JP2010523714A5 - - Google Patents
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- Publication number
- JP2010523714A5 JP2010523714A5 JP2010503249A JP2010503249A JP2010523714A5 JP 2010523714 A5 JP2010523714 A5 JP 2010523714A5 JP 2010503249 A JP2010503249 A JP 2010503249A JP 2010503249 A JP2010503249 A JP 2010503249A JP 2010523714 A5 JP2010523714 A5 JP 2010523714A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- melatonin
- individual
- ketone bodies
- ketone
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000203 mixture Substances 0.000 claims description 52
- 150000002576 ketones Chemical class 0.000 claims description 28
- DRLFMBDRBRZALE-UHFFFAOYSA-N melatonin Chemical compound COC1=CC=C2NC=C(CCNC(C)=O)C2=C1 DRLFMBDRBRZALE-UHFFFAOYSA-N 0.000 claims description 28
- YJPIGAIKUZMOQA-UHFFFAOYSA-N Melatonin Natural products COC1=CC=C2N(C(C)=O)C=C(CCN)C2=C1 YJPIGAIKUZMOQA-UHFFFAOYSA-N 0.000 claims description 26
- 229960003987 melatonin Drugs 0.000 claims description 26
- 150000003839 salts Chemical class 0.000 claims description 8
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical group CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 claims description 6
- 239000007788 liquid Substances 0.000 claims description 6
- 239000002904 solvent Substances 0.000 claims description 6
- WHBMMWSBFZVSSR-GSVOUGTGSA-M (R)-3-hydroxybutyrate Chemical compound C[C@@H](O)CC([O-])=O WHBMMWSBFZVSSR-GSVOUGTGSA-M 0.000 claims description 4
- WDJHALXBUFZDSR-UHFFFAOYSA-M acetoacetate Chemical compound CC(=O)CC([O-])=O WDJHALXBUFZDSR-UHFFFAOYSA-M 0.000 claims description 4
- 150000001449 anionic compounds Chemical class 0.000 claims description 2
- 150000001875 compounds Chemical class 0.000 claims description 2
- 229910001412 inorganic anion Inorganic materials 0.000 claims description 2
- 208000028867 ischemia Diseases 0.000 claims description 2
- 239000000843 powder Substances 0.000 claims description 2
- 230000010410 reperfusion Effects 0.000 claims description 2
- 239000003381 stabilizer Substances 0.000 claims description 2
- 230000001225 therapeutic effect Effects 0.000 claims description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 2
- 239000008280 blood Substances 0.000 description 8
- 210000004369 blood Anatomy 0.000 description 8
- 101100366935 Caenorhabditis elegans sto-2 gene Proteins 0.000 description 5
- 230000037396 body weight Effects 0.000 description 4
- JVTAAEKCZFNVCJ-UHFFFAOYSA-M Lactate Chemical compound CC(O)C([O-])=O JVTAAEKCZFNVCJ-UHFFFAOYSA-M 0.000 description 3
- 230000007812 deficiency Effects 0.000 description 3
- 230000000740 bleeding effect Effects 0.000 description 1
- 230000035488 systolic blood pressure Effects 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US91146007P | 2007-04-12 | 2007-04-12 | |
| US2632108P | 2008-02-05 | 2008-02-05 | |
| PCT/US2008/060100 WO2008128095A1 (en) | 2007-04-12 | 2008-04-11 | Ischemia/reperfusion protection compositions and methods of using |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2010523714A JP2010523714A (ja) | 2010-07-15 |
| JP2010523714A5 true JP2010523714A5 (enExample) | 2012-04-26 |
Family
ID=42269849
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010503249A Pending JP2010523714A (ja) | 2007-04-12 | 2008-04-11 | 虚血／再灌流保護組成物および使用法 |
Country Status (12)
| Country | Link |
|---|---|
| US (4) | US9186340B2 (enExample) |
| EP (1) | EP2146711A4 (enExample) |
| JP (1) | JP2010523714A (enExample) |
