JP2009535342A5 - - Google Patents
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- Publication number
- JP2009535342A5 JP2009535342A5 JP2009507810A JP2009507810A JP2009535342A5 JP 2009535342 A5 JP2009535342 A5 JP 2009535342A5 JP 2009507810 A JP2009507810 A JP 2009507810A JP 2009507810 A JP2009507810 A JP 2009507810A JP 2009535342 A5 JP2009535342 A5 JP 2009535342A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- effective amount
- vasoconstrictor
- active agent
- osmotically active
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000013543 active substance Substances 0.000 claims description 36
- 239000000203 mixture Substances 0.000 claims description 32
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 30
- CNIIGCLFLJGOGP-UHFFFAOYSA-N 2-(1-naphthalenylmethyl)-4,5-dihydro-1H-imidazole Chemical group C=1C=CC2=CC=CC=C2C=1CC1=NCCN1 CNIIGCLFLJGOGP-UHFFFAOYSA-N 0.000 claims description 26
- 239000005526 vasoconstrictor agent Substances 0.000 claims description 24
- 239000002357 osmotic agent Substances 0.000 claims description 19
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 16
- 239000011780 sodium chloride Substances 0.000 claims description 15
- 229960005016 naphazoline Drugs 0.000 claims description 13
- WYWIFABBXFUGLM-UHFFFAOYSA-N oxymetazoline Chemical compound CC1=CC(C(C)(C)C)=C(O)C(C)=C1CC1=NCCN1 WYWIFABBXFUGLM-UHFFFAOYSA-N 0.000 claims description 12
- 235000011187 glycerol Nutrition 0.000 claims description 8
- 230000002016 colloidosmotic effect Effects 0.000 claims description 7
- QJYNZEYHSMRWBK-NIKIMHBISA-N 1,2,3,4,6-pentakis-O-galloyl-beta-D-glucose Chemical compound OC1=C(O)C(O)=CC(C(=O)OC[C@@H]2[C@H]([C@H](OC(=O)C=3C=C(O)C(O)=C(O)C=3)[C@@H](OC(=O)C=3C=C(O)C(O)=C(O)C=3)[C@H](OC(=O)C=3C=C(O)C(O)=C(O)C=3)O2)OC(=O)C=2C=C(O)C(O)=C(O)C=2)=C1 QJYNZEYHSMRWBK-NIKIMHBISA-N 0.000 claims description 6
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims description 6
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims description 6
- 229930195725 Mannitol Natural products 0.000 claims description 6
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims description 6
- 229930006000 Sucrose Natural products 0.000 claims description 6
- 239000008121 dextrose Substances 0.000 claims description 6
- 239000000594 mannitol Substances 0.000 claims description 6
- 235000010355 mannitol Nutrition 0.000 claims description 6
- 229960001528 oxymetazoline Drugs 0.000 claims description 6
- 239000005720 sucrose Substances 0.000 claims description 6
- BYJAVTDNIXVSPW-UHFFFAOYSA-N tetryzoline Chemical compound N1CCN=C1C1C2=CC=CC=C2CCC1 BYJAVTDNIXVSPW-UHFFFAOYSA-N 0.000 claims description 6
- FZWBNHMXJMCXLU-UHFFFAOYSA-N 2,3,4,5-tetrahydroxy-6-[3,4,5-trihydroxy-6-[[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxymethyl]oxan-2-yl]oxyhexanal Chemical compound OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OCC(O)C(O)C(O)C(O)C=O)O1 FZWBNHMXJMCXLU-UHFFFAOYSA-N 0.000 claims description 5
- 102000009027 Albumins Human genes 0.000 claims description 5
- 108010088751 Albumins Proteins 0.000 claims description 5
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims description 5
- 229920001612 Hydroxyethyl starch Polymers 0.000 claims description 5
- 229920000168 Microcrystalline cellulose Polymers 0.000 claims description 5
- 229920002123 Pentastarch Polymers 0.000 claims description 5
- 229940119744 dextran 40 Drugs 0.000 claims description 5
- 229940119743 dextran 70 Drugs 0.000 claims description 5
- 229940027278 hetastarch Drugs 0.000 claims description 5
- FZWBNHMXJMCXLU-BLAUPYHCSA-N isomaltotriose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)[C@@H](OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C=O)O1 FZWBNHMXJMCXLU-BLAUPYHCSA-N 0.000 claims description 5
