JP2009536201A5 - - Google Patents
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- Publication number
- JP2009536201A5 JP2009536201A5 JP2009509615A JP2009509615A JP2009536201A5 JP 2009536201 A5 JP2009536201 A5 JP 2009536201A5 JP 2009509615 A JP2009509615 A JP 2009509615A JP 2009509615 A JP2009509615 A JP 2009509615A JP 2009536201 A5 JP2009536201 A5 JP 2009536201A5
- Authority
- JP
- Japan
- Prior art keywords
- rage
- formulation
- fusion protein
- seq
- reconstituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 claims 39
- 238000009472 formulation Methods 0.000 claims 36
- 102000037865 fusion proteins Human genes 0.000 claims 29
- 108020001507 fusion proteins Proteins 0.000 claims 29
- 229920001184 polypeptide Polymers 0.000 claims 14
- 102000004196 processed proteins & peptides Human genes 0.000 claims 14
- 108090000765 processed proteins & peptides Proteins 0.000 claims 14
- 125000003275 alpha amino acid group Chemical group 0.000 claims 9
- 108060003951 Immunoglobulin Proteins 0.000 claims 8
- 102000018358 immunoglobulin Human genes 0.000 claims 8
- 238000000034 method Methods 0.000 claims 6
- 239000000872 buffer Substances 0.000 claims 5
- 239000003446 ligand Substances 0.000 claims 5
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims 4
- 229930006000 Sucrose Natural products 0.000 claims 4
- 239000003085 diluting agent Substances 0.000 claims 4
- 239000005720 sucrose Substances 0.000 claims 4
- HDTRYLNUVZCQOY-UHFFFAOYSA-N α-D-glucopyranosyl-α-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OC1C(O)C(O)C(O)C(CO)O1 HDTRYLNUVZCQOY-UHFFFAOYSA-N 0.000 claims 3
- 102000002110 C2 domains Human genes 0.000 claims 3
- 108050009459 C2 domains Proteins 0.000 claims 3
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims 3
- 102000006496 Immunoglobulin Heavy Chains Human genes 0.000 claims 3
- 108010019476 Immunoglobulin Heavy Chains Proteins 0.000 claims 3
- 229930195725 Mannitol Natural products 0.000 claims 3
- HDTRYLNUVZCQOY-WSWWMNSNSA-N Trehalose Natural products O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-WSWWMNSNSA-N 0.000 claims 3
- HDTRYLNUVZCQOY-LIZSDCNHSA-N alpha,alpha-trehalose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-LIZSDCNHSA-N 0.000 claims 3
- 239000002738 chelating agent Substances 0.000 claims 3
- 239000000945 filler Substances 0.000 claims 3
- 239000000594 mannitol Substances 0.000 claims 3
- 235000010355 mannitol Nutrition 0.000 claims 3
- 238000004519 manufacturing process Methods 0.000 claims 3
- 239000004094 surface-active agent Substances 0.000 claims 3
- 108010005094 Advanced Glycation End Products Proteins 0.000 claims 2
- 108020004414 DNA Proteins 0.000 claims 2
- 102000053602 DNA Human genes 0.000 claims 2
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 claims 2
- 239000004472 Lysine Substances 0.000 claims 2
- 210000004899 c-terminal region Anatomy 0.000 claims 2
- 206010012601 diabetes mellitus Diseases 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 claims 2
- 230000004054 inflammatory process Effects 0.000 claims 2
- 125000003588 lysine group Chemical group [H]N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 claims 2
- 210000000056 organ Anatomy 0.000 claims 2
- 238000002054 transplantation Methods 0.000 claims 2
- 208000024827 Alzheimer disease Diseases 0.000 claims 1
- 208000032456 Hemorrhagic Shock Diseases 0.000 claims 1
- 206010021143 Hypoxia Diseases 0.000 claims 1
- 206010061218 Inflammation Diseases 0.000 claims 1
- 208000022559 Inflammatory bowel disease Diseases 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 208000001132 Osteoporosis Diseases 0.000 claims 1
- 201000004681 Psoriasis Diseases 0.000 claims 1
- 206010061481 Renal injury Diseases 0.000 claims 1
- 206010040047 Sepsis Diseases 0.000 claims 1
