JP2009535419A5 - - Google Patents

Info

Publication number

JP2009535419A5

JP2009535419A5 JP2009509989A JP2009509989A JP2009535419A5 JP 2009535419 A5 JP2009535419 A5 JP 2009535419A5 JP 2009509989 A JP2009509989 A JP 2009509989A JP 2009509989 A JP2009509989 A JP 2009509989A JP 2009535419 A5 JP2009535419 A5 JP 2009535419A5

Authority

JP

Japan

Prior art keywords

therapeutic agent

agent according

day

crofelemer

ibs

Prior art date

2007-04-30

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

• Espacenet
• Global Dossier
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• 239000003814 drug Substances 0.000 claims 16
• 229940124597 therapeutic agent Drugs 0.000 claims 16
• 208000002551 irritable bowel syndrome Diseases 0.000 claims 7
• 229920001393 Crofelemer Polymers 0.000 claims 6
• 229940047615 crofelemer Drugs 0.000 claims 6
• ADNPLDHMAVUMIW-CUZNLEPHSA-N substance P Chemical compound C([C@@H](C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(N)=O)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CCCCN)NC(=O)[C@H]1N(CCC1)C(=O)[C@@H](N)CCCN=C(N)N)C1=CC=CC=C1 ADNPLDHMAVUMIW-CUZNLEPHSA-N 0.000 claims 6
• 239000000203 mixture Substances 0.000 claims 5
• 241000894007 species Species 0.000 claims 5
• JPFCOVZKLAXXOE-XBNSMERZSA-N (3r)-2-(3,5-dihydroxy-4-methoxyphenyl)-8-[(2r,3r,4r)-3,5,7-trihydroxy-2-(4-hydroxyphenyl)-3,4-dihydro-2h-chromen-4-yl]-3,4-dihydro-2h-chromene-3,5,7-triol Chemical compound C1=C(O)C(OC)=C(O)C=C1C1[C@H](O)CC(C(O)=CC(O)=C2[C@H]3C4=C(O)C=C(O)C=C4O[C@@H]([C@@H]3O)C=3C=CC(O)=CC=3)=C2O1 JPFCOVZKLAXXOE-XBNSMERZSA-N 0.000 claims 4
• 229920001991 Proanthocyanidin Polymers 0.000 claims 4
• 241001246270 Calophyllum Species 0.000 claims 3
• 206010010774 Constipation Diseases 0.000 claims 3
• XMOCLSLCDHWDHP-IUODEOHRSA-N epi-Gallocatechin Chemical compound C1([C@H]2OC3=CC(O)=CC(O)=C3C[C@H]2O)=CC(O)=C(O)C(O)=C1 XMOCLSLCDHWDHP-IUODEOHRSA-N 0.000 claims 3
• 208000024891 symptom Diseases 0.000 claims 3
• 206010012735 Diarrhoea Diseases 0.000 claims 2
• XMOCLSLCDHWDHP-UHFFFAOYSA-N L-Epigallocatechin Natural products OC1CC2=C(O)C=C(O)C=C2OC1C1=CC(O)=C(O)C(O)=C1 XMOCLSLCDHWDHP-UHFFFAOYSA-N 0.000 claims 2
• DZYNKLUGCOSVKS-UHFFFAOYSA-N epigallocatechin Natural products OC1Cc2cc(O)cc(O)c2OC1c3cc(O)c(O)c(O)c3 DZYNKLUGCOSVKS-UHFFFAOYSA-N 0.000 claims 2
• 239000004816 latex Substances 0.000 claims 2
• 229920000126 latex Polymers 0.000 claims 2
• 238000006116 polymerization reaction Methods 0.000 claims 2
• XMOCLSLCDHWDHP-SWLSCSKDSA-N (+)-Epigallocatechin Natural products C1([C@H]2OC3=CC(O)=CC(O)=C3C[C@@H]2O)=CC(O)=C(O)C(O)=C1 XMOCLSLCDHWDHP-SWLSCSKDSA-N 0.000 claims 1
• PFTAWBLQPZVEMU-DZGCQCFKSA-N (+)-catechin Chemical compound C1([C@H]2OC3=CC(O)=CC(O)=C3C[C@@H]2O)=CC=C(O)C(O)=C1 PFTAWBLQPZVEMU-DZGCQCFKSA-N 0.000 claims 1
• PFTAWBLQPZVEMU-ZFWWWQNUSA-N (+)-epicatechin Natural products C1([C@@H]2OC3=CC(O)=CC(O)=C3C[C@@H]2O)=CC=C(O)C(O)=C1 PFTAWBLQPZVEMU-ZFWWWQNUSA-N 0.000 claims 1
• PFTAWBLQPZVEMU-UKRRQHHQSA-N (-)-epicatechin Chemical compound C1([C@H]2OC3=CC(O)=CC(O)=C3C[C@H]2O)=CC=C(O)C(O)=C1 PFTAWBLQPZVEMU-UKRRQHHQSA-N 0.000 claims 1
• 206010000059 abdominal discomfort Diseases 0.000 claims 1
• ADRVNXBAWSRFAJ-UHFFFAOYSA-N catechin Natural products OC1Cc2cc(O)cc(O)c2OC1c3ccc(O)c(O)c3 ADRVNXBAWSRFAJ-UHFFFAOYSA-N 0.000 claims 1
• 235000005487 catechin Nutrition 0.000 claims 1
• 229950001002 cianidanol Drugs 0.000 claims 1
• 230000013872 defecation Effects 0.000 claims 1
• LPTRNLNOHUVQMS-UHFFFAOYSA-N epicatechin Natural products Cc1cc(O)cc2OC(C(O)Cc12)c1ccc(O)c(O)c1 LPTRNLNOHUVQMS-UHFFFAOYSA-N 0.000 claims 1
• 235000012734 epicatechin Nutrition 0.000 claims 1
• 239000000178 monomer Substances 0.000 claims 1
• 229920000642 polymer Polymers 0.000 claims 1