| KR (1) | KR20100016456A (enExample) |
| CN (1) | CN101677996A (enExample) |
| AU (1) | AU2008240211A1 (enExample) |
| BR (1) | BRPI0811052A2 (enExample) |
| CA (1) | CA2684213A1 (enExample) |
| IL (1) | IL201406A0 (enExample) |
| MX (1) | MX2009011002A (enExample) |
| RU (1) | RU2459624C2 (enExample) |
| WO (1) | WO2008128095A1 (enExample) |
Families Citing this family (55)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9186340B2 (en) * | 2007-04-12 | 2015-11-17 | Regents Of The University Of Minnesota | Ischemia/reperfusion protection compositions and methods of using |
| US9393025B2 (en) * | 2010-04-08 | 2016-07-19 | The Hospital For Sick Children | Use of remote ischemic conditioning for traumatic injury |
| NL2004569C2 (en) * | 2010-04-16 | 2011-10-18 | Angteq B V | Compounds for prevention of cell injury. |
| US9532952B2 (en) | 2011-01-28 | 2017-01-03 | Physician's Seal, LLC | Controlled-release compositions of melatonin combined with sedative and/or analgesic ingredients |
| US8691275B2 (en) | 2011-01-28 | 2014-04-08 | Zx Pharma, Llc | Controlled-release melatonin compositions and related methods |
| US10531655B2 (en) | 2011-12-02 | 2020-01-14 | The Regents Of The University Of California | Reperfusion protection solution and uses thereof |
| RU2488388C1 (ru) | 2012-05-24 | 2013-07-27 | Ооо "Валента Интеллект" | Фармацевтическая композиция для профилактики и лечения психических, поведенческих, когнитивных расстройств |
| ITMI20120913A1 (it) * | 2012-05-28 | 2013-11-29 | Nicoletta Maxia | Uso della n-acetil-5-metossitriptamina o suoi analoghi per favorire il meccanismo di impianto dell' embrione, e relative composizioni e mezzi di coltura |
| UA107653U (uk) | 2012-10-01 | 2016-06-24 | Общєство С Огранічєнной Отвєтствєнностью "Валєнта-Інтєллєкт" | Композиція лікарських засобів для лікування та профілактики поведінкових, психічних та когнітивних розладів |
| EP2976073B1 (en) | 2013-03-19 | 2019-08-28 | University Of South Florida | Compositions and methods for producing elevated and sustained ketosis |
| CN104208059A (zh) * | 2014-09-05 | 2014-12-17 | 中国医学科学院北京协和医院 | 褪黑素在制备保护吸烟引起血管损伤药物中的应用 |
| US10596131B2 (en) | 2017-11-22 | 2020-03-24 | Axcess Global Sciences, Llc | Non-racemic beta-hydroxybutyrate compounds and compositions enriched with the R-enantiomer and methods of use |
| US10292952B2 (en) | 2016-03-11 | 2019-05-21 | Axcess Global Sciences, Llc | Mixed salt compositions for maintaining or restoring electrolyte balance while producing elevated and sustained ketosis |
| US10245242B1 (en) | 2017-11-22 | 2019-04-02 | Axcess Global Sciences, Llc | Non-racemic beta-hydroxybutyrate compounds and compositions enriched with the R-enantiomer and methods of use |
| US10596129B2 (en) | 2017-11-22 | 2020-03-24 | Axcess Global Sciences, Llc | Non-racemic beta-hydroxybutyrate compounds and compositions enriched with the R-enantiomer and methods of use |
| US10973792B2 (en) | 2019-02-13 | 2021-04-13 | Axcess Global Sciences, Llc | Racemic beta-hydroxybutyrate mixed salt-acid compositions and methods of use |
| US11103470B2 (en) | 2017-11-22 | 2021-08-31 | Axcess Global Sciences, Llc | Non-racemic beta-hydroxybutyrate compounds and compositions enriched with the R-enantiomer and methods of use |
| US10596130B2 (en) | 2017-12-19 | 2020-03-24 | Axcess Global Sciences, Llc | Non-racemic beta-hydroxybutyrate compounds and compositions enriched with the S-enantiomer and methods of use |
