JP2014530847A5 - - Google Patents
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- Publication number
- JP2014530847A5 JP2014530847A5 JP2014536350A JP2014536350A JP2014530847A5 JP 2014530847 A5 JP2014530847 A5 JP 2014530847A5 JP 2014536350 A JP2014536350 A JP 2014536350A JP 2014536350 A JP2014536350 A JP 2014536350A JP 2014530847 A5 JP2014530847 A5 JP 2014530847A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- pharmaceutically acceptable
- acceptable salt
- combination
- oxymetazoline
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 150000003839 salts Chemical class 0.000 claims 21
- 239000008194 pharmaceutical composition Substances 0.000 claims 20
- WYWIFABBXFUGLM-UHFFFAOYSA-N oxymetazoline Chemical compound CC1=CC(C(C)(C)C)=C(O)C(C)=C1CC1=NCCN1 WYWIFABBXFUGLM-UHFFFAOYSA-N 0.000 claims 14
- 150000001875 compounds Chemical class 0.000 claims 12
- XYLJNLCSTIOKRM-UHFFFAOYSA-N Alphagan Chemical compound C1=CC2=NC=CN=C2C(Br)=C1NC1=NCCN1 XYLJNLCSTIOKRM-UHFFFAOYSA-N 0.000 claims 7
- 229960003679 brimonidine Drugs 0.000 claims 7
- 229960001528 oxymetazoline Drugs 0.000 claims 7
- HUCJFAOMUPXHDK-UHFFFAOYSA-N Xylometazoline Chemical compound CC1=CC(C(C)(C)C)=CC(C)=C1CC1=NCCN1 HUCJFAOMUPXHDK-UHFFFAOYSA-N 0.000 claims 6
- KSRGADMGIRTXAF-UHFFFAOYSA-N a-Methyldopamine Chemical compound CC(N)CC1=CC=C(O)C(O)=C1 KSRGADMGIRTXAF-UHFFFAOYSA-N 0.000 claims 6
- 208000001969 capillary hemangioma Diseases 0.000 claims 4
- 239000000203 mixture Substances 0.000 claims 4
- SFLSHLFXELFNJZ-QMMMGPOBSA-N (-)-norepinephrine Chemical compound NC[C@H](O)C1=CC=C(O)C(O)=C1 SFLSHLFXELFNJZ-QMMMGPOBSA-N 0.000 claims 3
- UCTWMZQNUQWSLP-VIFPVBQESA-N (R)-adrenaline Chemical compound CNC[C@H](O)C1=CC=C(O)C(O)=C1 UCTWMZQNUQWSLP-VIFPVBQESA-N 0.000 claims 3
- 229930182837 (R)-adrenaline Natural products 0.000 claims 3
- KWTSXDURSIMDCE-QMMMGPOBSA-N (S)-amphetamine Chemical compound C[C@H](N)CC1=CC=CC=C1 KWTSXDURSIMDCE-QMMMGPOBSA-N 0.000 claims 3
- WDZVGELJXXEGPV-YIXHJXPBSA-N Guanabenz Chemical compound NC(N)=N\N=C\C1=C(Cl)C=CC=C1Cl WDZVGELJXXEGPV-YIXHJXPBSA-N 0.000 claims 3
- INJOMKTZOLKMBF-UHFFFAOYSA-N Guanfacine Chemical compound NC(=N)NC(=O)CC1=C(Cl)C=CC=C1Cl INJOMKTZOLKMBF-UHFFFAOYSA-N 0.000 claims 3
- WJAJPNHVVFWKKL-UHFFFAOYSA-N Methoxamine Chemical compound COC1=CC=C(OC)C(C(O)C(C)N)=C1 WJAJPNHVVFWKKL-UHFFFAOYSA-N 0.000 claims 3
- DUGOZIWVEXMGBE-UHFFFAOYSA-N Methylphenidate Chemical compound C=1C=CC=CC=1C(C(=O)OC)C1CCCCN1 DUGOZIWVEXMGBE-UHFFFAOYSA-N 0.000 claims 3
- WPNJAUFVNXKLIM-UHFFFAOYSA-N Moxonidine Chemical compound COC1=NC(C)=NC(Cl)=C1NC1=NCCN1 WPNJAUFVNXKLIM-UHFFFAOYSA-N 0.000 claims 3
- 229940025084 amphetamine Drugs 0.000 claims 3
- 229960004253 dexmedetomidine Drugs 0.000 claims 3
- HRLIOXLXPOHXTA-NSHDSACASA-N dexmedetomidine Chemical compound C1([C@@H](C)C=2C(=C(C)C=CC=2)C)=CN=C[N]1 HRLIOXLXPOHXTA-NSHDSACASA-N 0.000 claims 3
- 229960005139 epinephrine Drugs 0.000 claims 3
- 229960004553 guanabenz Drugs 0.000 claims 3
- 229960002048 guanfacine Drugs 0.000 claims 3
- 229960005209 lofexidine Drugs 0.000 claims 3
- KSMAGQUYOIHWFS-UHFFFAOYSA-N lofexidine Chemical compound N=1CCNC=1C(C)OC1=C(Cl)C=CC=C1Cl KSMAGQUYOIHWFS-UHFFFAOYSA-N 0.000 claims 3
- 229960005192 methoxamine Drugs 0.000 claims 3
- 229960001344 methylphenidate Drugs 0.000 claims 3
- 229960003938 moxonidine Drugs 0.000 claims 3
- 229960002748 norepinephrine Drugs 0.000 claims 3
- SFLSHLFXELFNJZ-UHFFFAOYSA-N norepinephrine Natural products NCC(O)C1=CC=C(O)C(O)=C1 SFLSHLFXELFNJZ-UHFFFAOYSA-N 0.000 claims 3
