JP2010523714A5 - - Google Patents
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- Publication number
- JP2010523714A5 JP2010523714A5 JP2010503249A JP2010503249A JP2010523714A5 JP 2010523714 A5 JP2010523714 A5 JP 2010523714A5 JP 2010503249 A JP2010503249 A JP 2010503249A JP 2010503249 A JP2010503249 A JP 2010503249A JP 2010523714 A5 JP2010523714 A5 JP 2010523714A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- melatonin
- individual
- ketone bodies
- ketone
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000203 mixture Substances 0.000 claims description 52
- 150000002576 ketones Chemical class 0.000 claims description 28
- DRLFMBDRBRZALE-UHFFFAOYSA-N melatonin Chemical compound COC1=CC=C2NC=C(CCNC(C)=O)C2=C1 DRLFMBDRBRZALE-UHFFFAOYSA-N 0.000 claims description 28
- YJPIGAIKUZMOQA-UHFFFAOYSA-N Melatonin Natural products COC1=CC=C2N(C(C)=O)C=C(CCN)C2=C1 YJPIGAIKUZMOQA-UHFFFAOYSA-N 0.000 claims description 26
- 229960003987 melatonin Drugs 0.000 claims description 26
- 150000003839 salts Chemical class 0.000 claims description 8
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical group CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 claims description 6
- 239000007788 liquid Substances 0.000 claims description 6
- 239000002904 solvent Substances 0.000 claims description 6
- WHBMMWSBFZVSSR-GSVOUGTGSA-M (R)-3-hydroxybutyrate Chemical compound C[C@@H](O)CC([O-])=O WHBMMWSBFZVSSR-GSVOUGTGSA-M 0.000 claims description 4
- WDJHALXBUFZDSR-UHFFFAOYSA-M acetoacetate Chemical compound CC(=O)CC([O-])=O WDJHALXBUFZDSR-UHFFFAOYSA-M 0.000 claims description 4
- 150000001449 anionic compounds Chemical class 0.000 claims description 2
- 150000001875 compounds Chemical class 0.000 claims description 2
- 229910001412 inorganic anion Inorganic materials 0.000 claims description 2
- 208000028867 ischemia Diseases 0.000 claims description 2
- 239000000843 powder Substances 0.000 claims description 2
- 230000010410 reperfusion Effects 0.000 claims description 2
- 239000003381 stabilizer Substances 0.000 claims description 2
- 230000001225 therapeutic effect Effects 0.000 claims description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 2
- 239000008280 blood Substances 0.000 description 8
- 210000004369 blood Anatomy 0.000 description 8
- 101100366935 Caenorhabditis elegans sto-2 gene Proteins 0.000 description 5
- 230000037396 body weight Effects 0.000 description 4
- JVTAAEKCZFNVCJ-UHFFFAOYSA-M Lactate Chemical compound CC(O)C([O-])=O JVTAAEKCZFNVCJ-UHFFFAOYSA-M 0.000 description 3
- 230000007812 deficiency Effects 0.000 description 3
- 230000000740 bleeding effect Effects 0.000 description 1
- 230000035488 systolic blood pressure Effects 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US91146007P | 2007-04-12 | 2007-04-12 | |
| US2632108P | 2008-02-05 | 2008-02-05 | |
| PCT/US2008/060100 WO2008128095A1 (en) | 2007-04-12 | 2008-04-11 | Ischemia/reperfusion protection compositions and methods of using |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2010523714A JP2010523714A (ja) | 2010-07-15 |
| JP2010523714A5 true JP2010523714A5 (enExample) | 2012-04-26 |
Family
ID=42269849
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010503249A Pending JP2010523714A (ja) | 2007-04-12 | 2008-04-11 | 虚血／再灌流保護組成物および使用法 |
Country Status (12)
| Country | Link |
|---|---|
| US (4) | US9186340B2 (enExample) |
| EP (1) | EP2146711A4 (enExample) |
| JP (1) | JP2010523714A (enExample) |
| KR (1) | KR20100016456A (enExample) |
| CN (1) | CN101677996A (enExample) |
| AU (1) | AU2008240211A1 (enExample) |