- 206010049771 Shock haemorrhagic Diseases 0.000 claims 1
- 208000006011 Stroke Diseases 0.000 claims 1
- 206010002022 amyloidosis Diseases 0.000 claims 1
- 230000005784 autoimmunity Effects 0.000 claims 1
- 239000006172 buffering agent Substances 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 230000015556 catabolic process Effects 0.000 claims 1
- 210000004027 cell Anatomy 0.000 claims 1
- 238000006731 degradation reaction Methods 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000035475 disorder Diseases 0.000 claims 1
- 230000004927 fusion Effects 0.000 claims 1
- 230000007954 hypoxia Effects 0.000 claims 1
- 238000007918 intramuscular administration Methods 0.000 claims 1
- 208000037806 kidney injury Diseases 0.000 claims 1
- 239000012931 lyophilized formulation Substances 0.000 claims 1
- 230000001404 mediated effect Effects 0.000 claims 1
- 201000006417 multiple sclerosis Diseases 0.000 claims 1
- 208000010125 myocardial infarction Diseases 0.000 claims 1
- 201000008383 nephritis Diseases 0.000 claims 1
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 claims 1
- 229920000053 polysorbate 80 Polymers 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 1
- 238000007920 subcutaneous administration Methods 0.000 claims 1
- 208000024891 symptom Diseases 0.000 claims 1
- 210000001519 tissue Anatomy 0.000 claims 1
- 230000029663 wound healing Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US79845506P | 2006-05-05 | 2006-05-05 | |
| US60/798,455 | 2006-05-05 | ||
| PCT/US2007/010125 WO2007130302A2 (en) | 2006-05-05 | 2007-04-25 | Rage fusion proteins, formulations, and methods of use thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009536201A JP2009536201A (ja) | 2009-10-08 |
| JP2009536201A5 true JP2009536201A5 (cg-RX-API-DMAC7.html) | 2010-06-17 |
| JP5558810B2 JP5558810B2 (ja) | 2014-07-23 |
Family
ID=38521887
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009509615A Expired - Fee Related JP5558810B2 (ja) | 2006-05-05 | 2007-04-25 | Ｒａｇｅ融合タンパク質、製剤及びその使用方法 |
Country Status (21)
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1776459A1 (en) * | 2004-08-03 | 2007-04-25 | Transtech Pharma, Inc. | Rage fusion proteins and methods of use |
| MX2007001559A (es) * | 2004-08-03 | 2007-04-10 | Transtech Pharma Inc | Proteinas de fusion de receptor para productos finales glicados avanzados y metodos de uso. |
| WO2007073272A1 (en) * | 2005-12-23 | 2007-06-28 | Gcoder Systems Ab | Positioning pattern |
| BRPI0707640A2 (pt) * | 2006-02-09 | 2011-05-10 | Transtech Pharma Inc | proteÍnas de fusço do rage e mÉtodos de uso |
| NZ571692A (en) | 2006-05-05 | 2012-01-12 | Transtech Pharma Inc | Rage fusion proteins, formulations, and methods of use thereof |
| JP5241518B2 (ja) * | 2007-02-15 | 2013-07-17 | 国立大学法人九州大学 | 抗ｈｍｇｂ−１抗体を含む間質性肺疾患治療剤 |
| WO2008100470A2 (en) * | 2007-02-15 | 2008-08-21 | Transtech Pharma, Inc. | Rage - immunoglobulin fusion proteins |
| US20100173277A1 (en) * | 2007-02-15 | 2010-07-08 | Fukuoka University | Agent for Suppressing Rejection in Organ Transplantation Comprising Anti-HMGB-1 Antibody |
| WO2008099913A1 (ja) * | 2007-02-15 | 2008-08-21 | Kumamoto University | ヒトhmgb-1に特異的に結合する抗体を有効成分として含有する治療剤 |
| CA2690056C (en) | 2007-06-14 | 2017-08-29 | Galactica Pharmaceuticals, Inc. | Rage fusion proteins |
| KR20110139292A (ko) * | 2009-04-20 | 2011-12-28 | 화이자 인코포레이티드 | 단백질 글리코실화의 제어 및 그와 관련된 조성물 및 방법 |
| WO2011102845A1 (en) * | 2010-02-18 | 2011-08-25 | Transtech Pharma, Inc. | Rage fusion protein compositions and methods of use |
| US9345770B2 (en) | 2011-11-16 | 2016-05-24 | University of Pittsburgh—of the Commonwealth System of Higher Education | Immunogenic tumor associated stromal cell antigen peptides and methods of their use |
| PL2925338T3 (pl) * | 2012-11-28 | 2019-11-29 | Nono Inc | Liofilizowana formulacja TAT-NR2B9C |
