JP2009535342A5 - - Google Patents
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- Publication number
- JP2009535342A5 JP2009535342A5 JP2009507810A JP2009507810A JP2009535342A5 JP 2009535342 A5 JP2009535342 A5 JP 2009535342A5 JP 2009507810 A JP2009507810 A JP 2009507810A JP 2009507810 A JP2009507810 A JP 2009507810A JP 2009535342 A5 JP2009535342 A5 JP 2009535342A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- effective amount
- vasoconstrictor
- active agent
- osmotically active
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000013543 active substance Substances 0.000 claims description 36
- 239000000203 mixture Substances 0.000 claims description 32
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 30
- CNIIGCLFLJGOGP-UHFFFAOYSA-N 2-(1-naphthalenylmethyl)-4,5-dihydro-1H-imidazole Chemical group C=1C=CC2=CC=CC=C2C=1CC1=NCCN1 CNIIGCLFLJGOGP-UHFFFAOYSA-N 0.000 claims description 26
- 239000005526 vasoconstrictor agent Substances 0.000 claims description 24
- 239000002357 osmotic agent Substances 0.000 claims description 19
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 16
- 239000011780 sodium chloride Substances 0.000 claims description 15
- 229960005016 naphazoline Drugs 0.000 claims description 13
- WYWIFABBXFUGLM-UHFFFAOYSA-N oxymetazoline Chemical compound CC1=CC(C(C)(C)C)=C(O)C(C)=C1CC1=NCCN1 WYWIFABBXFUGLM-UHFFFAOYSA-N 0.000 claims description 12
- 235000011187 glycerol Nutrition 0.000 claims description 8
- 230000002016 colloidosmotic effect Effects 0.000 claims description 7
- QJYNZEYHSMRWBK-NIKIMHBISA-N 1,2,3,4,6-pentakis-O-galloyl-beta-D-glucose Chemical compound OC1=C(O)C(O)=CC(C(=O)OC[C@@H]2[C@H]([C@H](OC(=O)C=3C=C(O)C(O)=C(O)C=3)[C@@H](OC(=O)C=3C=C(O)C(O)=C(O)C=3)[C@H](OC(=O)C=3C=C(O)C(O)=C(O)C=3)O2)OC(=O)C=2C=C(O)C(O)=C(O)C=2)=C1 QJYNZEYHSMRWBK-NIKIMHBISA-N 0.000 claims description 6
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims description 6
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims description 6
- 229930195725 Mannitol Natural products 0.000 claims description 6
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims description 6
- 229930006000 Sucrose Natural products 0.000 claims description 6
- 239000008121 dextrose Substances 0.000 claims description 6
- 239000000594 mannitol Substances 0.000 claims description 6
- 235000010355 mannitol Nutrition 0.000 claims description 6
- 229960001528 oxymetazoline Drugs 0.000 claims description 6
- 239000005720 sucrose Substances 0.000 claims description 6
- BYJAVTDNIXVSPW-UHFFFAOYSA-N tetryzoline Chemical compound N1CCN=C1C1C2=CC=CC=C2CCC1 BYJAVTDNIXVSPW-UHFFFAOYSA-N 0.000 claims description 6
- FZWBNHMXJMCXLU-UHFFFAOYSA-N 2,3,4,5-tetrahydroxy-6-[3,4,5-trihydroxy-6-[[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxymethyl]oxan-2-yl]oxyhexanal Chemical compound OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OCC(O)C(O)C(O)C(O)C=O)O1 FZWBNHMXJMCXLU-UHFFFAOYSA-N 0.000 claims description 5
- 102000009027 Albumins Human genes 0.000 claims description 5
- 108010088751 Albumins Proteins 0.000 claims description 5
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims description 5
- 229920001612 Hydroxyethyl starch Polymers 0.000 claims description 5
- 229920000168 Microcrystalline cellulose Polymers 0.000 claims description 5
- 229920002123 Pentastarch Polymers 0.000 claims description 5
- 229940119744 dextran 40 Drugs 0.000 claims description 5
- 229940119743 dextran 70 Drugs 0.000 claims description 5
- 229940027278 hetastarch Drugs 0.000 claims description 5
- FZWBNHMXJMCXLU-BLAUPYHCSA-N isomaltotriose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)[C@@H](OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C=O)O1 FZWBNHMXJMCXLU-BLAUPYHCSA-N 0.000 claims description 5