| US10245243B1 (en) | 2017-12-19 | 2019-04-02 | Axcess Global Sciences, Llc | Non-racemic beta-hydroxybutyrate compounds and compositions enriched with the S-enantiomer and methods of use |
| US10973786B2 (en) | 2016-03-11 | 2021-04-13 | Axcess Global Sciences, Llc | R-beta-hydroxybutyrate, S-beta-hydroxybutyrate, and RS-beta-hydroxybutyrate mixed salt compositions |
| US10736861B2 (en) | 2016-03-11 | 2020-08-11 | Axcess Global Sciences, Llc | Mixed salt compositions for producing elevated and sustained ketosis |
| US11185518B2 (en) | 2017-12-19 | 2021-11-30 | Axcess Global Sciences, Llc | S-beta-hydroxybutyrate compounds and compositions enriched with S-enantiomer |
| US11241403B2 (en) | 2016-03-11 | 2022-02-08 | Axcess Global Sciences, Llc | Beta-hydroxybutyrate mixed salt compositions and methods of use |
| US20170266147A1 (en) * | 2016-03-18 | 2017-09-21 | Csilla Ari D'Agostino | Methods of increasing latency of anesthetic induction using ketone supplementation |
| US20190099394A1 (en) * | 2016-03-21 | 2019-04-04 | Csilla Ari D'Agostino | Methods of improving motor function using ketone supplementation |
| US12109182B2 (en) | 2016-04-19 | 2024-10-08 | Axcess Global Sciences, Llc | Administration of R-beta-hydroxybutyrate and related compounds in humans |
| US11202769B2 (en) | 2017-11-22 | 2021-12-21 | Axcess Global Sciences, Llc | Ketone body esters of s-beta-hydroxybutyrate and/or s-1,3-butanediol for modifying metabolic function |
| US11806324B2 (en) | 2018-04-18 | 2023-11-07 | Axcess Global Sciences, Llc | Beta-hydroxybutyric acid compositions and methods for oral delivery of ketone bodies |
| US10925843B2 (en) | 2018-04-18 | 2021-02-23 | Axcess Global Sciences, Llc | Compositions and methods for keto stacking with beta-hydroxybutyrate and acetoacetate |
| EP3509580A4 (en) * | 2016-09-12 | 2020-05-13 | University of South Florida | NEUROREGENERATION IMPROVED BY KETONE |
| US10307398B2 (en) | 2016-09-20 | 2019-06-04 | Regents Of The University Of Minnesota | Resuscitation composition and methods of making and using |
| US9925164B1 (en) | 2017-01-12 | 2018-03-27 | Neuroenergy Ventures, Inc. | Glyceryl 3-hydroxybutyrates for traumatic brain injury |
| WO2018167273A1 (en) * | 2017-03-16 | 2018-09-20 | Repoceuticals Aps | Compositions for retarding the decomposition of melatonin in solution |
| WO2018187852A1 (en) * | 2017-04-12 | 2018-10-18 | Cavaleri Franco | Butyrate and beta-hydroxybutyrate compositions and methods of use thereof |
| WO2018195067A1 (en) | 2017-04-17 | 2018-10-25 | The University Of Chicago | Polymer materials for delivery of short-chain fatty acids to the intestine for applications in human health and treatment of disease |
| US10179095B2 (en) * | 2017-06-07 | 2019-01-15 | Dr. Raymond Laboratories | Autophage activating resveratrol topical composition for skin improvement and treatment |
| US12090129B2 (en) | 2017-11-22 | 2024-09-17 | Axcess Global Sciences, Llc | Non-racemic beta-hydroxybutyrate compounds and compositions enriched with the R-enantiomer and methods of use |
| US11944598B2 (en) | 2017-12-19 | 2024-04-02 | Axcess Global Sciences, Llc | Compositions containing s-beta-hydroxybutyrate or non-racemic mixtures enriched with the s-enatiomer |
| US12329734B2 (en) | 2017-12-19 | 2025-06-17 | Axcess Global Sciences, Llc | Use of S-beta-hydroxybutyrate compounds for induction and maintenance of flow |
| US11129802B2 (en) | 2018-08-27 | 2021-09-28 | Axcess Global Sciences, Llc | Compositions and methods for delivering cannabidiol and ketone bodies |