| BR (1) | BRPI0811052A2 (enExample) |
| CA (1) | CA2684213A1 (enExample) |
| IL (1) | IL201406A0 (enExample) |
| MX (1) | MX2009011002A (enExample) |
| RU (1) | RU2459624C2 (enExample) |
| WO (1) | WO2008128095A1 (enExample) |
Families Citing this family (62)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2459624C2 (ru) * | 2007-04-12 | 2012-08-27 | Риджентс Оф Дзе Юниверсити Оф Миннесота | Защитные композиции от ишемии/реперфузии и способы применения |
| TWI621420B (zh) * | 2010-04-08 | 2018-04-21 | 病童醫院 | 遠距缺血處理於創傷性傷害的用途 |
| NL2004569C2 (en) * | 2010-04-16 | 2011-10-18 | Angteq B V | Compounds for prevention of cell injury. |
| WO2012103411A2 (en) | 2011-01-28 | 2012-08-02 | Zx Pharma, Llc | Controlled-release melatonin composition and related methods |
| US9532952B2 (en) | 2011-01-28 | 2017-01-03 | Physician's Seal, LLC | Controlled-release compositions of melatonin combined with sedative and/or analgesic ingredients |
| WO2013082458A1 (en) | 2011-12-02 | 2013-06-06 | The Regents Of The University Of California | Reperfusion protection solution and uses thereof |
| RU2488388C1 (ru) | 2012-05-24 | 2013-07-27 | Ооо "Валента Интеллект" | Фармацевтическая композиция для профилактики и лечения психических, поведенческих, когнитивных расстройств |
| ITMI20120913A1 (it) | 2012-05-28 | 2013-11-29 | Nicoletta Maxia | Uso della n-acetil-5-metossitriptamina o suoi analoghi per favorire il meccanismo di impianto dell' embrione, e relative composizioni e mezzi di coltura |
| UA107653U (uk) | 2012-10-01 | 2016-06-24 | Общєство С Огранічєнной Отвєтствєнностью "Валєнта-Інтєллєкт" | Композиція лікарських засобів для лікування та профілактики поведінкових, психічних та когнітивних розладів |
| MY180761A (en) | 2013-03-19 | 2020-12-08 | Univ South Florida | Compositions and methods for producing elevated and sustained ketosis |
| CN104208059A (zh) * | 2014-09-05 | 2014-12-17 | 中国医学科学院北京协和医院 | 褪黑素在制备保护吸烟引起血管损伤药物中的应用 |
| US11103470B2 (en) | 2017-11-22 | 2021-08-31 | Axcess Global Sciences, Llc | Non-racemic beta-hydroxybutyrate compounds and compositions enriched with the R-enantiomer and methods of use |
| US11241403B2 (en) | 2016-03-11 | 2022-02-08 | Axcess Global Sciences, Llc | Beta-hydroxybutyrate mixed salt compositions and methods of use |
| US10245242B1 (en) | 2017-11-22 | 2019-04-02 | Axcess Global Sciences, Llc | Non-racemic beta-hydroxybutyrate compounds and compositions enriched with the R-enantiomer and methods of use |
| US10245243B1 (en) | 2017-12-19 | 2019-04-02 | Axcess Global Sciences, Llc | Non-racemic beta-hydroxybutyrate compounds and compositions enriched with the S-enantiomer and methods of use |
| US10973792B2 (en) | 2019-02-13 | 2021-04-13 | Axcess Global Sciences, Llc | Racemic beta-hydroxybutyrate mixed salt-acid compositions and methods of use |
| US11185518B2 (en) | 2017-12-19 | 2021-11-30 | Axcess Global Sciences, Llc | S-beta-hydroxybutyrate compounds and compositions enriched with S-enantiomer |
| US10596129B2 (en) | 2017-11-22 | 2020-03-24 | Axcess Global Sciences, Llc | Non-racemic beta-hydroxybutyrate compounds and compositions enriched with the R-enantiomer and methods of use |
| US10292952B2 (en) | 2016-03-11 | 2019-05-21 | Axcess Global Sciences, Llc | Mixed salt compositions for maintaining or restoring electrolyte balance while producing elevated and sustained ketosis |
| US10596130B2 (en) | 2017-12-19 | 2020-03-24 | Axcess Global Sciences, Llc | Non-racemic beta-hydroxybutyrate compounds and compositions enriched with the S-enantiomer and methods of use |