- 235000019813 microcrystalline cellulose Nutrition 0.000 claims description 5
- 239000008108 microcrystalline cellulose Substances 0.000 claims description 5
- 229940016286 microcrystalline cellulose Drugs 0.000 claims description 5
- 229940101738 pentastarch Drugs 0.000 claims description 5
- 239000000600 sorbitol Substances 0.000 claims description 5
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 claims description 4
- 239000003795 chemical substances by application Substances 0.000 claims description 4
- 210000000744 eyelid Anatomy 0.000 claims description 4
- 230000008961 swelling Effects 0.000 claims description 4
- 241000167854 Bourreria succulenta Species 0.000 claims description 3
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 claims description 3
- 241000196324 Embryophyta Species 0.000 claims description 3
- 241000208680 Hamamelis mollis Species 0.000 claims description 3
- 240000007049 Juglans regia Species 0.000 claims description 3
- 235000009496 Juglans regia Nutrition 0.000 claims description 3
- 244000305267 Quercus macrolepis Species 0.000 claims description 3
- 229940050528 albumin Drugs 0.000 claims description 3
- 229940037003 alum Drugs 0.000 claims description 3
- 239000003212 astringent agent Substances 0.000 claims description 3
- 235000019693 cherries Nutrition 0.000 claims description 3
- 125000004387 flavanoid group Chemical group 0.000 claims description 3
- 229960001802 phenylephrine Drugs 0.000 claims description 3
- SONNWYBIRXJNDC-VIFPVBQESA-N phenylephrine Chemical compound CNC[C@H](O)C1=CC=CC(O)=C1 SONNWYBIRXJNDC-VIFPVBQESA-N 0.000 claims description 3
- 229910000367 silver sulfate Inorganic materials 0.000 claims description 3
- YPNVIBVEFVRZPJ-UHFFFAOYSA-L silver sulfate Chemical compound [Ag+].[Ag+].[O-]S([O-])(=O)=O YPNVIBVEFVRZPJ-UHFFFAOYSA-L 0.000 claims description 3
- 239000001648 tannin Substances 0.000 claims description 3
- 229920001864 tannin Polymers 0.000 claims description 3
- 235000018553 tannin Nutrition 0.000 claims description 3
- 229960000337 tetryzoline Drugs 0.000 claims description 3
- 235000020234 walnut Nutrition 0.000 claims description 3
- 229940118846 witch hazel Drugs 0.000 claims description 3
- NWONKYPBYAMBJT-UHFFFAOYSA-L zinc sulfate Chemical compound [Zn+2].[O-]S([O-])(=O)=O NWONKYPBYAMBJT-UHFFFAOYSA-L 0.000 claims description 3
- 229910000368 zinc sulfate Inorganic materials 0.000 claims description 3
- 229960001763 zinc sulfate Drugs 0.000 claims description 3
- 239000003937 drug carrier Substances 0.000 claims description 2
- 239000008194 pharmaceutical composition Substances 0.000 claims description 2
- 230000002265 prevention Effects 0.000 claims description 2
- 239000012049 topical pharmaceutical composition Substances 0.000 claims description 2
- 230000002792 vascular Effects 0.000 claims 1
- 238000000034 method Methods 0.000 description 16
- 210000004204 blood vessel Anatomy 0.000 description 2
- 230000003204 osmotic effect Effects 0.000 description 2
- 206010035664 Pneumonia Diseases 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US79498306P | 2006-04-26 | 2006-04-26 | |
| US84547906P | 2006-09-18 | 2006-09-18 | |
| PCT/US2007/010177 WO2007127333A2 (en) | 2006-04-26 | 2007-04-26 | Compositions for the treatment and prevention of eyelid swelling |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2009535342A JP2009535342A (ja) | 2009-10-01 |
| JP2009535342A5 true JP2009535342A5 (enExample) | 2011-06-16 |
Family
ID=38656195
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009507810A Pending JP2009535342A (ja) | 2006-04-26 | 2007-04-26 | 眼瞼腫脹の予防および処置のための組成物 |
Country Status (7)
| Country | Link |
|---|---|
| US (3) | US8685439B2 (enExample) |
| EP (1) | EP2015733A2 (enExample) |
| JP (1) | JP2009535342A (enExample) |
| AU (1) | AU2007243334A1 (enExample) |