| US11419836B2 (en) | 2019-02-13 | 2022-08-23 | Axcess Global Sciences, Llc | Racemic and near racemic beta-hydroxybutyrate mixed salt-acid compositions |
| US10512615B1 (en) | 2018-08-27 | 2019-12-24 | Axcess Global Sciences, Llc | Compositions and methods for delivering cannabidiol and ketone bodies |
| US11241401B2 (en) | 2020-02-06 | 2022-02-08 | Axcess Global Sciences, Llc | Enantiomerically pure r-beta-hydroxybutyrate mixed salt-acid compositions |
| US10980772B2 (en) | 2018-08-27 | 2021-04-20 | Axcess Global Sciences, Llc | Compositions and methods for delivering tetrahydrocannabinol and ketone bodies |
| AU2018260927B1 (en) * | 2018-05-25 | 2019-02-21 | Graham Sherard Baldwin | Methods and compositions for inhibiting a noxious insult |
| JP2020125254A (ja) * | 2019-02-04 | 2020-08-20 | 株式会社協和 | 化粧料、紫外線に対する細胞保護剤、光老化防止剤 |
| US12472200B2 (en) | 2019-05-15 | 2025-11-18 | Axcess Global Sciences, Llc | Autobiotic compositions and method for promoting healthy gut microbiome |
| MX2021014546A (es) * | 2019-05-30 | 2022-01-06 | Neuroenergy Ventures Inc | Tris (beta-hidroxibutirato) de glicerilo y ataques isquemicos transitorios neuronales. |
| US11950616B2 (en) | 2019-06-21 | 2024-04-09 | Axcess Global Sciences, Llc | Non-vasoconstricting energy-promoting compositions containing ketone bodies |
| US12167993B2 (en) | 2019-06-21 | 2024-12-17 | Axcess Global Sciences, Llc | Non-vasoconstricting energy-promoting compositions containing ketone bodies |
| US11033553B2 (en) | 2019-06-21 | 2021-06-15 | Axcess Global Sciences, Llc | Non-vasoconstricting energy-promoting compositions containing ketone bodies |
| US11969430B1 (en) | 2023-03-10 | 2024-04-30 | Axcess Global Sciences, Llc | Compositions containing paraxanthine and beta-hydroxybutyrate or precursor for increasing neurological and physiological performance |
| US12186297B2 (en) | 2020-08-26 | 2025-01-07 | Axcess Global Sciences, Llc | Compositions and methods for increasing lean-to-fat mass ratio |
| EP4631364A2 (en) * | 2022-03-04 | 2025-10-15 | 2508 Biosciences LLC | Compositions and methods to promote brain health |
| CN119345192B (zh) * | 2024-11-27 | 2025-10-28 | 广西医科大学 | N-乙酰血清素在防治糖尿病中的应用 |
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-
2008
- 2008-04-11 US US12/595,586 patent/US9186340B2/en active Active
- 2008-04-11 WO PCT/US2008/060100 patent/WO2008128095A1/en not_active Ceased
- 2008-04-11 EP EP08745661A patent/EP2146711A4/en not_active Withdrawn
- 2008-04-11 US US12/082,526 patent/US8728532B2/en active Active
- 2008-04-11 CN CN200880016109A patent/CN101677996A/zh active Pending
- 2008-04-11 JP JP2010503249A patent/JP2010523714A/ja active Pending
- 2008-04-11 CA CA002684213A patent/CA2684213A1/en not_active Abandoned
- 2008-04-11 RU RU2009141713/15A patent/RU2459624C2/ru not_active IP Right Cessation
- 2008-04-11 MX MX2009011002A patent/MX2009011002A/es not_active Application Discontinuation
- 2008-04-11 BR BRPI0811052-2A2A patent/BRPI0811052A2/pt not_active IP Right Cessation
- 2008-04-11 KR KR1020097023554A patent/KR20100016456A/ko not_active Withdrawn
- 2008-04-11 AU AU2008240211A patent/AU2008240211A1/en not_active Abandoned
-
2009
- 2009-10-11 IL IL201406A patent/IL201406A0/en unknown
-
2014
- 2014-04-24 US US14/260,377 patent/US9149450B2/en active Active
-
2015
- 2015-09-23 US US14/862,416 patent/US20160008325A1/en not_active Abandoned
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