| US10736861B2 (en) | 2016-03-11 | 2020-08-11 | Axcess Global Sciences, Llc | Mixed salt compositions for producing elevated and sustained ketosis |
| US10973786B2 (en) | 2016-03-11 | 2021-04-13 | Axcess Global Sciences, Llc | R-beta-hydroxybutyrate, S-beta-hydroxybutyrate, and RS-beta-hydroxybutyrate mixed salt compositions |
| US10596131B2 (en) | 2017-11-22 | 2020-03-24 | Axcess Global Sciences, Llc | Non-racemic beta-hydroxybutyrate compounds and compositions enriched with the R-enantiomer and methods of use |
| US20170266147A1 (en) * | 2016-03-18 | 2017-09-21 | Csilla Ari D'Agostino | Methods of increasing latency of anesthetic induction using ketone supplementation |
| AU2017238103A1 (en) * | 2016-03-21 | 2018-11-22 | University Of South Florida | Methods of improving motor function using ketone supplementation |
| US12109182B2 (en) | 2016-04-19 | 2024-10-08 | Axcess Global Sciences, Llc | Administration of R-beta-hydroxybutyrate and related compounds in humans |
| US11202769B2 (en) | 2017-11-22 | 2021-12-21 | Axcess Global Sciences, Llc | Ketone body esters of s-beta-hydroxybutyrate and/or s-1,3-butanediol for modifying metabolic function |
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| US12329734B2 (en) | 2017-12-19 | 2025-06-17 | Axcess Global Sciences, Llc | Use of S-beta-hydroxybutyrate compounds for induction and maintenance of flow |
| US11944598B2 (en) | 2017-12-19 | 2024-04-02 | Axcess Global Sciences, Llc | Compositions containing s-beta-hydroxybutyrate or non-racemic mixtures enriched with the s-enatiomer |
| US10925843B2 (en) | 2018-04-18 | 2021-02-23 | Axcess Global Sciences, Llc | Compositions and methods for keto stacking with beta-hydroxybutyrate and acetoacetate |
| US12496283B2 (en) | 2016-04-19 | 2025-12-16 | Axcess Global Sciences, Llc | Administration of R-beta-hydroxybutyrate and related compounds in humans |
| US12533346B2 (en) | 2016-04-19 | 2026-01-27 | Axcess Global Sciences, Llc | Administration of berberine metabolites |
| US12622889B2 (en) | 2016-04-19 | 2026-05-12 | Axcess Global Sciences, Llc | S-β-hydroxybutyrate esters for improving metabolic function |
| US11806324B2 (en) | 2018-04-18 | 2023-11-07 | Axcess Global Sciences, Llc | Beta-hydroxybutyric acid compositions and methods for oral delivery of ketone bodies |
| JP2019526607A (ja) * | 2016-09-12 | 2019-09-19 | ユニバーシティ・オブ・サウス・フロリダ | ケトンにより改善された神経再生 |
| US10307398B2 (en) | 2016-09-20 | 2019-06-04 | Regents Of The University Of Minnesota | Resuscitation composition and methods of making and using |
| US9925164B1 (en) | 2017-01-12 | 2018-03-27 | Neuroenergy Ventures, Inc. | Glyceryl 3-hydroxybutyrates for traumatic brain injury |
| EP3595628B1 (en) * | 2017-03-16 | 2021-12-01 | RepoCeuticals A/S | Compositions for retarding the decomposition of melatonin in solution |
| WO2018187852A1 (en) * | 2017-04-12 | 2018-10-18 | Cavaleri Franco | Butyrate and beta-hydroxybutyrate compositions and methods of use thereof |
| JP7136807B2 (ja) | 2017-04-17 | 2022-09-13 | ザ・ユニバーシティ・オブ・シカゴ | ヒトの健康及び疾患の治療用途向けの短鎖脂肪酸の腸への送達用ポリマー材料 |
| US10179095B2 (en) * | 2017-06-07 | 2019-01-15 | Dr. Raymond Laboratories | Autophage activating resveratrol topical composition for skin improvement and treatment |
| US12090129B2 (en) | 2017-11-22 | 2024-09-17 | Axcess Global Sciences, Llc | Non-racemic beta-hydroxybutyrate compounds and compositions enriched with the R-enantiomer and methods of use |
| US10980772B2 (en) | 2018-08-27 | 2021-04-20 | Axcess Global Sciences, Llc | Compositions and methods for delivering tetrahydrocannabinol and ketone bodies |