- 235000019813 microcrystalline cellulose Nutrition 0.000 claims description 5
- 239000008108 microcrystalline cellulose Substances 0.000 claims description 5
- 229940016286 microcrystalline cellulose Drugs 0.000 claims description 5
- 229940101738 pentastarch Drugs 0.000 claims description 5
- 239000000600 sorbitol Substances 0.000 claims description 5
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 claims description 4
- 239000003795 chemical substances by application Substances 0.000 claims description 4
- 210000000744 eyelid Anatomy 0.000 claims description 4
- 230000008961 swelling Effects 0.000 claims description 4
- 241000167854 Bourreria succulenta Species 0.000 claims description 3
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 claims description 3
- 241000196324 Embryophyta Species 0.000 claims description 3
- 241000208680 Hamamelis mollis Species 0.000 claims description 3
- 240000007049 Juglans regia Species 0.000 claims description 3
- 235000009496 Juglans regia Nutrition 0.000 claims description 3
- 244000305267 Quercus macrolepis Species 0.000 claims description 3
- 229940050528 albumin Drugs 0.000 claims description 3
- 229940037003 alum Drugs 0.000 claims description 3
- 239000003212 astringent agent Substances 0.000 claims description 3
- 235000019693 cherries Nutrition 0.000 claims description 3
- 125000004387 flavanoid group Chemical group 0.000 claims description 3
- 229960001802 phenylephrine Drugs 0.000 claims description 3
- SONNWYBIRXJNDC-VIFPVBQESA-N phenylephrine Chemical compound CNC[C@H](O)C1=CC=CC(O)=C1 SONNWYBIRXJNDC-VIFPVBQESA-N 0.000 claims description 3
- 229910000367 silver sulfate Inorganic materials 0.000 claims description 3
- YPNVIBVEFVRZPJ-UHFFFAOYSA-L silver sulfate Chemical compound [Ag+].[Ag+].[O-]S([O-])(=O)=O YPNVIBVEFVRZPJ-UHFFFAOYSA-L 0.000 claims description 3
- 239000001648 tannin Substances 0.000 claims description 3
- 229920001864 tannin Polymers 0.000 claims description 3
- 235000018553 tannin Nutrition 0.000 claims description 3
- 229960000337 tetryzoline Drugs 0.000 claims description 3
- 235000020234 walnut Nutrition 0.000 claims description 3
- 229940118846 witch hazel Drugs 0.000 claims description 3
- NWONKYPBYAMBJT-UHFFFAOYSA-L zinc sulfate Chemical compound [Zn+2].[O-]S([O-])(=O)=O NWONKYPBYAMBJT-UHFFFAOYSA-L 0.000 claims description 3
- 229910000368 zinc sulfate Inorganic materials 0.000 claims description 3
- 229960001763 zinc sulfate Drugs 0.000 claims description 3
- 239000003937 drug carrier Substances 0.000 claims description 2
- 239000008194 pharmaceutical composition Substances 0.000 claims description 2
- 230000002265 prevention Effects 0.000 claims description 2
- 239000012049 topical pharmaceutical composition Substances 0.000 claims description 2
- 230000002792 vascular Effects 0.000 claims 1
- 238000000034 method Methods 0.000 description 16
- 210000004204 blood vessel Anatomy 0.000 description 2
- 230000003204 osmotic effect Effects 0.000 description 2
- 206010035664 Pneumonia Diseases 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US79498306P | 2006-04-26 | 2006-04-26 | |
| US84547906P | 2006-09-18 | 2006-09-18 | |
| PCT/US2007/010177 WO2007127333A2 (en) | 2006-04-26 | 2007-04-26 | Compositions for the treatment and prevention of eyelid swelling |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2009535342A JP2009535342A (ja) | 2009-10-01 |
| JP2009535342A5 true JP2009535342A5 (enExample) | 2011-06-16 |
Family
ID=38656195
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009507810A Pending JP2009535342A (ja) | 2006-04-26 | 2007-04-26 | 眼瞼腫脹の予防および処置のための組成物 |
Country Status (7)
| Country | Link |
|---|---|
| US (3) | US8685439B2 (enExample) |
| EP (1) | EP2015733A2 (enExample) |
| JP (1) | JP2009535342A (enExample) |