- 229960001802 phenylephrine Drugs 0.000 claims 3
- SONNWYBIRXJNDC-VIFPVBQESA-N phenylephrine Chemical compound CNC[C@H](O)C1=CC=CC(O)=C1 SONNWYBIRXJNDC-VIFPVBQESA-N 0.000 claims 3
- 229960000833 xylometazoline Drugs 0.000 claims 3
- IWEGDQUCWQFKHS-UHFFFAOYSA-N 1-(1,3-dioxolan-2-ylmethyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazole Chemical group O1C(C)(C)C(C)(C)OB1C1=CN(CC2OCCO2)N=C1 IWEGDQUCWQFKHS-UHFFFAOYSA-N 0.000 claims 2
- 239000004480 active ingredient Substances 0.000 claims 2
- 229960001724 brimonidine tartrate Drugs 0.000 claims 2
- 239000003246 corticosteroid Substances 0.000 claims 2
- 229960001334 corticosteroids Drugs 0.000 claims 2
- 229960005162 oxymetazoline hydrochloride Drugs 0.000 claims 2
- BEEDODBODQVSIM-UHFFFAOYSA-N oxymetazoline hydrochloride Chemical group Cl.CC1=CC(C(C)(C)C)=C(O)C(C)=C1CC1=NCCN1 BEEDODBODQVSIM-UHFFFAOYSA-N 0.000 claims 2
- RLHGFJMGWQXPBW-UHFFFAOYSA-N 2-hydroxy-3-(1h-imidazol-5-ylmethyl)benzamide Chemical compound NC(=O)C1=CC=CC(CC=2NC=NC=2)=C1O RLHGFJMGWQXPBW-UHFFFAOYSA-N 0.000 claims 1
- 241001116389 Aloe Species 0.000 claims 1
- 102000014150 Interferons Human genes 0.000 claims 1
- 108010050904 Interferons Proteins 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- SHGAZHPCJJPHSC-YCNIQYBTSA-N all-trans-retinoic acid Chemical class OC(=O)\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C SHGAZHPCJJPHSC-YCNIQYBTSA-N 0.000 claims 1
- 235000011399 aloe vera Nutrition 0.000 claims 1
- 239000004037 angiogenesis inhibitor Substances 0.000 claims 1
- 230000000507 anthelmentic effect Effects 0.000 claims 1
- 229940124339 anthelmintic agent Drugs 0.000 claims 1
- 239000000921 anthelmintic agent Substances 0.000 claims 1
- 230000000844 anti-bacterial effect Effects 0.000 claims 1
- 229940124599 anti-inflammatory drug Drugs 0.000 claims 1
- 229940088710 antibiotic agent Drugs 0.000 claims 1
- 239000003963 antioxidant agent Substances 0.000 claims 1
- 238000002347 injection Methods 0.000 claims 1
- 239000007924 injection Substances 0.000 claims 1
- 229940079322 interferon Drugs 0.000 claims 1
- 238000002647 laser therapy Methods 0.000 claims 1
- -1 mibazelol Chemical compound 0.000 claims 1
- 229950010998 mivazerol Drugs 0.000 claims 1
- 229940021182 non-steroidal anti-inflammatory drug Drugs 0.000 claims 1
- 239000003755 preservative agent Substances 0.000 claims 1
- 230000002335 preservative effect Effects 0.000 claims 1
- 238000001959 radiotherapy Methods 0.000 claims 1
- 230000003637 steroidlike Effects 0.000 claims 1
- 230000000475 sunscreen effect Effects 0.000 claims 1
- 239000000516 sunscreening agent Substances 0.000 claims 1
- 238000007910 systemic administration Methods 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 claims 1
- 238000011200 topical administration Methods 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161548838P | 2011-10-19 | 2011-10-19 | |
| US61/548,838 | 2011-10-19 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2014530847A JP2014530847A (ja) | 2014-11-20 |
| JP2014530847A5 true JP2014530847A5 (enExample) | 2015-11-26 |
Family
ID=47630411
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014536350A Pending JP2014530847A (ja) | 2011-10-19 | 2012-10-15 | 毛細血管腫の治療方法 |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US20150044148A1 (enExample) |
| EP (1) | EP2768501A1 (enExample) |
| JP (1) | JP2014530847A (enExample) |