| US11419836B2 (en) | 2019-02-13 | 2022-08-23 | Axcess Global Sciences, Llc | Racemic and near racemic beta-hydroxybutyrate mixed salt-acid compositions |
| US11241401B2 (en) | 2020-02-06 | 2022-02-08 | Axcess Global Sciences, Llc | Enantiomerically pure r-beta-hydroxybutyrate mixed salt-acid compositions |
| US10512615B1 (en) | 2018-08-27 | 2019-12-24 | Axcess Global Sciences, Llc | Compositions and methods for delivering cannabidiol and ketone bodies |
| US11129802B2 (en) | 2018-08-27 | 2021-09-28 | Axcess Global Sciences, Llc | Compositions and methods for delivering cannabidiol and ketone bodies |
| AU2018260927B1 (en) * | 2018-05-25 | 2019-02-21 | Graham Sherard Baldwin | Methods and compositions for inhibiting a noxious insult |
| US20210267251A1 (en) * | 2018-06-21 | 2021-09-02 | Societe Des Produits Nestle S.A. | Compositions and methods using a nicotinamide adenine dinucleotide (nad+) precursor and at least one ketone or ketone precursor |
| JP2020125254A (ja) * | 2019-02-04 | 2020-08-20 | 株式会社協和 | 化粧料、紫外線に対する細胞保護剤、光老化防止剤 |
| US12472200B2 (en) | 2019-05-15 | 2025-11-18 | Axcess Global Sciences, Llc | Autobiotic compositions and method for promoting healthy gut microbiome |
| KR20220016145A (ko) * | 2019-05-30 | 2022-02-08 | 뉴로에너지 벤처스 인코포레이티드 | 글리세릴 트리스(베타-하이드록시부티레이트) 및 신경 일과성 허혈 발작 |
| US12167993B2 (en) | 2019-06-21 | 2024-12-17 | Axcess Global Sciences, Llc | Non-vasoconstricting energy-promoting compositions containing ketone bodies |
| US11950616B2 (en) | 2019-06-21 | 2024-04-09 | Axcess Global Sciences, Llc | Non-vasoconstricting energy-promoting compositions containing ketone bodies |
| US11969430B1 (en) | 2023-03-10 | 2024-04-30 | Axcess Global Sciences, Llc | Compositions containing paraxanthine and beta-hydroxybutyrate or precursor for increasing neurological and physiological performance |
| US11033553B2 (en) | 2019-06-21 | 2021-06-15 | Axcess Global Sciences, Llc | Non-vasoconstricting energy-promoting compositions containing ketone bodies |
| US12186297B2 (en) | 2020-08-26 | 2025-01-07 | Axcess Global Sciences, Llc | Compositions and methods for increasing lean-to-fat mass ratio |
| US20230277484A1 (en) * | 2022-03-04 | 2023-09-07 | Guardian Biosciences, LLC | Compositions and methods to promote brain health |
| CN119345192B (zh) * | 2024-11-27 | 2025-10-28 | 广西医科大学 | N-乙酰血清素在防治糖尿病中的应用 |
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-
2008
- 2008-04-11 RU RU2009141713/15A patent/RU2459624C2/ru not_active IP Right Cessation
- 2008-04-11 US US12/595,586 patent/US9186340B2/en active Active
- 2008-04-11 JP JP2010503249A patent/JP2010523714A/ja active Pending
- 2008-04-11 EP EP08745661A patent/EP2146711A4/en not_active Withdrawn
- 2008-04-11 CN CN200880016109A patent/CN101677996A/zh active Pending
- 2008-04-11 WO PCT/US2008/060100 patent/WO2008128095A1/en not_active Ceased
- 2008-04-11 CA CA002684213A patent/CA2684213A1/en not_active Abandoned
- 2008-04-11 MX MX2009011002A patent/MX2009011002A/es not_active Application Discontinuation
- 2008-04-11 BR BRPI0811052-2A2A patent/BRPI0811052A2/pt not_active IP Right Cessation
- 2008-04-11 AU AU2008240211A patent/AU2008240211A1/en not_active Abandoned
- 2008-04-11 US US12/082,526 patent/US8728532B2/en active Active
- 2008-04-11 KR KR1020097023554A patent/KR20100016456A/ko not_active Withdrawn
-
2009
- 2009-10-11 IL IL201406A patent/IL201406A0/en unknown
-
2014
- 2014-04-24 US US14/260,377 patent/US9149450B2/en active Active
-
2015
- 2015-09-23 US US14/862,416 patent/US20160008325A1/en not_active Abandoned
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