| US10251935B2 (en) * | 2012-11-28 | 2019-04-09 | Nono Inc. | Lyophilized formulation comprising tat-NR2B9C, histidine and trehalose |
| US10191033B2 (en) | 2013-12-05 | 2019-01-29 | The Broad Institute, Inc. | Biomarkers for detecting pre-cachexia or cachexia and methods of treatment thereof |
| CN107404863B (zh) * | 2014-10-01 | 2021-04-02 | 国立研究开发法人农业·食品产业技术综合研究机构 | 使用基因修饰的家蚕生产的生物素化和氧化ldl受体和晚期糖化终末产物受体 |
| EP3822291A1 (en) | 2015-06-10 | 2021-05-19 | The Broad Institute Inc. | Antibodies, compounds and screens for identifying and treating cachexia or pre-cachexia |
| US11111296B2 (en) | 2015-12-14 | 2021-09-07 | The Broad Institute, Inc. | Compositions and methods for treating cardiac dysfunction |
| CN112699601B (zh) * | 2020-12-28 | 2022-05-31 | 电子科技大学 | 一种传感器网络数据的空时重构方法 |
| US20230246158A1 (en) * | 2022-02-02 | 2023-08-03 | Enevate Corporation | Cycle life in si/li batteries using high temperature deep discharge cycling |
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| US4867973A (en) * | 1984-08-31 | 1989-09-19 | Cytogen Corporation | Antibody-therapeutic agent conjugates |
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| EP1776459A1 (en) * | 2004-08-03 | 2007-04-25 | Transtech Pharma, Inc. | Rage fusion proteins and methods of use |
| MX2007001559A (es) * | 2004-08-03 | 2007-04-10 | Transtech Pharma Inc | Proteinas de fusion de receptor para productos finales glicados avanzados y metodos de uso. |
| JP2008537874A (ja) * | 2004-09-27 | 2008-10-02 | セントカー・インコーポレーテツド | ｓＲＡＧＥミメティボディ、組成物、方法および使用 |
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| BRPI0707640A2 (pt) * | 2006-02-09 | 2011-05-10 | Transtech Pharma Inc | proteÍnas de fusço do rage e mÉtodos de uso |
| NZ571692A (en) | 2006-05-05 | 2012-01-12 | Transtech Pharma Inc | Rage fusion proteins, formulations, and methods of use thereof |
| WO2008100470A2 (en) * | 2007-02-15 | 2008-08-21 | Transtech Pharma, Inc. | Rage - immunoglobulin fusion proteins |
-
2007
- 2007-04-25 NZ NZ571692A patent/NZ571692A/en not_active IP Right Cessation
- 2007-04-25 US US11/789,637 patent/US7981424B2/en not_active Expired - Fee Related
- 2007-04-25 CN CNA200780018207XA patent/CN101548012A/zh active Pending
- 2007-04-25 JP JP2009509615A patent/JP5558810B2/ja not_active Expired - Fee Related
- 2007-04-25 WO PCT/US2007/010125 patent/WO2007130302A2/en not_active Ceased
- 2007-04-25 EP EP11167432A patent/EP2380983A3/en not_active Withdrawn
- 2007-04-25 BR BRPI0711193-2A patent/BRPI0711193A2/pt not_active IP Right Cessation
- 2007-04-25 EA EA200870502A patent/EA017291B1/ru not_active IP Right Cessation
- 2007-04-25 CA CA002651348A patent/CA2651348A1/en not_active Abandoned
- 2007-04-25 AU AU2007248784A patent/AU2007248784B2/en not_active Ceased
- 2007-04-25 KR KR1020087029731A patent/KR20090008459A/ko not_active Withdrawn
- 2007-04-25 EP EP07794379A patent/EP2021474A2/en not_active Withdrawn
- 2007-04-25 SG SG201103296-8A patent/SG171670A1/en unknown
- 2007-04-25 MX MX2008013863A patent/MX2008013863A/es active IP Right Grant
- 2007-05-04 PE PE2007000550A patent/PE20080397A1/es not_active Application Discontinuation
- 2007-05-04 NL NL2000626A patent/NL2000626A1/nl not_active IP Right Cessation
- 2007-05-04 TW TW096115905A patent/TW200801036A/zh unknown
- 2007-05-04 DO DO2007000089A patent/DOP2007000089A/es unknown
- 2007-05-04 UY UY30324A patent/UY30324A1/es not_active Application Discontinuation
- 2007-05-04 AR ARP070101949A patent/AR060862A1/es not_active Application Discontinuation
-
2008
- 2008-10-02 IL IL194482A patent/IL194482A0/en unknown
- 2008-11-03 ZA ZA200809394A patent/ZA200809394B/xx unknown
-
2011
- 2011-06-13 US US13/158,748 patent/US8344120B2/en not_active Expired - Fee Related
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