| KR (1) | KR20140091544A (enExample) |
| CN (1) | CN103889416A (enExample) |
| AU (1) | AU2012324544B2 (enExample) |
| BR (1) | BR112014009209A2 (enExample) |
| CA (1) | CA2850277A1 (enExample) |
| IL (1) | IL231821A0 (enExample) |
| MX (1) | MX2014004386A (enExample) |
| PH (1) | PH12014500785A1 (enExample) |
| RU (1) | RU2014119919A (enExample) |
| WO (1) | WO2013057580A1 (enExample) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI704933B (zh) | 2013-10-07 | 2020-09-21 | 美商帝國製藥美國股份有限公司 | 右美托咪啶經皮輸送裝置及使用其之方法 |
| TWI709417B (zh) | 2013-10-07 | 2020-11-11 | 美商帝國製藥美國股份有限公司 | 使用右美托咪啶經皮組成物用於治療注意力不足過動症、焦慮及失眠的方法及組成物 |
| CN105764496B (zh) | 2013-10-07 | 2020-09-25 | 帝国制药美国公司 | 用于经皮递送非镇静量的右旋美托咪啶的方法和组合物 |
| EP4138803A1 (en) * | 2020-04-21 | 2023-03-01 | Université catholique de Louvain | Alpha-2 adrenergic receptor agonists for the treatment of cancer |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3278447A (en) | 1963-12-02 | 1966-10-11 | Cloro Bac Products Inc | Process for stabilizing chlorine dioxide solution |
| CA2003198C (en) | 1988-11-29 | 1995-03-21 | Anthony J. Dziabo, Jr. | Aqueous ophthalmic solutions and method for preserving same |
| US5736165A (en) | 1993-05-25 | 1998-04-07 | Allergan | In-the-eye use of chlorine dioxide-containing compositions |
| CN1108565A (zh) * | 1994-10-21 | 1995-09-20 | 孙强 | 百草滴鼻液及其制备方法 |
| US6194415B1 (en) | 1995-06-28 | 2001-02-27 | Allergan Sales, Inc. | Method of using (2-imidazolin-2-ylamino) quinoxoalines in treating neural injury |
| US6468989B1 (en) | 2000-07-13 | 2002-10-22 | Dow Pharmaceutical Sciences | Gel compositions containing metronidazole |
| US6387383B1 (en) | 2000-08-03 | 2002-05-14 | Dow Pharmaceutical Sciences | Topical low-viscosity gel composition |
| CN1391901A (zh) * | 2001-06-18 | 2003-01-22 | 赵培玲 | 治疗血管瘤的注射剂 |
| US7439241B2 (en) | 2003-05-27 | 2008-10-21 | Galderma Laboratories, Inc. | Compounds, formulations, and methods for treating or preventing rosacea |
| US20050244463A1 (en) * | 2004-04-30 | 2005-11-03 | Allergan, Inc. | Sustained release intraocular implants and methods for treating ocular vasculopathies |
| US20070082070A1 (en) * | 2005-10-11 | 2007-04-12 | Stookey Evangeline L | Treating skin disorders |
| US8633181B2 (en) * | 2009-04-09 | 2014-01-21 | Rutgers, The State University Of New Jersey | Treatment of cutaneous hemangioma |
| CN101962404A (zh) * | 2010-06-17 | 2011-02-02 | 中国热带农业科学院热带生物技术研究所 | 一种用于治疗血管瘤的蛋白质 |
-
2012
- 2012-10-15 CA CA2850277A patent/CA2850277A1/en not_active Abandoned
- 2012-10-15 US US14/344,091 patent/US20150044148A1/en not_active Abandoned
- 2012-10-15 JP JP2014536350A patent/JP2014530847A/ja active Pending
- 2012-10-15 RU RU2014119919/15A patent/RU2014119919A/ru not_active Application Discontinuation
- 2012-10-15 KR KR1020147011913A patent/KR20140091544A/ko not_active Withdrawn
- 2012-10-15 AU AU2012324544A patent/AU2012324544B2/en not_active Ceased
- 2012-10-15 BR BR112014009209A patent/BR112014009209A2/pt not_active IP Right Cessation
- 2012-10-15 CN CN201280051518.7A patent/CN103889416A/zh active Pending
- 2012-10-15 PH PH1/2014/500785A patent/PH12014500785A1/en unknown
- 2012-10-15 EP EP12820881.6A patent/EP2768501A1/en not_active Withdrawn
- 2012-10-15 MX MX2014004386A patent/MX2014004386A/es unknown
- 2012-10-15 WO PCT/IB2012/002509 patent/WO2013057580A1/en not_active Ceased
-
2014
- 2014-03-31 IL IL231821A patent/IL231821A0/en unknown
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