| AU (1) | AU2007243334A1 (enExample) |
| CA (1) | CA2650592A1 (enExample) |
| MX (1) | MX2008013783A (enExample) |
| WO (1) | WO2007127333A2 (enExample) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007127333A2 (en) | 2006-04-26 | 2007-11-08 | Aciex, Inc. | Compositions for the treatment and prevention of eyelid swelling |
| EP2219630A2 (en) * | 2007-11-08 | 2010-08-25 | Aciex Therapeutics, Inc. | Compositions for the treatment and prevention of eyelid swelling comprising an osmotically active ingredient and a vasoconstrictor |
| RU2600863C2 (ru) * | 2007-12-10 | 2016-10-27 | Сентисс Фарма Прайвит Лимитед | Офтальмическая композиция, включающая фенилэфрин |
| US8778999B2 (en) | 2009-03-05 | 2014-07-15 | Insite Vision Incorporated | Non-steroidal anti-inflammatory ophthalmic compositions |
| MX2012002437A (es) * | 2009-08-26 | 2012-06-27 | Mary Kay Inc | Formulaciones topicas para el cuidado de la piel que comprenden extractos de plantas. |
| US20120225918A1 (en) * | 2011-03-03 | 2012-09-06 | Voom, Llc | Compositions and Methods for Non-Surgical Treatment of Ptosis |
| WO2013052770A1 (en) | 2011-10-05 | 2013-04-11 | Sanders Jennifer L | Methods and compositions for treating foot or hand pain |
| US20150044136A1 (en) * | 2013-08-12 | 2015-02-12 | George H. Scherr | Ophthalmological treatment for michobial infections |
| US9874379B2 (en) * | 2014-07-09 | 2018-01-23 | Hamilton Sundstrand Corporation | Expendable driven heat pump cycles |
| US9820954B2 (en) | 2015-08-19 | 2017-11-21 | Jenivision Inc. | Quantitative peri-orbital application of ophthalmology drugs |
| CN108883308A (zh) | 2016-01-26 | 2018-11-23 | 利维申制药有限公司 | α-肾上腺素能药剂的组合物和用途 |
| EP3820438A4 (en) * | 2018-07-12 | 2022-05-04 | Ocusoft, Inc. | ANTI-ALLERGEN EYE COMPOSITIONS AND CLEANSING WIPES FOR EYELIDS |
| US11077150B2 (en) * | 2018-10-09 | 2021-08-03 | Massoumeh Kharazmi | Methods and compositions for treatment of eye conditions |
| US10814001B1 (en) | 2019-05-06 | 2020-10-27 | Rvl Pharmaceuticals, Inc. | Oxymetazoline compositions |
| BR112022010038A2 (pt) * | 2019-11-26 | 2022-08-16 | Standard Of Care Corp | Composições de hialuronidase e métodos de uso das mesmas para tratar o encovamento periorbital e deformidades do sulco lacrimal |
| CA3185754A1 (en) * | 2020-09-11 | 2022-03-17 | Padma Nanduri | Compositions and methods for treating presbyopia, hyperopia, astigmatism, decreased stereopsis, and decreased contrast sensitivity |
| KR20250083499A (ko) | 2022-09-29 | 2025-06-10 | 아도라 애니멀 헬스 코포레이션 | 통증 및 다른 의학적 병태의 치료를 위한 황화 글리코사미노글리칸 및 이것에서 유래한 단편의 저장에 안정한 제형 |
Family Cites Families (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2618428A (en) * | 1947-01-27 | 1952-11-18 | John K M Harrison | Shock resistant container |
| JPS6056684B2 (ja) | 1977-11-07 | 1985-12-11 | 東興薬品工業株式会社 | 点眼剤 |
| US4271143A (en) * | 1978-01-25 | 1981-06-02 | Alcon Laboratories, Inc. | Sustained release ophthalmic drug dosage |
| US4407792A (en) * | 1979-05-09 | 1983-10-04 | Alcon Laboratories, Inc. | Sustained release ophthalmic drug dosage |
| LU83173A1 (fr) * | 1981-02-27 | 1981-06-05 | Oreal | Nouvelles compositions cosmetiques pour le traitement des cheveux et de la peau contenant une poudre resultant de la pulverisation d'au moins une plante et un agent de cohesion |
| US4407791A (en) * | 1981-09-28 | 1983-10-04 | Alcon Laboratories, Inc. | Ophthalmic solutions |
| US4454151A (en) * | 1982-03-22 | 1984-06-12 | Syntex (U.S.A.) Inc. | Use of pyrrolo pyrroles in treatment of ophthalmic diseases |
| DE3486448T2 (de) * | 1983-11-14 | 1997-10-09 | Columbia Lab Inc | Bioadhäsive Mittel |
| US5188826A (en) | 1988-02-08 | 1993-02-23 | Insite Vision Incorporated | Topical ophthalmic suspensions |