| CA (1) | CA2650592A1 (enExample) |
| MX (1) | MX2008013783A (enExample) |
| WO (1) | WO2007127333A2 (enExample) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2650592A1 (en) * | 2006-04-26 | 2007-11-08 | Aciex, Inc. | Compositions for the treatment and prevention of eyelid swelling |
| MX2010005012A (es) * | 2007-11-08 | 2010-06-23 | Aciex Therapeutics Inc | Composiciones para el tratamieno y prevencion de inflamacion de los parpados que comprenden un ingrediente osmoticamente activo y un vasocosntrictor. |
| WO2009074853A2 (en) * | 2007-12-10 | 2009-06-18 | Promed Research Centre | Ophthalmic composition comprising phenylephrine |
| US8778999B2 (en) | 2009-03-05 | 2014-07-15 | Insite Vision Incorporated | Non-steroidal anti-inflammatory ophthalmic compositions |
| KR101769294B1 (ko) | 2009-08-26 | 2017-08-18 | 마리 케이 인코포레이티드 | 식물 추출물을 포함하는 국소 피부 케어 제형 |
| US20120225918A1 (en) | 2011-03-03 | 2012-09-06 | Voom, Llc | Compositions and Methods for Non-Surgical Treatment of Ptosis |
| WO2013052770A1 (en) | 2011-10-05 | 2013-04-11 | Sanders Jennifer L | Methods and compositions for treating foot or hand pain |
| US20150044136A1 (en) * | 2013-08-12 | 2015-02-12 | George H. Scherr | Ophthalmological treatment for michobial infections |
| US9874379B2 (en) * | 2014-07-09 | 2018-01-23 | Hamilton Sundstrand Corporation | Expendable driven heat pump cycles |
| US9820954B2 (en) | 2015-08-19 | 2017-11-21 | Jenivision Inc. | Quantitative peri-orbital application of ophthalmology drugs |
| JP2019509330A (ja) | 2016-01-26 | 2019-04-04 | レベーション ファーマ リミテッド | アルファアドレナリン作動薬の組成物および使用 |
| MX2021000186A (es) * | 2018-07-12 | 2021-03-25 | Ocusoft Inc | Composiciones oculares antialergenicas y toallitas limpiadoras de parpados. |
| US11077150B2 (en) * | 2018-10-09 | 2021-08-03 | Massoumeh Kharazmi | Methods and compositions for treatment of eye conditions |
| US10799481B1 (en) | 2019-05-06 | 2020-10-13 | Rvl Pharmaceuticals, Inc. | Compositions and methods for treating ocular disorders |
| WO2021108426A1 (en) * | 2019-11-26 | 2021-06-03 | Standard Of Care Corporation | Hyaluronidase compositions and methods of using same to treat peri-orbital hollowness and tear through deformities |
| WO2022055796A1 (en) * | 2020-09-11 | 2022-03-17 | Intratus-Nevada, Inc. | Compositions and methods for treating presbyopia, hyperopia, astigmatism, decreased stereopsis, and decreased contrast sensitivity |
| CN120112299A (zh) | 2022-09-29 | 2025-06-06 | 爱多拉动物健康公司 | 用于治疗疼痛和其他医学病症的硫酸化糖胺聚糖及其衍生片段的储存稳定的制剂 |
Family Cites Families (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2618428A (en) * | 1947-01-27 | 1952-11-18 | John K M Harrison | Shock resistant container |
| JPS6056684B2 (ja) | 1977-11-07 | 1985-12-11 | 東興薬品工業株式会社 | 点眼剤 |
| US4271143A (en) * | 1978-01-25 | 1981-06-02 | Alcon Laboratories, Inc. | Sustained release ophthalmic drug dosage |
| US4407792A (en) * | 1979-05-09 | 1983-10-04 | Alcon Laboratories, Inc. | Sustained release ophthalmic drug dosage |
| LU83173A1 (fr) * | 1981-02-27 | 1981-06-05 | Oreal | Nouvelles compositions cosmetiques pour le traitement des cheveux et de la peau contenant une poudre resultant de la pulverisation d'au moins une plante et un agent de cohesion |
| US4407791A (en) * | 1981-09-28 | 1983-10-04 | Alcon Laboratories, Inc. | Ophthalmic solutions |
| US4454151A (en) * | 1982-03-22 | 1984-06-12 | Syntex (U.S.A.) Inc. | Use of pyrrolo pyrroles in treatment of ophthalmic diseases |
| DE3486448T2 (de) * | 1983-11-14 | 1997-10-09 | Columbia Lab Inc | Bioadhäsive Mittel |
| US5188826A (en) | 1988-02-08 | 1993-02-23 | Insite Vision Incorporated | Topical ophthalmic suspensions |
| US4960799A (en) * | 1988-09-13 | 1990-10-02 | Ciba-Geigy Corporation | Stabilized aqueous solutions of pharmaceutically acceptable salts of ortho-(2,6-dichlorophenyl)-aminophenylacetic acid for opthalmic use |
