening method |
| CA2541651C (en) * | 2003-10-22 | 2011-05-24 | Keck Graduate Institute | Methods of synthesizing heteromultimeric polypeptides in yeast using a haploid mating strategy |
| GB0412973D0 (en) | 2004-06-10 | 2004-07-14 | Celltech R&D Ltd | Identification of antibody producing cells |
| US20060051348A1 (en) * | 2004-09-09 | 2006-03-09 | Jorn Gorlach | Method of producing a plurality of isolated antibodies to a plurality of cognate antigens |
| CN101048426A (zh) * | 2004-10-22 | 2007-10-03 | 金克克国际有限公司 | 分离人抗体 |
| US7462697B2 (en) * | 2004-11-08 | 2008-12-09 | Epitomics, Inc. | Methods for antibody engineering |
| GB0425972D0 (en) | 2004-11-25 | 2004-12-29 | Celltech R&D Ltd | Biological products |
| JO3058B1 (ar) * | 2005-04-29 | 2017-03-15 | Applied Molecular Evolution Inc | الاجسام المضادة لمضادات -اي ال-6,تركيباتها طرقها واستعمالاتها |
| US20070092943A1 (en) * | 2005-09-28 | 2007-04-26 | The University Of Chicago | Versatile vectors for expression of foreign proteins in photosynthetic bacteria |
-
2007
- 2007-05-21 EP EP07861311.4A patent/EP2021463B1/en not_active Revoked
- 2007-05-21 NZ NZ572807A patent/NZ572807A/en not_active IP Right Cessation
- 2007-05-21 DK DK07861311.4T patent/DK2021463T3/en active
- 2007-05-21 WO PCT/US2007/011980 patent/WO2008045140A1/en not_active Ceased
- 2007-05-21 JP JP2009512060A patent/JP5607357B2/ja not_active Expired - Fee Related
- 2007-05-21 CA CA2652392A patent/CA2652392C/en not_active Expired - Fee Related
- 2007-05-21 US US11/802,235 patent/US20070269868A1/en not_active Abandoned
- 2007-05-21 AU AU2007307324A patent/AU2007307324B2/en not_active Ceased
- 2007-05-21 CN CN200780027028.2A patent/CN101600793B/zh not_active Expired - Fee Related
- 2007-05-21 MX MX2008014692A patent/MX2008014692A/es active IP Right Grant
-
2008
- 2008-11-13 IL IL195285A patent/IL195285A/en active IP Right Grant
- 2008-11-18 NO NO20084835A patent/NO20084835L/no unknown
-
2011
- 2011-08-08 US US13/204,915 patent/US20120141982A1/en not_active Abandoned
-
2013
- 2013-04-12 US US13/861,518 patent/US20130316353A1/en not_active Abandoned
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