| US4960799A (en) * | 1988-09-13 | 1990-10-02 | Ciba-Geigy Corporation | Stabilized aqueous solutions of pharmaceutically acceptable salts of ortho-(2,6-dichlorophenyl)-aminophenylacetic acid for opthalmic use |
| IT1248014B (it) | 1991-06-07 | 1995-01-05 | Inverni Della Beffa Spa | Preparazioni oftalmiche a rilascio protratto |
| US5556848A (en) * | 1993-12-27 | 1996-09-17 | Senju Pharmaceutical Co., Ltd. | Ophthalmic suspension containing diflupredonate |
| JP3781792B2 (ja) * | 1993-12-27 | 2006-05-31 | 千寿製薬株式会社 | ジフルプレドナート含有点眼用懸濁液剤 |
| US5811446A (en) * | 1997-04-18 | 1998-09-22 | Cytos Pharmaceuticals Llc | Prophylactic and therapeutic methods for ocular degenerative diseases and inflammations and histidine compositions therefor |
| EP0903151A1 (en) * | 1997-09-22 | 1999-03-24 | ASTA Medica Aktiengesellschaft | Use of combinations comprising non-sedating antihistamines and alpha-adrenergic drugs for the topical treatment of rhinitis/conjunctivitis and cold, cold-like and/or flu symptoms |
| US7691829B2 (en) * | 1998-03-24 | 2010-04-06 | Petito George D | Composition and method for healing tissues |
| US6274626B1 (en) | 1998-12-22 | 2001-08-14 | Bausch & Lomb Incorporated | Pheniramine-containing compositions and method for treating allergic responses |
| HK1045813B (zh) * | 1999-06-08 | 2004-11-26 | Naturveda | 局部敷用的含甘油及斗篷草精華的非固體合成劑 |
| DE50001217D1 (de) * | 1999-06-22 | 2003-03-13 | Boehringer Ingelheim Int | Stabile xylometazolin- und oxymetazolinlösung |
| JP2001187728A (ja) | 1999-12-28 | 2001-07-10 | Lion Corp | 眼科用組成物 |
| DE10000612A1 (de) | 2000-01-10 | 2001-07-19 | Min Becker | Flüssigkeitspräparate für Augen- und Nasen-Tropfen bzw. Nasenspray ohne Konservierungsmittel |
| KR100784653B1 (ko) * | 2000-01-26 | 2007-12-12 | 교린 세이야꾸 가부시키 가이샤 | 점안제 |
| CA2423354C (en) * | 2000-09-20 | 2009-12-15 | Lee Shahinian Jr. | Self-preserved nasal, inhalable, and topical ophthalmic preparations and medications |
| JP2002308775A (ja) | 2001-04-06 | 2002-10-23 | Rohto Pharmaceut Co Ltd | 外用組成物 |
| US6806364B2 (en) * | 2002-07-29 | 2004-10-19 | Ast Products, Inc. | Ophthalmic compositions |
| JP2004123729A (ja) | 2002-09-09 | 2004-04-22 | Santen Pharmaceut Co Ltd | ラタノプロストを有効成分とする澄明な点眼液 |
| WO2004024187A2 (en) * | 2002-09-13 | 2004-03-25 | Zicam, Llc. | Compositions to reduce congestion and methods for application thereof to the nasal membrane |
| US20050059639A1 (en) * | 2003-09-11 | 2005-03-17 | Wei Edward T. | Ophthalmic compositions and method for treating eye discomfort and pain |
| US7288263B2 (en) | 2004-09-13 | 2007-10-30 | Evera Laboratories, Llc | Compositions and methods for treatment of skin discoloration |
| EP2522365B1 (en) | 2004-11-24 | 2016-10-26 | Meda Pharmaceuticals Inc. | Compositions comprising azelastine and methods of use thereof |
| JP2006232792A (ja) | 2005-02-21 | 2006-09-07 | Aile De Beaute:Kk | 肌老化改善化粧料 |
| PL3150209T3 (pl) | 2006-03-31 | 2020-03-31 | Vistakon Pharmaceuticals, Llc | Leczenie alergii oczu |
| WO2007127333A2 (en) | 2006-04-26 | 2007-11-08 | Aciex, Inc. | Compositions for the treatment and prevention of eyelid swelling |
-
2007
- 2007-04-26 WO PCT/US2007/010177 patent/WO2007127333A2/en not_active Ceased
- 2007-04-26 EP EP07776298A patent/EP2015733A2/en not_active Withdrawn
- 2007-04-26 CA CA002650592A patent/CA2650592A1/en not_active Abandoned
- 2007-04-26 US US11/796,278 patent/US8685439B2/en active Active
- 2007-04-26 MX MX2008013783A patent/MX2008013783A/es not_active Application Discontinuation
- 2007-04-26 JP JP2009507810A patent/JP2009535342A/ja active Pending
- 2007-04-26 AU AU2007243334A patent/AU2007243334A1/en not_active Abandoned
-
2011
- 2011-09-21 US US13/238,891 patent/US20120021072A1/en not_active Abandoned
-
2014
- 2014-02-12 US US14/178,846 patent/US20140161903A1/en not_active Abandoned
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