| IT1248014B (it) | 1991-06-07 | 1995-01-05 | Inverni Della Beffa Spa | Preparazioni oftalmiche a rilascio protratto |
| JP3781792B2 (ja) * | 1993-12-27 | 2006-05-31 | 千寿製薬株式会社 | ジフルプレドナート含有点眼用懸濁液剤 |
| AU684115B2 (en) * | 1993-12-27 | 1997-12-04 | Mitsubishi Chemical Corporation | Ophthalmic suspension containing diflupredonate |
| US5811446A (en) * | 1997-04-18 | 1998-09-22 | Cytos Pharmaceuticals Llc | Prophylactic and therapeutic methods for ocular degenerative diseases and inflammations and histidine compositions therefor |
| EP0903151A1 (en) * | 1997-09-22 | 1999-03-24 | ASTA Medica Aktiengesellschaft | Use of combinations comprising non-sedating antihistamines and alpha-adrenergic drugs for the topical treatment of rhinitis/conjunctivitis and cold, cold-like and/or flu symptoms |
| US7691829B2 (en) * | 1998-03-24 | 2010-04-06 | Petito George D | Composition and method for healing tissues |
| US6274626B1 (en) | 1998-12-22 | 2001-08-14 | Bausch & Lomb Incorporated | Pheniramine-containing compositions and method for treating allergic responses |
| ES2216515T3 (es) * | 1999-06-08 | 2004-10-16 | Naturveda | Composicion no solida para aplicacion local que comprende glicerol y un extracto de alchemilla vulgaris. |
| ATE232099T1 (de) * | 1999-06-22 | 2003-02-15 | Boehringer Ingelheim Int | Stabile xylometazolin- und oxymetazolinlösung |
| JP2001187728A (ja) | 1999-12-28 | 2001-07-10 | Lion Corp | 眼科用組成物 |
| DE10000612A1 (de) | 2000-01-10 | 2001-07-19 | Min Becker | Flüssigkeitspräparate für Augen- und Nasen-Tropfen bzw. Nasenspray ohne Konservierungsmittel |
| WO2001054684A1 (en) * | 2000-01-26 | 2001-08-02 | Kyorin Pharmaceutical Co., Ltd. | Eye drops |
| CA2423354C (en) * | 2000-09-20 | 2009-12-15 | Lee Shahinian Jr. | Self-preserved nasal, inhalable, and topical ophthalmic preparations and medications |
| JP2002308775A (ja) | 2001-04-06 | 2002-10-23 | Rohto Pharmaceut Co Ltd | 外用組成物 |
| US6806364B2 (en) * | 2002-07-29 | 2004-10-19 | Ast Products, Inc. | Ophthalmic compositions |
| JP2004123729A (ja) | 2002-09-09 | 2004-04-22 | Santen Pharmaceut Co Ltd | ラタノプロストを有効成分とする澄明な点眼液 |
| AU2003272517A1 (en) * | 2002-09-13 | 2004-04-30 | Zicam, Llc. | Compositions to reduce congestion and methods for application thereof to the nasal membrane |
| US20050059639A1 (en) * | 2003-09-11 | 2005-03-17 | Wei Edward T. | Ophthalmic compositions and method for treating eye discomfort and pain |
| US7288263B2 (en) | 2004-09-13 | 2007-10-30 | Evera Laboratories, Llc | Compositions and methods for treatment of skin discoloration |
| MX344036B (es) | 2004-11-24 | 2016-12-02 | Meda Pharmaceuticals Inc | Composiciones que comprenden azelastina y metodos de uso de la misma. |
| JP2006232792A (ja) | 2005-02-21 | 2006-09-07 | Aile De Beaute:Kk | 肌老化改善化粧料 |
| DK2004196T3 (en) | 2006-03-31 | 2016-09-05 | Vistakon Pharmaceuticals Llc | Ocular allergy treatments |
| CA2650592A1 (en) | 2006-04-26 | 2007-11-08 | Aciex, Inc. | Compositions for the treatment and prevention of eyelid swelling |
-
2007
- 2007-04-26 CA CA002650592A patent/CA2650592A1/en not_active Abandoned
- 2007-04-26 WO PCT/US2007/010177 patent/WO2007127333A2/en not_active Ceased
- 2007-04-26 EP EP07776298A patent/EP2015733A2/en not_active Withdrawn
- 2007-04-26 MX MX2008013783A patent/MX2008013783A/es not_active Application Discontinuation
- 2007-04-26 JP JP2009507810A patent/JP2009535342A/ja active Pending
- 2007-04-26 AU AU2007243334A patent/AU2007243334A1/en not_active Abandoned
- 2007-04-26 US US11/796,278 patent/US8685439B2/en active Active
-
2011
- 2011-09-21 US US13/238,891 patent/US20120021072A1/en not_active Abandoned
-
2014
- 2014-02-12 US US14/178,846 patent/US20140161903A1/en not_active Abandoned
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